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A common allele in FGF21 associated with preference for sugar consumption lowers body fat in the lower body and increases blood pressure

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1001/jama.2016.14568openalex-snapshot
Association Between Low-Density Lipoprotein Cholesterol–Lowering Genetic Variants and Risk of Type 2 Diabetes
inferredcites →https://doi.org/10.1007/978-1-4614-0887-1_2openalex-snapshot
Klotho and βKlotho
inferredcites →https://doi.org/10.1016/j.cmet.2013.08.005openalex-snapshot
The Effects of LY2405319, an FGF21 Analog, in Obese Human Subjects with Type 2 Diabetes
inferredcites →https://doi.org/10.1016/j.cmet.2013.08.014openalex-snapshot
FGF21 Mimetic Shows Therapeutic Promise
inferredcites →https://doi.org/10.1016/j.cmet.2015.12.003openalex-snapshot
FGF21 Mediates Endocrine Control of Simple Sugar Intake and Sweet Taste Preference by the Liver
inferredcites →https://doi.org/10.1016/j.cmet.2015.12.008openalex-snapshot
FGF21 Regulates Sweet and Alcohol Preference
inferredcites →https://doi.org/10.1016/j.cmet.2016.02.001openalex-snapshot
A Long-Acting FGF21 Molecule, PF-05231023, Decreases Body Weight and Improves Lipid Profile in Non-human Primates and Type 2 Diabetic Subjects
inferredcites →https://doi.org/10.1016/j.cmet.2017.04.009openalex-snapshot
FGF21 Is a Sugar-Induced Hormone Associated with Sweet Intake and Preference in Humans
inferredcites →https://doi.org/10.1016/j.cmet.2017.09.005openalex-snapshot
FGF19, FGF21, and an FGFR1/β-Klotho-Activating Antibody Act on the Nervous System to Regulate Body Weight and Glycemia
inferredcites →https://doi.org/10.1016/s2213-8587(16)30396-5openalex-snapshot
PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study
inferredcites →https://doi.org/10.1038/79216openalex-snapshot
The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes
inferredcites →https://doi.org/10.1038/nature14132openalex-snapshot
New genetic loci link adipose and insulin biology to body fat distribution
inferredcites →https://doi.org/10.1038/nature14177openalex-snapshot
Genetic studies of body mass index yield new insights for obesity biology
inferredcites →https://doi.org/10.1038/ncomms10495openalex-snapshot
New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
inferredcites →https://doi.org/10.1038/ng.210openalex-snapshot
Common variants of FUT2 are associated with plasma vitamin B12 levels
inferredcites →https://doi.org/10.1038/ng.2385openalex-snapshot
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways
inferredcites →https://doi.org/10.1038/ng.2797openalex-snapshot
Discovery and refinement of loci associated with lipid levels
inferredcites →https://doi.org/10.1038/ng.2897openalex-snapshot
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility
inferredcites →https://doi.org/10.1038/ng.3097openalex-snapshot
Defining the role of common variation in the genomic and biological architecture of adult human height
inferredcites →https://doi.org/10.1038/ng.3396openalex-snapshot
A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease
inferredcites →https://doi.org/10.1038/ng.3714openalex-snapshot
Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance
inferredcites →https://doi.org/10.1038/ng.866openalex-snapshot
Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile
inferredcites →https://doi.org/10.1038/ng.970openalex-snapshot
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma
inferredcites →https://doi.org/10.1038/nm.3249openalex-snapshot
FGF21 regulates metabolism and circadian behavior by acting on the nervous system
inferredcites →https://doi.org/10.1038/nm.3250openalex-snapshot
FGF21 contributes to neuroendocrine control of female reproduction
inferredcites →https://doi.org/10.1038/nrd.2016.187openalex-snapshot
Erratum: Impact of genetically supported target selection on R&D productivity
inferredcites →https://doi.org/10.1056/nejmoa1604304openalex-snapshot
Variation inPCSK9andHMGCRand Risk of Cardiovascular Disease and Diabetes
inferredcites →https://doi.org/10.1073/pnas.1200797109openalex-snapshot
Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ
inferredcites →https://doi.org/10.1073/pnas.1611243113openalex-snapshot
KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference
inferredcites →https://doi.org/10.1093/hmg/ddt032openalex-snapshot
Novel locus including FGF21 is associated with dietary macronutrient intake
inferredcites →https://doi.org/10.1111/dom.13023openalex-snapshot
Once‐weekly administration of a long‐acting fibroblast growth factor 21 analogue modulates lipids, bone turnover markers, blood pressure and body weight differently in obese people with hypertriglyceridaemia and in non‐human primates
inferredcites →https://doi.org/10.1111/joim.12580openalex-snapshot
Fibroblast growth factor 21 night watch: advances and uncertainties in the field
inferredcites →https://doi.org/10.1124/mol.108.044826openalex-snapshot
Adipose Fibroblast Growth Factor 21 Is Up-Regulated by Peroxisome Proliferator-Activated Receptor γ and Altered Metabolic States
inferredcites →https://doi.org/10.1161/hypertensionaha.117.09438openalex-snapshot
Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney
inferredcites →https://doi.org/10.1172/jci23606openalex-snapshot
FGF-21 as a novel metabolic regulator
inferredcites →https://doi.org/10.1210/en.2006-1168openalex-snapshot
The Metabolic State of Diabetic Monkeys Is Regulated by Fibroblast Growth Factor-21
inferredcites →https://doi.org/10.1210/en.2008-0816openalex-snapshot
Fibroblast Growth Factor 21 Corrects Obesity in Mice
inferredcites →https://doi.org/10.1210/en.2009-0221openalex-snapshot
Fibroblast Growth Factor 21 Controls Glycemia via Regulation of Hepatic Glucose Flux and Insulin Sensitivity
inferredcites →https://doi.org/10.1371/journal.pmed.1001779openalex-snapshot
UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age
inferredcites →https://doi.org/10.2337/db14-0318openalex-snapshot
Genetic Evidence for a Normal-Weight “Metabolically Obese” Phenotype Linking Insulin Resistance, Hypertension, Coronary Artery Disease, and Type 2 Diabetes
inferredcites →https://doi.org/10.2337/db14-0319openalex-snapshot
Common Genetic Variants Highlight the Role of Insulin Resistance and Body Fat Distribution in Type 2 Diabetes, Independent of Obesity
inferredcites →https://doi.org/10.2337/db15-0458openalex-snapshot
Blood Lipids and Type 2 Diabetes Risk: Can Genetics Help Untangle the Web?
inferredcites →https://doi.org/10.2337/db15-1671openalex-snapshot
Genetic Evidence for a Link Between Favorable Adiposity and Lower Risk of Type 2 Diabetes, Hypertension, and Heart Disease
inferredcites →https://doi.org/10.2337/diabetes.52.4.910openalex-snapshot
Human Metabolic Syndrome Resulting From Dominant-Negative Mutations in the Nuclear Receptor Peroxisome Proliferator-Activated Receptor-γ
inferredcites →https://doi.org/10.3945/ajcn.112.052183openalex-snapshot
Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1101/265629openalex-snapshot
Evidence of a common causal relationship between body mass index and inflammatory skin disease: a Mendelian Randomization study
inferred← citeshttps://doi.org/10.1210/en.2018-00208openalex-snapshot
Parsing the Potential Neuroendocrine Actions of FGF21 in Primates
inferred← citeshttps://doi.org/10.70675/5c14c2c4z469bz40fazb55cz985ea78d6c2aopenalex-snapshot
Rôle des aminoacides ramifiés dans le déterminisme génétique de la résistance à l’insuline
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