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Ruxolitinib clears CRYAB p.Arg120Gly aggregates through the ubiquitin-proteasome system
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/ajh.24572openalex-snapshot
Risk factors for infections in myelofibrosis: role of disease status and treatment. A multicenter study of 507 patients
inferredcites →https://doi.org/10.1002/ajh.24976openalex-snapshot
Ruxolitinib‐associated infections: A systematic review and meta‐analysis
inferredcites →https://doi.org/10.1007/s10875-023-01629-xopenalex-snapshot
Ruxolitinib Rescues Multiorgan Clinical Autoimmunity in Patients with APS-1
inferredcites →https://doi.org/10.1007/s12551-018-0443-2openalex-snapshot
Intermediate filaments in cardiomyopathy
inferredcites →https://doi.org/10.1016/j.biochi.2023.10.002openalex-snapshot
Desmin and its molecular chaperone, the αB-crystallin: How post-translational modifications modulate their functions in heart and skeletal muscles?
inferredcites →https://doi.org/10.1016/j.cell.2016.07.001openalex-snapshot
UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome
inferredcites →https://doi.org/10.1016/j.jaci.2021.08.004openalex-snapshot
JAK-STAT signaling in human disease: From genetic syndromes to clinical inhibition
inferredcites →https://doi.org/10.1016/j.scr.2023.103188openalex-snapshot
Generation of a homozygous CRYAB p.Arg120Gly mutant (UKEi001-A-1) from a human iPSC line
inferredcites →https://doi.org/10.1016/j.yjmcc.2010.09.004openalex-snapshot
Selective degradation of aggregate-prone CryAB mutants by HSPB1 is mediated by ubiquitin–proteasome pathways
inferredcites →https://doi.org/10.1016/j.yjmcc.2015.08.020openalex-snapshot
The E3 ubiquitin ligase Asb2β is downregulated in a mouse model of hypertrophic cardiomyopathy and targets desmin for proteasomal degradation
inferredcites →https://doi.org/10.1016/j.yjmcc.2017.10.003openalex-snapshot
TFEB activation protects against cardiac proteotoxicity via increasing autophagic flux
inferredcites →https://doi.org/10.1016/s0008-6363(02)00664-8openalex-snapshot
Activation of signal transducer and activator of transcription (STAT) pathways in failing human hearts
inferredcites →https://doi.org/10.1016/s0092-8674(00)81166-6openalex-snapshot
Disruption of the Jak1 Gene Demonstrates Obligatory and Nonredundant Roles of the Jaks in Cytokine-Induced Biologic Responses
inferredcites →https://doi.org/10.1038/1765openalex-snapshot
A missense mutation in the αB-crystallin chaperone gene causes a desmin-related myopathy
inferredcites →https://doi.org/10.1038/nprot.2017.033openalex-snapshot
Differentiation of cardiomyocytes and generation of human engineered heart tissue
inferredcites →https://doi.org/10.1038/s41375-023-01979-wopenalex-snapshot
The JAK1/2 inhibitor ruxolitinib in patients with COVID-19 triggered hyperinflammation: the RuxCoFlam trial
inferredcites →https://doi.org/10.1073/pnas.0401900101openalex-snapshot
Desmin-related cardiomyopathy in transgenic mice: A cardiac amyloidosis
inferredcites →https://doi.org/10.1073/pnas.1610970113openalex-snapshot
Epigenetic gene regulation by Janus kinase 1 in diffuse large B-cell lymphoma
inferredcites →https://doi.org/10.1073/pnas.2134694100openalex-snapshot
Cardiomyocyte-restricted knockout of STAT3 results in higher sensitivity to inflammation, cardiac fibrosis, and heart failure with advanced age
inferredcites →https://doi.org/10.1073/pnas.97.1.315openalex-snapshot
Signal transducer and activator of transcription 3 in the heart transduces not only a hypertrophic signal but a protective signal against doxorubicin-induced cardiomyopathy
inferredcites →https://doi.org/10.1074/jbc.m809739200openalex-snapshot
Intranuclear Degradation of Polyglutamine Aggregates by the Ubiquitin-Proteasome System
inferredcites →https://doi.org/10.1080/15548627.2020.1856493openalex-snapshot
A high-throughput screening identifies ZNF418 as a novel regulator of the ubiquitin-proteasome system and autophagy-lysosomal pathway
inferredcites →https://doi.org/10.1097/hjh.0000000000000358openalex-snapshot
Deletion of interleukin-6 prevents cardiac inflammation, fibrosis and dysfunction without affecting blood pressure in angiotensin II-high salt-induced hypertension
inferredcites →https://doi.org/10.1128/mcb.00980-14openalex-snapshot
PERK-Dependent Activation of JAK1 and STAT3 Contributes to Endoplasmic Reticulum Stress-Induced Inflammation
inferredcites →https://doi.org/10.1146/annurev-biochem-061516-045115openalex-snapshot
Protein Misfolding, Amyloid Formation, and Human Disease: A Summary of Progress Over the Last Decade
inferredcites →https://doi.org/10.1146/annurev-med-051113-024537openalex-snapshot
The JAK-STAT Pathway: Impact on Human Disease and Therapeutic Intervention
inferredcites →https://doi.org/10.1152/ajpheart.00601.2011openalex-snapshot
Desmin-related cardiomyopathy: an unfolding story
inferredcites →https://doi.org/10.1161/01.cir.0000057545.82749.ffopenalex-snapshot
Alterations in Janus Kinase (JAK)-Signal Transducers and Activators of Transcription (STAT) Signaling in Patients With End-Stage Dilated Cardiomyopathy
inferredcites →https://doi.org/10.1161/01.cir.98.4.346openalex-snapshot
Activation of gp130 Transduces Hypertrophic Signals via STAT3 in Cardiac Myocytes
inferredcites →https://doi.org/10.1161/01.res.0000134921.50377.61openalex-snapshot
Signal Transducer and Activator of Transcription 3 Is Required for Myocardial Capillary Growth, Control of Interstitial Matrix Deposition, and Heart Protection From Ischemic Injury
inferredcites →https://doi.org/10.1161/01.res.0000189262.92896.0bopenalex-snapshot
Intrasarcoplasmic Amyloidosis Impairs Proteolytic Function of Proteasomes in Cardiomyocytes by Compromising Substrate Uptake
inferredcites →https://doi.org/10.1161/circresaha.117.310945openalex-snapshot
An Unbiased High-Throughput Screen to Identify Novel Effectors That Impact on Cardiomyocyte Aggregate Levels
inferredcites →https://doi.org/10.1161/circresaha.118.313089openalex-snapshot
Myofibroblast-Specific TGFβ Receptor II Signaling in the Fibrotic Response to Cardiac Myosin Binding Protein C-Induced Cardiomyopathy
inferredcites →https://doi.org/10.1161/circresaha.119.316444openalex-snapshot
Ube2v1 Positively Regulates Protein Aggregation by Modulating Ubiquitin Proteasome System Performance Partially Through K63 Ubiquitination
inferredcites →https://doi.org/10.1161/circresaha.123.322887openalex-snapshot
S14-Phosphorylated RPN6 Mediates Proteasome Activation by PKA and Alleviates Proteinopathy
inferredcites →https://doi.org/10.1161/circresaha.124.324387openalex-snapshot
Chronic Activation of Tubulin Tyrosination Improves Heart Function
inferredcites →https://doi.org/10.1161/hh1301.092687openalex-snapshot
Temporally Regulated and Tissue-Specific Gene Manipulations in the Adult and Embryonic Heart Using a Tamoxifen-Inducible Cre Protein
inferredcites →https://doi.org/10.1161/hh1301.092688openalex-snapshot
Expression of R120G–αB-Crystallin Causes Aberrant Desmin and αB-Crystallin Aggregation and Cardiomyopathy in Mice
inferredcites →https://doi.org/10.1172/jci70877openalex-snapshot
Enhanced autophagy ameliorates cardiac proteinopathy
inferredcites →https://doi.org/10.1182/blood-2013-03-484642openalex-snapshot
The JAK-inhibitor ruxolitinib impairs dendritic cell function in vitro and in vivo
inferredcites →https://doi.org/10.2217/fon.11.81openalex-snapshot
Ruxolitinib: A New JAK1/2 Inhibitor That Offers Promising Options for Treatment of Myelofibrosis
inferredcites →https://doi.org/10.3389/fcell.2022.986718openalex-snapshot
Desmin variants: Trigger for cardiac arrhythmias?
inferredcites →https://doi.org/10.3389/fncel.2019.00446openalex-snapshot
Janus Kinase 1 Is Required for Transcriptional Reprograming of Murine Astrocytes in Response to Endoplasmic Reticulum Stress
inferredcites →https://doi.org/10.3390/cells9020491openalex-snapshot
Is Desmin Propensity to Aggregate Part of its Protective Function?
inferredcites →https://doi.org/10.3390/molecules26020407openalex-snapshot
Ubiquitin Ligases at the Heart of Skeletal Muscle Atrophy Control
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1101/2025.10.02.680018openalex-snapshot
A Micro-Engineered Heart Tissue Model of Desmin-related Cardiomyopathy Caused by Mutant αB Crystallin
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