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Accelerated human liver progenitor generation from pluripotent stem cells by inhibiting formation of unwanted lineages

https://doi.org/10.1101/174698
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Outgoing claims: the papers this work cites, builds on, or argues with.

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LIVER COMA, WITH PARTICULAR REFERENCE TO MANAGEMENT
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Mutations in the fumarylacetoacetate hydrolase gene causing hereditary tyrosinemia type I: Overview
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Definitive endoderm of the mouse embryo: Formation, cell fates, and morphogenetic function
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Vertebrate intestinal endoderm development
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Directed differentiation of human embryonic stem cells into functional hepatic cells†
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Flow cytometric isolation and clonal identification of self-renewing bipotent hepatic progenitor cells in adult mouse liver
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Highly Efficient Generation of Human Hepatocyte–Like Cells From Induced Pluripotent Stem Cells
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Generation of Functional Hepatocytes From Human Embryonic Stem Cells Under Chemically Defined Conditions That Recapitulate Liver Development
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Ionizing Radiation Induces Ataxia Telangiectasia Mutated-Dependent Checkpoint Signaling and G2 But Not G1 Cell Cycle Arrest in Pluripotent Human Embryonic Stem Cells
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Liver Zonation
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Zonation of metabolism and gene expression in liver
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Mapping the Pairwise Choices Leading from Pluripotency to Human Bone, Heart, and Other Mesoderm Cell Types
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Bmp2 Signaling Regulates the Hepatic versus Pancreatic Fate Decision
inferredcites →https://doi.org/10.1016/j.devcel.2009.05.012openalex-snapshot
Sox17 Regulates Organ Lineage Segregation of Ventral Foregut Progenitor Cells
inferredcites →https://doi.org/10.1016/j.devcel.2014.01.006openalex-snapshot
Prostaglandin E2 Regulates Liver versus Pancreas Cell-Fate Decisions and Endodermal Outgrowth
inferredcites →https://doi.org/10.1016/j.mod.2011.07.005openalex-snapshot
Wnt signaling specifies and patterns intestinal endoderm
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Reprogramming Fibroblasts into Bipotential Hepatic Stem Cells by Defined Factors
inferredcites →https://doi.org/10.1016/j.stem.2013.12.007openalex-snapshot
Efficient Endoderm Induction from Human Pluripotent Stem Cells by Logically Directing Signals Controlling Lineage Bifurcations
inferredcites →https://doi.org/10.1016/j.stem.2014.01.003openalex-snapshot
Direct Reprogramming of Human Fibroblasts to Functional and Expandable Hepatocytes
inferredcites →https://doi.org/10.1016/j.stem.2014.04.010openalex-snapshot
Stem/Progenitor Cells in Liver Development, Homeostasis, Regeneration, and Reprogramming
inferredcites →https://doi.org/10.1016/j.stem.2016.01.010openalex-snapshot
Direct Reprogramming of Hepatic Myofibroblasts into Hepatocytes In Vivo Attenuates Liver Fibrosis
inferredcites →https://doi.org/10.1016/j.ydbio.2005.01.003openalex-snapshot
Distinct populations of endoderm cells converge to generate the embryonic liver bud and ventral foregut tissues
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Foetal rise in hepatic enzymes follows decline in c-met and hepatocyte growth factor expression
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Mechanisms controlling early development of the liver
inferredcites →https://doi.org/10.1016/s0960-9822(02)00929-6openalex-snapshot
Retinoic Acid Signaling Is Required for a Critical Early Step in Zebrafish Pancreatic Development
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Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells
inferredcites →https://doi.org/10.1038/cr.2012.144openalex-snapshot
Promotion of the efficient metabolic maturation of human pluripotent stem cell-derived hepatocytes by correcting specification defects
inferredcites →https://doi.org/10.1038/nature09691openalex-snapshot
Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro
inferredcites →https://doi.org/10.1038/nature10263openalex-snapshot
Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors
inferredcites →https://doi.org/10.1038/nature12271openalex-snapshot
Vascularized and functional human liver from an iPSC-derived organ bud transplant
inferredcites →https://doi.org/10.1038/nature13020openalex-snapshot
Mouse liver repopulation with hepatocytes generated from human fibroblasts
inferredcites →https://doi.org/10.1038/nature16526openalex-snapshot
High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects
inferredcites →https://doi.org/10.1038/nbt.1927openalex-snapshot
Genetic engineering of human ES and iPS cells using TALE nucleases
inferredcites →https://doi.org/10.1038/nbt.2249openalex-snapshot
Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors
inferredcites →https://doi.org/10.1038/nbt.3275openalex-snapshot
Cholangiocytes derived from human induced pluripotent stem cells for disease modeling and drug validation
inferredcites →https://doi.org/10.1038/nbt.3294openalex-snapshot
Directed differentiation of cholangiocytes from human pluripotent stem cells
inferredcites →https://doi.org/10.1038/nbt.3777openalex-snapshot
Combined small-molecule inhibition accelerates the derivation of functional cortical neurons from human pluripotent stem cells
inferredcites →https://doi.org/10.1038/nbt1163openalex-snapshot
Efficient differentiation of human embryonic stem cells to definitive endoderm
inferredcites →https://doi.org/10.1038/nbt1258openalex-snapshot
BMP-4 is required for hepatic specification of mouse embryonic stem cell–derived definitive endoderm
inferredcites →https://doi.org/10.1038/nbt1326openalex-snapshot
Robust expansion of human hepatocytes in Fah−/−/Rag2−/−/Il2rg−/− mice
inferredcites →https://doi.org/10.1038/nbt957openalex-snapshot
Correction of multi-gene deficiency in vivo using a single 'self-cleaving' 2A peptide–based retroviral vector
inferredcites →https://doi.org/10.1038/ng0396-266openalex-snapshot
Hepatocytes corrected by gene therapy are selected in vivo in a murine model of hereditary tyrosinaemia type I
inferredcites →https://doi.org/10.1038/ng0506-500openalex-snapshot
GenePattern 2.0
inferredcites →https://doi.org/10.1038/nmeth.2171openalex-snapshot
Improving FRET dynamic range with bright green and red fluorescent proteins
inferredcites →https://doi.org/10.1038/nprot.2008.211openalex-snapshot
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
inferredcites →https://doi.org/10.1038/nrg2938openalex-snapshot
Turning straw into gold: directing cell fate for regenerative medicine
inferredcites →https://doi.org/10.1038/s41591-018-0050-6openalex-snapshot
p53 inhibits CRISPR–Cas9 engineering in human pluripotent stem cells
inferredcites →https://doi.org/10.1038/srep03355openalex-snapshot
Generation of mutant mice by pronuclear injection of circular plasmid expressing Cas9 and single guided RNA
inferredcites →https://doi.org/10.1053/j.gastro.2008.10.047openalex-snapshot
Differentiation and Transplantation of Human Embryonic Stem Cell–Derived Hepatocytes
inferredcites →https://doi.org/10.1053/j.gastro.2009.03.035openalex-snapshot
Mechanisms of Liver Development: Concepts for Understanding Liver Disorders and Design of Novel Therapies
inferredcites →https://doi.org/10.1073/pnas.85.1.160openalex-snapshot
Distribution of glutamine synthetase and carbamoyl-phosphate synthetase I in vertebrate liver.
inferredcites →https://doi.org/10.1093/hmg/2.7.941openalex-snapshot
Characterization of the human fumarylacetoacetate hydrolase gene and identification of a missense mutation abolishing enzymatic activity
inferredcites →https://doi.org/10.1093/nar/gkn923openalex-snapshot
Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists
inferredcites →https://doi.org/10.1101/gad.904601openalex-snapshot
Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endoderm
inferredcites →https://doi.org/10.1111/j.1365-2443.2008.01201.xopenalex-snapshot
Differentiation of mouse and human embryonic stem cells into hepatic lineages
inferredcites →https://doi.org/10.1126/science.1174497openalex-snapshot
Dynamic Signaling Network for the Specification of Embryonic Pancreas and Liver Progenitors
inferredcites →https://doi.org/10.1126/science.1231143openalex-snapshot
Multiplex Genome Engineering Using CRISPR/Cas Systems
inferredcites →https://doi.org/10.1126/science.284.5422.1998openalex-snapshot
Initiation of Mammalian Liver Development from Endoderm by Fibroblast Growth Factors
inferredcites →https://doi.org/10.1126/science.aad5227openalex-snapshot
Rationally engineered Cas9 nucleases with improved specificity
inferredcites →https://doi.org/10.1146/annurev-physiol-021113-170255openalex-snapshot
Cellular Homeostasis and Repair in the Mammalian Liver
inferredcites →https://doi.org/10.1146/annurev.cellbio.042308.113344openalex-snapshot
Vertebrate Endoderm Development and Organ Formation
inferredcites →https://doi.org/10.1172/jci43122openalex-snapshot
Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells
inferredcites →https://doi.org/10.1172/jci43267openalex-snapshot
Induced pluripotent stem cell–derived hepatocytes have the functional and proliferative capabilities needed for liver regeneration in mice
inferredcites →https://doi.org/10.1172/jci75456openalex-snapshot
Engrafted human stem cell–derived hepatocytes establish an infectious HCV murine model
inferredcites →https://doi.org/10.1182/blood-2006-08-040956openalex-snapshot
Human plasma fibrinogen is synthesized in the liver
inferredcites →https://doi.org/10.1186/cc11218openalex-snapshot
Human albumin in the management of complications of liver cirrhosis
inferredcites →https://doi.org/10.1242/dev.000281openalex-snapshot
Bmp and Fgf signaling are essential for liver specification in zebrafish
inferredcites →https://doi.org/10.1242/dev.001230openalex-snapshot
Repression of Wnt/β-catenin signaling in the anterior endoderm is essential for liver and pancreas development
inferredcites →https://doi.org/10.1242/dev.090266openalex-snapshot
Three-dimensional culture and cAMP signaling promote the maturation of human pluripotent stem cell-derived hepatocytes
inferredcites →https://doi.org/10.1242/dev.113.1.217openalex-snapshot
Hepatocyte differentiation initiates during endodermal-mesenchymal interactions prior to liver formation
inferredcites →https://doi.org/10.1242/dev.113.3.891openalex-snapshot
Clonal analysis of epiblast fate during germ layer formation in the mouse embryo
inferredcites →https://doi.org/10.1242/dev.114215openalex-snapshot
Orchestrating liver development
inferredcites →https://doi.org/10.1242/dev.12.4.651openalex-snapshot
Induction de l’endoderme pré-hépatique par le mésoderme de l’aire cardiaque chez l’embryon de poulet
inferredcites →https://doi.org/10.1242/dev.125.1.85openalex-snapshot
Hex: a homeobox gene revealing peri-implantation asymmetry in the mouse embryo and an early transient marker of endothelial cell precursors
inferredcites →https://doi.org/10.1242/dev.63.1.111openalex-snapshot
Hepatic induction in the avian embryo: Specificity of reactive endoderm and inductive mesoderm
inferredcites →https://doi.org/10.1242/dev.99.1.109openalex-snapshot
The formation of mesodermal tissues in the mouse embryo during gastrulation and early organogenesis
inferredcites →https://doi.org/10.1371/journal.pone.0005845openalex-snapshot
Retinoic Acid Signaling Organizes Endodermal Organ Specification along the Entire Antero-Posterior Axis
inferredcites →https://doi.org/10.1371/journal.pone.0013410openalex-snapshot
DNA Damage Responses in Human Induced Pluripotent Stem Cells and Embryonic Stem Cells
inferredcites →https://doi.org/10.1371/journal.pone.0018556openalex-snapshot
High Cleavage Efficiency of a 2A Peptide Derived from Porcine Teschovirus-1 in Human Cell Lines, Zebrafish and Mice
inferredcites →https://doi.org/10.1387/ijdb.041946agopenalex-snapshot
Antero-posterior patterning of the vertebrate digestive tract: 40 years after Nicole Le Douarin's PhD thesis
inferredcites →https://doi.org/10.1634/stemcells.2007-1102openalex-snapshot
Efficient Differentiation of Functional Hepatocytes from Human Embryonic Stem Cells
inferredcites →https://doi.org/10.2144/000112517openalex-snapshot
ImageJ for Microscopy
inferredcites →https://doi.org/10.4172/2157-7633.s10-007openalex-snapshot
Embryonic Stem Cells: A Perfect Tool for Studying Mammalian Transcriptional Enhancers
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Generation of Functional Hepatic Cells from Pluripotent Stem Cells
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