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Independent Polygenic Component Scores Link Multivariate Brain Imaging Genetics to Diverse Phenotypes

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Polygenic scores via penalized regression on summary statistics
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Total cholesterol as a risk factor for coronary heart disease and stroke in women compared with men: A systematic review and meta-analysis
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Brain Structure and Function Show Distinct Relations With Genetic Predispositions to Mental Health and Cognition
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Specificity of Psychiatric Polygenic Risk Scores and Their Effects on Associated Risk Phenotypes
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Common genetic variants and gene expression associated with white matter microstructure in the human brain
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Image processing and Quality Control for the first 10,000 brain imaging datasets from UK Biobank
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Exploring the genetic correlation between obesity-related traits and regional brain volumes: Evidence from UK Biobank cohort
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Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
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Novel genetic loci associated with hippocampal volume
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High cholesterol level is essential for myelin membrane growth
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Genomic prediction of cognitive traits in childhood and adolescence
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The P-factor and its genomic and neural equivalents: an integrated perspective
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Genetic liability to major psychiatric disorders contributes to multi-faceted quality of life outcomes in children and adults
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Functional mapping and annotation of genetic associations with FUMA
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Polygenic prediction via Bayesian regression and continuous shrinkage priors
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Understanding the genetic determinants of the brain with MOSTest
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Abundant pleiotropy across neuroimaging modalities identified through a multivariate genome-wide association study
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Genomic structural equation modelling provides insights into the multivariate genetic architecture of complex traits
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Genome-wide association studies of brain imaging phenotypes in UK Biobank
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The UK Biobank resource with deep phenotyping and genomic data
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Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection
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Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
inferredcites →https://doi.org/10.1038/s41588-018-0152-6openalex-snapshot
Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence
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Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder
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A global overview of pleiotropy and genetic architecture in complex traits
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An expanded set of genome-wide association studies of brain imaging phenotypes in UK Biobank
inferredcites →https://doi.org/10.1038/s41593-021-00908-3openalex-snapshot
Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction
inferredcites →https://doi.org/10.1038/s41596-020-0353-1openalex-snapshot
Tutorial: a guide to performing polygenic risk score analyses
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Parameter tuning differentiates granule cell subtypes enriching transmission properties at the cerebellum input stage
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Structure and biological function of ENPP6, a choline-specific glycerophosphodiester-phosphodiesterase
inferredcites →https://doi.org/10.1073/pnas.0909969107openalex-snapshot
Genetic control over the resting brain
inferredcites →https://doi.org/10.1093/cercor/bhr013openalex-snapshot
Genetic and Environmental Contributions to Regional Cortical Surface Area in Humans: A Magnetic Resonance Imaging Twin Study
inferredcites →https://doi.org/10.1093/gigascience/giz082openalex-snapshot
PRSice-2: Polygenic Risk Score software for biobank-scale data
inferredcites →https://doi.org/10.1101/2024.05.03.592285openalex-snapshot
GUIDE deconstructs genetic architectures using association studies
inferredcites →https://doi.org/10.1101/2025.04.07.25324950openalex-snapshot
The Genetic Architecture of Brain Structure and Function: A Data-Driven Interpretation Using genomICA
inferredcites →https://doi.org/10.1109/tmi.2003.822821openalex-snapshot
Probabilistic Independent Component Analysis for Functional Magnetic Resonance Imaging
inferredcites →https://doi.org/10.1111/gbb.12876openalex-snapshot
Principal and independent genomic components of brain structure and function
inferredcites →https://doi.org/10.1111/jcpp.12295openalex-snapshot
Research Review: Polygenic methods and their application to psychiatric traits
inferredcites →https://doi.org/10.1126/science.aay6690openalex-snapshot
The genetic architecture of the human cerebral cortex
inferredcites →https://doi.org/10.1136/bmj.c3666openalex-snapshot
The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysis
inferredcites →https://doi.org/10.1161/hypertensionaha.111.00430openalex-snapshot
High Blood Pressure and Cerebral White Matter Lesion Progression in the General Population
inferredcites →https://doi.org/10.1177/2470547020924844openalex-snapshot
Heterogeneity and Polygenicity in Psychiatric Disorders: A Genome-Wide Perspective
inferredcites →https://doi.org/10.1186/s12939-017-0595-xopenalex-snapshot
Determinants of self-perceived health for Canadians aged 40 and older and policy implications
inferredcites →https://doi.org/10.1186/s12939-020-01304-2openalex-snapshot
The effect of objective income and perceived economic resources on self-rated health
inferredcites →https://doi.org/10.1186/s13742-015-0047-8openalex-snapshot
Second-generation PLINK: rising to the challenge of larger and richer datasets
inferredcites →https://doi.org/10.1371/journal.pcbi.1004219openalex-snapshot
MAGMA: Generalized Gene-Set Analysis of GWAS Data
inferredcites →https://doi.org/10.1371/journal.pgen.1003348openalex-snapshot
Power and Predictive Accuracy of Polygenic Risk Scores
inferredcites →https://doi.org/10.14740/jocmr3362wopenalex-snapshot
An Improvement of Cardiovascular Risk Factors by Omega-3 Polyunsaturated Fatty Acids
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Central nervous system: cholesterol turnover, brain development and neurodegeneration
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Cardiovascular risk of smoking and benefits of smoking cessation
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Perceived Health as Related to Income, Socio-economic Status, Lifestyle, and Social Support Factors in a Middle-aged Japanese
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