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Making data-driven hypotheses for gene functions by integrating dependency, expression, and literature data

https://doi.org/10.1101/2020.07.17.208751

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1016/j.cell.2017.01.013openalex-snapshot

Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras

inferredcites →https://doi.org/10.1016/j.cell.2017.07.005openalex-snapshot

Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening

inferredcites →https://doi.org/10.1016/j.cell.2018.06.010openalex-snapshot

Mapping the Genetic Landscape of Human Cells

inferredcites →https://doi.org/10.1016/j.cels.2018.04.011openalex-snapshot

Interrogation of Mammalian Protein Complex Structure, Function, and Membership Using Genome-Scale Fitness Screens

inferredcites →https://doi.org/10.1038/ng.3984openalex-snapshot

Computational correction of copy number effect improves specificity of CRISPR–Cas9 essentiality screens in cancer cells

inferredcites →https://doi.org/10.1038/nrg2918openalex-snapshot

Network medicine: a network-based approach to human disease

inferredcites →https://doi.org/10.1038/s42255-020-0206-9openalex-snapshot

Metabolic coessentiality mapping identifies C12orf49 as a regulator of SREBP processing and cholesterol metabolism

inferredcites →https://doi.org/10.1093/nar/gkw377openalex-snapshot

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

inferredcites →https://doi.org/10.1093/nar/gkz389openalex-snapshot

PubTator central: automated concept annotation for biomedical full text articles

inferredcites →https://doi.org/10.1126/science.1091317openalex-snapshot

Global Mapping of the Yeast Genetic Interaction Network

inferredcites →https://doi.org/10.1186/gb-2007-8-11-r252openalex-snapshot

Using protein complexes to predict phenotypic effects of gene mutation

inferredcites →https://doi.org/10.1186/s12859-019-3024-xopenalex-snapshot

Measuring similarity between gene interaction profiles

inferredcites →https://doi.org/10.1186/s13059-019-1621-7openalex-snapshot

Multiple-gene targeting and mismatch tolerance can confound analysis of genome-wide pooled CRISPR screens

inferredcites →https://doi.org/10.15252/msb.20188594openalex-snapshot

High‐resolution mapping of cancer cell networks using co‐functional interactions

inferredcites →https://doi.org/10.26508/lsa.201800278openalex-snapshot

A network of human functional gene interactions from knockout fitness screens in cancer cells

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