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African swine fever virus I196L is a virulence determinant and its deletant induces robust protection in Domestic pig

https://doi.org/10.1101/2023.06.22.546121
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1007/s11427-020-1657-9openalex-snapshot
A seven-gene-deleted African swine fever virus is safe and effective as a live attenuated vaccine in pigs
inferredcites →https://doi.org/10.1007/s12250-021-00375-xopenalex-snapshot
African Swine Fever Virus Protein E199L Promotes Cell Autophagy through the Interaction of PYCR2
inferredcites →https://doi.org/10.1016/j.antiviral.2016.11.021openalex-snapshot
Different routes and doses influence protection in pigs immunised with the naturally attenuated African swine fever virus isolate OURT88/3
inferredcites →https://doi.org/10.1016/j.antiviral.2019.02.018openalex-snapshot
African swine fever
inferredcites →https://doi.org/10.1016/j.chom.2019.11.004openalex-snapshot
Cryo-EM Structure of the African Swine Fever Virus
inferredcites →https://doi.org/10.1016/j.vaccine.2018.03.040openalex-snapshot
African swine fever virus (ASFV) protection mediated by NH/P68 and NH/P68 recombinant live-attenuated viruses
inferredcites →https://doi.org/10.1016/j.virusres.2006.01.009openalex-snapshot
Evolutionary genomics of nucleo-cytoplasmic large DNA viruses
inferredcites →https://doi.org/10.1016/j.virusres.2012.10.030openalex-snapshot
Epidemiology of African swine fever virus
inferredcites →https://doi.org/10.1016/j.virusres.2020.198099openalex-snapshot
African swine fever – A review of current knowledge
inferredcites →https://doi.org/10.1038/s41598-021-02949-xopenalex-snapshot
Optimization in the expression of ASFV proteins for the development of subunit vaccines using poxviruses as delivery vectors
inferredcites →https://doi.org/10.1073/pnas.2210808120openalex-snapshot
African swine fever virus I73R is a critical virulence-related gene: A potential target for attenuation
inferredcites →https://doi.org/10.1099/0022-1317-82-3-513openalex-snapshot
The non-haemadsorbing African swine fever virus isolate ASFV/NH/P68 provides a model for defining the protective anti-virus immune response
inferredcites →https://doi.org/10.1111/tbed.13540openalex-snapshot
The evolution of African swine fever virus in Sardinia (1978 to 2014) as revealed by whole genome sequencing and comparative analysis
inferredcites →https://doi.org/10.1128/cvi.00395-16openalex-snapshot
Induction of Robust Immune Responses in Swine by Using a Cocktail of Adenovirus-Vectored African Swine Fever Virus Antigens
inferredcites →https://doi.org/10.1128/jvi.00119-20openalex-snapshot
The African Swine Fever Virus Transcriptome
inferredcites →https://doi.org/10.1128/jvi.00554-15openalex-snapshot
African Swine Fever Virus Georgia Isolate Harboring Deletions of MGF360 and MGF505 Genes Is Attenuated in Swine and Confers Protection against Challenge with Virulent Parental Virus
inferredcites →https://doi.org/10.1128/jvi.01139-21openalex-snapshot
Deletion of the A137R Gene from the Pandemic Strain of African Swine Fever Virus Attenuates the Strain and Offers Protection against the Virulent Pandemic Virus
inferredcites →https://doi.org/10.1128/jvi.01199-21openalex-snapshot
African Swine Fever Virus Bearing an I226R Gene Deletion Elicits Robust Immunity in Pigs to African Swine Fever
inferredcites →https://doi.org/10.1128/jvi.01419-21openalex-snapshot
Deletion of E184L, a Putative DIVA Target from the Pandemic Strain of African Swine Fever Virus, Produces a Reduction in Virulence and Protection against Virulent Challenge
inferredcites →https://doi.org/10.1128/jvi.01500-21openalex-snapshot
A QP509L/QP383R-Deleted African Swine Fever Virus Is Highly Attenuated in Swine but Does Not Confer Protection against Parental Virus Challenge
inferredcites →https://doi.org/10.1128/jvi.01939-21openalex-snapshot
African Swine Fever Virus and Host Response: Transcriptome Profiling of the Georgia 2007/1 Strain and Porcine Macrophages
inferredcites →https://doi.org/10.1128/mbio.00789-20openalex-snapshot
African Swine Fever Virus Protein pE199L Mediates Virus Entry by Enabling Membrane Fusion and Core Penetration
inferredcites →https://doi.org/10.1146/annurev-animal-021419-083741openalex-snapshot
African Swine Fever Epidemiology and Control
inferredcites →https://doi.org/10.1371/journal.pone.0177007openalex-snapshot
Adenovirus-vectored novel African Swine Fever Virus antigens elicit robust immune responses in swine
inferredcites →https://doi.org/10.3201/eid1704.101283openalex-snapshot
Genomic Analysis of Highly Virulent Georgia 2007/1 Isolate of African Swine Fever Virus
inferredcites →https://doi.org/10.3389/fvets.2020.578474openalex-snapshot
Genetic Analysis of African Swine Fever Virus From the 2018 Outbreak in South-Eastern Burundi
inferredcites →https://doi.org/10.3390/v11090846openalex-snapshot
A Deep-Sequencing Workflow for the Fast and Efficient Generation of High-Quality African Swine Fever Virus Whole-Genome Sequences
inferredcites →https://doi.org/10.3390/v12060676openalex-snapshot
The C962R ORF of African Swine Fever Strain Georgia Is Non-Essential and Not Required for Virulence in Swine
inferredcites →https://doi.org/10.3390/v12121474openalex-snapshot
Live Attenuated African Swine Fever Viruses as Ideal Tools to Dissect the Mechanisms Involved in Cross-Protection
inferredcites →https://doi.org/10.3390/v14010053openalex-snapshot
I267L Is Neither the Virulence- Nor the Replication-Related Gene of African Swine Fever Virus and Its Deletant Is an Ideal Fluorescent-Tagged Virulence Strain
inferredcites →https://doi.org/10.3390/v8100291openalex-snapshot
Association of the Host Immune Response with Protection Using a Live Attenuated African Swine Fever Virus Model
inferredcites →https://doi.org/10.3390/v9070185openalex-snapshot
Vertebrate Reservoirs of Arboviruses: Myth, Synonym of Amplifier, or Reality?
inferredcites →https://doi.org/10.3390/vaccines7020056openalex-snapshot
Subunit Vaccine Approaches for African Swine Fever Virus

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1007/s11259-025-10884-9openalex-snapshot
ASF outbreaks in Vietnam (2019–2024): insights and lessons learned
inferred← citeshttps://doi.org/10.3390/v15091945openalex-snapshot
A Whole-Genome Analysis of the African Swine Fever Virus That Circulated during the First Outbreak in Vietnam in 2019 and Subsequently in 2022
inferred← citeshttps://doi.org/10.3390/v17050603openalex-snapshot
Deletion of the African Swine Fever Virus Gen I196L in the Georgia2010 Isolate Genome Does Not Affect Virus Replication or Virulence in Domestic Pigs
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