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Tissue protective role of Ganetespib in SARS-CoV-2-infected Syrian golden hamsters

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Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19
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Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China
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Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area
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Molecular Chaperones and Protein Quality Control
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Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition
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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
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Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19
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SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis
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The Roborovski Dwarf Hamster Is A Highly Susceptible Model for a Rapid and Fatal Course of SARS-CoV-2 Infection
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CASE REPORT OF SEVERE PULMONARY FIBROSIS AS A SEQUELAE OF COVID-19 INFECTION
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Transcriptomic profiling of SARS-CoV-2 infected human cell lines identifies HSP90 as target for COVID-19 therapy
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Oral Hsp90 inhibitor SNX-5422 attenuates SARS-CoV-2 replication and dampens inflammation in airway cells
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SARS coronavirus accessory proteins
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Key benefits of dexamethasone and antibody treatment in COVID-19 hamster models revealed by single-cell transcriptomics
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Pulmonary fibrosis secondary to COVID-19: a call to arms?
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Pulmonary fibrosis and COVID-19: the potential role for antifibrotic therapy
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The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity
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COVID-19 in people with diabetes: understanding the reasons for worse outcomes
inferredcites →https://doi.org/10.1038/nrm3658openalex-snapshot
Chaperone machines for protein folding, unfolding and disaggregation
inferredcites →https://doi.org/10.1038/s41467-021-25030-7openalex-snapshot
Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19
inferredcites →https://doi.org/10.1038/s41577-019-0182-zopenalex-snapshot
Interferon-λ orchestrates innate and adaptive mucosal immune responses
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A new coronavirus associated with human respiratory disease in China
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Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype
inferredcites →https://doi.org/10.1038/s41587-020-0602-4openalex-snapshot
COVID-19 severity correlates with airway epithelium–immune cell interactions identified by single-cell analysis
inferredcites →https://doi.org/10.1038/s41590-020-0778-2openalex-snapshot
SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function
inferredcites →https://doi.org/10.1038/s41591-020-0901-9openalex-snapshot
Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19
inferredcites →https://doi.org/10.1038/s41591-020-0944-yopenalex-snapshot
A single-cell atlas of the peripheral immune response in patients with severe COVID-19
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SARS-CoV-2 infection induces a pro-inflammatory cytokine response through cGAS-STING and NF-κB
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Dexamethasone in Hospitalized Patients with Covid-19
inferredcites →https://doi.org/10.1056/nejmoa2101643openalex-snapshot
Tofacitinib in Patients Hospitalized with Covid-19 Pneumonia
inferredcites →https://doi.org/10.1056/nejmra1608077openalex-snapshot
Acute Respiratory Distress Syndrome
inferredcites →https://doi.org/10.1074/mcp.m111.014654openalex-snapshot
Quantitative Proteomics Reveals That Hsp90 Inhibition Preferentially Targets Kinases and the DNA Damage Response
inferredcites →https://doi.org/10.1080/10428194.2016.1213823openalex-snapshot
Ganetespib, an HSP90 inhibitor, kills Epstein–Barr virus (EBV)-infected B and T cells and reduces the percentage of EBV-infected cells in the blood
inferredcites →https://doi.org/10.1084/jem.20162152openalex-snapshot
Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span
inferredcites →https://doi.org/10.1093/cvr/cvs158openalex-snapshot
HSP90 inhibition by 17-DMAG attenuates oxidative stress in experimental atherosclerosis
inferredcites →https://doi.org/10.1093/nar/gkz114openalex-snapshot
The R package Rsubread is easier, faster, cheaper and better for alignment and quantification of RNA sequencing reads
inferredcites →https://doi.org/10.1096/fj.202100431ropenalex-snapshot
Quantitative proteomics of hamster lung tissues infected with SARS‐CoV‐2 reveal host factors having implication in the disease pathogenesis and severity
inferredcites →https://doi.org/10.1101/2020.03.05.20031906openalex-snapshot
COVID-19 early warning score: a multi-parameter screening tool to identify highly suspected patients
inferredcites →https://doi.org/10.1101/2021.11.29.470337openalex-snapshot
Dexamethasone induces senescence of lung epithelial cells and augments TGF-β1-mediated production of the fibrosis mediator serpin E1 (plasminogen activator inhibitor-1)
inferredcites →https://doi.org/10.1101/2022.04.21.489072openalex-snapshot
Impaired immune response drives age-dependent severity of COVID-19
inferredcites →https://doi.org/10.1128/aac.48.3.867-872.2004openalex-snapshot
Geldanamycin, a Ligand of Heat Shock Protein 90, Inhibits the Replication of Herpes Simplex Virus Type 1 In Vitro
inferredcites →https://doi.org/10.1128/jvi.00110-21openalex-snapshot
SARS-CoV-2 Causes Severe Epithelial Inflammation and Barrier Dysfunction
inferredcites →https://doi.org/10.1128/jvi.01415-17openalex-snapshot
The Cellular Chaperone Heat Shock Protein 90 Is Required for Foot-and-Mouth Disease Virus Capsid Precursor Processing and Assembly of Capsid Pentamers
inferredcites →https://doi.org/10.1128/jvi.02220-16openalex-snapshot
Heat Shock Protein 90 Ensures Efficient Mumps Virus Replication by Assisting with Viral Polymerase Complex Formation
inferredcites →https://doi.org/10.1128/jvi.76.3.1379-1390.2002openalex-snapshot
Molecular Chaperone Hsp90 Is Important for Vaccinia Virus Growth in Cells
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Inhibition of Beta Interferon Induction by Severe Acute Respiratory Syndrome Coronavirus Suggests a Two-Step Model for Activation of Interferon Regulatory Factor 3
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Pathogenic Influenza Viruses and Coronaviruses Utilize Similar and Contrasting Approaches To Control Interferon-Stimulated Gene Responses
inferredcites →https://doi.org/10.1136/annrheumdis-2012-203095openalex-snapshot
Heat shock protein 90 (Hsp90) inhibition targets canonical TGF-β signalling to prevent fibrosis
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Ly6Chi Monocytes Direct Alternatively Activated Profibrotic Macrophage Regulation of Lung Fibrosis
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Senescence of Alveolar Type 2 Cells Drives Progressive Pulmonary Fibrosis
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Heat Shock Protein 90 Inhibitors Protect and Restore Pulmonary Endothelial Barrier Function
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Neutrophil extracellular traps in COVID-19
inferredcites →https://doi.org/10.1172/jci.insight.91454openalex-snapshot
Hsp90 regulation of fibroblast activation in pulmonary fibrosis
inferredcites →https://doi.org/10.1172/jci143361openalex-snapshot
COVID-19 and myeloid cells: complex interplay correlates with lung severity
inferredcites →https://doi.org/10.1183/13993003.01870-2021openalex-snapshot
A randomised trial of anti-GM-CSF otilimab in severe COVID-19 pneumonia (OSCAR)
inferredcites →https://doi.org/10.1186/1743-422x-11-17openalex-snapshot
Inhibition of HSP90 attenuates porcine reproductive and respiratory syndrome virus production in vitro
inferredcites →https://doi.org/10.1186/s13059-014-0550-8openalex-snapshot
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
inferredcites →https://doi.org/10.12688/f1000research.7214.1openalex-snapshot
Molecular chaperones: guardians of the proteome in normal and disease states
inferredcites →https://doi.org/10.15252/msb.202010188openalex-snapshot
SARS‐CoV‐2 infection remodels the host protein thermal stability landscape
inferredcites →https://doi.org/10.21037/jtd.2019.09.03openalex-snapshot
Elevation of pulmonary CD163+ and CD204+ macrophages is associated with the clinical course of idiopathic pulmonary fibrosis patients
inferredcites →https://doi.org/10.2147/ott.s65804openalex-snapshot
Ganetespib: research and clinical development
inferredcites →https://doi.org/10.2174/138161213804143617openalex-snapshot
Hsp90 Inhibitors as Anti-Cancer Agents, from Basic Discoveries to Clinical Development
inferredcites →https://doi.org/10.2174/157340810791233033openalex-snapshot
TGF-β : Titan of Lung Fibrogenesis
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Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR
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Immune Phenotyping Based on the Neutrophil-to-Lymphocyte Ratio and IgG Level Predicts Disease Severity and Outcome for Patients With COVID-19
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The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative Diseases
inferredcites →https://doi.org/10.3389/fphys.2022.812199openalex-snapshot
HSP90 Inhibitors Modulate SARS-CoV-2 Spike Protein Subunit 1-Induced Human Pulmonary Microvascular Endothelial Activation and Barrier Dysfunction
inferredcites →https://doi.org/10.3390/ijms21155286openalex-snapshot
HSP90 Inhibition and Modulation of the Proteome: Therapeutical Implications for Idiopathic Pulmonary Fibrosis (IPF)
inferredcites →https://doi.org/10.3390/v12070779openalex-snapshot
Age-Dependent Progression of SARS-CoV-2 Infection in Syrian Hamsters
inferredcites →https://doi.org/10.4049/jimmunol.180.10.6808openalex-snapshot
NAIP and Ipaf Control Legionella pneumophila Replication in Human Cells
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