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The Fraser complex interconnects tissue layers to support basal epidermis and osteoblast integrated morphogenesis underlying fin skeletal patterning

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/ajmg.1320250111openalex-snapshot
Isolated and syndromic cryptophthalmos
inferredcites →https://doi.org/10.1002/ajmg.1320490206openalex-snapshot
Sclerocornea, hypertelorism, syndactyly, and ambiguous genitalia
inferredcites →https://doi.org/10.1002/ajmg.a.32440openalex-snapshot
Molecular study of 33 families with Fraser syndrome new data and mutation review
inferredcites →https://doi.org/10.1002/dvdy.21729openalex-snapshot
Expression of the fras1/frem gene family during zebrafish development and fin morphogenesis
inferredcites →https://doi.org/10.1002/dvdy.24389openalex-snapshot
Syndactyly in a novel Fras1rdf mutant results from interruption of signals for interdigital apoptosis
inferredcites →https://doi.org/10.1002/dvdy.24630openalex-snapshot
Evolution of caudal fin ray development and caudal fin hypural diastema complex in spotted gar, teleosts, and other neopterygian fishes
inferredcites →https://doi.org/10.1002/dvdy.475openalex-snapshot
Coordinated patterning of zebrafish caudal fin symmetry by a central and two peripheral organizers
inferredcites →https://doi.org/10.1002/wdev.367openalex-snapshot
Recent advancements in understanding fin regeneration in zebrafish
inferredcites →https://doi.org/10.1007/s00403-007-0763-8openalex-snapshot
Ultrastructural localization of Fras1 in the sublamina densa of embryonic epithelial basement membranes
inferredcites →https://doi.org/10.1016/j.celrep.2014.01.010openalex-snapshot
Sequential and Opposing Activities of Wnt and BMP Coordinate Zebrafish Bone Regeneration
inferredcites →https://doi.org/10.1016/j.devcel.2012.10.015openalex-snapshot
Hoxd13 Contribution to the Evolution of Vertebrate Appendages
inferredcites →https://doi.org/10.1016/j.devcel.2020.01.032openalex-snapshot
Epithelial Migration and Non-adhesive Periderm Are Required for Digit Separation during Mammalian Development
inferredcites →https://doi.org/10.1016/j.matbio.2007.05.008openalex-snapshot
Basement membrane localization of Frem3 is independent of the Fras1/Frem1/Frem2 protein complex within the sublamina densa
inferredcites →https://doi.org/10.1016/j.matbio.2018.07.005openalex-snapshot
Gene profile of zebrafish fin regeneration offers clues to kinetics, organization and biomechanics of basement membrane
inferredcites →https://doi.org/10.1016/j.ydbio.2006.11.004openalex-snapshot
Cooperation of sonic hedgehog enhancers in midline expression
inferredcites →https://doi.org/10.1016/j.ydbio.2012.03.008openalex-snapshot
Laser ablation of the sonic hedgehog-a-expressing cells during fin regeneration affects ray branching morphogenesis
inferredcites →https://doi.org/10.1016/j.ydbio.2016.05.035openalex-snapshot
Pharyngeal morphogenesis requires fras1 - itga8 -dependent epithelial-mesenchymal interaction
inferredcites →https://doi.org/10.1016/j.ydbio.2021.04.010openalex-snapshot
Basal epidermis collective migration and local Sonic hedgehog signaling promote skeletal branching morphogenesis in zebrafish fins
inferredcites →https://doi.org/10.1016/j.ydbio.2023.05.008openalex-snapshot
Insulin-like growth factor receptor / mTOR signaling elevates global translation to accelerate zebrafish fin regenerative outgrowth
inferredcites →https://doi.org/10.1038/375678a0openalex-snapshot
Hox gene expression in teleost fins and the origin of vertebrate digits
inferredcites →https://doi.org/10.1038/nature04637openalex-snapshot
The pectoral fin of Tiktaalik roseae and the origin of the tetrapod limb
inferredcites →https://doi.org/10.1038/nature07339openalex-snapshot
The pectoral fin of Panderichthys and the origin of digits
inferredcites →https://doi.org/10.1038/nature07891openalex-snapshot
Deep homology and the origins of evolutionary novelty
inferredcites →https://doi.org/10.1038/nature19322openalex-snapshot
Digits and fin rays share common developmental histories
inferredcites →https://doi.org/10.1038/ng1142openalex-snapshot
Fraser syndrome and mouse blebbed phenotype caused by mutations in FRAS1/Fras1 encoding a putative extracellular matrix protein
inferredcites →https://doi.org/10.1038/ng1168openalex-snapshot
Fras1 deficiency results in cryptophthalmos, renal agenesis and blebbed phenotype in mice
inferredcites →https://doi.org/10.1038/ng1292openalex-snapshot
A direct functional link between the multi-PDZ domain protein GRIP1 and the Fraser syndrome protein Fras1
inferredcites →https://doi.org/10.1038/ng1549openalex-snapshot
Identification of a new gene mutated in Fraser syndrome and mouse myelencephalic blebs
inferredcites →https://doi.org/10.1038/s41588-018-0080-5openalex-snapshot
A conserved Shh cis-regulatory module highlights a common developmental origin of unpaired and paired fins
inferredcites →https://doi.org/10.1073/pnas.0402760101openalex-snapshot
The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis
inferredcites →https://doi.org/10.1073/pnas.0601011103openalex-snapshot
Breakdown of the reciprocal stabilization of QBRICK/Frem1, Fras1, and Frem2 at the basement membrane provokes Fraser syndrome-like defects
inferredcites →https://doi.org/10.1073/pnas.122571799openalex-snapshot
Bone patterning is altered in the regenerating zebrafish caudal fin after ectopic expression of sonic hedgehog and bmp2b or exposure to cyclopamine
inferredcites →https://doi.org/10.1073/pnas.2209231119openalex-snapshot
Fin ray branching is defined by TRAP + osteolytic tubules in zebrafish
inferredcites →https://doi.org/10.1080/10520290701333558openalex-snapshot
A two-color acid-free cartilage and bone stain for zebrafish larvae
inferredcites →https://doi.org/10.1093/ageing/afl109openalex-snapshot
Fraser syndrome in a 96-year-old female
inferredcites →https://doi.org/10.1093/hmg/ddi262openalex-snapshot
The genetics of Fraser syndrome and the blebs mouse mutants
inferredcites →https://doi.org/10.1111/jfb.14300openalex-snapshot
Transgene‐mediated skeletal phenotypic variation in zebrafish
inferredcites →https://doi.org/10.1136/jmg.39.9.623openalex-snapshot
Fraser syndrome and cryptophthalmos: review of the diagnostic criteria and evidence for phenotypic modules in complex malformation syndromes
inferredcites →https://doi.org/10.1186/s12861-016-0102-4openalex-snapshot
Revisiting in vivo staining with alizarin red S - a valuable approach to analyse zebrafish skeletal mineralization during development and regeneration
inferredcites →https://doi.org/10.1242/dev.074906openalex-snapshot
fras1shapes endodermal pouch 1 and stabilizes zebrafish pharyngeal skeletal development
inferredcites →https://doi.org/10.1242/dev.143792openalex-snapshot
Shh promotes direct interactions between epidermal cells and osteoblast progenitors to shape regenerated zebrafish bone
inferredcites →https://doi.org/10.1371/journal.pbio.1001773openalex-snapshot
Conservation and Divergence of Regulatory Strategies at Hox Loci and the Origin of Tetrapod Digits
inferredcites →https://doi.org/10.1371/journal.pgen.1000907openalex-snapshot
Genetic Analysis of Fin Development in Zebrafish Identifies Furin and Hemicentin1 as Potential Novel Fraser Syndrome Disease Genes
inferredcites →https://doi.org/10.1371/journal.pgen.1002762openalex-snapshot
Attenuation of Notch and Hedgehog Signaling Is Required for Fate Specification in the Spinal Cord
inferredcites →https://doi.org/10.1371/journal.pgen.1005199openalex-snapshot
Beyond Glycolysis: GAPDHs Are Multi-functional Enzymes Involved in Regulation of ROS, Autophagy, and Plant Immune Responses
inferredcites →https://doi.org/10.1371/journal.pone.0076342openalex-snapshot
bfb, a Novel ENU-Induced blebs Mutant Resulting from a Missense Mutation in Fras1
inferredcites →https://doi.org/10.4103/0975-9727.128965openalex-snapshot
Fraser syndrome
inferredcites →https://doi.org/10.4236/ojoph.2011.11001openalex-snapshot
Fraser Syndrome: Case Report with Review of Literature

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1101/2024.11.15.623835openalex-snapshot
Early exercise disrupts a pro-repair extracellular matrix program during zebrafish fin regeneration
inferred← citeshttps://doi.org/10.1101/2025.11.07.687116openalex-snapshot
Sonic hedgehog signaling promotes basal epidermal fibrillin 3 expression for zebrafish fin ray branching
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