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Endogenous Staphylococcus aureus CRISPR- cas system limits phage proliferation and efficiently excises from the genome as part of the SCC mec cassette

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/bies.201200112openalex-snapshot
Coagulase‐negative staphylococci as reservoirs of genes facilitating MRSA infection
inferredcites →https://doi.org/10.1007/978-1-62703-664-1_8openalex-snapshot
Staphylococcal Cassette Chromosome mec (SCCmec) Analysis of MRSA
inferredcites →https://doi.org/10.1016/j.cell.2015.04.027openalex-snapshot
Co-transcriptional DNA and RNA Cleavage during Type III CRISPR-Cas Immunity
inferredcites →https://doi.org/10.1016/j.cell.2015.12.053openalex-snapshot
Degradation of Phage Transcripts by CRISPR-Associated RNases Enables Type III CRISPR-Cas Immunity
inferredcites →https://doi.org/10.1016/j.cell.2017.11.032openalex-snapshot
The Biology of CRISPR-Cas: Backward and Forward
inferredcites →https://doi.org/10.1016/j.chom.2017.07.016openalex-snapshot
Broad Targeting Specificity during Bacterial Type III CRISPR-Cas Immunity Constrains Viral Escape
inferredcites →https://doi.org/10.1016/j.ijmm.2016.08.005openalex-snapshot
Identification and functional study of type III-A CRISPR-Cas systems in clinical isolates of Staphylococcus aureus
inferredcites →https://doi.org/10.1016/j.mib.2017.08.001openalex-snapshot
Staphylococcal pathogenicity islands — movers and shakers in the genomic firmament
inferredcites →https://doi.org/10.1016/j.mib.2022.102238openalex-snapshot
Synergy and regulation of antiphage systems: toward the existence of a bacterial immune system?
inferredcites →https://doi.org/10.1016/j.micres.2016.09.003openalex-snapshot
Characterization of CRISPR-Cas system in clinical Staphylococcus epidermidis strains revealed its potential association with bacterial infection sites
inferredcites →https://doi.org/10.1016/j.molcel.2016.08.038openalex-snapshot
CRISPR-Cas Systems Optimize Their Immune Response by Specifying the Site of Spacer Integration
inferredcites →https://doi.org/10.1038/nature13637openalex-snapshot
Conditional tolerance of temperate phages via transcription-dependent CRISPR-Cas targeting
inferredcites →https://doi.org/10.1038/nrmicro2577openalex-snapshot
Evolution and classification of the CRISPR–Cas systems
inferredcites →https://doi.org/10.1038/s41467-022-29877-2openalex-snapshot
Natural transformation allows transfer of SCCmec-mediated methicillin resistance in Staphylococcus aureus biofilms
inferredcites →https://doi.org/10.1038/s41467-022-30269-9openalex-snapshot
Systematic and quantitative view of the antiviral arsenal of prokaryotes
inferredcites →https://doi.org/10.1038/s41564-019-0400-2openalex-snapshot
Recombination between phages and CRISPR−cas loci facilitates horizontal gene transfer in staphylococci
inferredcites →https://doi.org/10.1038/s41564-021-00996-8openalex-snapshot
Prophage integration into CRISPR loci enables evasion of antiviral immunity in Streptococcus pyogenes
inferredcites →https://doi.org/10.1038/s41579-018-0071-7openalex-snapshot
Molecular mechanisms of CRISPR–Cas spacer acquisition
inferredcites →https://doi.org/10.1038/s41579-019-0299-xopenalex-snapshot
Evolutionary classification of CRISPR–Cas systems: a burst of class 2 and derived variants
inferredcites →https://doi.org/10.1038/s41586-021-03440-3openalex-snapshot
Type III-A CRISPR immunity promotes mutagenesis of staphylococci
inferredcites →https://doi.org/10.1046/j.1365-2958.2002.02839.xopenalex-snapshot
Identification of genes that are associated with DNA repeats in prokaryotes
inferredcites →https://doi.org/10.1080/15476286.2018.1493334openalex-snapshot
The ribonuclease activity of Csm6 is required for anti-plasmid immunity by Type III-A CRISPR-Cas systems
inferredcites →https://doi.org/10.1080/22221751.2019.1595161openalex-snapshot
Decreasing methicillin-resistant Staphylococcus aureus (MRSA) infections is attributable to the disappearance of predominant MRSA ST239 clones, Shanghai, 2008–2017
inferredcites →https://doi.org/10.1089/crispr.2021.0046openalex-snapshot
Functional Characterization of Type III-A CRISPR-Cas in a Clinical Human Methicillin-R Staphylococcus aureus Strain
inferredcites →https://doi.org/10.1093/nar/gkab1299openalex-snapshot
Different modes of spacer acquisition by the Staphylococcus epidermidis type III-A CRISPR-Cas system
inferredcites →https://doi.org/10.1093/nar/gkab859openalex-snapshot
CRISPR-Cas systems are widespread accessory elements across bacterial and archaeal plasmids
inferredcites →https://doi.org/10.1093/nar/gkab883openalex-snapshot
Identification and classification of antiviral defence systems in bacteria and archaea with PADLOC reveals new system types
inferredcites →https://doi.org/10.1093/nar/gkac400openalex-snapshot
PADLOC: a web server for the identification of antiviral defence systems in microbial genomes
inferredcites →https://doi.org/10.1093/nar/gkx153openalex-snapshot
Antibiotics trigger initiation of SCCmec transfer by inducing SOS responses
inferredcites →https://doi.org/10.1093/nar/gky425openalex-snapshot
CRISPRCasFinder, an update of CRISRFinder, includes a portable version, enhanced performance and integrates search for Cas proteins
inferredcites →https://doi.org/10.1099/acmi.0.000193openalex-snapshot
From cloning to mutant in 5 days: rapid allelic exchange in Staphylococcus aureus
inferredcites →https://doi.org/10.1099/ijs.0.062752-0openalex-snapshot
Novel staphylococcal species that form part of a Staphylococcus aureus-related complex: the non-pigmented Staphylococcus argenteus sp. nov. and the non-human primate-associated Staphylococcus schweitzeri sp. nov.
inferredcites →https://doi.org/10.1099/jmm.0.000869openalex-snapshot
Molecular characterization of Staphylococcus argenteus in Myanmar: identification of novel genotypes/clusters in staphylocoagulase, protein A, alpha-haemolysin and other virulence factors
inferredcites →https://doi.org/10.1101/2022.05.19.492656openalex-snapshot
High Frequency of Dynamic Rearrangements In Crispr loci
inferredcites →https://doi.org/10.1111/imr.12565openalex-snapshot
A bacteriophages journey through the human body
inferredcites →https://doi.org/10.1111/j.1365-2958.2006.05441.xopenalex-snapshot
Prophages of Staphylococcus aureus Newman and their contribution to virulence
inferredcites →https://doi.org/10.1111/mmi.12253openalex-snapshot
Roles of two large serine recombinases in mobilizing the methicillin‐resistance cassette SCCmec
inferredcites →https://doi.org/10.1126/science.1138140openalex-snapshot
CRISPR Provides Acquired Resistance Against Viruses in Prokaryotes
inferredcites →https://doi.org/10.1126/science.1165771openalex-snapshot
CRISPR Interference Limits Horizontal Gene Transfer in Staphylococci by Targeting DNA
inferredcites →https://doi.org/10.1128/aac.00579-09openalex-snapshot
Classification of Staphylococcal Cassette Chromosome mec (SCC mec ): Guidelines for Reporting Novel SCC mec Elements
inferredcites →https://doi.org/10.1128/aac.01058-13openalex-snapshot
Transduction of Staphylococcal Cassette Chromosome mec Elements between Strains of Staphylococcus aureus
inferredcites →https://doi.org/10.1128/aac.01689-12openalex-snapshot
Emergence of Sequence Type 779 Methicillin-Resistant Staphylococcus aureus Harboring a Novel Pseudo Staphylococcal Cassette Chromosome mec (SCC mec )-SCC-SCC CRISPR Composite Element in Irish Hospitals
inferredcites →https://doi.org/10.1128/cmr.00020-18openalex-snapshot
Methicillin-Resistant Staphylococcus aureus: Molecular Characterization, Evolution, and Epidemiology
inferredcites →https://doi.org/10.1128/jcm.38.3.1008-1015.2000openalex-snapshot
Multilocus Sequence Typing for Characterization of Methicillin-Resistant and Methicillin-Susceptible Clones ofStaphylococcus aureus
inferredcites →https://doi.org/10.1128/mra.00891-20openalex-snapshot
Complete Genome Sequences of Methicillin-Resistant Staphylococcus aureus Strains 110900 and 128254, Two Representatives of the CRISPR-Cas-Carrying Sequence Type 630/ spa Type t4549 Lineage
inferredcites →https://doi.org/10.1128/spectrum.01501-21openalex-snapshot
Genomic Analysis of the Unusual Staphylococcus aureus ST630 Isolates Harboring WTA Glycosyltransferase Genes tarM and tagN
inferredcites →https://doi.org/10.1128/spectrum.02423-21openalex-snapshot
Screening for Highly Transduced Genes in Staphylococcus aureus Revealed Both Lateral and Specialized Transduction
inferredcites →https://doi.org/10.1186/s12864-019-5439-1openalex-snapshot
CRISPR-Cas systems are present predominantly on mobile genetic elements in Vibrio species
inferredcites →https://doi.org/10.1371/journal.pone.0110726openalex-snapshot
MacSyFinder: A Program to Mine Genomes for Molecular Systems with an Application to CRISPR-Cas Systems
inferredcites →https://doi.org/10.3201/eid1604.091435openalex-snapshot
Livestock-associated Methicillin-ResistantStaphylococcus aureusSequence Type 398 in Humans, Canada
inferredcites →https://doi.org/10.3389/fcimb.2012.00006openalex-snapshot
Staphylococcus aureus Temperate Bacteriophage: Carriage and Horizontal Gene Transfer is Lineage Associated
inferredcites →https://doi.org/10.3389/fmicb.2017.00566openalex-snapshot
Phages in the Human Body
inferredcites →https://doi.org/10.3389/fmicb.2017.01545openalex-snapshot
CRISPR-Cas Systems Features and the Gene-Reservoir Role of Coagulase-Negative Staphylococci
inferredcites →https://doi.org/10.3389/fmicb.2021.664299openalex-snapshot
Pruning and Tending Immune Memories: Spacer Dynamics in the CRISPR Array
inferredcites →https://doi.org/10.3389/fmicb.2021.736565openalex-snapshot
Characterization of 67 Confirmed Clustered Regularly Interspaced Short Palindromic Repeats Loci in 52 Strains of Staphylococci

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.7717/peerj-cs.3427openalex-snapshot
A vector database solution for rational design of CRISPR defense-avoidant phage therapy
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