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Dopamine and serotonin differentially associated with reward and punishment processes in humans: A systematic review and meta-analysis

https://doi.org/10.1101/2025.01.08.631868

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Reward-Processing Behavior in Depressed Participants Relative to Healthy Volunteers

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Reinforcement Learning in Patients With Mood and Anxiety Disorders vs Control Individuals

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Mesolimbic Dopamine and the Regulation of Motivated Behavior

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Tonic dopamine: opportunity costs and the control of response vigor

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Human reward system activation is modulated by a single dose of olanzapine in healthy subjects in an event-related, double-blind, placebo-controlled fMRI study

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Single dose of a dopamine agonist impairs reinforcement learning in humans: Behavioral evidence from a laboratory-based measure of reward responsiveness

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Tryptophan depletion disinhibits punishment but not reward prediction: implications for resilience

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Differential, but not opponent, effects of l-DOPA and citalopram on action learning with reward and punishment

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Serotonin and dopamine differentially affect appetitive and aversive general Pavlovian-to-instrumental transfer

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The effect of single-dose methylphenidate on the rate of error-driven learning in healthy males: a randomized controlled trial

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Dopaminergic drug treatment remediates exaggerated cingulate prediction error responses in obsessive-compulsive disorder

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Bupropion increases activation in nucleus accumbens during anticipation of monetary reward

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No effect of a dopaminergic modulation fMRI task by amisulpride and L-DOPA on reward anticipation in healthy volunteers

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Dopaminergic modulation of reward discounting in healthy rats: a systematic review and meta-analysis

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The effects of pramipexole on motivational vigour during a saccade task: a placebo-controlled study in healthy adults

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Improved short-term spatial memory but impaired reversal learning following the dopamine D2 agonist bromocriptine in human volunteers

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Inverted-U–Shaped Dopamine Actions on Human Working Memory and Cognitive Control

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Pramipexole Enhances Reward Learning by Preserving Value Estimates

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Improving the Reliability of Cognitive Task Measures: A Narrative Review

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Optogenetic Activation of Dorsal Raphe Serotonin Neurons Enhances Patience for Future Rewards

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Stressor controllability and learned helplessness: The roles of the dorsal raphe nucleus, serotonin, and corticotropin-releasing factor

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The role of serotonin in reward, punishment and behavioural inhibition in humans: Insights from studies with acute tryptophan depletion

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The “highs and lows” of the human brain on dopaminergics: Evidence from neuropharmacology

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Striatal D1 and D2 signaling differentially predict learning from positive and negative outcomes

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l-DOPA and oxytocin influence the neurocomputational mechanisms of self-benefitting and prosocial reinforcement learning

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Midbrain Dopamine Neurons Encode a Quantitative Reward Prediction Error Signal

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Decision-making ability, psychopathology, and brain connectivity

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Fronto-striatal connectivity patterns account for the impact of methylphenidate on choice impulsivity among healthy adults

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Dopamine, serotonin and impulsivity

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Age moderates the effect of acute dopamine depletion on passive avoidance learning

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Action versus valence in decision making

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Comparative Efficacy and Acceptability of 21 Antidepressant Drugs for the Acute Treatment of Adults With Major Depressive Disorder: A Systematic Review and Network Meta-Analysis

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Effect of tryptophan depletion on impulsive behavior in men with or without a family history of alcoholism

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Acute Administration of d-Amphetamine Decreases Impulsivity in Healthy Volunteers

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Metalearning and neuromodulation

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Opponent interactions between serotonin and dopamine

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Personalized prediction of antidepressant v. placebo response: evidence from the EMBARC study

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The effects of acute tryptophan depletion on instrumental reward learning in anorexia nervosa – an fMRI study

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The selective serotonin reuptake inhibitor sertraline alters learning from aversive reinforcements in patients with depression: evidence from a randomized controlled trial

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Reconciling the role of central serotonin neurons in human and animal behavior

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A mechanistic account of striatal dopamine function in human cognition: Psychopharmacological studies with cabergoline and haloperidol.

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Opponent actor learning (OpAL): Modeling interactive effects of striatal dopamine on reinforcement learning and choice incentive.

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Dopamine-dependent prediction errors underpin reward-seeking behaviour in humans

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A selective role for dopamine in stimulus–reward learning

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A causal link between prediction errors, dopamine neurons and learning

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Mesolimbic dopamine signals the value of work

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Serotonin and Dopamine: Unifying Affective, Activational, and Decision Functions

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Opponency Revisited: Competition and Cooperation Between Dopamine and Serotonin

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The Roles of Dopamine and Serotonin in Decision Making: Evidence from Pharmacological Experiments in Humans

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Dopamine-Related Deficit in Reward Learning After Catecholamine Depletion in Unmedicated, Remitted Subjects with Bulimia Nervosa

inferredcites →https://doi.org/10.1038/npp.2012.75openalex-snapshot

Serotonin Modulates the Effects of Pavlovian Aversive Predictions on Response Vigor

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Serotonin Depletion Induces ‘Waiting Impulsivity’ on the Human Four-Choice Serial Reaction Time Task: Cross-Species Translational Significance

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Dopamine Modulates Reward-Related Vigor

inferredcites →https://doi.org/10.1038/npp.2014.84openalex-snapshot

Role of Dopamine D2 Receptors in Human Reinforcement Learning

inferredcites →https://doi.org/10.1038/s41380-020-0803-8openalex-snapshot

Precision weighting of cortical unsigned prediction error signals benefits learning, is mediated by dopamine, and is impaired in psychosis

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Serotonin depletion impairs both Pavlovian and instrumental reversal learning in healthy humans

inferredcites →https://doi.org/10.1038/s41386-020-00881-8openalex-snapshot

Attention-deficit/hyperactivity disorder and the explore/exploit trade-off

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The role of dopamine in dynamic effort-reward integration

inferredcites →https://doi.org/10.1038/s41386-020-0779-8openalex-snapshot

Dose-response effects of d-amphetamine on effort-based decision-making and reinforcement learning

inferredcites →https://doi.org/10.1038/s41386-022-01291-8openalex-snapshot

Cortical dopamine reduces the impact of motivational biases governing automated behaviour

inferredcites →https://doi.org/10.1038/s41386-022-01517-9openalex-snapshot

Disentangling the roles of dopamine and noradrenaline in the exploration-exploitation tradeoff during human decision-making

inferredcites →https://doi.org/10.1038/s41386-023-01762-6openalex-snapshot

Comparable roles for serotonin in rats and humans for computations underlying flexible decision-making

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Dopamine regulates decision thresholds in human reinforcement learning in males

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Direct serotonin release in humans shapes aversive learning and inhibition

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Neuroscience of apathy and anhedonia: a transdiagnostic approach

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Opponent control of reinforcement by striatal dopamine and serotonin

inferredcites →https://doi.org/10.1038/s42003-022-03690-5openalex-snapshot

Serotonin modulates asymmetric learning from reward and punishment in healthy human volunteers

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Tryptophan Depletion Disrupts the Motivational Guidance of Goal-Directed Behavior as a Function of Trait Impulsivity

inferredcites →https://doi.org/10.1038/sj.npp.1301055openalex-snapshot

Serotonin Transporter Polymorphism Mediates Vulnerability to Loss of Incentive Motivation Following Acute Tryptophan Depletion

inferredcites →https://doi.org/10.1038/sj.npp.1301182openalex-snapshot

The Impact of Tryptophan Depletion and 5-HTTLPR Genotype on Passive Avoidance and Response Reversal Instrumental Learning Tasks

inferredcites →https://doi.org/10.1038/sj.npp.1301598openalex-snapshot

Acute Tryptophan Depletion in Healthy Volunteers Enhances Punishment Prediction but Does not Affect Reward Prediction

inferredcites →https://doi.org/10.1038/tp.2016.113openalex-snapshot

Dopamine D2/3- and μ-opioid receptor antagonists reduce cue-induced responding and reward impulsivity in humans

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Menstrual cycle phase modulates reward-related neural function in women

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Action controls dopaminergic enhancement of reward representations

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Striatal Dopamine Can Enhance Learning, Both Fast and Slow, and Also Make it Cheaper

inferredcites →https://doi.org/10.1111/j.1460-9568.2012.08026.xopenalex-snapshot

Instrumental vigour in punishment and reward

inferredcites →https://doi.org/10.1126/science.275.5306.1593openalex-snapshot

A Neural Substrate of Prediction and Reward

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Dopamine promotes cognitive effort by biasing the benefits versus costs of cognitive work

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Illusory generalizability of clinical prediction models

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The PRISMA 2020 statement: an updated guideline for reporting systematic reviews

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Disrupted reward processing in Parkinson’s disease and its relationship with dopamine state and neuropsychiatric syndromes: a systematic review and meta-analysis

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Depression: A Decision-Theoretic Analysis

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Serotonin in Affective Control

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Effects of Acute Dopamine Precusor Depletion on Immediate Reward Selection Bias and Working Memory Depend on Catechol-O-methyltransferase Genotype

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Acute and Longer-Term Outcomes in Depressed Outpatients Requiring One or Several Treatment Steps: A STAR*D Report

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Methamphetamine-Induced Disruption of Frontostriatal Reward Learning Signals: Relation to Psychotic Symptoms

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Depression Subtypes in Predicting Antidepressant Response: A Report From the iSPOT-D Trial

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Dopaminergic Enhancement of Striatal Response to Reward in Major Depression

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Modafinil alters decision making based on feedback history – a randomized placebo-controlled double blind study in humans

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Arbitration between model-free and model-based control is not affected by transient changes in tonic serotonin levels

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5-HT and mechanisms of defence

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Dopamine and acetylcholine have distinct roles in delay- and effort-based decision-making in humans

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Serotonin, Inhibition, and Negative Mood

inferredcites →https://doi.org/10.1371/journal.pone.0001333openalex-snapshot

Serotonin Differentially Regulates Short- and Long-Term Prediction of Rewards in the Ventral and Dorsal Striatum

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Effects of L-dopa during Auditory Instrumental Learning in Humans

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Serotonin Selectively Modulates Reward Value in Human Decision-Making

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Dopaminergic Modulation of Human Intertemporal Choice: A Diffusion Model Analysis Using the D2-Receptor Antagonist Haloperidol

inferredcites →https://doi.org/10.1523/jneurosci.0757-14.2014openalex-snapshot

Differential Modulation of Reinforcement Learning by D2 Dopamine and NMDA Glutamate Receptor Antagonism

inferredcites →https://doi.org/10.1523/jneurosci.0786-25.2025openalex-snapshot

Dopamine and Temporal Discounting: Revisiting Pharmacology and Individual Differences

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Dopamine, Corticostriatal Connectivity, and Intertemporal Choice

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A framework for mesencephalic dopamine systems based on predictive Hebbian learning

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Dopamine Modulates Adaptive Prediction Error Coding in the Human Midbrain and Striatum

inferredcites →https://doi.org/10.1523/jneurosci.2749-13.2013openalex-snapshot

Serotonin and Aversive Pavlovian Control of Instrumental Behavior in Humans

inferredcites →https://doi.org/10.1523/jneurosci.3904-10.2011openalex-snapshot

Dopamine-Mediated Reinforcement Learning Signals in the Striatum and Ventromedial Prefrontal Cortex Underlie Value-Based Choices

inferredcites →https://doi.org/10.1523/jneurosci.4182-14.2015openalex-snapshot

Dopamine D2-Receptor Blockade Enhances Decoding of Prefrontal Signals in Humans

inferredcites →https://doi.org/10.1523/jneurosci.4387-11.2011openalex-snapshot

Amping Up Effort: Effects ofd-Amphetamine on Human Effort-Based Decision-Making

inferredcites →https://doi.org/10.1523/jneurosci.4982-07.2008openalex-snapshot

Low-Serotonin Levels Increase Delayed Reward Discounting in Humans

inferredcites →https://doi.org/10.1523/jneurosci.6028-09.2010openalex-snapshot

Dopamine, Time, and Impulsivity in Humans

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Conducting Meta-Analyses in R with the metafor Package

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The role of the noradrenergic system in the exploration-exploitation trade-off: a pharmacological study

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Differential Noradrenergic Modulation of Monetary Reward and Visual Erotic Stimulus Processing

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A Dissociation of the Acute Effects of Bupropion on Positive Emotional Processing and Reward Processing in Healthy Volunteers

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The Role of Serotonin in Fear Learning and Memory: A Systematic Review of Human Studies

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What Can Reinforcement Learning Models of Dopamine and Serotonin Tell Us about the Action of Antidepressants?

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Test-Retest Reliability of Two Computationally-Characterised Affective Bias Tasks

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Serotonergic neurons signal reward and punishment on multiple timescales

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A specific role for serotonin in overcoming effort cost

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The interpretation of computational model parameters depends on the context

inferredcites →https://doi.org/10.7554/elife.79661openalex-snapshot

Effects of dopamine D2/3 and opioid receptor antagonism on the trade-off between model-based and model-free behaviour in healthy volunteers

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Dopamine and serotonin inversely modulate D2 medium spiny neurons to regulate cocaine reward

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Different Sensitivity to Ethanol and Sucrose in DAT and SERT Knockout Rats

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