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Nitrogen partitioning between branched-chain amino acids and urea cycle enzymes sustains renal cancer progression

https://doi.org/10.1101/2021.09.17.460635

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Hypoxia affects Slc7a5 expression through HIF ‐2α in differentiated neuronal cells

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Epigenetic silencing of argininosuccinate synthetase confers resistance to platinum‐induced cell death but collateral sensitivity to arginine auxotrophy in ovarian cancer

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Computational Modeling of Human Metabolism and Its Application to Systems Biomedicine

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Regulation of branched-chain amino acid metabolism by hypoxia-inducible factor in glioblastoma

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Deficiency in expression and epigenetic DNA Methylation of ASS1 gene in nasopharyngeal carcinoma: negative prognostic impact and therapeutic relevance

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An Integrated Metabolic Atlas of Clear Cell Renal Cell Carcinoma

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Emerging Roles for Branched-Chain Amino Acid Metabolism in Cancer

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Hallmarks of Cancer: The Next Generation

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An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis

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Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells

inferredcites →https://doi.org/10.1016/j.cell.2016.12.039openalex-snapshot

Understanding the Intersections between Metabolism and Cancer Biology

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Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase

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Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma

inferredcites →https://doi.org/10.1016/j.cell.2019.10.007openalex-snapshot

Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma

inferredcites →https://doi.org/10.1016/j.celrep.2015.06.006openalex-snapshot

Suppression of PGC-1α Is Critical for Reprogramming Oxidative Metabolism in Renal Cell Carcinoma

inferredcites →https://doi.org/10.1016/j.celrep.2016.12.077openalex-snapshot

Arginine Deprivation Inhibits the Warburg Effect and Upregulates Glutamine Anaplerosis and Serine Biosynthesis in ASS1-Deficient Cancers

inferredcites →https://doi.org/10.1016/j.celrep.2018.06.032openalex-snapshot

The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma

inferredcites →https://doi.org/10.1016/j.cmet.2015.12.006openalex-snapshot

The Emerging Hallmarks of Cancer Metabolism

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Arginase 2 Suppresses Renal Carcinoma Progression via Biosynthetic Cofactor Pyridoxal Phosphate Depletion and Increased Polyamine Toxicity

inferredcites →https://doi.org/10.1016/j.cmet.2018.10.013openalex-snapshot

Quantitative Analysis of the Whole-Body Metabolic Fate of Branched-Chain Amino Acids

inferredcites →https://doi.org/10.1016/j.molcel.2012.09.017openalex-snapshot

HIF2α Acts as an mTORC1 Activator through the Amino Acid Carrier SLC7A5

inferredcites →https://doi.org/10.1016/j.molcel.2018.01.034openalex-snapshot

NADH Shuttling Couples Cytosolic Reductive Carboxylation of Glutamine with Glycolysis in Cells with Mitochondrial Dysfunction

inferredcites →https://doi.org/10.1016/j.molmet.2019.08.021openalex-snapshot

Adapt and conquer: Metabolic flexibility in cancer growth, invasion and evasion

inferredcites →https://doi.org/10.1016/j.tcb.2018.04.002openalex-snapshot

Metabolic Hallmarks of Metastasis Formation

inferredcites →https://doi.org/10.1016/j.ymben.2017.11.011openalex-snapshot

Post-translational regulation of metabolism in fumarate hydratase deficient cancer cells

inferredcites →https://doi.org/10.1038/cddis.2012.197openalex-snapshot

Epigenetic status of argininosuccinate synthetase and argininosuccinate lyase modulates autophagy and cell death in glioblastoma

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Reductive carboxylation supports growth in tumour cells with defective mitochondria

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Comprehensive molecular characterization of clear cell renal cell carcinoma

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Fructose-1,6-bisphosphatase opposes renal carcinoma progression

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Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis

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Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition

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BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation

inferredcites →https://doi.org/10.1038/ncb3357openalex-snapshot

The metabolic co-regulator PGC1α suppresses prostate cancer metastasis

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Tissue-specific and convergent metabolic transformation of cancer correlates with metastatic potential and patient survival

inferredcites →https://doi.org/10.1038/nm.3029openalex-snapshot

Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer

inferredcites →https://doi.org/10.1038/nrneph.2017.59openalex-snapshot

Metabolic reprogramming in clear cell renal cell carcinoma

inferredcites →https://doi.org/10.1038/s41467-019-11672-1openalex-snapshot

PAX8 activates metabolic genes via enhancer elements in Renal Cell Carcinoma

inferredcites →https://doi.org/10.1038/s41556-018-0118-zopenalex-snapshot

Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours

inferredcites →https://doi.org/10.1038/s41568-018-0054-zopenalex-snapshot

Rewiring urea cycle metabolism in cancer to support anabolism

inferredcites →https://doi.org/10.1038/s41568-020-00320-2openalex-snapshot

The metabolism of cancer cells during metastasis

inferredcites →https://doi.org/10.1038/s41589-018-0132-2openalex-snapshot

Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues

inferredcites →https://doi.org/10.1038/s41598-020-62853-8openalex-snapshot

Network-based metabolic characterization of renal cell carcinoma

inferredcites →https://doi.org/10.1056/nejmra1601333openalex-snapshot

Systemic Therapy for Metastatic Renal-Cell Carcinoma

inferredcites →https://doi.org/10.1073/pnas.1319196111openalex-snapshot

Chromosome 3p loss of heterozygosity is associated with a unique metabolic network in clear cell renal carcinoma

inferredcites →https://doi.org/10.1080/23723556.2018.1536843openalex-snapshot

Maintaining cytosolic aspartate levels is a major function of the TCA cycle in proliferating cells

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Network-aware reaction pattern recognition reveals regulatory signatures of mitochondrial dysfunction

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TGF-β signaling suppresses TCA cycle metabolism in renal cancer

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Improving the metabolic fidelity of cancer models with a physiological cell culture medium

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Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras -driven cancers

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Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors

inferredcites →https://doi.org/10.1146/annurev-physiol-020518-114455openalex-snapshot

Branched Chain Amino Acids

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Prognostic and Therapeutic Impact of Argininosuccinate Synthetase 1 Control in Bladder Cancer as Monitored Longitudinally by PET Imaging

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PGC1α Suppresses Prostate Cancer Cell Invasion through ERRα Transcriptional Control

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ASS1 as a Novel Tumor Suppressor Gene in Myxofibrosarcomas: Aberrant Loss via Epigenetic DNA Methylation Confers Aggressive Phenotypes, Negative Prognostic Impact, and Therapeutic Relevance

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NF-κB–Dependent Lymphoid Enhancer Co-option Promotes Renal Carcinoma Metastasis

inferredcites →https://doi.org/10.1158/2159-8290.cd-20-0844openalex-snapshot

Targeting Metabolic Plasticity and Flexibility Dynamics for Cancer Therapy

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Down-regulation of argininosuccinate synthetase is associated with cisplatin resistance in hepatocellular carcinoma cell lines: implications for PEGylated arginine deiminase combination therapy

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The contributions of cancer cell metabolism to metastasis

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Causal integration of multi‐omics data with prior knowledge to generate mechanistic hypotheses

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Disruption of the TCA cycle reveals an ATF4-dependent integration of redox and amino acid metabolism

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1093/bioinformatics/btac055openalex-snapshot

FUNKI: interactive functional footprint-based analysis of omics data

inferred← citeshttps://doi.org/10.26724/2079-8334-2024-3-89-82-88openalex-snapshot

NITRIC OXIDE – A BIOMARKER OF THE PROGRESS AND METASTASIS OF RENAL CELL CANCER INTO THE BRAIN

inferred← citeshttps://doi.org/10.3390/cancers15245797openalex-snapshot

Disturbances in Nitric Oxide Cycle and Related Molecular Pathways in Clear Cell Renal Cell Carcinoma

inferred← citeshttps://doi.org/10.3390/metabo13010089openalex-snapshot

Dietary Isoleucine and Valine: Effects on Lipid Metabolism and Ureagenesis in Pigs Fed with Protein Restricted Diets

inferred← citeshttps://doi.org/10.7554/elife.81289openalex-snapshot

Pancreatic tumors exhibit myeloid-driven amino acid stress and upregulate arginine biosynthesis

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