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mRNA vaccine CVnCoV protects non-human primates from SARS-CoV-2 challenge infection

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/1521-4141(200001)30:1<1::aid-immu1>3.0.co;2-#openalex-snapshot
In vivo application of RNA leads to induction of specific cytotoxic T lymphocytes and antibodies
inferredcites →https://doi.org/10.1002/jgm.2605openalex-snapshot
Highly potent mRNA based cancer vaccines represent an attractive platform for combination therapies supporting an improved therapeutic effect
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Safety and immunogenicity of an mRNA-lipid nanoparticle vaccine candidate against SARS-CoV-2
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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
inferredcites →https://doi.org/10.1016/j.cell.2020.05.015openalex-snapshot
Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals
inferredcites →https://doi.org/10.1016/j.cell.2020.08.017openalex-snapshot
Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19
inferredcites →https://doi.org/10.1016/j.immuni.2020.04.023openalex-snapshot
Detection of SARS-CoV-2-Specific Humoral and Cellular Immunity in COVID-19 Convalescent Individuals
inferredcites →https://doi.org/10.1016/j.vaccine.2020.10.064openalex-snapshot
NVX-CoV2373 vaccine protects cynomolgus macaque upper and lower airways against SARS-CoV-2 challenge
inferredcites →https://doi.org/10.1016/j.vaccine.2020.12.070openalex-snapshot
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inferredcites →https://doi.org/10.1038/nbt.2436openalex-snapshot
Protective efficacy of in vitro synthesized, specific mRNA vaccines against influenza A virus infection
inferredcites →https://doi.org/10.1038/s41401-020-0485-4openalex-snapshot
Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19
inferredcites →https://doi.org/10.1038/s41467-021-21389-9openalex-snapshot
Comparison of rhesus and cynomolgus macaques as an infection model for COVID-19
inferredcites →https://doi.org/10.1038/s41541-017-0032-6openalex-snapshot
Unmodified mRNA in LNPs constitutes a competitive technology for prophylactic vaccines
inferredcites →https://doi.org/10.1038/s41541-021-00311-wopenalex-snapshot
mRNA-based SARS-CoV-2 vaccine candidate CVnCoV induces high levels of virus-neutralising antibodies and mediates protection in rodents
inferredcites →https://doi.org/10.1038/s41564-020-00789-5openalex-snapshot
Antibody-dependent enhancement and SARS-CoV-2 vaccines and therapies
inferredcites →https://doi.org/10.1038/s41564-020-0688-yopenalex-snapshot
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inferredcites →https://doi.org/10.1038/s41586-020-03041-6openalex-snapshot
Correlates of protection against SARS-CoV-2 in rhesus macaques
inferredcites →https://doi.org/10.1038/s41586-020-2012-7openalex-snapshot
A pneumonia outbreak associated with a new coronavirus of probable bat origin
inferredcites →https://doi.org/10.1038/s41586-020-2381-yopenalex-snapshot
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inferredcites →https://doi.org/10.1038/s41586-020-2599-8openalex-snapshot
A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity
inferredcites →https://doi.org/10.1038/s41586-020-2607-zopenalex-snapshot
Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques
inferredcites →https://doi.org/10.1038/s41586-020-2639-4openalex-snapshot
Phase I/II study of COVID-19 RNA vaccine BNT162b1 in adults
inferredcites →https://doi.org/10.1038/s41586-020-2787-6openalex-snapshot
Animal models for COVID-19
inferredcites →https://doi.org/10.1038/s41598-018-34171-7openalex-snapshot
Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis
inferredcites →https://doi.org/10.1038/s41598-018-36918-8openalex-snapshot
Publisher Correction: Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis
inferredcites →https://doi.org/10.1056/nejmoa2024671openalex-snapshot
Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates
inferredcites →https://doi.org/10.1056/nejmoa2028436openalex-snapshot
Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults
inferredcites →https://doi.org/10.1056/nejmoa2034577openalex-snapshot
Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine
inferredcites →https://doi.org/10.1073/pnas.1707304114openalex-snapshot
Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen
inferredcites →https://doi.org/10.1097/cji.0b013e3181f7dbe8openalex-snapshot
Messenger RNA-based Vaccines With Dual Activity Induce Balanced TLR-7 Dependent Adaptive Immune Responses and Provide Antitumor Activity
inferredcites →https://doi.org/10.1101/2020.05.13.093195openalex-snapshot
ChAdOx1 nCoV-19 vaccination prevents SARS-CoV-2 pneumonia in rhesus macaques
inferredcites →https://doi.org/10.1101/2020.09.08.280818openalex-snapshot
A prefusion SARS-CoV-2 spike RNA vaccine is highly immunogenic and prevents lung infection in non-human primates
inferredcites →https://doi.org/10.1101/2020.10.14.337535openalex-snapshot
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inferredcites →https://doi.org/10.1126/science.abb8923openalex-snapshot
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inferredcites →https://doi.org/10.1128/jvi.66.2.956-965.1992openalex-snapshot
Monoclonal antibodies to the spike protein of feline infectious peritonitis virus mediate antibody-dependent enhancement of infection of feline macrophages
inferredcites →https://doi.org/10.1186/s40425-015-0068-yopenalex-snapshot
Self-adjuvanted mRNA vaccination in advanced prostate cancer patients: a first-in-man phase I/IIa study
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inferredcites →https://doi.org/10.1371/journal.pntd.0006108openalex-snapshot
A thermostable messenger RNA based vaccine against rabies
inferredcites →https://doi.org/10.3389/fmicb.2018.02991openalex-snapshot
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inferredcites →https://doi.org/10.3389/fmicb.2019.01781openalex-snapshot
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What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1002/rmv.2313openalex-snapshot
Covid‐19 vaccines and variants of concern: A review
inferred← citeshttps://doi.org/10.1007/978-3-031-08415-7_2openalex-snapshot
Messenger RNA for Prophylaxis
inferred← citeshttps://doi.org/10.1007/s00508-021-01922-yopenalex-snapshot
Safety and immunogenicity of an mRNA-lipid nanoparticle vaccine candidate against SARS-CoV-2
inferred← citeshttps://doi.org/10.1007/s11908-021-00752-3openalex-snapshot
Status Report on COVID-19 Vaccines Development
inferred← citeshttps://doi.org/10.1007/s12010-022-04181-3openalex-snapshot
SARS-CoV-2 Vaccines: Types, Working Principle, and Its Impact on Thrombosis and Gastrointestinal Disorders
inferred← citeshttps://doi.org/10.1016/b978-0-323-90248-9.00014-0openalex-snapshot
RNA-based vaccines against SARS-CoV-2
inferred← citeshttps://doi.org/10.1016/j.biologicals.2021.08.001openalex-snapshot
Animal experiments show impact of vaccination on reduction of SARS-CoV-2 virus circulation: A model for vaccine development?
inferred← citeshttps://doi.org/10.1016/j.coviro.2023.101375openalex-snapshot
Pathogenesis of severe acute respiratory syndrome coronavirus-2 in nonhuman primates
inferred← citeshttps://doi.org/10.1016/j.critrevonc.2023.104198openalex-snapshot
Advances, opportunities and challenges in developing therapeutic cancer vaccines
inferred← citeshttps://doi.org/10.1016/j.ebiom.2022.104264openalex-snapshot
Accelerating model-informed decisions for COVID-19 vaccine candidates using a model-based meta-analysis approach
inferred← citeshttps://doi.org/10.1016/j.intimp.2021.107679openalex-snapshot
Essential considerations during vaccine design against COVID-19 and review of pioneering vaccine candidate platforms
inferred← citeshttps://doi.org/10.1016/j.jconrel.2021.03.043openalex-snapshot
The dawn of mRNA vaccines: The COVID-19 case
inferred← citeshttps://doi.org/10.1016/j.molmed.2021.12.001openalex-snapshot
Medical imaging of pulmonary disease in SARS-CoV-2-exposed non-human primates
inferred← citeshttps://doi.org/10.1016/j.omtm.2022.10.001openalex-snapshot
A third dose of the unmodified COVID-19 mRNA vaccine CVnCoV enhances quality and quantity of immune responses
inferred← citeshttps://doi.org/10.1016/j.vaccine.2021.06.057openalex-snapshot
One or two dose regimen of the SARS-CoV-2 synthetic DNA vaccine INO-4800 protects against respiratory tract disease burden in nonhuman primate challenge model
inferred← citeshttps://doi.org/10.1016/s1473-3099(21)00677-0openalex-snapshot
Efficacy and safety of the CVnCoV SARS-CoV-2 mRNA vaccine candidate in ten countries in Europe and Latin America (HERALD): a randomised, observer-blinded, placebo-controlled, phase 2b/3 trial
inferred← citeshttps://doi.org/10.1021/acs.nanolett.1c01284openalex-snapshot
Lipid Nanoparticle RBD-hFc mRNA Vaccine Protects hACE2 Transgenic Mice against a Lethal SARS-CoV-2 Infection
inferred← citeshttps://doi.org/10.1038/s41392-022-00950-yopenalex-snapshot
Advances in COVID-19 mRNA vaccine development
inferred← citeshttps://doi.org/10.1038/s41467-021-24339-7openalex-snapshot
CVnCoV and CV2CoV protect human ACE2 transgenic mice from ancestral B BavPat1 and emerging B.1.351 SARS-CoV-2
inferred← citeshttps://doi.org/10.1038/s41467-022-31005-zopenalex-snapshot
Low-dose self-amplifying mRNA COVID-19 vaccine drives strong protective immunity in non-human primates against SARS-CoV-2 infection
inferred← citeshttps://doi.org/10.1038/s41541-025-01103-2openalex-snapshot
A systems biology approach to define SARS-CoV-2 correlates of protection
inferred← citeshttps://doi.org/10.1038/s41586-021-03275-yopenalex-snapshot
BNT162b vaccines protect rhesus macaques from SARS-CoV-2
inferred← citeshttps://doi.org/10.1088/1748-605x/acecebopenalex-snapshot
Future prospects in mRNA vaccine development
inferred← citeshttps://doi.org/10.1093/infdis/jiae056openalex-snapshot
A Bivalent Adenovirus-Vectored Vaccine Induces a Robust Humoral Response, but Does Not Protect Cynomolgus Macaques Against a Lethal Challenge With Sudan Virus
inferred← citeshttps://doi.org/10.1101/2021.05.13.443734openalex-snapshot
Optimised non-coding regions of mRNA SARS-CoV-2 vaccine CV2CoV improves homogeneous and heterogenous neutralising antibody responses
inferred← citeshttps://doi.org/10.1101/2021.08.13.456316openalex-snapshot
Optimization of Non-Coding Regions Improves Protective Efficacy of an mRNA SARS-CoV-2 Vaccine in Nonhuman Primates
inferred← citeshttps://doi.org/10.1101/2021.11.08.467773openalex-snapshot
A self-amplifying mRNA COVID-19 vaccine drives potent and broad immune responses at low doses that protects non-human primates against SARS-CoV-2
inferred← citeshttps://doi.org/10.1126/sciadv.aei4853openalex-snapshot
Exposure route, not dose, is the primary driver of infection patterns for a respiratory virus
inferred← citeshttps://doi.org/10.1146/annurev-med-042420-112725openalex-snapshot
mRNA Vaccines in the COVID-19 Pandemic and Beyond
inferred← citeshttps://doi.org/10.12688/openreseurope.14375.1openalex-snapshot
Assessment of the efficacy of SARS-CoV-2 vaccines in non-human primate studies: a systematic review
inferred← citeshttps://doi.org/10.20344/amp.16096openalex-snapshot
Hypersensitivity Reactions to Vaccines: Current Evidence and Standards for SARS-CoV-2 Vaccines
inferred← citeshttps://doi.org/10.31219/osf.io/u3fwjopenalex-snapshot
Assessment of the efficacy of SARS-CoV-2 vaccines in non-human primate studies - a systematic review
inferred← citeshttps://doi.org/10.3389/fimmu.2021.680134openalex-snapshot
Neutrophils and COVID-19: Active Participants and Rational Therapeutic Targets
inferred← citeshttps://doi.org/10.3389/fimmu.2023.1166664openalex-snapshot
Pre-clinical models to define correlates of protection for SARS-CoV-2
inferred← citeshttps://doi.org/10.3389/fmicb.2022.984536openalex-snapshot
Viral vector and nucleic acid vaccines against COVID-19: A narrative review
inferred← citeshttps://doi.org/10.3390/v13081645openalex-snapshot
Immunogenicity of Low-Dose Prime-Boost Vaccination of mRNA Vaccine CV07050101 in Non-Human Primates
inferred← citeshttps://doi.org/10.3390/vaccines10081209openalex-snapshot
Recent Updates on mRNA Vaccines
inferred← citeshttps://doi.org/10.3390/vaccines10081251openalex-snapshot
Optimised Non-Coding Regions of mRNA SARS-CoV-2 Vaccine CV2CoV Improves Homologous and Heterologous Neutralising Antibody Responses
inferred← citeshttps://doi.org/10.3390/vaccines9010061openalex-snapshot
Immune Responses Induced by mRNA Vaccination in Mice, Monkeys and Humans
inferred← citeshttps://doi.org/10.3390/vaccines9020147openalex-snapshot
SARS-CoV-2 mRNA Vaccines: Immunological Mechanism and Beyond
inferred← citeshttps://doi.org/10.3390/vaccines9040390openalex-snapshot
mRNA-Based Vaccines
inferred← citeshttps://doi.org/10.3390/vaccines9080886openalex-snapshot
COVID-19 Research: Lessons from Non-Human Primate Models
inferred← citeshttps://doi.org/10.3390/vaccines9111345openalex-snapshot
The Importance of RNA-Based Vaccines in the Fight against COVID-19: An Overview
inferred← citeshttps://doi.org/10.36105/psrua.2021v1n2.03openalex-snapshot
mRNA-based COVID-19 vaccines: a new age
inferred← citeshttps://doi.org/10.37201//3406openalex-snapshot
inferred← citeshttps://doi.org/10.46683/jmvi.2020.20openalex-snapshot
mRNA Based SARS-CoV-2 Vaccines and Ongoing Researches
inferred← citeshttps://doi.org/10.64898/2026.03.03.709384openalex-snapshot
Exposure route drives SARS-CoV-2 infection patterns in non-human primates
inferred← citeshttps://doi.org/10.7150/ijbs.59233openalex-snapshot
mRNA vaccines for COVID-19: what, why and how
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