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SARS-CoV-2 D614 and G614 spike variants impair neuronal synapses and exhibit differential fusion ability

https://doi.org/10.1101/2020.12.03.409763
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Neuropathogenesis and Neurologic Manifestations of the Coronaviruses in the Age of Coronavirus Disease 2019
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Developmentally regulated expression of a cell surface protein, neuropilin, in the mouse nervous system
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Central nervous system involvement by severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2)
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Potential neuroinvasive pathways of SARS‐CoV‐2: Deciphering the spectrum of neurological deficit seen in coronavirus disease‐2019 (COVID‐19)
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Understanding the neurotropic characteristics of SARS-CoV-2: from neurological manifestations of COVID-19 to potential neurotropic mechanisms
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Post-Discharge Health Status and Symptoms in Patients with Severe COVID-19
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Involvement of the Nervous System in SARS-CoV-2 Infection
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Small glutamine-rich tetratricopeptide repeat-containing protein is composed of three structural units with distinct functions
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Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein
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The Global Phosphorylation Landscape of SARS-CoV-2 Infection
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Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus
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The Impact of Mutations in SARS-CoV-2 Spike on Viral Infectivity and Antigenicity
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Effects of COVID-19 on the Nervous System
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Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant
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A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells
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COVID-19 and the Chemical Senses: Supporting Players Take Center Stage
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Sars-Cov-2: Underestimated damage to nervous system
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Furin cleavage of the SARS coronavirus spike glycoprotein enhances cell–cell fusion but does not affect virion entry
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Pathogenetic mechanisms of severe acute respiratory syndrome
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Neuropilin Is a Receptor for the Axonal Chemorepellent Semaphorin III
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Neuropilin Is a Semaphorin III Receptor
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Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
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Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding
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Neurological associations of COVID-19
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Neurological and neuropsychiatric complications of COVID-19 in 153 patients: a UK-wide surveillance study
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The lasting misery of coronavirus long-haulers
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Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV
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SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity
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A new coronavirus associated with human respiratory disease in China
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Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor
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A review on the cleavage priming of the spike protein on coronavirus by angiotensin-converting enzyme-2 and furin
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Sarm1, a negative regulator of innate immunity, interacts with syndecan-2 and regulates neuronal morphology
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Endosomal TLR3, TLR7, and TLR8 control neuronal morphology through different transcriptional programs
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Neuroinvasion of SARS-CoV-2 in human and mouse brain
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The emerging spectrum of COVID-19 neurology: clinical, radiological and laboratory findings
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Neurological Manifestations of Hospitalized Patients with COVID-19 in Wuhan, China: A Retrospective Case Series Study
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Synaptic Dysfunction in Neurodevelopmental Disorders Associated with Autism and Intellectual Disabilities
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Does SARS‐Cov‐2 invade the brain? Translational lessons from animal models
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SARS‐CoV‐2 viral spike G614 mutation exhibits higher case fatality rate
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Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2
inferredcites →https://doi.org/10.1126/science.abb9983openalex-snapshot
Site-specific glycan analysis of the SARS-CoV-2 spike
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Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity
inferredcites →https://doi.org/10.1126/science.abd3072openalex-snapshot
Neuropilin-1 is a host factor for SARS-CoV-2 infection
inferredcites →https://doi.org/10.1126/science.abd4251openalex-snapshot
Distinct conformational states of SARS-CoV-2 spike protein
inferredcites →https://doi.org/10.1128/jvi.00737-08openalex-snapshot
Severe Acute Respiratory Syndrome Coronavirus Infection Causes Neuronal Death in the Absence of Encephalitis in Mice Transgenic for Human ACE2
inferredcites →https://doi.org/10.1128/jvi.78.11.6048-6054.2004openalex-snapshot
Cleavage Inhibition of the Murine Coronavirus Spike Protein by a Furin-Like Enzyme Affects Cell-Cell but Not Virus-Cell Fusion
inferredcites →https://doi.org/10.1146/annurev-virology-110615-042301openalex-snapshot
Structure, Function, and Evolution of Coronavirus Spike Proteins
inferredcites →https://doi.org/10.1146/annurev.neuro.28.061604.135757openalex-snapshot
THE ACTIN CYTOSKELETON: Integrating Form and Function at the Synapse
inferredcites →https://doi.org/10.1152/physrev.00026.2002openalex-snapshot
Actin Binding Proteins: Regulation of Cytoskeletal Microfilaments
inferredcites →https://doi.org/10.14573/altex.2006111openalex-snapshot
Infectability of Human BrainSphere Neurons Suggests Neurotropism of SARS-CoV-2*
inferredcites →https://doi.org/10.1523/jneurosci.09-08-02982.1989openalex-snapshot
Dendritic spines of CA 1 pyramidal cells in the rat hippocampus: serial electron microscopy with reference to their biophysical characteristics
inferredcites →https://doi.org/10.15252/embr.201642586openalex-snapshot
TLR3 downregulates expression of schizophrenia gene Disc1 via MYD88 to control neuronal morphology
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UK-Wide Surveillance of Neurological and Neuropsychiatric Complications of COVID-19: The First 153 Patients
inferredcites →https://doi.org/10.3389/fneur.2020.573095openalex-snapshot
The Spatial and Cell-Type Distribution of SARS-CoV-2 Receptor ACE2 in the Human and Mouse Brains
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Neuron-specific regulation on F-actin cytoskeletons
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Neurological Complications of Coronavirus Disease (COVID-19): Encephalopathy

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Effect of mutation and vaccination on spread, severity, and mortality of COVID‐19 disease
inferred← citeshttps://doi.org/10.1007/978-981-16-3108-5_3openalex-snapshot
Structure of SARS-CoV-2 Proteins
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Sex-biased response to and brain cell infection by SARS-CoV-2 in a highly susceptible human ACE2 transgenic model
inferred← citeshttps://doi.org/10.1101/2023.10.02.560570openalex-snapshot
SARS-CoV-2 neurotropism-induced anxiety/depression-like behaviors require Microglia activation
inferred← citeshttps://doi.org/10.1186/s40249-022-00961-5openalex-snapshot
Infection fatality rate and infection attack rate of COVID-19 in South American countries
inferred← citeshttps://doi.org/10.12688/f1000research.22149.4openalex-snapshot
Use of the informational spectrum methodology for rapid biological analysis of the novel coronavirus 2019-nCoV: prediction of potential receptor, natural reservoir, tropism and therapeutic/vaccine target
inferred← citeshttps://doi.org/10.6084/m9.figshare.19522635openalex-snapshot
Additional file 1 of Infection fatality rate and infection attack rate of COVID-19 in South American countries
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