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Cellular Activities of SARS-CoV-2 Main Protease Inhibitors Reveal Their Unique Characteristics

https://doi.org/10.1101/2021.06.08.447613

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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A Quick Route to Multiple Highly Potent SARS‐CoV‐2 Main Protease Inhibitors**

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Human SARS CoV ‐2 spike protein mutations

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Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors

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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

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Furin Inhibitors Block SARS-CoV-2 Spike Protein Cleavage to Suppress Virus Production and Cytopathic Effects

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Stable Benzotriazole Esters as Mechanism-Based Inactivators of the Severe Acute Respiratory Syndrome 3CL Protease

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A Structural View of the Inactivation of the SARS Coronavirus Main Proteinase by Benzotriazole Esters

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SARS-CoV-2 spike E484K mutation reduces antibody neutralisation

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Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19

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An Overview of Severe Acute Respiratory Syndrome–Coronavirus (SARS-CoV) 3CL Protease Inhibitors: Peptidomimetics and Small Molecule Chemotherapy

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A Clinical-Stage Cysteine Protease Inhibitor blocks SARS-CoV-2 Infection of Human and Monkey Cells

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A Genetically Encoded FRET Sensor for Intracellular Heme

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Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development

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COVID-19 vaccines: where we stand and challenges ahead

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Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease

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Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease

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Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

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Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur

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In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

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The Calcium Channel Blocker Bepridil Demonstrates Efficacy in the Murine Model of Marburg Virus Disease

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A simplified cell-based assay to identify coronavirus 3CL protease inhibitors

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Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against M pro and cathepsin L

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Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors

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Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease

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SARS-CoV-2 M pro inhibitors with antiviral activity in a transgenic mouse model

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X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease

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Broad-Spectrum Antivirals against 3C or 3C-Like Proteases of Picornaviruses, Noroviruses, and Coronaviruses

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A drug repurposing screen identifies hepatitis C antivirals as inhibitors of the SARS-CoV2 main protease

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The role of cysteine peptidases in coronavirus cell entry and replication: The therapeutic potential of cathepsin inhibitors

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Hydroxychloroquine-mediated inhibition of SARS-CoV-2 entry is attenuated by TMPRSS2

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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MPI8 is Potent against SARS‐CoV‐2 by Inhibiting Dually and Selectively the SARS‐CoV‐2 Main Protease and the Host Cathepsin L**

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Targeting 3CLpro for broad-spectrum antiviral therapy: Structural insights, inhibitor development, and the future of PROTACs

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Validation and invalidation of SARS-CoV-2 main protease inhibitors using the Flip-GFP and Protease-Glo luciferase assays

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Development of de-novo coronavirus 3-chymotrypsin-like protease (3CLpro) inhibitors since COVID-19 outbreak: A strategy to tackle challenges of persistent virus infection

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Structure-Guided Design of Potent Inhibitors of SARS-CoV-2 3CL Protease: Structural, Biochemical, and Cell-Based Studies

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Validation and Invalidation of SARS-CoV-2 Papain-like Protease Inhibitors

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The P3 O - Tert -Butyl-Threonine is Key to High Cellular and Antiviral Potency for Aldehyde-Based SARS-CoV-2 Main Protease Inhibitors

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The N -Terminal Carbamate is Key to High Cellular and Antiviral Potency for Boceprevir-Based SARS-CoV-2 Main Protease Inhibitors

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Structural and Biochemical Analysis of the Dual Inhibition of MG-132 against SARS-CoV-2 Main Protease (Mpro/3CLpro) and Human Cathepsin-L

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