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Aprepitant as a combinant with Dexamethasone reduces the inflammation via Neurokinin 1 Receptor Antagonism in severe to critical Covid-19 patients and potentiates respiratory recovery: A novel therapeutic approach

https://doi.org/10.1101/2020.08.01.20166678

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Distribution of Substance P in Brain and Periphery and its Possible Role as a Co‐Transmitter

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Substance P-immunoreactive sensory nerves in the lower respiratory tract of various mammals including man

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Neurogenic inflammation in the rat trachea. II. Identity and distribution of nerves mediating the increase in vascular permeability

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Neuropeptide substance P and the immune response

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Reciprocal Regulation of Substance P and IL-12/IL-23 and the Associated Cytokines, IFNγ/IL-17: A Perspective on the Relevance of This Interaction to Multiple Sclerosis

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The binding of endogenous and exogenous substance-P in human plasma

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Substance P stimulates neovascularization in vivo and proliferation of cultured endothelial cells

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Serotonin and substance P: Synergy or competition in the control of breathing

inferredcites →https://doi.org/10.1016/j.chest.2019.08.001openalex-snapshot

The Neurokinin-1 Receptor Antagonist Orvepitant Is a Novel Antitussive Therapy for Chronic Refractory Cough

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Substance P in heart failure: The good and the bad

inferredcites →https://doi.org/10.1016/j.neuron.2017.03.024openalex-snapshot

Respiratory Network Stability and Modulatory Response to Substance P Require Nalcn

inferredcites →https://doi.org/10.1016/j.npep.2019.101993openalex-snapshot

Substance P: A neuropeptide involved in the psychopathology of anxiety disorders

inferredcites →https://doi.org/10.1016/j.peptides.2019.03.004openalex-snapshot

Neurokinin-1 receptor antagonist decreases [Ca2+]i in airway smooth muscle cells by reducing the reverse-mode Na+/Ca2+ exchanger current

inferredcites →https://doi.org/10.1016/j.prp.2014.09.016openalex-snapshot

Role of neurotransmitter Substance P in progression of oral squamous cell carcinoma

inferredcites →https://doi.org/10.1016/j.pupt.2019.101853openalex-snapshot

Emerging targets for cough therapies; NK1 receptor antagonists

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Respiratory actions of tachykinins in the nucleus of the solitary tract: effect of neonatal capsaicin pretreatment

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A substance P antagonist inhibits vagally induced increase in vascular permeability and bronchial smooth muscle contraction in the guinea pig

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Neutral endopeptidase 24.11 (enkephalinase) and related regulators of peptide hormones 1

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Elevated substance P levels in HIV-infected men

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Intense expression of Neurokinin-1 Receptor is associated with Urothelial carcinoma

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Elevated Neurokinin 1-Receptor Expression in uterine products of conception is associated with first trimester Miscarriages

inferredcites →https://doi.org/10.1111/j.1440-1789.2010.01190.xopenalex-snapshot

Developmental alterations of the spinal trigeminal nucleus disclosed by substance P immunohistochemistry in fetal and infant sudden unexplained deaths

inferredcites →https://doi.org/10.1146/annurev.ph.52.030190.003205openalex-snapshot

Pathways to Regulated Exocytosis in Neurons

inferredcites →https://doi.org/10.1152/jappl.1971.31.1.15openalex-snapshot

Stimulation of lung irritant receptors by cigarette smoke, carbon dust, and histamine aerosol.

inferredcites →https://doi.org/10.1152/jappl.1987.63.4.1401openalex-snapshot

Enkephalinase inhibitor potentiates substance P- and electrically induced contraction in ferret trachea

inferredcites →https://doi.org/10.1152/jappl.1989.66.6.2653openalex-snapshot

Neutral endopeptidase and neurogenic inflammation in rats with respiratory infections

inferredcites →https://doi.org/10.1159/000067268openalex-snapshot

Substance P-Fibronectin-Cytokine Interactions in Myeloproliferative Disorders with Bone Marrow Fibrosis

inferredcites →https://doi.org/10.1159/000330419openalex-snapshot

Plasma Substance P Levels in Patients with Persistent Cough

inferredcites →https://doi.org/10.1164/arrd.1977.115.5.811openalex-snapshot

Effect of kallidin, substance P, and other basic polypeptides on the production of respiratory macromolecules.

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Nitric oxide mediates angiogenesis in vivo and endothelial cell growth and migration in vitro promoted by substance P.

inferredcites →https://doi.org/10.1517/14712598.6.2.109openalex-snapshot

G protein-coupled receptors in haematopoietic disruption

inferredcites →https://doi.org/10.20944/preprints202007.0015.v1openalex-snapshot

SARS-Corona Virus-2 May Initially Infect Brainstem through Trigeminal Ganglion-Latency May Be Present-A New Perspective

inferredcites →https://doi.org/10.26355/eurrev_202003_20711openalex-snapshot

Clinical characteristics of 161 cases of corona virus disease 2019 (COVID-19) in Changsha.

inferredcites →https://doi.org/10.2741/1484openalex-snapshot

Tachykinin-mediated modulation of the immune response

inferredcites →https://doi.org/10.3389/fimmu.2018.00166openalex-snapshot

The Neurokinin-1 Receptor Contributes to the Early Phase of Lipopolysaccharide-Induced Fever via Stimulation of Peripheral Cyclooxygenase-2 Protein Expression in Mice

inferredcites →https://doi.org/10.3389/fneur.2017.00082openalex-snapshot

Substance P/Neurokinin 1 and Trigeminal System: A Possible Link to the Pathogenesis in Sudden Perinatal Deaths

inferredcites →https://doi.org/10.3389/fphys.2020.554766openalex-snapshot

Elevated Neurokinin-1 Receptor Expression in Uterine Products of Conception Is Associated With First Trimester Miscarriages

inferredcites →https://doi.org/10.4049/jimmunol.1601751openalex-snapshot

Role of Substance P Neuropeptide in Inflammation, Wound Healing, and Tissue Homeostasis

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Systemic corticosteroids for the treatment of COVID-19: Equity-related analyses and update on evidence

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Effectiveness of aprepitant in post‐acute COVID19 syndrome

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Races of small molecule clinical trials for the treatment of COVID‐19: An up‐to‐date comprehensive review

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Substance P and Prokineticin-2 are overexpressed in olfactory neurons and play differential roles in persons with persistent post-COVID-19 olfactory dysfunction

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Neurokinin-1 Receptor as a potential drug target for COVID-19 treatment

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In silico identification of available drugs targeting cell surface BiP to disrupt SARS-CoV-2 binding and replication: Drug repurposing approach

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Carbohydrate-Based NK1R Antagonists with Broad-Spectrum Anticancer Activity

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Post COVID-19 complications and follow up biomarkers

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A Systematic Review and Network Meta-Analysis for COVID-19 Treatments

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A comparison of the effect on pain management of two non‐pharmacological methods used during administration of Pfizer–BioNTech COVID ‐19 vaccine ( BNT162b2 ): A randomized controlled study

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Drug treatments for covid-19: living systematic review and network meta-analysis

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Identification of Therapeutic Agents Targeting Mitogen-Activated Protein Kinase 14 in the Treatment and Management of Asthma

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Interventions for treatment of COVID-19: Second edition of a living systematic review with meta-analyses and trial sequential analyses (The LIVING Project)

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Assessment of COVID-19 vaccination among healthcare workers in Iraq; adverse effects and hesitancy

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Assessing the adverse effects of COVID-19 vaccine in different scenarios in Saudi Arabia

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CLINICAL MANAGEMENT OF PATIENTS WITH COVID-19. “LIVE” CLINICAL INSTRUCTION (2021)

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Substance P/ Neurokinin-1 Receptor, Trigeminal Ganglion, Latency, and Coronavirus Infection-Is There Any Link?

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The role of Substance P in the defense line of the respiratory tract and neurological manifestations post COVID-19 infection

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Role of endothelial cells and angiotensin converting enzyme-II in COVID-19 and brain damages post-infection

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Elevated Neurokinin-1 Receptor Expression in Uterine Products of Conception Is Associated With First Trimester Miscarriages

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Potential COVID-19 Therapies from Computational Repurposing of Drugs and Natural Products against the SARS-CoV-2 Helicase

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SARS-CoV-2 Post Vaccinated Adverse Effects and Efficacy in the Egyptian Population

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Side Effects and Efficacy of COVID-19 Vaccines among the Egyptian Population

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Classification and detection of Covid-19 based on X-Ray and CT images using deep learning and machine learning techniques: A bibliometric analysis

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Immunolocalization of neurokinin 1 receptor in WHO grade 4 astrocytomas, oral squamous cell and urothelial carcinoma

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Local and Systemic side effects of COVID-19 Vaccines

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