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Single-cell image-based genetic screens systematically identify regulators of Ebola virus subcellular infection dynamics

https://doi.org/10.1101/2024.04.06.588168

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Optical Pooled Screens in Human Cells

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An Intrinsically Disordered Peptide from Ebola Virus VP35 Controls Viral RNA Synthesis by Modulating Nucleoprotein-RNA Interactions

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A VP35 Mutant Ebola Virus Lacks Virulence but Can Elicit Protective Immunity to Wild-Type Virus Challenge

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Disruption of Ebola NP0VP35 Inclusion Body-like Structures reduce Viral Infection

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Elucidation of the Cellular Interactome of Ebola Virus Nucleoprotein and Identification of Therapeutic Targets

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High-Throughput Minigenome System for Identifying Small-Molecule Inhibitors of Ebola Virus Replication

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Direct observation of individual endogenous protein complexes in situ by proximity ligation

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Cell Painting, a high-content image-based assay for morphological profiling using multiplexed fluorescent dyes

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A genome-wide CRISPR screen identifies N-acetylglucosamine-1-phosphate transferase as a potential antiviral target for Ebola virus

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Systematic functional interrogation of SARS-CoV-2 host factors using Perturb-seq

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Pooled genetic perturbation screens with image-based phenotypes

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High-content CRISPR screening

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High-content CRISPR screening

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The spatio-temporal distribution dynamics of Ebola virus proteins and RNA in infected cells

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Differential transcriptional responses to Ebola and Marburg virus infection in bat and human cells

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The Ongoing Ebola Epidemic in the Democratic Republic of Congo, 2018–2019

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Orthogonal genome-wide screens of bat cells identify MTHFD1 as a target of broad antiviral therapy

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Ebola virus-like particles protect from lethal Ebola virus infection

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Probing the Virus Host Interaction in High Containment: An Approach Using Pooled Short Hairpin RNA

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MHC class II transactivator CIITA induces cell resistance to Ebola virus and SARS-like coronaviruses

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inferredcites →https://doi.org/10.1128/jvi.01525-12openalex-snapshot

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inferredcites →https://doi.org/10.1128/jvi.02100-19openalex-snapshot

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inferredcites →https://doi.org/10.1128/mbio.02565-19openalex-snapshot

Serine-Arginine Protein Kinase 1 Regulates Ebola Virus Transcription

inferredcites →https://doi.org/10.1128/mbio.03002-21openalex-snapshot

VPS29 Exerts Opposing Effects on Endocytic Viral Entry

inferredcites →https://doi.org/10.1146/annurev-med-052915-015604openalex-snapshot

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inferredcites →https://doi.org/10.1186/s13073-018-0570-1openalex-snapshot

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inferredcites →https://doi.org/10.1242/dev.165753openalex-snapshot

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Lipid droplet density alters the early innate immune response to viral infection

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TRIM25 and ZAP target the Ebola virus ribonucleoprotein complex to mediate interferon-induced restriction

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The Cellular Protein CAD is Recruited into Ebola Virus Inclusion Bodies by the Nucleoprotein NP to Facilitate Genome Replication and Transcription

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What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Optical Pooled Screening for the Discovery of Regulators of the Alternative Lengthening of Telomeres Pathway

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MORPH Predicts the Single-Cell Outcome of Genetic Perturbations Across Conditions and Data Modalities

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