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Broad kinase inhibition mitigates early neuronal dysfunction and cognitive deficits in tauopathy

https://doi.org/10.1101/2020.07.31.229583

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Factors other than hTau overexpression that contribute to tauopathy-like phenotype in rTg4510 mice

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PACSIN1, a Tau-interacting Protein, Regulates Axonal Elongation and Branching by Facilitating Microtubule Instability

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Altered Levels of Visinin-Like Protein 1 Correspond to Regional Neuronal Loss in Alzheimer Disease and Frontotemporal Lobar Degeneration

inferredcites →https://doi.org/10.1093/jnen/nly037openalex-snapshot

Gene Expression Profile in Frontal Cortex in Sporadic Frontotemporal Lobar Degeneration-TDP

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The reactome pathway knowledgebase

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CSF VILIP-1 predicts rates of cognitive decline in early Alzheimer disease

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All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis

inferredcites →https://doi.org/10.1373/clinchem.2006.070912openalex-snapshot

Identification of Novel Brain Biomarkers

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The Brain Injury Biomarker VLP-1 Is Increased in the Cerebrospinal Fluid of Alzheimer Disease Patients

inferredcites →https://doi.org/10.1523/jneurosci.0587-07.2007openalex-snapshot

Accumulation of Pathological Tau Species and Memory Loss in a Conditional Model of Tauopathy

inferredcites →https://doi.org/10.1523/jneurosci.0628-17.2017openalex-snapshot

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inferredcites →https://doi.org/10.1523/jneurosci.0984-06.2006openalex-snapshot

Parkinson's Disease Brain Mitochondrial Complex I Has Oxidatively Damaged Subunits and Is Functionally Impaired and Misassembled

inferredcites →https://doi.org/10.1523/jneurosci.3029-15.2016openalex-snapshot

Pathological Tau Promotes Neuronal Damage by Impairing Ribosomal Function and Decreasing Protein Synthesis

inferredcites →https://doi.org/10.1523/jneurosci.5397-12.2013openalex-snapshot

Tau Accumulation Activates the Unfolded Protein Response by Impairing Endoplasmic Reticulum-Associated Degradation

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PERK-opathies: An Endoplasmic Reticulum Stress Mechanism Underlying Neurodegeneration

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Roles of 3-nitrotyrosine- and 4-hydroxynonenal-modified brain proteins in the progression and pathogenesis of Alzheimer's disease

inferredcites →https://doi.org/10.3233/jad-150060openalex-snapshot

The Role of Visinin-Like Protein-1 in the Pathophysiology of Alzheimer’s Disease

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PERK Pathway Activation Promotes Intracerebral Hemorrhage Induced Secondary Brain Injury by Inducing Neuronal Apoptosis Both in Vivo and in Vitro

inferredcites →https://doi.org/10.3389/fnmol.2018.00118openalex-snapshot

Connexin-Mediated Functional and Metabolic Coupling Between Astrocytes and Neurons

inferredcites →https://doi.org/10.3892/etm.2017.4905openalex-snapshot

Dynamical differential networks and modules inferring disrupted genes associated with the progression of Alzheimer's disease

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Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.3389/fnagi.2021.791679openalex-snapshot

Magnetic Resonance Imaging in Tauopathy Animal Models

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