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Alveolar early progenitors in the aged human lung have increased expression of ACE2 accompanied with genes involved in beta-amyloid clearance: Indication of SARS-CoV-2 also using soluble ACE2 in aged-lungs to enter ACE2-negative cells

https://doi.org/10.1101/2020.05.25.115774

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Clinical characteristics and drug therapies in patients with the common-type coronavirus disease 2019 in Hunan, China

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Apolipoprotein E uptake and degradation via chloroquine-sensitive pathway in cultivated monkey cells overexpressing low density lipoprotein receptor

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Alzheimer’s Disease Risk Genes and Mechanisms of Disease Pathogenesis

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Comprehensive Integration of Single-Cell Data

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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

inferredcites →https://doi.org/10.1016/j.cell.2020.04.035openalex-snapshot

SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues

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Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

inferredcites →https://doi.org/10.1016/j.neuron.2016.06.015openalex-snapshot

TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia

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Regeneration of the lung alveolus by an evolutionarily conserved epithelial progenitor

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Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation

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A critical appraisal of amyloid-β-targeting therapies for Alzheimer disease

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Charting the cis-regulome of activated B cells by coupling structural and functional genomics

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Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19

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Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1

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A Novel Coronavirus from Patients with Pneumonia in China, 2019

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Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19

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Tumor Necrosis Factor-α Convertase (ADAM17) Mediates Regulated Ectodomain Shedding of the Severe-acute Respiratory Syndrome-Coronavirus (SARS-CoV) Receptor, Angiotensin-converting Enzyme-2 (ACE2)

inferredcites →https://doi.org/10.1093/bioinformatics/btl567openalex-snapshot

Using GOstats to test gene lists for GO term association

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STAR: ultrafast universal RNA-seq aligner

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CellMarker: a manually curated resource of cell markers in human and mouse

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Cathepsin L Functionally Cleaves the Severe Acute Respiratory Syndrome Coronavirus Class I Fusion Protein Upstream of Rather than Adjacent to the Fusion Peptide

inferredcites →https://doi.org/10.1152/ajplung.00071.2009openalex-snapshot

Ectodomain shedding of angiotensin converting enzyme 2 in human airway epithelia

inferredcites →https://doi.org/10.1152/ajpregu.00222.2010openalex-snapshot

ACE2/ANG-(1–7)/Mas pathway in the brain: the axis of good

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Association of Inpatient Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers With Mortality Among Patients With Hypertension Hospitalized With COVID-19

inferredcites →https://doi.org/10.1164/rccm.201712-2410ocopenalex-snapshot

Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis

inferredcites →https://doi.org/10.1172/jci.insight.137662openalex-snapshot

Characteristics and diagnosis rate of 5630 subjects receiving SARS-CoV-2 nucleic acid tests from Wuhan, China

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Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease

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The lung in amyloidosis

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Slingshot: cell lineage and pseudotime inference for single-cell transcriptomics

inferredcites →https://doi.org/10.1186/s13195-016-0217-7openalex-snapshot

Angiotensin-converting enzyme 2 is reduced in Alzheimer’s disease in association with increasing amyloid-β and tau pathology

inferredcites →https://doi.org/10.1212/wnl.0000000000004733openalex-snapshot

Increased florbetapir binding in the temporal neocortex from age 20 to 60 years

inferredcites →https://doi.org/10.2174/1567205013666160930110551openalex-snapshot

Targeting Tumor Necrosis Factor Alpha for Alzheimer’s Disease

inferredcites →https://doi.org/10.4062/biomolther.2012.20.3.245openalex-snapshot

Mechanisms of Amyloid-β Peptide Clearance: Potential Therapeutic Targets for Alzheimer's Disease

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1126/scisignal.abe5137openalex-snapshot

CISH attenuates homeostatic cytokine signaling to promote lung-specific macrophage programming and function

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