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Pre-symptomatic reduction of individuality in the App NL-F knock-in model of Alzheimer’s disease

https://doi.org/10.1101/2022.08.18.504396

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Outgoing claims: the papers this work cites, builds on, or argues with.

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Seizure severity‐dependent selective vulnerability of the granule cell layer and aberrant neurogenesis in the rat hippocampus

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Alternate day fasting and endurance exercise combine to reduce body weight and favorably alter plasma lipids in obese humans

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ggplot2

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Alzheimer disease: are we intervening too late?

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A cross-sectional comparison of brain glucose and ketone metabolism in cognitively healthy older adults, mild cognitive impairment and early Alzheimer's disease

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Adult neurogenesis is functionally associated with AD-like neurodegeneration

inferredcites →https://doi.org/10.1016/j.nbd.2012.03.033openalex-snapshot

Neurogenic abnormalities in Alzheimer's disease differ between stages of neurogenesis and are partly related to cholinergic pathology

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Hippocampal hypometabolism predicts cognitive decline from normal aging

inferredcites →https://doi.org/10.1016/j.neurobiolaging.2009.03.009openalex-snapshot

Impaired neurogenesis, neuronal loss, and brain functional deficits in the APPxPS1-Ki mouse model of Alzheimer's disease

inferredcites →https://doi.org/10.1016/j.neurobiolaging.2012.05.013openalex-snapshot

Transient enriched housing before amyloidosis onset sustains cognitive improvement in Tg2576 mice

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The neurogenic reserve hypothesis: what is adult hippocampal neurogenesis good for?

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Potential for primary prevention of Alzheimer's disease: an analysis of population-based data

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The nature of nurture: Genetic influence on “environmental” measures

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Nonshared environment: A theoretical, methodological, and quantitative review.

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Single App knock-in mouse models of Alzheimer's disease

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Environmental enrichment preserves a young DNA methylation landscape in the aged mouse hippocampus

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Environmental enrichment, new neurons and the neurobiology of individuality

inferredcites →https://doi.org/10.1038/s41591-019-0375-9openalex-snapshot

Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer’s disease

inferredcites →https://doi.org/10.1073/pnas.0403678101openalex-snapshot

Enhanced neurogenesis in Alzheimer's disease transgenic (PDGF-APP Sw,Ind ) mice

inferredcites →https://doi.org/10.1073/pnas.2634794100openalex-snapshot

Increased hippocampal neurogenesis in Alzheimer's disease

inferredcites →https://doi.org/10.1080/23262133.2017.1322666openalex-snapshot

The effects of aging on Amyloid-β42-induced neurodegeneration and regeneration in adult zebrafish brain

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Activity Dependency and Aging in the Regulation of Adult Neurogenesis

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Post-training reversible inactivation of the hippocampus enhances novel object recognition memory

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Lipid metabolism and Alzheimer's disease: clinical evidence, mechanistic link and therapeutic promise

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Early-life environmental enrichment generates persistent individualized behavior in mice

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Emergence of Individuality in Genetically Identical Mice

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Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

inferredcites →https://doi.org/10.1126/science.abl5163openalex-snapshot

Impact of neurodegenerative diseases on human adult hippocampal neurogenesis

inferredcites →https://doi.org/10.1159/000356430openalex-snapshot

The Hippocampus in Neurodegenerative Disease

inferredcites →https://doi.org/10.1186/1471-2202-7-77openalex-snapshot

Variability of doublecortin-associated dendrite maturation in adult hippocampal neurogenesis is independent of the regulation of precursor cell proliferation

inferredcites →https://doi.org/10.1212/01.wnl.0000163856.13524.08openalex-snapshot

Reduced hippocampal metabolism in MCI and AD

inferredcites →https://doi.org/10.1212/01.wnl.0000194507.39504.17openalex-snapshot

Cholesterol, APOE genotype, and Alzheimer disease

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Total daily physical activity and the risk of AD and cognitive decline in older adults

inferredcites →https://doi.org/10.1212/wnl.0b013e31828f17deopenalex-snapshot

Higher serum glucose levels are associated with cerebral hypometabolism in Alzheimer regions

inferredcites →https://doi.org/10.1371/journal.pbio.3000585openalex-snapshot

Neuron-glia interaction through Serotonin-BDNF-NGFR axis enables regenerative neurogenesis in Alzheimer’s model of adult zebrafish brain

inferredcites →https://doi.org/10.1371/journal.pone.0002935openalex-snapshot

Impaired Adult Neurogenesis in the Dentate Gyrus of a Triple Transgenic Mouse Model of Alzheimer's Disease

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Aerobic exercise for Alzheimer's disease: A randomized controlled pilot trial

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Hypertriglyceridemia: its etiology, effects and treatment

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APP mouse models for Alzheimer's disease preclinical studies

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Oxidative Stress, Amyloid-β Peptide, and Altered Key Molecular Pathways in the Pathogenesis and Progression of Alzheimer’s Disease

inferredcites →https://doi.org/10.3233/jad-2007-12304openalex-snapshot

Increased Neurogenesis in Young Transgenic Mice Overexpressing Human APPSw,Ind

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Embodied Prevention

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Selective increases in inter-individual variability in response to environmental enrichment in female mice

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Individual behavioral trajectories shape whole-brain connectivity in mice

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