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Epistatic interactions shape the interplay between beneficial alleles and gain or loss of pathways in the evolution of novel metabolism

https://doi.org/10.1101/2020.10.20.347948

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Outgoing claims: the papers this work cites, builds on, or argues with.

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Development of improved versatile broad-host-range vectors for use in methylotrophs and other Gram-negative bacteria The GenBank accession numbers for the sequences reported in this paper are AF327711, AF327712, AF327713, AF327714, AF327715, AF327716, AF327717, AF327718, AF327719 and AF327720.

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Modularity of methylotrophy, revisited

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Diminishing Returns Epistasis Among Beneficial Mutations Decelerates Adaptation

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Negative Epistasis Between Beneficial Mutations in an Evolving Bacterial Population

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Real-Time Evolution of New Genes by Innovation, Amplification, and Divergence

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S-formylglutathione hydrolase of Paracoccus denitrificans is homologous to human esterase D: a universal pathway for formaldehyde detoxification?

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Formaldehyde-Detoxifying Role of theTetrahydromethanopterin-Linked Pathway in Methylobacteriumextorquens AM1

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Multiple Formaldehyde Oxidation/Detoxification Pathways in Burkholderia fungorum LB400

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THE THIOBACILLI, 12

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MULTIPLE FITNESS PEAKS AND EPISTASIS

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Additive Phenotypes Underlie Epistasis of Fitness Effects

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PERSPECTIVE:SIGN EPISTASIS AND GENETIC CONSTRAINT ON EVOLUTIONARY TRAJECTORIES

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Mechanisms of plasmid stable maintenance with special focus on plasmid addiction systems.

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The Recruitment Model of Metabolic Evolution: Jasmonate-Responsive Transcription Factors and a Conceptual Model for the Evolution of Metabolic Pathways

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