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Molecular Visualization of Neuronal TDP43 Pathology In Situ
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Transcription Factor–Mediated Differentiation of Human iPSCs into Neurons
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UCSF ChimeraX: Meeting modern challenges in visualization and analysis
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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
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Functional recovery in new mouse models of ALS/FTLD after clearance of pathological cytoplasmic TDP-43
inferredcites →https://doi.org/10.1007/s13311-015-0340-3openalex-snapshot
Linking RNA Dysfunction and Neurodegeneration in Amyotrophic Lateral Sclerosis
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Aging: Central role for autophagy and the lysosomal degradative system
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The crucial impact of lysosomes in aging and longevity
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The aging lysosome: An essential catalyst for late-onset neurodegenerative diseases
inferredcites →https://doi.org/10.1016/j.bbapap.2023.140916openalex-snapshot
Thermodynamic modulation of folding and aggregation energy landscape by DNA binding of functional domains of TDP-43
inferredcites →https://doi.org/10.1016/j.bbrc.2006.10.093openalex-snapshot
TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
inferredcites →https://doi.org/10.1016/j.bbrep.2024.101664openalex-snapshot
The effect of pH alterations on TDP-43 in a cellular model of amyotrophic lateral sclerosis
inferredcites →https://doi.org/10.1016/j.bpj.2015.10.053openalex-snapshot
Site-Specific Cryo-focused Ion Beam Sample Preparation Guided by 3D Correlative Microscopy
inferredcites →https://doi.org/10.1016/j.brainres.2018.01.015openalex-snapshot
TDP43 and RNA instability in amyotrophic lateral sclerosis
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Nuclear RNA binding regulates TDP-43 nuclear localization and passive nuclear export
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Myotubularin-related phosphatase 5 is a critical determinant of autophagy in neurons
inferredcites →https://doi.org/10.1016/j.isci.2024.110109openalex-snapshot
Multivalent GU-rich oligonucleotides sequester TDP-43 in the nucleus by inducing high molecular weight RNP complexes
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Development of a specific live-cell assay for native autophagic flux
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Automated electron microscope tomography using robust prediction of specimen movements
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Dynamo: A flexible, user-friendly development tool for subtomogram averaging of cryo-EM data in high-performance computing environments
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Robust membrane detection based on tensor voting for electron tomography
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m6A Facilitates eIF4F-Independent mRNA Translation
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inferredcites →https://doi.org/10.1016/j.molcel.2022.12.019openalex-snapshot
RNA methylation influences TDP43 binding and disease pathogenesis in models of amyotrophic lateral sclerosis and frontotemporal dementia
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RNA m6A methylation across the transcriptome
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Molecular determinants of condensate composition
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A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD
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Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS
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Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities
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RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43
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TDP-43 seeding induces cytoplasmic aggregation heterogeneity and nuclear loss of function of TDP-43
inferredcites →https://doi.org/10.1016/j.neuron.2025.03.008openalex-snapshot
Seeded aggregation of TDP-43 induces its loss of function and reveals early pathological signatures
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Isolation of autophagic fractions from mouse liver for biochemical analyses
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Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
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Mutations of optineurin in amyotrophic lateral sclerosis
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Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS
inferredcites →https://doi.org/10.1038/nature12730openalex-snapshot
N6-methyladenosine-dependent regulation of messenger RNA stability
inferredcites →https://doi.org/10.1038/nchembio.1563openalex-snapshot
Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models
inferredcites →https://doi.org/10.1038/ng.132openalex-snapshot
TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis
inferredcites →https://doi.org/10.1038/ng.536openalex-snapshot
Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions
inferredcites →https://doi.org/10.1038/nmeth.2019openalex-snapshot
Fiji: an open-source platform for biological-image analysis
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Bright photoactivatable fluorophores for single-molecule imaging
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Characterizing the RNA targets and position-dependent splicing regulation by TDP-43
inferredcites →https://doi.org/10.1038/nn.2779openalex-snapshot
Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43
inferredcites →https://doi.org/10.1038/nn.3584openalex-snapshot
State of play in amyotrophic lateral sclerosis genetics
inferredcites →https://doi.org/10.1038/nn.3688openalex-snapshot
Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis
inferredcites →https://doi.org/10.1038/nprot.2016.124openalex-snapshot
Resolving macromolecular structures from electron cryo-tomography data using subtomogram averaging in RELION
inferredcites →https://doi.org/10.1038/nsmb.2053openalex-snapshot
An ALS-associated mutation affecting TDP-43 enhances protein aggregation, fibril formation and neurotoxicity
inferredcites →https://doi.org/10.1038/s41467-018-05049-zopenalex-snapshot
Abnormal RNA stability in amyotrophic lateral sclerosis
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Genetically encoded cell-death indicators (GEDI) to detect an early irreversible commitment to neurodegeneration
inferredcites →https://doi.org/10.1038/s41467-025-59117-2openalex-snapshot
The motor neuron m6A repertoire governs neuronal homeostasis and FTO inhibition mitigates ALS symptom manifestation
inferredcites →https://doi.org/10.1038/s41467-025-62482-7openalex-snapshot
Sporadic ALS induced pluripotent stem cell derived neurons reveal hallmarks of TDP-43 loss of function
inferredcites →https://doi.org/10.1038/s41556-022-00988-8openalex-snapshot
Heat-shock chaperone HSPB1 regulates cytoplasmic TDP-43 phase separation and liquid-to-gel transition
inferredcites →https://doi.org/10.1038/s41586-018-0665-2openalex-snapshot
TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle
inferredcites →https://doi.org/10.1038/s41586-021-04199-3openalex-snapshot
Structure of pathological TDP-43 filaments from ALS with FTLD
inferredcites →https://doi.org/10.1038/s41586-022-04424-7openalex-snapshot
TDP-43 represses cryptic exon inclusion in the FTD–ALS gene UNC13A
inferredcites →https://doi.org/10.1038/s41586-022-04436-3openalex-snapshot
TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A
inferredcites →https://doi.org/10.1038/s41586-023-06405-wopenalex-snapshot
TDP-43 forms amyloid filaments with a distinct fold in type A FTLD-TDP
inferredcites →https://doi.org/10.1038/s41592-019-0580-yopenalex-snapshot
Real-time cryo-electron microscopy data preprocessing with Warp
inferredcites →https://doi.org/10.1038/s41592-019-0630-5openalex-snapshot
Tailoring cryo-electron microscopy grids by photo-micropatterning for in-cell structural studies
inferredcites →https://doi.org/10.1038/s41593-018-0293-zopenalex-snapshot
Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration
inferredcites →https://doi.org/10.1038/s41593-018-0300-4openalex-snapshot
ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair
inferredcites →https://doi.org/10.1038/s41593-023-01341-4openalex-snapshot
Seeding the aggregation of TDP-43 requires post-fibrillization proteolytic cleavage
inferredcites →https://doi.org/10.1038/s41593-023-01374-9openalex-snapshot
Globally reduced N6-methyladenosine (m6A) in C9ORF72-ALS/FTD dysregulates RNA metabolism and contributes to neurodegeneration
inferredcites →https://doi.org/10.1038/s41594-018-0064-2openalex-snapshot
Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation
inferredcites →https://doi.org/10.1038/s41594-019-0248-4openalex-snapshot
Cryo-EM structures of four polymorphic TDP-43 amyloid cores
inferredcites →https://doi.org/10.1042/bst20130186openalex-snapshot
The role of TDP-43 in the pathogenesis of ALS and FTLD
inferredcites →https://doi.org/10.1073/pnas.1917371117openalex-snapshot
ALS/FTD mutations in UBQLN2 impede autophagy by reducing autophagosome acidification through loss of function
inferredcites →https://doi.org/10.1073/pnas.2311416120openalex-snapshot
Oxidative regulation of TDP-43 self-association by a β-to-α conformational switch
inferredcites →https://doi.org/10.1074/jbc.m800342200openalex-snapshot
Disturbance of Nuclear and Cytoplasmic TAR DNA-binding Protein (TDP-43) Induces Disease-like Redistribution, Sequestration, and Aggregate Formation
inferredcites →https://doi.org/10.1080/15548627.2019.1644076openalex-snapshot
ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway
inferredcites →https://doi.org/10.1080/15548627.2021.1926656openalex-snapshot
Autophagy and ALS: mechanistic insights and therapeutic implications
inferredcites →https://doi.org/10.1080/15548627.2021.2013653openalex-snapshot
SQSTM1-mediated clearance of cytoplasmic mutant TARDBP/TDP-43 in the monkey brain
inferredcites →https://doi.org/10.1080/27694127.2025.2474796openalex-snapshot
The role of autophagy in the pathogenesis and treatment of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD)
inferredcites →https://doi.org/10.1083/jcb.202110151openalex-snapshot
Secretory autophagy maintains proteostasis upon lysosome inhibition
inferredcites →https://doi.org/10.1083/jcb.202401136openalex-snapshot
Neuronal constitutive endolysosomal perforations enable α-synuclein aggregation by internalized PFFs
inferredcites →https://doi.org/10.1083/jcb.202403116openalex-snapshot
Heterogeneity of late endosome/lysosomes shown by multiplexed DNA-PAINT imaging
inferredcites →https://doi.org/10.1091/mbc.e20-09-0583openalex-snapshot
SuperPlotsOfData—a web app for the transparent display and quantitative comparison of continuous data from different conditions
inferredcites →https://doi.org/10.1093/brain/awy284openalex-snapshot
Frontotemporal dementia causative CHMP2B impairs neuronal endolysosomal traffic-rescue byTMEM106Bknockdown
inferredcites →https://doi.org/10.1093/brain/awz099openalex-snapshot
Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report
inferredcites →https://doi.org/10.1093/hmg/ddr021openalex-snapshot
TAR DNA-binding protein 43 (TDP-43) regulates stress granule dynamics via differential regulation of G3BP and TIA-1
inferredcites →https://doi.org/10.1093/hmg/ddx011openalex-snapshot
Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes
inferredcites →https://doi.org/10.1101/2024.01.05.574336openalex-snapshot
MemBrain v2: an end-to-end tool for the analysis of membranes in cryo-electron tomography
inferredcites →https://doi.org/10.1101/2024.01.16.575687openalex-snapshot
Enhanced legumain activity links progranulin deficiency to TDP-43 pathology in frontotemporal lobar degeneration
inferredcites →https://doi.org/10.1101/2024.07.22.604579openalex-snapshot
ASO-enhancement of TARDBP exitron splicing mitigates TDP-43 proteinopathies
inferredcites →https://doi.org/10.1101/2024.09.04.611121openalex-snapshot
Acetylation of lysine 82 initiates TDP-43 nuclear loss of function by disrupting its nuclear import
inferredcites →https://doi.org/10.1101/cshperspect.a033993openalex-snapshot
The Autophagy Lysosomal Pathway and Neurodegeneration
inferredcites →https://doi.org/10.1111/j.1365-2818.1993.tb03313.xopenalex-snapshot
Measurement of co‐localization of objects in dual‐colour confocal images
inferredcites →https://doi.org/10.1126/science.1134108openalex-snapshot
Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis
inferredcites →https://doi.org/10.1126/science.1154584openalex-snapshot
TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis
inferredcites →https://doi.org/10.1126/science.1165942openalex-snapshot
Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6
inferredcites →https://doi.org/10.1126/science.1166066openalex-snapshot
Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis
inferredcites →https://doi.org/10.1126/science.aab0983openalex-snapshot
TDP-43 repression of nonconserved cryptic exons is compromised in ALS-FTD
inferredcites →https://doi.org/10.1126/science.aar7366openalex-snapshot
RNA buffers the phase separation behavior of prion-like RNA binding proteins
inferredcites →https://doi.org/10.1126/science.abi6983openalex-snapshot
OpenCell: Endogenous tagging for the cartography of human cellular organization
inferredcites →https://doi.org/10.1126/scitranslmed.adg7162openalex-snapshot
Mis-spliced transcripts generate de novo proteins in TDP-43–related ALS/FTD
inferredcites →https://doi.org/10.1155/2012/736905openalex-snapshot
Aggrephagy: Selective Disposal of Protein Aggregates by Macroautophagy
inferredcites →https://doi.org/10.1172/jci130988openalex-snapshot
Shortened TDP43 isoforms upregulated by neuronal hyperactivity drive TDP43 pathology in ALS
inferredcites →https://doi.org/10.1172/jci139741openalex-snapshot
Truncated stathmin-2 is a marker of TDP-43 pathology in frontotemporal dementia
inferredcites →https://doi.org/10.1186/s12920-017-0274-1openalex-snapshot
Quantitative analysis of cryptic splicing associated with TDP-43 depletion
inferredcites →https://doi.org/10.1186/s13024-020-00420-5openalex-snapshot
Induction of autophagy mitigates TDP-43 pathology and translational repression of neurofilament mRNAs in mouse models of ALS/FTD
inferredcites →https://doi.org/10.1186/s13024-023-00673-wopenalex-snapshot
Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons
inferredcites →https://doi.org/10.1186/s13041-019-0504-xopenalex-snapshot
Autophagic and endo-lysosomal dysfunction in neurodegenerative disease
inferredcites →https://doi.org/10.1186/s40478-018-0564-7openalex-snapshot
Poly-GR dipeptide repeat polymers correlate with neurodegeneration and Clinicopathological subtypes in C9ORF72-related brain disease
inferredcites →https://doi.org/10.1186/s40478-023-01648-0openalex-snapshot
A toxic gain-of-function mechanism in C9orf72 ALS impairs the autophagy-lysosome pathway in neurons
inferredcites →https://doi.org/10.1242/dev.165753openalex-snapshot
Third-generation in situ hybridization chain reaction: multiplexed, quantitative, sensitive, versatile, robust
inferredcites →https://doi.org/10.1261/rna.047647.114openalex-snapshot
Studies of alternative isoforms provide insight into TDP-43 autoregulation and pathogenesis
inferredcites →https://doi.org/10.1371/journal.pbio.3001319openalex-snapshot
A flexible framework for multi-particle refinement in cryo-electron tomography
inferredcites →https://doi.org/10.1371/journal.pbio.3002527openalex-snapshot
RNA-mediated ribonucleoprotein assembly controls TDP-43 nuclear retention
inferredcites →https://doi.org/10.1371/journal.pone.0013250openalex-snapshot
Tar DNA Binding Protein-43 (TDP-43) Associates with Stress Granules: Analysis of Cultured Cells and Pathological Brain Tissue
inferredcites →https://doi.org/10.1371/journal.pone.0022850openalex-snapshot
Cytoplasmic Accumulation and Aggregation of TDP-43 upon Proteasome Inhibition in Cultured Neurons
inferredcites →https://doi.org/10.1371/journal.pone.0169506openalex-snapshot
Functional Maturation of Human Stem Cell-Derived Neurons in Long-Term Cultures
inferredcites →https://doi.org/10.1371/journal.pone.0298080openalex-snapshot
Generation and characterization of monoclonal antibodies against pathologically phosphorylated TDP-43
inferredcites →https://doi.org/10.1515/revneuro.2010.21.4.251openalex-snapshot
Pathogenic TARDBP Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia: Disease-Associated Pathways
inferredcites →https://doi.org/10.1523/jneurosci.4988-09.2010openalex-snapshot
Cytoplasmic Mislocalization of TDP-43 Is Toxic to Neurons and Enhanced by a Mutation Associated with Familial Amyotrophic Lateral Sclerosis
inferredcites →https://doi.org/10.15252/embr.202050219openalex-snapshot
Loss of TMEM106B and PGRN leads to severe lysosomal abnormalities and neurodegeneration in mice
inferredcites →https://doi.org/10.15252/embr.202357265openalex-snapshot
Lysosomes in senescence and aging
inferredcites →https://doi.org/10.15252/msb.20145508openalex-snapshot
Rapid neurogenesis through transcriptional activation in human stem cells
inferredcites →https://doi.org/10.2353/ajpath.2008.080003openalex-snapshot
Enrichment of C-Terminal Fragments in TAR DNA-Binding Protein-43 Cytoplasmic Inclusions in Brain but not in Spinal Cord of Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis
inferredcites →https://doi.org/10.3389/fneur.2022.995747openalex-snapshot
m6A RNA methylation in brain injury and neurodegenerative disease
inferredcites →https://doi.org/10.3389/fnins.2019.00335openalex-snapshot
The Pathobiology of TDP-43 C-Terminal Fragments in ALS and FTLD
inferredcites →https://doi.org/10.3389/fnmol.2020.00019openalex-snapshot
Chaperone Mediated Autophagy Degrades TDP-43 Protein and Is Affected by TDP-43 Aggregation
inferredcites →https://doi.org/10.3390/ijms10010232openalex-snapshot
Molecular Neuropathology of TDP-43 Proteinopathies
inferredcites →https://doi.org/10.3791/59036openalex-snapshot
Monitoring Neuronal Survival via Longitudinal Fluorescence Microscopy
inferredcites →https://doi.org/10.7554/elife.01456openalex-snapshot
Collaboration gets the most out of software
inferredcites →https://doi.org/10.7554/elife.31311openalex-snapshot
YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs
inferredcites →https://doi.org/10.7554/elife.78923openalex-snapshot
A pulse-chasable reporter processing assay for mammalian autophagic flux with HaloTag
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1002/alz.71713openalex-snapshot
TMEM106B is a selective modulator of TDP‐43 pathology in Alzheimer's disease
inferred← citeshttps://doi.org/10.1038/s41594-026-01792-wopenalex-snapshot
Cracking the code of native amyloid fibrils: advances and next steps to enable pathology-informed therapeutic and diagnostic
inferred← citeshttps://doi.org/10.1101/2024.01.05.574336openalex-snapshot
MemBrain v2: an end-to-end tool for the analysis of membranes in cryo-electron tomography
inferred← citeshttps://doi.org/10.1101/2024.10.24.620053openalex-snapshot
Endogenous retrovirus-like proteins recruit UBQLN2 to stress granules and alter their functional properties
inferred← citeshttps://doi.org/10.1126/sciadv.adu6354openalex-snapshot
Endogenous retrovirus-like proteins recruit UBQLN2 to stress granules and shape their functional biology
inferred← citeshttps://doi.org/10.1172/jci199846openalex-snapshot
Splicing the narrative: alternative TARDBP splicing and its relation to neurodegeneration in ALS and FTD
inferred← citeshttps://doi.org/10.1186/s13024-025-00839-8openalex-snapshot
Molecular mechanisms and consequences of TDP-43 phosphorylation in neurodegeneration
inferred← citeshttps://doi.org/10.3390/ijms27031136openalex-snapshot
From Evasion to Collapse: The Kinetic Cascade of TDP-43 and the Failure of Proteostasis
inferred← citeshttps://doi.org/10.64898/2026.03.26.714634openalex-snapshot
Neurodegeneration risk variants promote lysosomal TMEM106B fibril accumulation
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