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Severely ill COVID-19 patients display augmented functional properties in SARS-CoV-2-reactive CD8 + T cells

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1007/978-3-319-15774-0_10openalex-snapshot
Immune Memory and Exhaustion: Clinically Relevant Lessons from the LCMV Model
inferredcites →https://doi.org/10.1016/j.antiviral.2012.03.009openalex-snapshot
Polyfunctional CD8+ T cells are associated with the vaccination-induced control of a novel recombinant influenza virus expressing an HCV epitope
inferredcites →https://doi.org/10.1016/j.cell.2016.08.052openalex-snapshot
A Distinct Gene Module for Dysfunction Uncoupled from Activation in Tumor-Infiltrating T Cells
inferredcites →https://doi.org/10.1016/j.cell.2016.09.050openalex-snapshot
Regulatory T Cell Specificity Directs Tolerance versus Allergy against Aeroantigens in Humans
inferredcites →https://doi.org/10.1016/j.cell.2017.05.035openalex-snapshot
Landscape of Infiltrating T Cells in Liver Cancer Revealed by Single-Cell Sequencing
inferredcites →https://doi.org/10.1016/j.cell.2018.09.006openalex-snapshot
A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade
inferredcites →https://doi.org/10.1016/j.cell.2018.10.038openalex-snapshot
Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma
inferredcites →https://doi.org/10.1016/j.cell.2018.11.043openalex-snapshot
Dysfunctional CD8 T Cells Form a Proliferative, Dynamically Regulated Compartment within Human Melanoma
inferredcites →https://doi.org/10.1016/j.cell.2019.01.041openalex-snapshot
Human Anti-fungal Th17 Immunity and Pathology Rely on Cross-Reactivity against Candida albicans
inferredcites →https://doi.org/10.1016/j.cell.2019.05.031openalex-snapshot
Comprehensive Integration of Single-Cell Data
inferredcites →https://doi.org/10.1016/j.cell.2020.05.015openalex-snapshot
Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals
inferredcites →https://doi.org/10.1016/j.cell.2020.08.017openalex-snapshot
Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19
inferredcites →https://doi.org/10.1016/j.cell.2020.10.001openalex-snapshot
Imbalance of Regulatory and Cytotoxic SARS-CoV-2-Reactive CD4+ T Cells in COVID-19
inferredcites →https://doi.org/10.1016/j.cytogfr.2008.01.001openalex-snapshot
Interferon and cytokine responses to SARS-coronavirus infection
inferredcites →https://doi.org/10.1016/j.immuni.2007.12.014openalex-snapshot
Apoptosis Regulators Bim and Fas Function Concurrently to Control Autoimmunity and CD8+ T Cell Contraction
inferredcites →https://doi.org/10.1016/j.immuni.2017.09.006openalex-snapshot
Early Transcriptional Divergence Marks Virus-Specific Primary Human CD8+ T Cells in Chronic versus Acute Infection
inferredcites →https://doi.org/10.1016/j.immuni.2019.08.013openalex-snapshot
The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8+ T Cell Fitness and Functionality
inferredcites →https://doi.org/10.1016/j.immuni.2019.10.007openalex-snapshot
Large-Scale HLA Tetramer Tracking of T Cells during Dengue Infection Reveals Broad Acute Activation and Differentiation into Two Memory Cell Fates
inferredcites →https://doi.org/10.1016/j.xcrm.2020.100092openalex-snapshot
Robust T Cell Response Toward Spike, Membrane, and Nucleocapsid SARS-CoV-2 Proteins Is Not Associated with Recovery in Critical COVID-19 Patients
inferredcites →https://doi.org/10.1016/s0264-410x(02)00067-1openalex-snapshot
HIV T cell vaccines, the importance of clades
inferredcites →https://doi.org/10.1016/s0264-410x(97)00226-0openalex-snapshot
Enhancement of MHC class I-restricted peptide-specific T cell induction by a DNA prime/MVA boost vaccination regime
inferredcites →https://doi.org/10.1038/nbt.2859openalex-snapshot
The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells
inferredcites →https://doi.org/10.1038/ncomms4551openalex-snapshot
Bhlhe40 controls cytokine production by T cells and is essential for pathogenicity in autoimmune neuroinflammation
inferredcites →https://doi.org/10.1038/nri2204openalex-snapshot
BLIMP1 guides the fate of effector B and T cells
inferredcites →https://doi.org/10.1038/nri2802openalex-snapshot
Immunity and immunopathology to viruses: what decides the outcome?
inferredcites →https://doi.org/10.1038/s41556-018-0217-xopenalex-snapshot
Metabolism as a guiding force for immunity
inferredcites →https://doi.org/10.1038/s41577-020-0308-3openalex-snapshot
COVID-19: immunopathology and its implications for therapy
inferredcites →https://doi.org/10.1038/s41586-019-1325-xopenalex-snapshot
TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion
inferredcites →https://doi.org/10.1038/s41586-019-1805-zopenalex-snapshot
c-Jun overexpression in CAR T cells induces exhaustion resistance
inferredcites →https://doi.org/10.1038/s41586-020-2598-9openalex-snapshot
SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19
inferredcites →https://doi.org/10.1038/s41587-020-0602-4openalex-snapshot
COVID-19 severity correlates with airway epithelium–immune cell interactions identified by single-cell analysis
inferredcites →https://doi.org/10.1038/s41590-019-0403-4openalex-snapshot
Single-cell RNA-seq reveals TOX as a key regulator of CD8+ T cell persistence in chronic infection
inferredcites →https://doi.org/10.1038/s41590-020-0622-8openalex-snapshot
A molecular network regulating the proinflammatory phenotype of human memory T lymphocytes
inferredcites →https://doi.org/10.1038/s41590-020-0782-6openalex-snapshot
Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19
inferredcites →https://doi.org/10.1038/s41591-018-0045-3openalex-snapshot
Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing
inferredcites →https://doi.org/10.1038/s41591-020-0819-2openalex-snapshot
Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe COVID-19
inferredcites →https://doi.org/10.1038/s41591-020-0858-8openalex-snapshot
T cell-inducing vaccine durably prevents mucosal SHIV infection even with lower neutralizing antibody titers
inferredcites →https://doi.org/10.1038/s41591-020-0901-9openalex-snapshot
Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19
inferredcites →https://doi.org/10.1038/s41591-020-1038-6openalex-snapshot
A dynamic COVID-19 immune signature includes associations with poor prognosis
inferredcites →https://doi.org/10.1038/s41598-021-86002-xopenalex-snapshot
Comprehensive transcriptomic analysis of COVID-19 blood, lung, and airway
inferredcites →https://doi.org/10.1073/pnas.0707570104openalex-snapshot
Skewed association of polyfunctional antigen-specific CD8 T cell populations with HLA-B genotype
inferredcites →https://doi.org/10.1073/pnas.1808849116openalex-snapshot
CD4 + T help promotes influenza virus-specific CD8 + T cell memory by limiting metabolic dysfunction
inferredcites →https://doi.org/10.1073/pnas.2636938100openalex-snapshot
Antigen-driven effector CD8 T cell function regulated by T-bet
inferredcites →https://doi.org/10.1093/bioinformatics/btx364openalex-snapshot
UpSetR: an R package for the visualization of intersecting sets and their properties
inferredcites →https://doi.org/10.1101/2020.06.29.174888openalex-snapshot
Robust T cell immunity in convalescent individuals with asymptomatic or mild COVID-19
inferredcites →https://doi.org/10.1101/2020.07.01.182741openalex-snapshot
SARS-CoV-2 reactive T cells in uninfected individuals are likely expanded by beta-coronaviruses
inferredcites →https://doi.org/10.1101/cshperspect.a000182openalex-snapshot
Roles of the NF- B Pathway in Lymphocyte Development and Function
inferredcites →https://doi.org/10.1126/science.1235208openalex-snapshot
Blockade of Chronic Type I Interferon Signaling to Control Persistent LCMV Infection
inferredcites →https://doi.org/10.1126/science.1235214openalex-snapshot
Persistent LCMV Infection Is Controlled by Blockade of Type I Interferon Signaling
inferredcites →https://doi.org/10.1126/science.aad0501openalex-snapshot
Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq
inferredcites →https://doi.org/10.1126/science.aad2035openalex-snapshot
Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes
inferredcites →https://doi.org/10.1126/science.abc8511openalex-snapshot
Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications
inferredcites →https://doi.org/10.1126/sciimmunol.aai8593openalex-snapshot
The TCF1-Bcl6 axis counteracts type I interferon to repress exhaustion and maintain T cell stemness
inferredcites →https://doi.org/10.1126/sciimmunol.abd2071openalex-snapshot
Phenotype and kinetics of SARS-CoV-2–specific T cells in COVID-19 patients with acute respiratory distress syndrome
inferredcites →https://doi.org/10.1128/jvi.00873-11openalex-snapshot
Polyfunctional T Cells Accumulate in Large Human Cytomegalovirus-Specific T Cell Responses
inferredcites →https://doi.org/10.1128/jvi.01350-07openalex-snapshot
Control of Virus-Specific CD8+T-Cell Exhaustion and Immune-Mediated Pathology by E3 Ubiquitin Ligase Cbl-b during Chronic Viral Infection
inferredcites →https://doi.org/10.1172/jci.insight.126047openalex-snapshot
Vaccine induction of antibodies and tissue-resident CD8+ T cells enhances protection against mucosal SHIV-infection in young macaques
inferredcites →https://doi.org/10.1186/s13059-015-0844-5openalex-snapshot
MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data
inferredcites →https://doi.org/10.1615/critrevimmunol.v29.i6.20openalex-snapshot
Costimulation Signals for Memory CD8+ T Cells During Viral Infections
inferredcites →https://doi.org/10.2139/ssrn.3606763openalex-snapshot
The SARS-COV-2 T-Cell Immunity is Directed Against the Spike, Membrane, and Nucleocapsid Protein and Associated with COVID 19 Severity
inferredcites →https://doi.org/10.2139/ssrn.3641939openalex-snapshot
Single-Cell Transcriptomic Analysis of SARS-CoV-2 Reactive CD4 + T Cells
inferredcites →https://doi.org/10.3389/fcell.2018.00122openalex-snapshot
mTOR Regulation of Glycolytic Metabolism in T Cells
inferredcites →https://doi.org/10.3389/fimmu.2017.01809openalex-snapshot
Life and Death of Activated T Cells: How Are They Different from Naïve T Cells?
inferredcites →https://doi.org/10.3389/fimmu.2018.02987openalex-snapshot
Regulation of Effector and Memory CD8 T Cell Differentiation by IL-2—A Balancing Act
inferredcites →https://doi.org/10.3389/fimmu.2019.02568openalex-snapshot
Gene Expression-Based Identification of Antigen-Responsive CD8+ T Cells on a Single-Cell Level
inferredcites →https://doi.org/10.3389/fimmu.2020.00827openalex-snapshot
Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19)
inferredcites →https://doi.org/10.4049/jimmunol.0803903openalex-snapshot
The Yellow Fever Virus Vaccine Induces a Broad and Polyfunctional Human Memory CD8+ T Cell Response
inferredcites →https://doi.org/10.4049/jimmunol.0901248openalex-snapshot
CRTAM Confers Late-Stage Activation of CD8+ T Cells to Regulate Retention within Lymph Node
inferredcites →https://doi.org/10.4049/jimmunol.1202221openalex-snapshot
Antigen-Reactive T Cell Enrichment for Direct, High-Resolution Analysis of the Human Naive and Memory Th Cell Repertoire

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1016/j.addr.2021.02.009openalex-snapshot
Adaptive immune responses to SARS-CoV-2
inferred← citeshttps://doi.org/10.1038/s41392-021-00733-xopenalex-snapshot
Therapeutic targets and interventional strategies in COVID-19: mechanisms and clinical studies
inferred← citeshttps://doi.org/10.1038/s41577-020-00460-4openalex-snapshot
Cross-reactive memory T cells and herd immunity to SARS-CoV-2
inferred← citeshttps://doi.org/10.1038/s41577-020-0389-zopenalex-snapshot
Pre-existing immunity to SARS-CoV-2: the knowns and unknowns
inferred← citeshttps://doi.org/10.1080/08830185.2020.1840567openalex-snapshot
How could we forget immunometabolism in SARS-CoV2 infection or COVID-19?
inferred← citeshttps://doi.org/10.1080/19490976.2024.2342497openalex-snapshot
The gut microbe pair of Oribacterium sp. GMB0313 and Ruminococcus sp. GMB0270 confers complete protection against SARS-CoV-2 infection by activating CD8+ T cell-mediated immunity
inferred← citeshttps://doi.org/10.1093/bib/bbaa377openalex-snapshot
Comprehensive pathway enrichment analysis workflows: COVID-19 case study
inferred← citeshttps://doi.org/10.1186/s43556-021-00067-8openalex-snapshot
Stem cell therapy for COVID-19 pneumonia
inferred← citeshttps://doi.org/10.2174/0118715303265274231204075802openalex-snapshot
A Review on Role of Inflammation in Coronavirus Disease
inferred← citeshttps://doi.org/10.3389/fimmu.2020.571481openalex-snapshot
Will SARS-CoV-2 Infection Elicit Long-Lasting Protective or Sterilising Immunity? Implications for Vaccine Strategies (2020)
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