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Glioblastoma initiation, migration, and cell types are regulated by core bHLH transcription factors ASCL1 and OLIG2
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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ASCL 1 regulates proliferation of NG 2‐glia in the embryonic and adult spinal cord
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c‐Abl ‐induced Olig2 phosphorylation regulates the proliferation of oligodendrocyte precursor cells
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Expression of Ribosomal RNA and Protein Genes in Human Embryonic Stem Cells Is Associated With the Activating H3K4me3 Histone Mark
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3D‐conformal very‐high energy electron therapy as candidate modality for FLASH‐RT: A treatment planning study for glioblastoma and lung cancer
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Cytochrome c oxidase subunit IV is essential for assembly and respiratory function of the enzyme complex
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C-Fos-activated circRPPH1 contributes to glioma stemness
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Cystatins in cancer progression: More than just cathepsin inhibitors
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Olig2-Dependent Reciprocal Shift in PDGF and EGF Receptor Signaling Regulates Tumor Phenotype and Mitotic Growth in Malignant Glioma
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Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment
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Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1
inferredcites →https://doi.org/10.1016/j.ccr.2010.10.023openalex-snapshot
TGF-β Receptor Inhibitors Target the CD44high/Id1high Glioma-Initiating Cell Population in Human Glioblastoma
inferredcites →https://doi.org/10.1016/j.cell.2013.09.034openalex-snapshot
The Somatic Genomic Landscape of Glioblastoma
inferredcites →https://doi.org/10.1016/j.cell.2014.02.030openalex-snapshot
Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells
inferredcites →https://doi.org/10.1016/j.cell.2019.06.024openalex-snapshot
An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma
inferredcites →https://doi.org/10.1016/j.celrep.2016.08.040openalex-snapshot
Lineage-Restricted OLIG2-RTK Signaling Governs the Molecular Subtype of Glioma Stem-like Cells
inferredcites →https://doi.org/10.1016/j.celrep.2016.12.064openalex-snapshot
Oncogenes Activate an Autonomous Transcriptional Regulatory Circuit That Drives Glioblastoma
inferredcites →https://doi.org/10.1016/j.celrep.2020.108189openalex-snapshot
Single-Nucleus RNA-Seq Is Not Suitable for Detection of Microglial Activation Genes in Humans
inferredcites →https://doi.org/10.1016/j.celrep.2021.109647openalex-snapshot
Transcriptional control of brain tumor stem cells by a carbohydrate binding protein
inferredcites →https://doi.org/10.1016/j.celrep.2022.110493openalex-snapshot
CRISPR-Cas9 screen identifies oxidative phosphorylation as essential for cancer cell survival at low extracellular pH
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SOX2 is essential for astrocyte maturation and its deletion leads to hyperactive behavior in mice
inferredcites →https://doi.org/10.1016/j.devcel.2018.07.005openalex-snapshot
Transcriptional Convergence of Oligodendrocyte Lineage Progenitors during Development
inferredcites →https://doi.org/10.1016/j.humpath.2010.04.020openalex-snapshot
Expression of the ribosomal proteins Rplp0, Rplp1, and Rplp2 in gynecologic tumors
inferredcites →https://doi.org/10.1016/j.molonc.2009.05.003openalex-snapshot
The role of protein synthesis in cell cycling and cancer
inferredcites →https://doi.org/10.1016/j.nbd.2019.104705openalex-snapshot
Enhanced SPARCL1 expression in cancer stem cells improves preclinical modeling of glioblastoma by promoting both tumor infiltration and angiogenesis
inferredcites →https://doi.org/10.1016/j.nec.2020.08.002openalex-snapshot
Role of Resection in Glioblastoma Management
inferredcites →https://doi.org/10.1016/j.neuron.2014.02.039openalex-snapshot
Prospective Identification and Purification of Quiescent Adult Neural Stem Cells from Their In Vivo Niche
inferredcites →https://doi.org/10.1016/j.omtn.2020.05.019openalex-snapshot
RPL32 Promotes Lung Cancer Progression by Facilitating p53 Degradation
inferredcites →https://doi.org/10.1016/j.stem.2009.03.003openalex-snapshot
SSEA-1 Is an Enrichment Marker for Tumor-Initiating Cells in Human Glioblastoma
inferredcites →https://doi.org/10.1016/j.stem.2010.02.018openalex-snapshot
Integrin Alpha 6 Regulates Glioblastoma Stem Cells
inferredcites →https://doi.org/10.1016/j.stem.2015.07.002openalex-snapshot
Single-Cell Transcriptomics Reveals a Population of Dormant Neural Stem Cells that Become Activated upon Brain Injury
inferredcites →https://doi.org/10.1016/j.stem.2017.06.004openalex-snapshot
ASCL1 Reorganizes Chromatin to Direct Neuronal Fate and Suppress Tumorigenicity of Glioblastoma Stem Cells
inferredcites →https://doi.org/10.1016/j.stem.2019.03.006openalex-snapshot
Single-Cell Transcriptomics Uncovers Glial Progenitor Diversity and Cell Fate Determinants during Development and Gliomagenesis
inferredcites →https://doi.org/10.1016/j.yexcr.2004.02.009openalex-snapshot
Ribosomal proteins S13 and L23 promote multidrug resistance in gastric cancer cells by suppressing drug-induced apoptosis
inferredcites →https://doi.org/10.1016/j.yexcr.2008.10.045openalex-snapshot
Tubulin cofactor B regulates microtubule densities during microglia transition to the reactive states
inferredcites →https://doi.org/10.1016/j.yexcr.2019.03.022openalex-snapshot
ITGA6 and RPSA synergistically promote pancreatic cancer invasion and metastasis via PI3K and MAPK signaling pathways
inferredcites →https://doi.org/10.1016/s0092-8674(02)00678-5openalex-snapshot
Common Developmental Requirement for Olig Function Indicates a Motor Neuron/Oligodendrocyte Connection
inferredcites →https://doi.org/10.1016/s0896-6273(01)00414-7openalex-snapshot
The bHLH Transcription Factor Olig2 Promotes Oligodendrocyte Differentiation in Collaboration with Nkx2.2
inferredcites →https://doi.org/10.1021/acsomega.9b04483openalex-snapshot
Role for Metallothionein-3 in the Resistance of Human U87 Glioblastoma Cells to Temozolomide
inferredcites →https://doi.org/10.1038/nature08797openalex-snapshot
Direct conversion of fibroblasts to functional neurons by defined factors
inferredcites →https://doi.org/10.1038/nature11287openalex-snapshot
A restricted cell population propagates glioblastoma growth after chemotherapy
inferredcites →https://doi.org/10.1038/nature23666openalex-snapshot
Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy
inferredcites →https://doi.org/10.1038/nbt.1630openalex-snapshot
GREAT improves functional interpretation of cis-regulatory regions
inferredcites →https://doi.org/10.1038/nbt.3192openalex-snapshot
Spatial reconstruction of single-cell gene expression data
inferredcites →https://doi.org/10.1038/ncomms14049openalex-snapshot
Massively parallel digital transcriptional profiling of single cells
inferredcites →https://doi.org/10.1038/ncomms8391openalex-snapshot
Somatic CRISPR/Cas9-mediated tumour suppressor disruption enables versatile brain tumour modelling
inferredcites →https://doi.org/10.1038/nm.4399openalex-snapshot
Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells
inferredcites →https://doi.org/10.1038/nmeth.1923openalex-snapshot
Fast gapped-read alignment with Bowtie 2
inferredcites →https://doi.org/10.1038/onc.2011.535openalex-snapshot
The immediate early gene Ier2 promotes tumor cell motility and metastasis, and predicts poor survival of colorectal cancer patients
inferredcites →https://doi.org/10.1038/s41388-021-02027-6openalex-snapshot
IER2-induced senescence drives melanoma invasion through osteopontin
inferredcites →https://doi.org/10.1038/s41388-023-02738-yopenalex-snapshot
Glioblastoma heterogeneity at single cell resolution
inferredcites →https://doi.org/10.1038/s41467-020-17186-5openalex-snapshot
Single-cell RNA-seq reveals that glioblastoma recapitulates a normal neurodevelopmental hierarchy
inferredcites →https://doi.org/10.1038/s41467-022-29068-zopenalex-snapshot
The Oligodendrocyte Transcription Factor 2 OLIG2 regulates transcriptional repression during myelinogenesis in rodents
inferredcites →https://doi.org/10.1038/s41467-022-29963-5openalex-snapshot
ASCL1 activates neuronal stem cell-like lineage programming through remodeling of the chromatin landscape in prostate cancer
inferredcites →https://doi.org/10.1038/s41467-022-33263-3openalex-snapshot
A stem cell roadmap of ribosome heterogeneity reveals a function for RPL10A in mesoderm production
inferredcites →https://doi.org/10.1038/s41598-022-06248-xopenalex-snapshot
ASCL1 phosphorylation and ID2 upregulation are roadblocks to glioblastoma stem cell differentiation
inferredcites →https://doi.org/10.1038/sj.emboj.7600447openalex-snapshot
Mash1 specifies neurons and oligodendrocytes in the postnatal brain
inferredcites →https://doi.org/10.1038/srep46376openalex-snapshot
HILI destabilizes microtubules by suppressing phosphorylation and Gigaxonin-mediated degradation of TBCB
inferredcites →https://doi.org/10.1042/bj20080049openalex-snapshot
Functional characterization of ribosomal P1/P2 proteins in human cells
inferredcites →https://doi.org/10.1056/nejmoa043330openalex-snapshot
Radiotherapy Plus Concomitant and Adjuvant Temozolomide for Glioblastoma
inferredcites →https://doi.org/10.1073/pnas.1219747110openalex-snapshot
Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics
inferredcites →https://doi.org/10.1073/pnas.1510595112openalex-snapshot
Transgenic expression of the proneural transcription factor Ascl1 in Müller glia stimulates retinal regeneration in young mice
inferredcites →https://doi.org/10.1073/pnas.2014389117openalex-snapshot
High-resolution mouse subventricular zone stem-cell niche transcriptome reveals features of lineage, anatomy, and aging
inferredcites →https://doi.org/10.1073/pnas.89.10.4678openalex-snapshot
Thymosin beta 4 (Fx peptide) is a potent regulator of actin polymerization in living cells.
inferredcites →https://doi.org/10.1093/bioinformatics/btab806openalex-snapshot
Make Interactive Complex Heatmaps in R
inferredcites →https://doi.org/10.1093/bioinformatics/btw313openalex-snapshot
Complex heatmaps reveal patterns and correlations in multidimensional genomic data
inferredcites →https://doi.org/10.1093/bioinformatics/btw777openalex-snapshot
Scater: pre-processing, quality control, normalization and visualization of single-cell RNA-seq data in R
inferredcites →https://doi.org/10.1093/brain/awt333openalex-snapshot
Thymosin beta 4 gene silencing decreases stemness and invasiveness in glioblastoma
inferredcites →https://doi.org/10.1093/neuonc/noac202openalex-snapshot
CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2015–2019
inferredcites →https://doi.org/10.1093/noajnl/vdac102openalex-snapshot
Butterfly glioblastoma: Clinical characteristics, treatment strategies and outcomes in a population-based cohort
inferredcites →https://doi.org/10.1101/2020.02.20.958132openalex-snapshot
ASCL1 regulates neurodevelopmental transcription factors and cell cycle genes in glioblastoma
inferredcites →https://doi.org/10.1101/gad.323196.118openalex-snapshot
High Hes1 expression and resultant Ascl1 suppression regulate quiescent vs. active neural stem cells in the adult mouse brain
inferredcites →https://doi.org/10.1111/j.1582-4934.2009.00969.xopenalex-snapshot
Human ribosomal protein S13 promotes gastric cancer growth through down-regulating p27Kip1
inferredcites →https://doi.org/10.1126/science.1242366openalex-snapshot
Oscillatory Control of Factors Determining Multipotency and Fate in Mouse Neural Progenitors
inferredcites →https://doi.org/10.1126/science.1254257openalex-snapshot
Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma
inferredcites →https://doi.org/10.1126/science.aaf6463openalex-snapshot
Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system
inferredcites →https://doi.org/10.1158/0008-5472.can-06-1010openalex-snapshot
Stem Cell–like Glioma Cells Promote Tumor Angiogenesis through Vascular Endothelial Growth Factor
inferredcites →https://doi.org/10.1158/0008-5472.can-21-3713openalex-snapshot
Inhibition of Karyopherin β1-Mediated Nuclear Import Disrupts Oncogenic Lineage-Defining Transcription Factor Activity in Small Cell Lung Cancer
inferredcites →https://doi.org/10.1158/1078-0432.ccr-12-3725openalex-snapshot
S100B Promotes Glioma Growth through Chemoattraction of Myeloid-Derived Macrophages
inferredcites →https://doi.org/10.1177/17590914221102065openalex-snapshot
GFAP Alternative Splicing and the Relevance for Disease – A Focus on Diffuse Gliomas
inferredcites →https://doi.org/10.1186/1471-2407-6-223openalex-snapshot
Medulloblastoma outcome is adversely associated with overexpression of EEF1D, RPL30, and RPS20 on the long arm of chromosome 8
inferredcites →https://doi.org/10.1186/1476-4598-10-128openalex-snapshot
Chemoresistance of glioblastoma cancer stem cells - much more complex than expected
inferredcites →https://doi.org/10.1186/s12920-015-0137-6openalex-snapshot
High metallothionein predicts poor survival in glioblastoma multiforme
inferredcites →https://doi.org/10.1186/s12935-018-0658-0openalex-snapshot
RPLP1 promotes tumor metastasis and is associated with a poor prognosis in triple-negative breast cancer patients
inferredcites →https://doi.org/10.1186/s13046-021-02077-4openalex-snapshot
Downregulated CLIP3 induces radioresistance by enhancing stemness and glycolytic flux in glioblastoma
inferredcites →https://doi.org/10.1186/s13046-022-02429-8openalex-snapshot
SH3GLB1-related autophagy mediates mitochondrial metabolism to acquire resistance against temozolomide in glioblastoma
inferredcites →https://doi.org/10.1186/s13059-015-0844-5openalex-snapshot
MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data
inferredcites →https://doi.org/10.1186/s13059-019-1874-1openalex-snapshot
Normalization and variance stabilization of single-cell RNA-seq data using regularized negative binomial regression
inferredcites →https://doi.org/10.1242/dev.001255openalex-snapshot
Combinatorial actions of patterning and HLH transcription factors in the spatiotemporal control of neurogenesis and gliogenesis in the developing spinal cord
inferredcites →https://doi.org/10.1242/dev.015370openalex-snapshot
Ascl1 is required for oligodendrocyte development in the spinal cord
inferredcites →https://doi.org/10.1242/dev.105270openalex-snapshot
Ascl1 controls the number and distribution of astrocytes and oligodendrocytes in the gray matter and white matter of the spinal cord
inferredcites →https://doi.org/10.1242/dev.106377openalex-snapshot
The phosphorylation status of Ascl1 is a key determinant of neuronal differentiation and maturation in vivo and in vitro
inferredcites →https://doi.org/10.1242/dev.115.2.535openalex-snapshot
PDGF receptors in the rat CNS: during late neurogenesis, PDGF alpha-receptor expression appears to be restricted to glial cells of the oligodendrocyte lineage
inferredcites →https://doi.org/10.1242/jcs.056895openalex-snapshot
Downregulation of thymosin β4 in neural progenitor grafts promotes spinal cord regeneration
inferredcites →https://doi.org/10.1242/jcs.077511openalex-snapshot
ID1 and ID3 represent conserved negative regulators of human embryonic and induced pluripotent stem cell hematopoiesis
inferredcites →https://doi.org/10.12688/f1000research.73600.2openalex-snapshot
Doublet identification in single-cell sequencing data using scDblFinder
inferredcites →https://doi.org/10.1371/journal.pbio.2005211openalex-snapshot
In vivo clonal analysis reveals spatiotemporal regulation of thalamic nucleogenesis
inferredcites →https://doi.org/10.1371/journal.pone.0061035openalex-snapshot
Prognostic Relevance of Cytochrome c Oxidase in Primary Glioblastoma Multiforme
inferredcites →https://doi.org/10.1371/journal.pone.0141334openalex-snapshot
Ribosomal Proteins RPS11 and RPS20, Two Stress-Response Markers of Glioblastoma Stem Cells, Are Novel Predictors of Poor Prognosis in Glioblastoma Patients
inferredcites →https://doi.org/10.1523/jneurosci.0126-07.2007openalex-snapshot
The Proneural GeneMash1Specifies an Early Population of Telencephalic Oligodendrocytes
inferredcites →https://doi.org/10.1523/jneurosci.1860-14.2014openalex-snapshot
An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex
inferredcites →https://doi.org/10.1523/jneurosci.3655-14.2015openalex-snapshot
Sox2 Sustains Recruitment of Oligodendrocyte Progenitor Cells following CNS Demyelination and Primes Them for Differentiation during Remyelination
inferredcites →https://doi.org/10.15698/cst2022.04.266openalex-snapshot
COX4-1 promotes mitochondrial supercomplex assembly and limits reactive oxide species production in radioresistant GBM
inferredcites →https://doi.org/10.1590/1678-4685-gmb-2022-0323openalex-snapshot
TMEM147 is a novel biomarker for diagnosis and prognosis of hepatocellular carcinoma
inferredcites →https://doi.org/10.18632/oncotarget.3015openalex-snapshot
Nuclear-encoded cytochrome c oxidase subunit 4 regulates BMI1 expression and determines proliferative capacity of high-grade gliomas
inferredcites →https://doi.org/10.18632/oncotarget.3278openalex-snapshot
Targeting tumor-initiating cells: Eliminating anabolic cancer stem cells with inhibitors of protein synthesis or by mimicking caloric restriction
inferredcites →https://doi.org/10.21037/atm.2020.03.92openalex-snapshot
High RPS11 level in hepatocellular carcinoma associates with poor prognosis after curative resection
inferredcites →https://doi.org/10.3389/fcell.2019.00304openalex-snapshot
Thymosin β4 Regulates Focal Adhesion Formation in Human Melanoma Cells and Affects Their Migration and Invasion
inferredcites →https://doi.org/10.3389/fcell.2020.00549openalex-snapshot
TRPM7/RPSA Complex Regulates Pancreatic Cancer Cell Migration
inferredcites →https://doi.org/10.3389/fgene.2018.00650openalex-snapshot
Apolipoprotein E Overexpression Is Associated With Tumor Progression and Poor Survival in Colorectal Cancer
inferredcites →https://doi.org/10.3389/fncel.2015.00288openalex-snapshot
Real-time imaging of bHLH transcription factors reveals their dynamic control in the multipotency and fate choice of neural stem cells
inferredcites →https://doi.org/10.3389/fnmol.2022.933855openalex-snapshot
Immunological and prognostic analysis of PSENEN in low-grade gliomas: An immune infiltration-related prognostic biomarker
inferredcites →https://doi.org/10.3389/fonc.2022.859247openalex-snapshot
GFAPδ: A Promising Biomarker and Therapeutic Target in Glioblastoma
inferredcites →https://doi.org/10.3892/or.2014.3660openalex-snapshot
Galanin plays an important role in cancer invasiveness and is associated with poor prognosis in stage II colorectal cancer
inferredcites →https://doi.org/10.4049/jimmunol.1602057openalex-snapshot
The Ribosomal Protein S19 Suppresses Antitumor Immune Responses via the Complement C5a Receptor 1
inferredcites →https://doi.org/10.4161/cc.27031openalex-snapshot
Hypoxia-resistant profile implies vulnerability of cancer stem cells to physiological agents, which suggests new therapeutic targets
inferredcites →https://doi.org/10.4161/cc.28401openalex-snapshot
Partial inhibition of Cdk1 in G2phase overrides the SAC and decouples mitotic events
inferredcites →https://doi.org/10.7554/elife.70514openalex-snapshot
Activity-dependent modulation of synapse-regulating genes in astrocytes
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1007/s11033-024-09853-3openalex-snapshot
Navigating glioblastoma complexity: the interplay of neurotransmitters and chromatin
inferred← citeshttps://doi.org/10.1038/s42003-024-05833-2openalex-snapshot
Gliomas: a reflection of temporal gliogenic principles
inferred← citeshttps://doi.org/10.3390/biomedicines12102237openalex-snapshot
Unveiling the Molecular Mechanisms of Glioblastoma through an Integrated Network-Based Approach
inferred← citeshttps://doi.org/10.3390/ijms27031543openalex-snapshot
Targeting Pediatric Glioblastomas by Combining OLIG2 Inhibitor CT-179 with Fractionated Radiation in a Panel of Patient-Derived Orthotopic Xenograft Mouse Models
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