On the public citation graph

Multi-OMIC analysis of Huntington disease reveals a neuroprotective astrocyte state

https://doi.org/10.1101/2023.09.08.556867

0 signed · 120 inferred · view as graph

Inferred edges come from two machine sources: sweeps of open repository metadata (mostly SSRN and Zenodo), and a bulk OpenAlex citation snapshot. Every row below is labelled with the one it came from. Neither is a complete citation index — absence here is not evidence of absence.

Is this your work? Sign in with ORCID and put your name on the claims that are yours.

Claim with ORCID

Reference health. See whether every reference in this work resolves to a known work and none has been retracted — and get a dated CiteStamped badge you can embed.

See reference health

What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/cpz1.90openalex-snapshot

Gene Set Knowledge Discovery with Enrichr

inferredcites →https://doi.org/10.1002/glia.23022openalex-snapshot

Astrocytes are key but indirect contributors to the development of the symptomatology and pathophysiology of Huntington's disease

inferredcites →https://doi.org/10.1006/nbdi.2001.0430openalex-snapshot

Impaired Glutamate Uptake in the R6 Huntington's Disease Transgenic Mice

inferredcites →https://doi.org/10.1007/7854_2014_354openalex-snapshot

The Neuropathology of Huntington’s Disease

inferredcites →https://doi.org/10.1007/978-3-319-19285-7openalex-snapshot

The Neuropathology of Huntington’s Disease: Classical Findings, Recent Developments and Correlation to Functional Neuroanatomy

inferredcites →https://doi.org/10.1007/s10048-011-0294-5openalex-snapshot

Up-regulation of metallothionein gene expression in Parkinsonian astrocytes

inferredcites →https://doi.org/10.1007/s10571-011-9725-yopenalex-snapshot

Adenoviral Astrocyte-Specific Expression of BDNF in the Striata of Mice Transgenic for Huntington’s Disease Delays the Onset of the Motor Phenotype

inferredcites →https://doi.org/10.1007/s12640-014-9480-1openalex-snapshot

Neuroprotective Effects of Metallothionein Against Rotenone-Induced Myenteric Neurodegeneration in Parkinsonian Mice

inferredcites →https://doi.org/10.1016/0306-4522(93)90294-popenalex-snapshot

Compartmental loss of NADPH diaphorase in the neuropil of the human striatum in huntington's disease

inferredcites →https://doi.org/10.1016/0896-6273(88)90162-6openalex-snapshot

Glutamate neurotoxicity and diseases of the nervous system

inferredcites →https://doi.org/10.1016/j.biocel.2006.09.010openalex-snapshot

Metallothioneins I and II: Neuroprotective significance during CNS pathology

inferredcites →https://doi.org/10.1016/j.cbi.2010.04.010openalex-snapshot

The transition metals copper and iron in neurodegenerative diseases

inferredcites →https://doi.org/10.1016/j.cell.2015.07.003openalex-snapshot

Identification of Genetic Factors that Modify Clinical Onset of Huntington’s Disease

inferredcites →https://doi.org/10.1016/j.celrep.2020.108189openalex-snapshot

Single-Nucleus RNA-Seq Is Not Suitable for Detection of Microglial Activation Genes in Humans

inferredcites →https://doi.org/10.1016/j.celrep.2021.109308openalex-snapshot

Cell-intrinsic glial pathology is conserved across human and murine models of Huntington’s disease

inferredcites →https://doi.org/10.1016/j.isci.2022.105732openalex-snapshot

Single-nuclei transcriptome analysis of Huntington disease iPSC and mouse astrocytes implicates maturation and functional deficits

inferredcites →https://doi.org/10.1016/j.jacl.2009.11.003openalex-snapshot

Altered cholesterol and fatty acid metabolism in Huntington disease

inferredcites →https://doi.org/10.1016/j.jasms.2003.08.006openalex-snapshot

Characterization of acylphosphatidylglycerols from salmonella typhimurium by tandem mass spectrometry with electrospray ionization

inferredcites →https://doi.org/10.1016/j.jchemneu.2004.02.005openalex-snapshot

Differential loss of striatal projection systems in Huntington’s disease: a quantitative immunohistochemical study

inferredcites →https://doi.org/10.1016/j.nbd.2007.07.004openalex-snapshot

Progressive dysfunction of the cholesterol biosynthesis pathway in the R6/2 mouse model of Huntington’s disease

inferredcites →https://doi.org/10.1016/j.neuron.2009.08.021openalex-snapshot

Polycomb Limits the Neurogenic Competence of Neural Precursor Cells to Promote Astrogenic Fate Transition

inferredcites →https://doi.org/10.1016/j.neuron.2018.08.015openalex-snapshot

Reducing Astrocyte Calcium Signaling In Vivo Alters Striatal Microcircuits and Causes Repetitive Behavior

inferredcites →https://doi.org/10.1016/j.neuron.2020.06.021openalex-snapshot

Cell Type-Specific Transcriptomics Reveals that Mutant Huntingtin Leads to Mitochondrial RNA Release and Neuronal Innate Immune Activation

inferredcites →https://doi.org/10.1016/j.semcdb.2020.07.017openalex-snapshot

Lipid metabolism in astrocytic structure and function

inferredcites →https://doi.org/10.1016/j.taap.2009.03.026openalex-snapshot

Metallothionein protection of cadmium toxicity

inferredcites →https://doi.org/10.1016/s0072-9752(07)01256-0openalex-snapshot

Neuropathology of Huntington's Disease

inferredcites →https://doi.org/10.1016/s0092-8674(00)81369-0openalex-snapshot

Exon 1 of the HD Gene with an Expanded CAG Repeat Is Sufficient to Cause a Progressive Neurological Phenotype in Transgenic Mice

inferredcites →https://doi.org/10.1016/s0306-4522(00)00008-7openalex-snapshot

The pattern of neurodegeneration in Huntington's disease: a comparative study of cannabinoid, dopamine, adenosine and GABAA receptor alterations in the human basal ganglia in Huntington's disease

inferredcites →https://doi.org/10.1038/gt.2010.71openalex-snapshot

BDNF regulation under GFAP promoter provides engineered astrocytes as a new approach for long-term protection in Huntington's disease

inferredcites →https://doi.org/10.1038/nbt.4096openalex-snapshot

Integrating single-cell transcriptomic data across different conditions, technologies, and species

inferredcites →https://doi.org/10.1038/ncomms11758openalex-snapshot

Human glia can both induce and rescue aspects of disease phenotype in Huntington disease

inferredcites →https://doi.org/10.1038/nm.3514openalex-snapshot

Neuronal targets for reducing mutant huntingtin expression to ameliorate disease in a mouse model of Huntington's disease

inferredcites →https://doi.org/10.1038/nn.3691openalex-snapshot

Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice

inferredcites →https://doi.org/10.1038/nn.4632openalex-snapshot

An xQTL map integrates the genetic architecture of the human brain's transcriptome and epigenome

inferredcites →https://doi.org/10.1038/s41418-021-00914-9openalex-snapshot

The evolutionary history of the polyQ tract in huntingtin sheds light on its functional pro-neural activities

inferredcites →https://doi.org/10.1038/s41467-020-14766-3openalex-snapshot

Trajectory-based differential expression analysis for single-cell sequencing data

inferredcites →https://doi.org/10.1038/s41467-020-17041-7openalex-snapshot

Analysis of compositions of microbiomes with bias correction

inferredcites →https://doi.org/10.1038/s41467-022-35388-xopenalex-snapshot

Huntington disease oligodendrocyte maturation deficits revealed by single-nucleus RNAseq are rescued by thiamine-biotin supplementation

inferredcites →https://doi.org/10.1038/s41467-022-35752-xopenalex-snapshot

Transcriptional vulnerabilities of striatal neurons in human and rodent models of Huntington’s disease

inferredcites →https://doi.org/10.1038/s41467-023-38186-1openalex-snapshot

Re-convolving the compositional landscape of primary and recurrent glioblastoma reveals prognostic and targetable tissue states

inferredcites →https://doi.org/10.1038/s41586-022-04521-7openalex-snapshot

Single-cell dissection of the human brain vasculature

inferredcites →https://doi.org/10.1038/s41587-021-01186-xopenalex-snapshot

Multiscale PHATE identifies multimodal signatures of COVID-19

inferredcites →https://doi.org/10.1038/s41593-018-0075-7openalex-snapshot

Striatal neurons directly converted from Huntington’s disease patient fibroblasts recapitulate age-associated disease phenotypes

inferredcites →https://doi.org/10.1038/s41593-022-01185-4openalex-snapshot

Age-related Huntington’s disease progression modeled in directly reprogrammed patient-derived striatal neurons highlights impaired autophagy

inferredcites →https://doi.org/10.1038/s41598-020-76973-8openalex-snapshot

Cholesteryl ester levels are elevated in the caudate and putamen of Huntington’s disease patients

inferredcites →https://doi.org/10.1046/j.0305-1846.2001.00299.xopenalex-snapshot

The selective vulnerability of nerve cells in Huntington's disease

inferredcites →https://doi.org/10.1046/j.1471-4159.2003.02193.xopenalex-snapshot

Neuron‐glia communication: metallothionein expression is specifically up‐regulated by astrocytes in response to neuronal injury

inferredcites →https://doi.org/10.1073/pnas.0800048105openalex-snapshot

DNA instability in postmitotic neurons

inferredcites →https://doi.org/10.1073/pnas.0911503106openalex-snapshot

Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms

inferredcites →https://doi.org/10.1073/pnas.85.15.5733openalex-snapshot

Differential loss of striatal projection neurons in Huntington disease.

inferredcites →https://doi.org/10.1074/jbc.m109.083287openalex-snapshot

Mutant Huntingtin in Glial Cells Exacerbates Neurological Symptoms of Huntington Disease Mice

inferredcites →https://doi.org/10.1074/jbc.m111.274142openalex-snapshot

Comparative Lipidomic Analysis of Mouse and Human Brain with Alzheimer Disease

inferredcites →https://doi.org/10.1074/jbc.m111263200openalex-snapshot

Growth Inhibitory Factor Prevents Neurite Extension and the Death of Cortical Neurons Caused by High Oxygen Exposure through Hydroxyl Radical Scavenging

inferredcites →https://doi.org/10.1074/jbc.m708446200openalex-snapshot

Redefining the Role of Metallothionein within the Injured Brain

inferredcites →https://doi.org/10.1083/jcb.200908048openalex-snapshot

BMP-induced REST regulates the establishment and maintenance of astrocytic identity

inferredcites →https://doi.org/10.1093/bioinformatics/btp616openalex-snapshot

edgeR : a Bioconductor package for differential expression analysis of digital gene expression data

inferredcites →https://doi.org/10.1093/bioinformatics/btq466openalex-snapshot

ChEA: transcription factor regulation inferred from integrating genome-wide ChIP-X experiments

inferredcites →https://doi.org/10.1093/bioinformatics/bts635openalex-snapshot

STAR: ultrafast universal RNA-seq aligner

inferredcites →https://doi.org/10.1093/bioinformatics/btw777openalex-snapshot

Scater: pre-processing, quality control, normalization and visualization of single-cell RNA-seq data in R

inferredcites →https://doi.org/10.1093/biostatistics/kxj037openalex-snapshot

Adjusting batch effects in microarray expression data using empirical Bayes methods

inferredcites →https://doi.org/10.1093/brain/awn025openalex-snapshot

Cerebral cortex and the clinical expression of Huntington's disease: complexity and heterogeneity

inferredcites →https://doi.org/10.1093/brain/awv214openalex-snapshot

Altered PDE10A expression detectable early before symptomatic onset in Huntington’s disease

inferredcites →https://doi.org/10.1093/hmg/ddl013openalex-snapshot

Regional and cellular gene expression changes in human Huntington's disease brain

inferredcites →https://doi.org/10.1093/hmg/ddm054openalex-snapshot

Triplet repeat mutation length gains correlate with cell-type specific vulnerability in Huntington disease brain

inferredcites →https://doi.org/10.1093/hmg/ddm170openalex-snapshot

Cholesterol biosynthesis pathway is disturbed in YAC128 mice and is modulated by huntingtin mutation

inferredcites →https://doi.org/10.1093/hmg/ddp242openalex-snapshot

Somatic expansion of the Huntington's disease CAG repeat in the brain is associated with an earlier age of disease onset

inferredcites →https://doi.org/10.1093/hmg/ddq212openalex-snapshot

In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's disease subjects

inferredcites →https://doi.org/10.1093/hmg/ddt036openalex-snapshot

A critical role of astrocyte-mediated nuclear factor-κB-dependent inflammation in Huntington's disease

inferredcites →https://doi.org/10.1093/hmg/ddw028openalex-snapshot

αB-Crystallin overexpression in astrocytes modulates the phenotype of the BACHD mouse model of Huntington's disease

inferredcites →https://doi.org/10.1093/hmg/ddy363openalex-snapshot

Mutant huntingtin reduction in astrocytes slows disease progression in the bachd conditional huntington’s disease mouse model

inferredcites →https://doi.org/10.1093/nar/gkab152openalex-snapshot

Somatic CAG expansion in Huntington's disease is dependent on the MLH3 endonuclease domain, which can be excluded via splice redirection

inferredcites →https://doi.org/10.1093/nar/gkv007openalex-snapshot

limma powers differential expression analyses for RNA-sequencing and microarray studies

inferredcites →https://doi.org/10.1093/nar/gkw377openalex-snapshot

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

inferredcites →https://doi.org/10.1093/nar/gkz369openalex-snapshot

g:Profiler: a web server for functional enrichment analysis and conversions of gene lists (2019 update)

inferredcites →https://doi.org/10.1096/fasebj.13.9.1099openalex-snapshot

Expression of the Huntington's disease gene is regulated in astrocytes in the arcuate nucleus of the hypothalamus of postpartum rats

inferredcites →https://doi.org/10.1097/00005072-198511000-00003openalex-snapshot

Neuropathological Classification of Huntingtonʼs Disease

inferredcites →https://doi.org/10.1097/00005072-199501000-00013openalex-snapshot

Early Loss of Neostriatal Striosome Neurons in Huntingtonʼs Disease

inferredcites →https://doi.org/10.1101/gr.1239303openalex-snapshot

Cytoscape: A Software Environment for Integrated Models of Biomolecular Interaction Networks

inferredcites →https://doi.org/10.1111/j.1471-4159.2004.02356.xopenalex-snapshot

Anti‐PrP antibodies block PrPSc replication in prion‐infected cell cultures by accelerating PrPC degradation

inferredcites →https://doi.org/10.1111/nan.12286openalex-snapshot

Evidence for altered cholesterol metabolism in H untington's disease post mortem brain tissue

inferredcites →https://doi.org/10.1111/neup.12578openalex-snapshot

Clinicopathological differences between the motor onset and psychiatric onset of Huntington's disease, focusing on the nucleus accumbens

inferredcites →https://doi.org/10.1126/science.1059581openalex-snapshot

Loss of Huntingtin-Mediated BDNF Gene Transcription in Huntington's Disease

inferredcites →https://doi.org/10.1126/science.277.5334.1990openalex-snapshot

Aggregation of Huntingtin in Neuronal Intranuclear Inclusions and Dystrophic Neurites in Brain

inferredcites →https://doi.org/10.1126/scitranslmed.aaw8546openalex-snapshot

Astrocyte molecular signatures in Huntington’s disease

inferredcites →https://doi.org/10.1126/scitranslmed.aax3519openalex-snapshot

Chi3l1 /YKL-40 is controlled by the astrocyte circadian clock and regulates neuroinflammation and Alzheimer’s disease pathogenesis

inferredcites →https://doi.org/10.1136/jnnp.48.5.422openalex-snapshot

Neuronal distribution in the putamen in Huntington's disease.

inferredcites →https://doi.org/10.1139/o59-099openalex-snapshot

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

inferredcites →https://doi.org/10.1155/2013/606083openalex-snapshot

Alpha 1-Antichymotrypsin, an Inflammatory Protein Overexpressed in the Brains of Patients with Alzheimer’s Disease, Induces Tau Hyperphosphorylation through c-Jun N-Terminal Kinase Activation

inferredcites →https://doi.org/10.1186/1471-2105-9-559openalex-snapshot

WGCNA: an R package for weighted correlation network analysis

inferredcites →https://doi.org/10.1186/s12864-018-4772-0openalex-snapshot

Slingshot: cell lineage and pseudotime inference for single-cell transcriptomics

inferredcites →https://doi.org/10.1186/s12964-021-00812-0openalex-snapshot

Scavenger receptors in host defense: from functional aspects to mode of action

inferredcites →https://doi.org/10.1186/s12974-017-0893-7openalex-snapshot

YKL-40 (Chitinase 3-like I) is expressed in a subset of astrocytes in Alzheimer’s disease and other tauopathies

inferredcites →https://doi.org/10.1186/s13024-020-00416-1openalex-snapshot

Astrocyte-derived clusterin suppresses amyloid formation in vivo

inferredcites →https://doi.org/10.1186/s13024-021-00426-7openalex-snapshot

Clusterin secreted from astrocyte promotes excitatory synaptic transmission and ameliorates Alzheimer’s disease neuropathology

inferredcites →https://doi.org/10.1186/s13041-020-00654-wopenalex-snapshot

Metallothionein-3 as a multifunctional player in the control of cellular processes and diseases

inferredcites →https://doi.org/10.1186/s40478-020-0880-6openalex-snapshot

Single-nucleus RNA-seq identifies Huntington disease astrocyte states

inferredcites →https://doi.org/10.12688/f1000research.6358.1openalex-snapshot

The unfolded protein response and its potential role in Huntington s disease elucidated by a systems biology approach

inferredcites →https://doi.org/10.12688/f1000research.6358.2openalex-snapshot

The unfolded protein response and its potential role in Huntington's disease elucidated by a systems biology approach

inferredcites →https://doi.org/10.1371/journal.pcbi.1001057openalex-snapshot

Is My Network Module Preserved and Reproducible?

inferredcites →https://doi.org/10.1371/journal.pcbi.1005752openalex-snapshot

mixOmics: An R package for ‘omics feature selection and multiple data integration

inferredcites →https://doi.org/10.1371/journal.pone.0143563openalex-snapshot

RNA Sequence Analysis of Human Huntington Disease Brain Reveals an Extensive Increase in Inflammatory and Developmental Gene Expression

inferredcites →https://doi.org/10.1523/jneurosci.17-04-01271.1997openalex-snapshot

Disruption of the Metallothionein-III Gene in Mice: Analysis of Brain Zinc, Behavior, and Neuron Vulnerability to Metals, Aging, and Seizures

inferredcites →https://doi.org/10.1523/jneurosci.2074-20.2021openalex-snapshot

Single-Nucleus RNA-Seq Reveals Dysregulation of Striatal Cell Identity Due to Huntington's Disease Mutations

inferredcites →https://doi.org/10.1523/jneurosci.22-14-05879.2002openalex-snapshot

Serial Analysis of Gene Expression Identifies Metallothionein-II as Major Neuroprotective Gene in Mouse Focal Cerebral Ischemia

inferredcites →https://doi.org/10.1523/jneurosci.3044-08.2008openalex-snapshot

Dysregulation of Gene Expression in Primary Neuron Models of Huntington's Disease Shows That Polyglutamine-Related Effects on the Striatal Transcriptome May Not Be Dependent on Brain Circuitry

inferredcites →https://doi.org/10.1523/jneurosci.3355-05.2005openalex-snapshot

Dysfunction of the Cholesterol Biosynthetic Pathway in Huntington's Disease

inferredcites →https://doi.org/10.1523/jneurosci.3404-07.2007openalex-snapshot

The Transcriptome and Metabolic Gene Signature of Protoplasmic Astrocytes in the Adult Murine Cortex

inferredcites →https://doi.org/10.1523/jneurosci.3693-15.2016openalex-snapshot

Dysfunctional Calcium and Glutamate Signaling in Striatal Astrocytes from Huntington's Disease Model Mice

inferredcites →https://doi.org/10.1523/jneurosci.4037-13.2014openalex-snapshot

Phenotypic Heterogeneity and Plasticity of Isocortical and Hippocampal Astrocytes in the Human Brain

inferredcites →https://doi.org/10.3233/jhd-150170openalex-snapshot

Brain Cholesterol Synthesis and Metabolism is Progressively Disturbed in the R6/1 Mouse Model of Huntington’s Disease: A Targeted GC-MS/MS Sterol Analysis

inferredcites →https://doi.org/10.3233/jhd-200445openalex-snapshot

What is the Pathogenic CAG Expansion Length in Huntington’s Disease?

inferredcites →https://doi.org/10.3389/fimmu.2020.01416openalex-snapshot

Crosstalk Between Astrocytes and Microglia: An Overview

inferredcites →https://doi.org/10.3389/fnins.2023.1198219openalex-snapshot

The link between SARS-CoV-2 related microglial reactivity and astrocyte pathology in the inferior olivary nucleus

inferredcites →https://doi.org/10.3390/biom4020435openalex-snapshot

Metallothioneins, Unconventional Proteins from Unconventional Animals: A Long Journey from Nematodes to Mammals

inferredcites →https://doi.org/10.3390/cells13020129openalex-snapshot

The Matrix Receptor CD44 Is Present in Astrocytes throughout the Human Central Nervous System and Accumulates in Hypoxia and Seizures

inferredcites →https://doi.org/10.3390/cells8020182openalex-snapshot

Apolipoprotein E4 Alters Astrocyte Fatty Acid Metabolism and Lipid Droplet Formation

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1038/s41467-025-62478-3openalex-snapshot

The spatial landscape of glial pathology and T cell response in Parkinson’s disease substantia nigra

inferred← citeshttps://doi.org/10.1186/s13024-026-00960-2openalex-snapshot

Temporal single-cell atlas of full-length Huntington’s disease mouse model defines stage-specific signatures of corticostriatal dysfunction

inferred← citeshttps://doi.org/10.3390/antiox13070825openalex-snapshot

Metallothionein: A Comprehensive Review of Its Classification, Structure, Biological Functions, and Applications

inferred← citeshttps://doi.org/10.64898/2026.01.07.698249openalex-snapshot

Temporal single-cell atlas of full-length Huntington’s disease mouse model defines stage-specific signatures of corticostriatal dysfunction

Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.