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Mechanism-based enzyme activating compounds

https://doi.org/10.1101/2020.04.08.032235

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Structural Basis of Sirtuin 6 Activation by Synthetic Small Molecules

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Brought to life: targeted activation of enzyme function with small molecules

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Numerical integration of the cartesian equations of motion of a system with constraints: molecular dynamics of n-alkanes

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Structural Role of RKS Motifs in Chromatin Interactions: A Molecular Dynamics Study of HP1 Bound to a Variably Modified Histone Tail

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SIRT3 Reverses Aging-Associated Degeneration

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The SIRT1 Activator SRT1720 Extends Lifespan and Improves Health of Mice Fed a Standard Diet

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Chemical Activation of Sir2-Dependent Silencing by Relief of Nicotinamide Inhibition

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Structural Basis for Allosteric Regulation of the Monomeric Allosteric Enzyme Human Glucokinase

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Sequence optimization and designability of enzyme active sites

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Ex-527 inhibits Sirtuins by exploiting their unique NAD + -dependent deacetylation mechanism

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Activation of the Protein Deacetylase SIRT6 by Long-chain Fatty Acids and Widespread Deacylation by Mammalian Sirtuins

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Mutations inSaccharomyces cerevisiaeGeneSIR2Can Have Differential Effects on In Vivo Silencing Phenotypes and In Vitro Histone Deacetylation Activity

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Nonallosteric Sirtuin Enzyme Activation: Characterization of Hit Compounds

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The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

inferredcites →https://doi.org/10.1111/acel.12220openalex-snapshot

SRT 2104 extends survival of male mice on a standard diet and preserves bone and muscle mass

inferredcites →https://doi.org/10.1126/science.1108595openalex-snapshot

Allosteric Mechanisms of Signal Transduction

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Small Molecule-Induced Allosteric Activation of the Vibrio cholerae RTX Cysteine Protease Domain

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Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators

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A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging

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Small-Molecule Allosteric Activators of Sirtuins

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Mechanism of Inhibition of the Human Sirtuin Enzyme SIRT3 by Nicotinamide: Computational and Experimental Studies

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Biophysical characterization of hit compounds for mechanism-based enzyme activation

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SIRT2 induces the checkpoint kinase BubR1 to increase lifespan

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What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1016/j.bmc.2022.116999openalex-snapshot

Discovery of novel compounds as potent activators of Sirt3

inferred← citeshttps://doi.org/10.1038/s44320-025-00111-7openalex-snapshot

An enzyme activation network reveals extensive regulatory crosstalk between metabolic pathways

inferred← citeshttps://doi.org/10.1101/2020.04.17.045187openalex-snapshot

Nonallosteric Sirtuin Enzyme Activation: Characterization of Hit Compounds

inferred← citeshttps://doi.org/10.1101/2023.11.16.567372openalex-snapshot

An enzyme activation network provides evidence for extensive regulatory crosstalk between metabolic pathways

inferred← citeshttps://doi.org/10.1103/physrevx.14.041019openalex-snapshot

Computationally Driven Discovery and Characterization of SIRT3-Activating Compounds that Fully Recover Catalytic Activity under NAD + Depletion

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