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Phenome-wide association studies (PheWAS) across large “real-world data” population cohorts support drug target validation
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/gepi.20456openalex-snapshot
Comparing apples and oranges: equating the power of case‐control and quantitative trait association studies
inferredcites →https://doi.org/10.1016/j.ajhg.2017.05.014openalex-snapshot
A Fast and Accurate Algorithm to Test for Binary Phenotypes and Its Application to PheWAS
inferredcites →https://doi.org/10.1016/j.amjmed.2016.02.001openalex-snapshot
North American Thrombosis Forum, AF Action Initiative Consensus Document
inferredcites →https://doi.org/10.1016/j.jaci.2012.07.054openalex-snapshot
Further replication studies of the EVE Consortium meta-analysis identifies 2 asthma risk loci in European Americans
inferredcites →https://doi.org/10.1016/j.jbi.2015.03.011openalex-snapshot
Building bridges across electronic health record systems through inferred phenotypic topics
inferredcites →https://doi.org/10.1016/j.jclinepi.2015.09.016openalex-snapshot
Million Veteran Program: A mega-biobank to study genetic influences on health and disease
inferredcites →https://doi.org/10.1016/j.jpeds.2009.06.020openalex-snapshot
A Genome-Wide Association Study Identifies a Locus for Nonsyndromic Cleft Lip with or without Cleft Palate on 8q24
inferredcites →https://doi.org/10.1038/ejhg.2013.290openalex-snapshot
Managing clinically significant findings in research: the UK10K example
inferredcites →https://doi.org/10.1038/nature09298openalex-snapshot
Integrating common and rare genetic variation in diverse human populations
inferredcites →https://doi.org/10.1038/nature11632openalex-snapshot
An integrated map of genetic variation from 1,092 human genomes
inferredcites →https://doi.org/10.1038/nature14177openalex-snapshot
Genetic studies of body mass index yield new insights for obesity biology
inferredcites →https://doi.org/10.1038/nature15394openalex-snapshot
An integrated map of structural variation in 2,504 human genomes
inferredcites →https://doi.org/10.1038/nbt.2749openalex-snapshot
Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data
inferredcites →https://doi.org/10.1038/nbt.3183openalex-snapshot
Opportunities for drug repositioning from phenome-wide association studies
inferredcites →https://doi.org/10.1038/ng.3043openalex-snapshot
Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease
inferredcites →https://doi.org/10.1038/ng.3314openalex-snapshot
The support of human genetic evidence for approved drug indications
inferredcites →https://doi.org/10.1038/ng.3359openalex-snapshot
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations
inferredcites →https://doi.org/10.1038/ng.3396openalex-snapshot
A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease
inferredcites →https://doi.org/10.1038/ng.3434openalex-snapshot
Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus
inferredcites →https://doi.org/10.1038/ng.3570openalex-snapshot
Detection and interpretation of shared genetic influences on 42 human traits
inferredcites →https://doi.org/10.1038/ng1847openalex-snapshot
Principal components analysis corrects for stratification in genome-wide association studies
inferredcites →https://doi.org/10.1038/ni.3766openalex-snapshot
The A946T variant of the RNA sensor IFIH1 mediates an interferon program that limits viral infection but increases the risk for autoimmunity
inferredcites →https://doi.org/10.1038/nmeth.2307openalex-snapshot
Improved whole-chromosome phasing for disease and population genetic studies
inferredcites →https://doi.org/10.1038/nrd4051openalex-snapshot
Validating therapeutic targets through human genetics
inferredcites →https://doi.org/10.1038/nrd4309openalex-snapshot
Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework
inferredcites →https://doi.org/10.1038/nrd4609openalex-snapshot
An analysis of the attrition of drug candidates from four major pharmaceutical companies
inferredcites →https://doi.org/10.1038/nrg.2015.36openalex-snapshot
Unravelling the human genome–phenome relationship using phenome-wide association studies
inferredcites →https://doi.org/10.1038/nrg.2016.87openalex-snapshot
Network biology concepts in complex disease comorbidities
inferredcites →https://doi.org/10.1038/nrg2999openalex-snapshot
Using electronic health records to drive discovery in disease genomics
inferredcites →https://doi.org/10.1038/nrg3208openalex-snapshot
Mining electronic health records: towards better research applications and clinical care
inferredcites →https://doi.org/10.1038/nrg3461openalex-snapshot
Pleiotropy in complex traits: challenges and strategies
inferredcites →https://doi.org/10.1038/s41588-018-0084-1openalex-snapshot
Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes
inferredcites →https://doi.org/10.1056/nejmoa0707865openalex-snapshot
Association of Systemic Lupus Erythematosus with C8orf13–BLK and ITGAM–ITGAX
inferredcites →https://doi.org/10.1056/nejmoa0906312openalex-snapshot
A Large-Scale, Consortium-Based Genomewide Association Study of Asthma
inferredcites →https://doi.org/10.1056/nejmoa1405760openalex-snapshot
Factor XI Antisense Oligonucleotide for Prevention of Venous Thrombosis
inferredcites →https://doi.org/10.1073/pnas.1704259114openalex-snapshot
Severe viral respiratory infections in children with IFIH1 loss-of-function mutations
inferredcites →https://doi.org/10.1084/jem.20041901openalex-snapshot
Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus
inferredcites →https://doi.org/10.1084/jem.20161759openalex-snapshot
Recurrent rhinovirus infections in a child with inherited MDA5 deficiency
inferredcites →https://doi.org/10.1086/519795openalex-snapshot
PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage Analyses
inferredcites →https://doi.org/10.1086/521987openalex-snapshot
Rapid and Accurate Haplotype Phasing and Missing-Data Inference for Whole-Genome Association Studies By Use of Localized Haplotype Clustering
inferredcites →https://doi.org/10.1093/bioinformatics/btq126openalex-snapshot
PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene–disease associations
inferredcites →https://doi.org/10.1093/bioinformatics/btu704openalex-snapshot
minimac2: faster genotype imputation
inferredcites →https://doi.org/10.1093/ehjci/jes179openalex-snapshot
Body mass index and the prevalence, severity, and risk of coronary artery disease: an international multicentre study of 13 874 patients
inferredcites →https://doi.org/10.1093/eurpub/cku174openalex-snapshot
Forty-year trends in cardiovascular risk factors in Finland
inferredcites →https://doi.org/10.1093/ije/dyt268openalex-snapshot
Cohort Profile: Estonian Biobank of the Estonian Genome Center, University of Tartu
inferredcites →https://doi.org/10.1111/imm.12195openalex-snapshot
The challenges, advantages and future of phenome‐wide association studies
inferredcites →https://doi.org/10.1111/j.2517-6161.1995.tb02031.xopenalex-snapshot
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
inferredcites →https://doi.org/10.1126/science.aaf6814openalex-snapshot
Distribution and clinical impact of functional variants in 50,726 whole-exome sequences from the DiscovEHR study
inferredcites →https://doi.org/10.1126/scitranslmed.3001807openalex-snapshot
Electronic Medical Records for Genetic Research: Results of the eMERGE Consortium
inferredcites →https://doi.org/10.1126/scitranslmed.aaf2608openalex-snapshot
Disciplined approach to drug discovery and early development
inferredcites →https://doi.org/10.1146/annurev-genom-090314-024956openalex-snapshot
Phenome-Wide Association Studies as a Tool to Advance Precision Medicine
inferredcites →https://doi.org/10.1164/rccm.201312-2235ocopenalex-snapshot
The Effect of Inhaled IFN-β on Worsening of Asthma Symptoms Caused by Viral Infections. A Randomized Trial
inferredcites →https://doi.org/10.1186/s12959-015-0048-yopenalex-snapshot
Contact pathway of coagulation and inflammation
inferredcites →https://doi.org/10.1186/s13073-015-0166-yopenalex-snapshot
Extracting research-quality phenotypes from electronic health records to support precision medicine
inferredcites →https://doi.org/10.1371/journal.pgen.1000529openalex-snapshot
A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies
inferredcites →https://doi.org/10.1371/journal.pgen.1000993openalex-snapshot
Web-Based, Participant-Driven Studies Yield Novel Genetic Associations for Common Traits
inferredcites →https://doi.org/10.1371/journal.pgen.1004383openalex-snapshot
Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics
inferredcites →https://doi.org/10.1371/journal.pgen.1004494openalex-snapshot
Distribution and Medical Impact of Loss-of-Function Variants in the Finnish Founder Population
inferredcites →https://doi.org/10.1371/journal.pmed.1001779openalex-snapshot
UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age
inferredcites →https://doi.org/10.2147/clep.s129779openalex-snapshot
Clinical epidemiology in the era of big data: new opportunities, familiar challenges
inferredcites →https://doi.org/10.3389/fgene.2014.00184openalex-snapshot
eMERGEing progress in genomics—the first seven years
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1001/jamacardio.2018.2287openalex-snapshot
Association of Interleukin 6 Receptor Variant With Cardiovascular Disease Effects of Interleukin 6 Receptor Blocking Therapy
inferred← citeshttps://doi.org/10.1007/s13369-020-05080-7openalex-snapshot
Probabilistic Neural Network-based Model for Identification of Parkinson’s Disease by using Voice Profile and Personal Data
inferred← citeshttps://doi.org/10.1016/j.tig.2018.04.004openalex-snapshot
Genetic-Driven Druggable Target Identification and Validation
inferred← citeshttps://doi.org/10.1038/s41467-019-09407-3openalex-snapshot
Phenotypes associated with genes encoding drug targets are predictive of clinical trial side effects
inferred← citeshttps://doi.org/10.1038/s41588-018-0222-9openalex-snapshot
Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program
inferred← citeshttps://doi.org/10.1038/s41588-020-0682-6openalex-snapshot
Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases
inferred← citeshttps://doi.org/10.1101/252270openalex-snapshot
Polygenic scores for UK Biobank scale data
inferred← citeshttps://doi.org/10.2217/pgs-2018-0007openalex-snapshot
Pharmacogenomics of Blood Lipid Regulation
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