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PDGFRα signaling in cardiac fibroblasts modulates quiescence, metabolism and self-renewal, and promotes anatomical and functional repair

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Dynamics of Cell Generation and Turnover in the Human Heart

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In Vivo Cellular Reprogramming: The Next Generation

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Regulation of Cell Cycle to Stimulate Adult Cardiomyocyte Proliferation and Cardiac Regeneration

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PDGF receptor signaling networks in normal and cancer cells

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Increased PDGFRα Activation Disrupts Connective Tissue Development and Drives Systemic Fibrosis

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Growth control and ribosomopathies

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The Role of Platelet-Derived Growth Factor Signaling in Healing Myocardial Infarcts

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Mesenchymal Cell Contributions to the Stem Cell Niche

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Pericytes of Multiple Organs Do Not Behave as Mesenchymal Stem Cells In Vivo

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PDGF-A and PDGF-B induces cardiac fibrosis in transgenic mice

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Platelet-derived growth factor involvement in myocardial remodeling following infarction

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Fibroblasts in myocardial infarction: A role in inflammation and repair

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Resident fibroblast expansion during cardiac growth and remodeling

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Transgenic Overexpression of Platelet-Derived Growth Factor-C in the Mouse Heart Induces Cardiac Fibrosis, Hypertrophy, and Dilated Cardiomyopathy

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Growth-factor-dependent mitogenesis requires two distinct phases of signalling

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Regulation of c-myc expression by PDGF through Rho GTPases

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Primary contribution to zebrafish heart regeneration by gata4+ cardiomyocytes

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mTORC1 controls the adaptive transition of quiescent stem cells from G0 to GAlert

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The extracellular matrix protein agrin promotes heart regeneration in mice

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Hippo pathway deficiency reverses systolic heart failure after infarction

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Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis

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Collagen VI regulates satellite cell self-renewal and muscle regeneration

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PDGFRα demarcates the cardiogenic clonogenic Sca1+ stem/progenitor cell in adult murine myocardium

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Evolution, comparative biology and ontogeny of vertebrate heart regeneration

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Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

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Redefining the identity of cardiac fibroblasts

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Novel therapeutic strategies targeting fibroblasts and fibrosis in heart disease

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An ordered sequence of events is required before BALB/c-3T3 cells become committed to DNA synthesis

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The platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) are major players in oncogenesis, drug resistance, and attractive oncologic targets in cancer

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The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions

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pcaMethods—a bioconductor package providing PCA methods for incomplete data

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Gene Expression Omnibus: NCBI gene expression and hybridization array data repository

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PANTHER version 11: expanded annotation data from Gene Ontology and Reactome pathways, and data analysis tool enhancements

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The STRING database in 2017: quality-controlled protein–protein association networks, made broadly accessible

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Platelet-derived growth factor improves cardiac function in a rodent myocardial infarction model

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c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation

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Involvement of Platelet-Derived Growth Factor Receptor-α in Hair Canal Formation

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Heterochronic parabiosis: historical perspective and methodological considerations for studies of aging and longevity

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Transient Regenerative Potential of the Neonatal Mouse Heart

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Repression of p27 kip1 Synthesis by Platelet-Derived Growth Factor in BALB/c 3T3 Cells

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Evolutionary Divergence of Platelet-Derived Growth Factor Alpha Receptor Signaling Mechanisms

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Hypertensive mechanisms associated with centrally administered aldosterone in dogs.

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Platelet-Derived Growth Factor D Induces Cardiac Fibrosis and Proliferation of Vascular Smooth Muscle Cells in Heart-Specific Transgenic Mice

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Cardiac Septal and Valvular Dysmorphogenesis in Mice Heterozygous for Mutations in the Homeobox Gene Nkx2-5

inferredcites →https://doi.org/10.1161/circresaha.107.149047openalex-snapshot

Genetic Manipulation of Periostin Expression Reveals a Role in Cardiac Hypertrophy and Ventricular Remodeling

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Epicardial-Derived Cell Epithelial-to-Mesenchymal Transition and Fate Specification Require PDGF Receptor Signaling

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Cardiogenic Genes Expressed in Cardiac Fibroblasts Contribute to Heart Development and Repair

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Cardiac Fibrosis

inferredcites →https://doi.org/10.1161/circresaha.116.308643openalex-snapshot

Targeted Ablation of Periostin-Expressing Activated Fibroblasts Prevents Adverse Cardiac Remodeling in Mice

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Infarct Fibroblasts Do Not Derive From Bone Marrow Lineages

inferredcites →https://doi.org/10.1161/circulationaha.106.639831openalex-snapshot

Local Controlled Intramyocardial Delivery of Platelet-Derived Growth Factor Improves Postinfarction Ventricular Function Without Pulmonary Toxicity

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Left Ventricular Dysfunction Switches Mesenchymal Stromal Cells Toward an Inflammatory Phenotype and Impairs Their Reparative Properties Via Toll-Like Receptor-4

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Platelet-Derived Growth Factor-AB Limits the Extent of Myocardial Infarction in a Rat Model

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Controlled delivery of PDGF-BB for myocardial protection using injectable self-assembling peptide nanofibers

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PDGF mediates cardiac microvascular communication.

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Cardiomyocyte PDGFR-β signaling is an essential component of the mouse cardiac response to load-induced stress

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Resident fibroblast lineages mediate pressure overload–induced cardiac fibrosis

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Specialized fibroblast differentiated states underlie scar formation in the infarcted mouse heart

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PDGFRα Expression During Mouse Embryogenesis: Immunolocalization Analyzed by Whole-mount Immunohistostaining Using the Monoclonal Anti-mouse PDGFRα Antibody APA5

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Bioconductor: open software development for computational biology and bioinformatics

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MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data

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Developmental origin and lineage plasticity of endogenous cardiac stem cells

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Role of PDGF-B and PDGFR-β in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse

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Defining the Cardiac Fibroblast

inferredcites →https://doi.org/10.1371/journal.pone.0049232openalex-snapshot

Quiescent Fibroblasts Are More Active in Mounting Robust Inflammatory Responses Than Proliferative Fibroblasts

inferredcites →https://doi.org/10.1371/journal.pone.0160930openalex-snapshot

Isoform-Specific Modulation of Inflammation Induced by Adenoviral Mediated Delivery of Platelet-Derived Growth Factors in the Adult Mouse Heart

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Pericytes. Morphofunction, interactions and pathology in a quiescent and activated mesenchymal cell niche.

inferredcites →https://doi.org/10.3389/fcell.2015.00024openalex-snapshot

Nuclear PI3K signaling in cell growth and tumorigenesis

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A Universal and Robust Integrated Platform for the Scalable Production of Human Cardiomyocytes From Pluripotent Stem Cells

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Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injury

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Hic1 deletion unleashes quiescent connective tissue stem cells and impairs skeletal muscle regeneration

inferred← citeshttps://doi.org/10.1007/s12551-020-00734-0openalex-snapshot

Growth factor therapy for cardiac repair: an overview of recent advances and future directions

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Fibroblasts: Origins, definitions, and functions in health and disease

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PDGF-PDGFR network differentially regulates the fate, migration, proliferation, and cell cycle progression of myogenic cells

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Platelet derived growth factor-A (Pdgf-a) gene transfer modulates scar composition and improves left ventricular function after myocardial infarction

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Regulators of cardiac fibroblast cell state

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Cardiac fibroblasts in myocardial injury and heart failure

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TGF-β-driven downregulation of the Wnt/β-Catenin transcription factor TCF7L2/TCF4 in PDGFRα + fibroblasts

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Platelet-derived growth factor-AB improves scar mechanics and vascularity after myocardial infarction

inferred← citeshttps://doi.org/10.1152/ajpheart.00054.2019openalex-snapshot

Platelet-derived growth factor receptor-α is essential for cardiac fibroblast survival

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Tropoelastin Improves Post-Infarct Cardiac Function

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Platelet‐Derived Growth Factor Receptor Type α Activation Drives Pulmonary Vascular Remodeling Via Progenitor Cell Proliferation and Induces Pulmonary Hypertension

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Origins, potency, and heterogeneity of skeletal muscle fibro-adipogenic progenitors—time for new definitions

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Cross-talk between TGF-β and PDGFRα signaling pathways regulates the fate of stromal fibro–adipogenic progenitors

inferred← citeshttps://doi.org/10.1242/jcs.242297openalex-snapshot

TGF-β-driven downregulation of the transcription factor TCF7L2 affects Wnt/β-catenin signaling in PDGFRα+ fibroblasts

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Essential growth factor receptors for fibroblast homeostasis and activation

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Essential growth factor receptors for fibroblast homeostasis and activation: Fibroblast Growth Factor Receptor (FGFR), Platelet Derived Growth Factor Receptor (PDGFR), and Transforming Growth Factor β Receptor (TGFβR)

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Role of PDGF-A/B Ligands in Cardiac Repair After Myocardial Infarction

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Cardiac Fibrosis and Cardiac Fibroblast Lineage-Tracing: Recent Advances

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Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injury

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