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Pharmacological inhibition of titan-like cells formation suggests that accumulation of endogenous free radicals that correlate with mitochondrial changes are required to induce this transition in Cryptococcus neoformans
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/jcb.30163openalex-snapshot
Target‐based drug repurposing against Candida albicans —A computational modeling, docking, and molecular dynamic simulations study
inferredcites →https://doi.org/10.1007/s11033-014-3417-xopenalex-snapshot
Ebselen, a promising antioxidant drug: mechanisms of action and targets of biological pathways
inferredcites →https://doi.org/10.1016/0140-6736(90)92283-nopenalex-snapshot
Ecology, life cycle, and infectious propagule of Cryptococcus neoformans
inferredcites →https://doi.org/10.1016/0161-5890(80)90096-6openalex-snapshot
Structure and antigenic activity of the capsular polysaccharide of Cryptococcus neoformans serotype A
inferredcites →https://doi.org/10.1016/j.cell.2006.06.010openalex-snapshot
Mitochondria: Dynamic Organelles in Disease, Aging, and Development
inferredcites →https://doi.org/10.1016/j.celrep.2012.12.021openalex-snapshot
Fungicidal Drugs Induce a Common Oxidative-Damage Cellular Death Pathway
inferredcites →https://doi.org/10.1016/j.cub.2006.09.032openalex-snapshot
Expulsion of Live Pathogenic Yeast by Macrophages
inferredcites →https://doi.org/10.1016/j.fgb.2006.07.010openalex-snapshot
The volume and hydration of the Cryptococcus neoformans polysaccharide capsule
inferredcites →https://doi.org/10.1016/j.mib.2010.05.003openalex-snapshot
Dueling in the lung: how Cryptococcus spores race the host for survival
inferredcites →https://doi.org/10.1016/j.mib.2013.03.006openalex-snapshot
Titan cells in Cryptococcus neoformans: cells with a giant impact
inferredcites →https://doi.org/10.1016/j.micinf.2011.01.015openalex-snapshot
Amphotericin B mediates killing in Cryptococcus neoformans through the induction of a strong oxidative burst
inferredcites →https://doi.org/10.1016/j.molcel.2017.07.019openalex-snapshot
Systematic Identification of MCU Modulators by Orthogonal Interspecies Chemical Screening
inferredcites →https://doi.org/10.1016/s0065-2164(09)01204-0openalex-snapshot
Chapter 4 The Capsule of the Fungal Pathogen Cryptococcus neoformans
inferredcites →https://doi.org/10.1016/s1074-7613(02)00328-xopenalex-snapshot
CR3 (CD11b/CD18) and CR4 (CD11c/CD18) Are Involved in Complement-Independent Antibody-Mediated Phagocytosis of Cryptococcus neoformans
inferredcites →https://doi.org/10.1016/s1473-3099(17)30243-8openalex-snapshot
Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis
inferredcites →https://doi.org/10.1038/nmeth.2019openalex-snapshot
Fiji: an open-source platform for biological-image analysis
inferredcites →https://doi.org/10.1038/nrm2256openalex-snapshot
ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis
inferredcites →https://doi.org/10.1038/s41598-020-64571-7openalex-snapshot
Repurposing approach identifies pitavastatin as a potent azole chemosensitizing agent effective against azole-resistant Candida species
inferredcites →https://doi.org/10.1073/pnas.052702799openalex-snapshot
Replication of Cryptococcus neoformans in macrophages is accompanied by phagosomal permeabilization and accumulation of vesicles containing polysaccharide in the cytoplasm
inferredcites →https://doi.org/10.1073/pnas.0902963106openalex-snapshot
The fatal fungal outbreak on Vancouver Island is characterized by enhanced intracellular parasitism driven by mitochondrial regulation
inferredcites →https://doi.org/10.1073/pnas.232568599openalex-snapshot
Killing of Caenorhabditis elegans by Cryptococcus neoformans as a model of yeast pathogenesis
inferredcites →https://doi.org/10.1073/pnas.261418798openalex-snapshot
Cryptococcus neoformans interactions with amoebae suggest an explanation for its virulence and intracellular pathogenic strategy in macrophages
inferredcites →https://doi.org/10.1073/pnas.87.3.950openalex-snapshot
Selective cleavage of kinetoplast DNA minicircles promoted by antitrypanosomal drugs.
inferredcites →https://doi.org/10.1080/1369378031000137260openalex-snapshot
Apoptosis induction by glucuronoxylomannan of Cryptococcus neoformans
inferredcites →https://doi.org/10.1080/21505594.2016.1196301openalex-snapshot
Repurposing auranofin as an antifungal: In vitro activity against a variety of medically important fungi
inferredcites →https://doi.org/10.1080/714030973openalex-snapshot
Immunoregulation by capsular components of Cryptococcus neoformans
inferredcites →https://doi.org/10.1083/jcb.201102095openalex-snapshot
Signal transduction by reactive oxygen species
inferredcites →https://doi.org/10.1084/jem.184.2.377openalex-snapshot
Effect of the laccase gene CNLAC1, on virulence of Cryptococcus neoformans.
inferredcites →https://doi.org/10.1089/ars.2008.2270openalex-snapshot
Regulation of Autophagy by Reactive Oxygen Species (ROS): Implications for Cancer Progression and Treatment
inferredcites →https://doi.org/10.1093/infdis/154.1.76openalex-snapshot
Amphotericin B-Induced Oxidative Damage and Killing of Candida albicans
inferredcites →https://doi.org/10.1093/infdis/167.1.186openalex-snapshot
Regulation of Cryptococcal Capsular Polysaccharide by Iron
inferredcites →https://doi.org/10.1097/qad.0b013e328322ffacopenalex-snapshot
Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS
inferredcites →https://doi.org/10.1099/00221287-147-8-2355openalex-snapshot
Dynamic changes in the morphology of Cryptococcus neoformans during murine pulmonary infection
inferredcites →https://doi.org/10.1101/2021.03.01.433276openalex-snapshot
Host-derived Reactive Nitrogen Species mediate the Cryptococcus neoformans yeast-to-titan switch via fungal-derived superoxide
inferredcites →https://doi.org/10.1101/cshperspect.a019661openalex-snapshot
Fungal Pathogens: Survival and Replication within Macrophages
inferredcites →https://doi.org/10.1111/cmi.12488openalex-snapshot
The formation of titan cells in Cryptococcus neoformans depends on the mouse strain and correlates with induction of Th2-type responses
inferredcites →https://doi.org/10.1111/j.1365-2958.2003.03957.xopenalex-snapshot
Molecular architecture of the Cryptococcus neoformans capsule
inferredcites →https://doi.org/10.1111/j.1462-5822.2008.01186.xopenalex-snapshot
Capsule enlargement in Cryptococcus neoformans confers resistance to oxidative stress suggesting a mechanism for intracellular survival
inferredcites →https://doi.org/10.1111/j.1751-0813.1997.tb14377.xopenalex-snapshot
Nasopharyngeal cryptococcosis
inferredcites →https://doi.org/10.1124/jpet.109.163329openalex-snapshot
Pharmacological Targeting of the Mitochondrial Phosphatase PTPMT1
inferredcites →https://doi.org/10.1128/aac.00680-13openalex-snapshot
High-Throughput Screening of a Collection of Known Pharmacologically Active Small Compounds for Identification of Candida albicans Biofilm Inhibitors
inferredcites →https://doi.org/10.1128/aac.01909-17openalex-snapshot
Repurposing and Reformulation of the Antiparasitic Agent Flubendazole for Treatment of Cryptococcal Meningoencephalitis, a Neglected Fungal Disease
inferredcites →https://doi.org/10.1128/aac.01921-19openalex-snapshot
Identification of Off-Patent Drugs That Show Synergism with Amphotericin B or That Present Antifungal Action against Cryptococcus neoformans and Candida spp
inferredcites →https://doi.org/10.1128/aac.03570-14openalex-snapshot
The Production of Reactive Oxygen Species Is a Universal Action Mechanism of Amphotericin B against Pathogenic Yeasts and Contributes to the Fungicidal Effect of This Drug
inferredcites →https://doi.org/10.1128/aac.41.2.379openalex-snapshot
A cytotoxicity assay for evaluation of candidate anti-Pneumocystis carinii agents
inferredcites →https://doi.org/10.1128/aac.48.5.1561-1569.2004openalex-snapshot
In Vitro Antifungal Activities of Inhibitors of Phospholipases from the Fungal Pathogen Cryptococcus neoformans
inferredcites →https://doi.org/10.1128/aem.03697-12openalex-snapshot
Susceptibility of Intact Germinating Arabidopsis thaliana to Human Fungal Pathogens Cryptococcus neoformans and C. gattii
inferredcites →https://doi.org/10.1128/aem.25.2.309-312.1973openalex-snapshot
Cryptococcus neoformans of Unusual Morphology
inferredcites →https://doi.org/10.1128/ec.00121-12openalex-snapshot
Titan Cells Confer Protection from Phagocytosis in Cryptococcus neoformans Infections
inferredcites →https://doi.org/10.1128/ec.00306-06openalex-snapshot
Radial Mass Density, Charge, and Epitope Distribution in theCryptococcus neoformansCapsule
inferredcites →https://doi.org/10.1128/ec.00314-12openalex-snapshot
A Repurposing Approach Identifies Off-Patent Drugs with Fungicidal Cryptococcal Activity, a Common Structural Chemotype, and Pharmacological Properties Relevant to the Treatment of Cryptococcosis
inferredcites →https://doi.org/10.1128/ec.3.2.413-419.2004openalex-snapshot
Challenge of Drosophila melanogaster with Cryptococcus neoformans and Role of the Innate Immune Response
inferredcites →https://doi.org/10.1128/iai.00542-09openalex-snapshot
Spores as Infectious Propagules ofCryptococcus neoformans
inferredcites →https://doi.org/10.1128/iai.00662-17openalex-snapshot
Regulated Release of Cryptococcal Polysaccharide Drives Virulence and Suppresses Immune Cell Infiltration into the Central Nervous System
inferredcites →https://doi.org/10.1128/iai.20.1.262-266.1978openalex-snapshot
Cryptococcus neoformans: pseudohyphal forms surviving culture with Acanthamoeba polyphaga
inferredcites →https://doi.org/10.1128/iai.62.11.4755-4761.1994openalex-snapshot
Pathogenesis of pulmonary Cryptococcus neoformans infection in the rat
inferredcites →https://doi.org/10.1128/iai.63.7.2632-2644.1995openalex-snapshot
Effects of the two varieties of Cryptococcus neoformans cells and culture filtrate antigens on neutrophil locomotion
inferredcites →https://doi.org/10.1128/iai.68.7.4225-4237.2000openalex-snapshot
Cryptococcus neoformansIs a Facultative Intracellular Pathogen in Murine Pulmonary Infection
inferredcites →https://doi.org/10.1128/iai.71.11.6155-6164.2003openalex-snapshot
Induction of Capsule Growth inCryptococcus neoformansby Mammalian Serum and CO2
inferredcites →https://doi.org/10.1128/iai.73.7.3842-3850.2005openalex-snapshot
Galleria mellonella as a Model System To Study Cryptococcus neoformans Pathogenesis
inferredcites →https://doi.org/10.1128/jb.173.1.401-403.1991openalex-snapshot
Catecholamine uptake, melanization, and oxygen toxicity in Cryptococcus neoformans
inferredcites →https://doi.org/10.1128/mbio.01375-18openalex-snapshot
Maintenance of Mitochondrial Morphology in Cryptococcus neoformans Is Critical for Stress Resistance and Virulence
inferredcites →https://doi.org/10.1136/jcp.25.11.1009-aopenalex-snapshot
Cryptococcal and other forms of mycotic meningitis.
inferredcites →https://doi.org/10.1172/jci112000openalex-snapshot
Virulence of Cryptococcus neoformans. Regulation of capsule synthesis by carbon dioxide.
inferredcites →https://doi.org/10.1186/s12941-015-0090-4openalex-snapshot
Repurposing FDA approved drugs against the human fungal pathogen, Candida albicans
inferredcites →https://doi.org/10.1189/jlb.1002476openalex-snapshot
The polysaccharide capsule of Cryptococcus neoformans interferes with human dendritic cell maturation and activation
inferredcites →https://doi.org/10.1248/bpb.25.53openalex-snapshot
Induction and Inhibition of Cytochrome P450 and Drug-Metabolizing Enzymes by Climbazole.
inferredcites →https://doi.org/10.1251/bpo68openalex-snapshot
Experimental modulation of capsule size in Cryptococcus neoformans
inferredcites →https://doi.org/10.1371/journal.ppat.1000945openalex-snapshot
Fungal Cell Gigantism during Mammalian Infection
inferredcites →https://doi.org/10.1371/journal.ppat.1000953openalex-snapshot
Cryptococcal Cell Morphology Affects Host Cell Interactions and Pathogenicity
inferredcites →https://doi.org/10.1371/journal.ppat.1006978openalex-snapshot
The Cryptococcus neoformans Titan cell is an inducible and regulated morphotype underlying pathogenesis
inferredcites →https://doi.org/10.1371/journal.ppat.1006982openalex-snapshot
Titan cells formation in Cryptococcus neoformans is finely tuned by environmental conditions and modulated by positive and negative genetic regulators
inferredcites →https://doi.org/10.1371/journal.ppat.1007007openalex-snapshot
Cryptococcus neoformans can form titan-like cells in vitro in response to multiple signals
inferredcites →https://doi.org/10.2217/imt.11.86openalex-snapshot
Cryptococcus Neoformans Galactoxylomannan is a Potent Negative Immunomodulator, Inspiring New Approaches in Anti-Inflammatory Immunotherapy
inferredcites →https://doi.org/10.3354/dao02471openalex-snapshot
Thirty year retrospective evaluation of pneumonia in a bottlenose dolphin Tursiops truncatus population
inferredcites →https://doi.org/10.3389/fcimb.2019.00083openalex-snapshot
Identification of Off-Patent Compounds That Present Antifungal Activity Against the Emerging Fungal Pathogen Candida auris
inferredcites →https://doi.org/10.3389/fcimb.2020.597931openalex-snapshot
Screening the CALIBR ReFRAME Library in Search for Inhibitors of Candida auris Biofilm Formation
inferredcites →https://doi.org/10.3389/fonc.2012.00064openalex-snapshot
Oxidative Stress and Programmed Cell Death in Yeast
inferredcites →https://doi.org/10.3390/jof5040092openalex-snapshot
Repositionable Compounds with Antifungal Activity against Multidrug Resistant Candida auris Identified in the Medicines for Malaria Venture’s Pathogen Box
inferredcites →https://doi.org/10.3390/jof7010029openalex-snapshot
Cryptococcus in Wildlife and Free-Living Mammals
inferredcites →https://doi.org/10.4049/jimmunol.120.5.1686openalex-snapshot
Complement Depletion in Cryptococcal Sepsis
inferredcites →https://doi.org/10.4049/jimmunol.166.7.4620openalex-snapshot
Toll-Like Receptor 4 Mediates Intracellular Signaling Without TNF-α Release in Response to Cryptococcus neoformans Polysaccharide Capsule
inferredcites →https://doi.org/10.4155/fmc-2019-0218openalex-snapshot
Mechanisms of Ebselen as a Therapeutic and Its Pharmacology Applications
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inferred← citeshttps://doi.org/10.3390/jof12080620openalex-snapshot
Reactive Oxygen Species-Responsive Signaling Networks and Oxidative Stress Adaptation in Critical Priority Fungal Pathogens
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