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Schizophrenia-associated 22q11.2 deletion elevates striatal acetylcholine and disrupts thalamostriatal projections to produce amotivation in mice

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Outgoing claims: the papers this work cites, builds on, or argues with.

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From Perception to Functional Outcome in Schizophrenia
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High Rates of Schizophrenia in Adults With Velo-Cardio-Facial Syndrome
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Efficacy of 42 Pharmacologic Cotreatment Strategies Added to Antipsychotic Monotherapy in Schizophrenia
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Generation of Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) Using Directed Molecular Evolution
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Confocal laser scanning microscopy and ultrastructural study of VGLUT2 thalamic input to striatal projection neurons in rats
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Immunocytochemical localization of choline acetyltransferase within the rat neostriatum: A correlated light and electron microscopic study of cholinergic neurons and synapses
inferredcites →https://doi.org/10.1002/cne.902670402openalex-snapshot
Identification of synaptic terminals of thalamic or cortical origin in contact with distinct medium‐size spiny neurons in the rat neostriatum
inferredcites →https://doi.org/10.1002/cne.903200207openalex-snapshot
Efferent connections of the centromedian and parafascicular thalamic nuclei in the squirrel monkey: A light and electron microscopic study of the thalamostriatal projection in relation to striatal heterogeneity
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Complex heatmap visualization
inferredcites →https://doi.org/10.1002/jnr.21666openalex-snapshot
Pivotal role of early B‐cell factor 1 in development of striatonigral medium spiny neurons in the matrix compartment
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Mesolimbic Dopamine and the Regulation of Motivated Behavior
inferredcites →https://doi.org/10.1007/978-0-387-98141-3openalex-snapshot
ggplot2: Elegant Graphics for Data Analysis
inferredcites →https://doi.org/10.1007/978-3-030-00934-2_30openalex-snapshot
Cell Detection with Star-Convex Polygons
inferredcites →https://doi.org/10.1007/s00213-006-0372-9openalex-snapshot
The group II metabotropic glutamate receptor agonist, LY379268, inhibits both cocaine- and food-seeking behavior in rats
inferredcites →https://doi.org/10.1007/s00213-006-0579-9openalex-snapshot
Viral restoration of dopamine signaling to the dorsal striatum restores instrumental conditioning to dopamine-deficient mice
inferredcites →https://doi.org/10.1007/s00429-013-0601-zopenalex-snapshot
Convergence of cortical and thalamic input to direct and indirect pathway medium spiny neurons in the striatum
inferredcites →https://doi.org/10.1007/s10072-014-1827-0openalex-snapshot
TRPC3 channel mediates excitation of striatal cholinergic interneurons
inferredcites →https://doi.org/10.1007/s40265-017-0789-yopenalex-snapshot
Treatment for Negative Symptoms in Schizophrenia: A Comprehensive Review
inferredcites →https://doi.org/10.1016/0024-3205(95)00030-aopenalex-snapshot
Diverse pre- and post-synaptic expression of m1–m4 muscarinic receptor proteins in neurons and afferents in the rat neostriatum
inferredcites →https://doi.org/10.1016/0165-0270(95)00153-0openalex-snapshot
Progressive ratio schedules in drug self-administration studies in rats: a method to evaluate reinforcing efficacy
inferredcites →https://doi.org/10.1016/0920-9964(91)90006-dopenalex-snapshot
Muscarinic cholinergic hyperactivity in schizophrenia
inferredcites →https://doi.org/10.1016/j.bbr.2014.12.025openalex-snapshot
Deep brain stimulation of the nucleus accumbens shell attenuates cue-induced reinstatement of both cocaine and sucrose seeking in rats
inferredcites →https://doi.org/10.1016/j.bcp.2013.06.031openalex-snapshot
Evaluating the role of the alpha-7 nicotinic acetylcholine receptor in the pathophysiology and treatment of schizophrenia
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Pharmacologic Rescue of Motivational Deficit in an Animal Model of the Negative Symptoms of Schizophrenia
inferredcites →https://doi.org/10.1016/j.biopsych.2012.12.022openalex-snapshot
Negative Symptoms of Schizophrenia Are Associated with Abnormal Effort-Cost Computations
inferredcites →https://doi.org/10.1016/j.biopsych.2015.12.022openalex-snapshot
Cocaine Self-Administration and Extinction Leads to Reduced Glial Fibrillary Acidic Protein Expression and Morphometric Features of Astrocytes in the Nucleus Accumbens Core
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Heroin Cue–Evoked Astrocytic Structural Plasticity at Nucleus Accumbens Synapses Inhibits Heroin Seeking
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Molecular Diversity and Specializations among the Cells of the Adult Mouse Brain
inferredcites →https://doi.org/10.1016/j.cell.2019.05.031openalex-snapshot
Comprehensive Integration of Single-Cell Data
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Integrated analysis of multimodal single-cell data
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Selective Activation of Cholinergic Interneurons Enhances Accumbal Phasic Dopamine Release: Setting the Tone for Reward Processing
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Schizophrenia-Related Microdeletion Impairs Emotional Memory through MicroRNA-Dependent Disruption of Thalamic Inputs to the Amygdala
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Diversity of Interneurons in the Dorsal Striatum Revealed by Single-Cell RNA Sequencing and PatchSeq
inferredcites →https://doi.org/10.1016/j.celrep.2019.01.044openalex-snapshot
Activation of the Rostral Intralaminar Thalamus Drives Reinforcement through Striatal Dopamine Release
inferredcites →https://doi.org/10.1016/j.celrep.2019.11.096openalex-snapshot
A Spatiomolecular Map of the Striatum
inferredcites →https://doi.org/10.1016/j.celrep.2024.114503openalex-snapshot
Synaptic plasticity in human thalamocortical assembloids
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Melanocortin-4 Receptors Expressed by Cholinergic Neurons Regulate Energy Balance and Glucose Homeostasis
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Dissociable encoding of motivated behavior by parallel thalamo-striatal projections
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Colocalization of association signals at nicotinic acetylcholine receptor genes between schizophrenia and smoking traits
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Psychopharmacology of the negative symptoms: Current status and prospects for progress
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Incentive motivation deficits in schizophrenia reflect effort computation impairments during cost-benefit decision-making
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Monitoring and switching of cortico-basal ganglia loop functions by the thalamo-striatal system
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Thalamic Gating of Corticostriatal Signaling by Cholinergic Interneurons
inferredcites →https://doi.org/10.1016/j.neuron.2012.04.038openalex-snapshot
Striatal Dopamine Release Is Triggered by Synchronized Activity in Cholinergic Interneurons
inferredcites →https://doi.org/10.1016/j.neuron.2016.01.040openalex-snapshot
DREADDs for Neuroscientists
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A Designer AAV Variant Permits Efficient Retrograde Access to Projection Neurons
inferredcites →https://doi.org/10.1016/j.neuron.2016.09.025openalex-snapshot
Amygdala and Ventral Striatum Make Distinct Contributions to Reinforcement Learning
inferredcites →https://doi.org/10.1016/j.neuron.2017.11.012openalex-snapshot
Endocannabinoid Actions on Cortical Terminals Orchestrate Local Modulation of Dopamine Release in the Nucleus Accumbens
inferredcites →https://doi.org/10.1016/j.neuron.2018.04.027openalex-snapshot
Pauses in Cholinergic Interneuron Activity Are Driven by Excitatory Input and Delayed Rectification, with Dopamine Modulation
inferredcites →https://doi.org/10.1016/j.neuropharm.2017.01.038openalex-snapshot
Metabotropic glutamate receptor 2 inhibits thalamically-driven glutamate and dopamine release in the dorsal striatum
inferredcites →https://doi.org/10.1016/j.neuropsychologia.2017.09.033openalex-snapshot
Apathy in schizophrenia: A review of neuropsychological and neuroanatomical studies
inferredcites →https://doi.org/10.1016/j.pbb.2012.01.014openalex-snapshot
mGluR5 receptors in the basolateral amygdala and nucleus accumbens regulate cue-induced reinstatement of ethanol-seeking behavior
inferredcites →https://doi.org/10.1016/j.pbiomolbio.2021.06.002openalex-snapshot
Ih from synapses to networks: HCN channel functions and modulation in neurons
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Neurocognitive profile in 22q11 deletion syndrome and schizophrenia
inferredcites →https://doi.org/10.1016/j.schres.2013.02.009openalex-snapshot
Clinical symptoms, mainly negative symptoms, mediate the influence of neurocognition and social cognition on functional outcome of schizophrenia
inferredcites →https://doi.org/10.1016/j.schres.2014.11.005openalex-snapshot
Altered cingulo-striatal function underlies reward drive deficits in schizophrenia
inferredcites →https://doi.org/10.1016/j.schres.2014.11.024openalex-snapshot
Impaired effort allocation in patients with schizophrenia
inferredcites →https://doi.org/10.1016/j.schres.2015.04.040openalex-snapshot
Motivational deficits in early schizophrenia: Prevalent, persistent, and key determinants of functional outcome
inferredcites →https://doi.org/10.1016/j.schres.2015.09.012openalex-snapshot
Measuring motivation in people with schizophrenia
inferredcites →https://doi.org/10.1016/j.schres.2015.12.006openalex-snapshot
Avolition in schizophrenia is associated with reduced willingness to expend effort for reward on a Progressive Ratio task
inferredcites →https://doi.org/10.1016/j.schres.2017.06.042openalex-snapshot
Relationship between effortful motivation and neurocognition in schizophrenia
inferredcites →https://doi.org/10.1016/j.schres.2024.08.001openalex-snapshot
Efficacy of KarXT on negative symptoms in acute schizophrenia: A post hoc analysis of pooled data from 3 trials
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Resolving organoid brain region identities by mapping single-cell genomic data to reference atlases
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The Role of Accumbens Dopamine in Lever Pressing and Response Allocation: Effects of 6-OHDA Injected into Core and Dorsomedial Shell
inferredcites →https://doi.org/10.1016/s0091-3057(98)00112-9openalex-snapshot
Effects of Dopamine Antagonists and Accumbens Dopamine Depletions on Time-Constrained Progressive-Ratio Performance
inferredcites →https://doi.org/10.1016/s0091-3057(99)00092-1openalex-snapshot
Nucleus Accumbens Dopamine Depletions and Time-Constrained Progressive Ratio Performance
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Efficacy and safety of the muscarinic receptor agonist KarXT (xanomeline–trospium) in schizophrenia (EMERGENT-2) in the USA: results from a randomised, double-blind, placebo-controlled, flexible-dose phase 3 trial
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Motivational views of reinforcement: implications for understanding the behavioral functions of nucleus accumbens dopamine
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A review of MRI findings in schizophrenia
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Is avolition in schizophrenia associated with a deficit of dorsal caudate activity? A functional magnetic resonance imaging study during reward anticipation and feedback
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Effects of regional striatal lesions on motor, motivational, and executive aspects of progressive-ratio performance in rats.
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Effort, anhedonia, and function in schizophrenia: Reduced effort allocation predicts amotivation and functional impairment.
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Congenital heart disease in mice deficient for the DiGeorge syndrome region
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Contrasting forms of cocaine-evoked plasticity control components of relapse
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Prefrontal cortex output circuits guide reward seeking through divergent cue encoding
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Spatial reconstruction of single-cell gene expression data
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Integrating single-cell transcriptomic data across different conditions, technologies, and species
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Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model
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Strong association of de novo copy number mutations with sporadic schizophrenia
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Fiji: an open-source platform for biological-image analysis
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A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
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Motivational neural circuits underlying reinforcement learning
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Dissociation of Hedonic Reaction to Reward and Incentive Motivation in an Animal Model of the Negative Symptoms of Schizophrenia
inferredcites →https://doi.org/10.1038/nrdp.2015.71openalex-snapshot
22q11.2 deletion syndrome
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22q11.2 microdeletions: linking DNA structural variation to brain dysfunction and schizophrenia
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Single nuclei transcriptomics in human and non-human primate striatum in opioid use disorder
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Local modulation by presynaptic receptors controls neuronal communication and behaviour
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Fast, sensitive and accurate integration of single-cell data with Harmony
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An optimized acetylcholine sensor for monitoring in vivo cholinergic activity
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Single-cell activity tracking reveals that orbitofrontal neurons acquire and maintain a long-term memory to guide behavioral adaptation
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Neural dynamics underlying associative learning in the dorsal and ventral hippocampus
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A single-cell trajectory atlas of striatal development
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Intravenous cocaine, morphine, and amphetamine preferentially increase extracellular dopamine in the "shell" as compared with the "core" of the rat nucleus accumbens.
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Trafficking and Gating of Hyperpolarization-activated Cyclic Nucleotide-gated Channels Are Regulated by Interaction with Tetratricopeptide Repeat-containing Rab8b-interacting Protein (TRIP8b) and Cyclic AMP at Distinct Sites
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Review and meta-analysis of add-on tranylcypromine with antipsychotic drugs for the treatment of schizophrenia with predominant negative symptoms: a restoration of evidence
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clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters
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STAR: ultrafast universal RNA-seq aligner
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Complex heatmaps reveal patterns and correlations in multidimensional genomic data
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SoupX removes ambient RNA contamination from droplet-based single-cell RNA sequencing data
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Pathogenic rare copy number variants in community-based schizophrenia suggest a potential role for clinical microarrays
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g:Profiler: a web server for functional enrichment analysis and conversions of gene lists (2019 update)
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Treatments of Negative Symptoms in Schizophrenia: Meta-Analysis of 168 Randomized Placebo-Controlled Trials
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Effort-Based Decision-Making Paradigms for Clinical Trials in Schizophrenia: Part 1—Psychometric Characteristics of 5 Paradigms
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Effort-Based Decision-Making Paradigms for Clinical Trials in Schizophrenia: Part 2—External Validity and Correlates
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Translational Rodent Paradigms to Investigate Neuromechanisms Underlying Behaviors Relevant to Amotivation and Altered Reward Processing in Schizophrenia
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Psychotic Illness in Patients Diagnosed with Velo-Cardio-Facial Syndrome and Their Relatives
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Manipulations of Serotonin Function in the Nucleus Accumbens Core Produce Differential Effects on Ethanol and Sucrose Seeking and Intake
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Update on the 22q11.2 deletion syndrome and its relevance to schizophrenia
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Efficacy and safety of antidepressant augmentation of continued antipsychotic treatment in patients with schizophrenia
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Cholinergic modulation of striatal microcircuits
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Striatal cholinergic interneurons exert inhibition on competing default behaviours controlled by the nucleus accumbens and dorsolateral striatum
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The role of the dorsomedial striatum in instrumental conditioning
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Blockade of NMDA receptors in the dorsomedial striatum prevents action–outcome learning in instrumental conditioning
inferredcites →https://doi.org/10.1111/jnc.15297openalex-snapshot
Circuit selectivity in drug versus natural reward seeking behaviors
inferredcites →https://doi.org/10.1113/jphysiol.2012.245233openalex-snapshot
Heterogeneous properties of central lateral and parafascicular thalamic synapses in the striatum
inferredcites →https://doi.org/10.1126/science.1253895openalex-snapshot
Specific disruption of thalamic inputs to the auditory cortex in schizophrenia models
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Progressive Ratio as a Measure of Reward Strength
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Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq
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Queer Current and Pacemaker: The Hyperpolarization-Activated Cation Current in Neurons
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Participation of the Thalamic CM-Pf Complex in Attentional Orienting
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Selective Muscarinic Receptor Agonist Xanomeline as a Novel Treatment Approach for Schizophrenia
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Efficacy and Safety of Antidepressants Added to Antipsychotics for Schizophrenia: A Systematic Review and Meta-Analysis
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RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome
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Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
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Corticostriatal and Thalamostriatal Synapses Have Distinctive Properties
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TrpC3/C7 and Slo2.1 Are Molecular Targets for Metabotropic Glutamate Receptor Signaling in Rat Striatal Cholinergic Interneurons
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Firing patterns and synaptic potentials of identified giant aspiny interneurons in the rat neostriatum
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Identification and localization of muscarinic acetylcholine receptor proteins in brain with subtype-specific antibodies
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2 -1 Signaling in Nucleus Accumbens Is Necessary for Cocaine-Induced Relapse
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Distribution of m1-m4 muscarinic receptor proteins in the rat striatum: light and electron microscopic immunocytochemistry using subtype- specific antibodies
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The Role of the Dorsal Striatum in Reward and Decision-Making: Figure 1.
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Cortical and Thalamic Innervation of Direct and Indirect Pathway Medium-Sized Spiny Neurons in Mouse Striatum
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Metabotropic Glutamate 2/3 Receptors in the Ventral Tegmental Area and the Nucleus Accumbens Shell Are Involved in Behaviors Relating to Nicotine Dependence
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Acquisition and Performance of Goal-Directed Instrumental Actions Depends on ERK Signaling in Distinct Regions of Dorsal Striatum in Rats
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The Circuitry Mediating Cocaine-Induced Reinstatement of Drug-Seeking Behavior
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Regulation of HCN Channel Surface Expression by a Novel C-Terminal Protein-Protein Interaction
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Limbic and Motor Circuitry Underlying Footshock-Induced Reinstatement of Cocaine-Seeking Behavior
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Novel and Distinct Operational Principles of Intralaminar Thalamic Neurons and Their Striatal Projections
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Alternative Splicing of the TRPC3 Ion Channel Calmodulin/IP 3 Receptor-Binding Domain in the Hindbrain Enhances Cation Flux
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A Case for Thalamic Mechanisms of Schizophrenia: Perspective From Modeling 22q11.2 Deletion Syndrome
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Striatal cholinergic interneuron regulation and circuit effects
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The thalamostriatal system in normal and diseased states
inferredcites →https://doi.org/10.3791/58413openalex-snapshot
Isolation of Adult Spinal Cord Nuclei for Massively Parallel Single-nucleus RNA Sequencing
inferredcites →https://doi.org/10.7554/elife.19103openalex-snapshot
A comprehensive excitatory input map of the striatum reveals novel functional organization
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The paraventricular thalamus is a critical mediator of top-down control of cue-motivated behavior in rats

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Progenitor Diversity and Architecture of the Human Ganglionic Eminences Shaping the Basal Ganglia
inferred← citeshttps://doi.org/10.64898/2026.05.18.726024openalex-snapshot
GLP-1 analogs restore inflammatory, mitochondrial and intercellular signaling networks in the Snca G51D/G51D knock-in mouse model of Parkinson’s disease
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