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Histone modifications and active gene expression are associated with enhanced CRISPR activity in de-silenced chromatin

https://doi.org/10.1101/228601
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/1873-3468.12707openalex-snapshot
Chromatin accessibility and guide sequence secondary structure affect CRISPR ‐Cas9 gene editing efficiency
inferredcites →https://doi.org/10.1006/jmbi.2000.3531openalex-snapshot
Sequence and position-dependence of the equilibrium accessibility of nucleosomal DNA target sites 1 1Edited by T. Richmond
inferredcites →https://doi.org/10.1016/0014-4827(71)90089-9openalex-snapshot
Histone acetyltransferase in chromatin
inferredcites →https://doi.org/10.1016/j.cell.2006.02.041openalex-snapshot
A Bivalent Chromatin Structure Marks Key Developmental Genes in Embryonic Stem Cells
inferredcites →https://doi.org/10.1016/j.cell.2013.06.044openalex-snapshot
CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes
inferredcites →https://doi.org/10.1016/j.cell.2017.08.002openalex-snapshot
Genome Regulation by Polycomb and Trithorax: 70 Years and Counting
inferredcites →https://doi.org/10.1016/j.jmb.2009.04.085openalex-snapshot
Chromatin Remodelers Act Globally, Sequence Positions Nucleosomes Locally
inferredcites →https://doi.org/10.1016/j.stem.2011.12.006openalex-snapshot
Nonoverlapping Functions of the Polycomb Group Cbx Family of Proteins in Embryonic Stem Cells
inferredcites →https://doi.org/10.1021/acsestwater.0c00105openalex-snapshot
Full-Scale Manipulation of the Empty Bed Contact Time to Optimize Dissolved Organic Matter Removal by Drinking Water Biofilters
inferredcites →https://doi.org/10.1021/acssynbio.5b00299openalex-snapshot
The Impact of Chromatin Dynamics on Cas9-Mediated Genome Editing in Human Cells
inferredcites →https://doi.org/10.1021/cb400133jopenalex-snapshot
An Orally Bioavailable Chemical Probe of the Lysine Methyltransferases EZH2 and EZH1
inferredcites →https://doi.org/10.1038/16476openalex-snapshot
The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus
inferredcites →https://doi.org/10.1038/35020506openalex-snapshot
Regulation of chromatin structure by site-specific histone H3 methyltransferases
inferredcites →https://doi.org/10.1038/353353a0openalex-snapshot
Sequence similarity between the mammalian bmi-1 proto-oncogene and the Drosophila regulatory genes Psc and Su(z)2
inferredcites →https://doi.org/10.1038/nbt.2889openalex-snapshot
Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells
inferredcites →https://doi.org/10.1038/ncb1787openalex-snapshot
A model for transmission of the H3K27me3 epigenetic mark
inferredcites →https://doi.org/10.1038/ncomms14958openalex-snapshot
Targeted activation of diverse CRISPR-Cas systems for mammalian genome editing via proximal CRISPR targeting
inferredcites →https://doi.org/10.1038/nrg3017openalex-snapshot
Determinants and dynamics of genome accessibility
inferredcites →https://doi.org/10.1074/jbc.m709322200openalex-snapshot
Polycomb Group Protein-associated Chromatin Is Reproduced in Post-mitotic G1 Phase and Is Required for S Phase Progression
inferredcites →https://doi.org/10.1093/nar/gku1003openalex-snapshot
STRING v10: protein–protein interaction networks, integrated over the tree of life
inferredcites →https://doi.org/10.1093/nar/gkw524openalex-snapshot
Probing the impact of chromatin conformation on genome editing tools
inferredcites →https://doi.org/10.1101/gad.13.20.2678openalex-snapshot
Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF
inferredcites →https://doi.org/10.1101/gr.073452.107openalex-snapshot
A novel 6C assay uncovers Polycomb-mediated higher order chromatin conformations
inferredcites →https://doi.org/10.1101/gr.179044.114openalex-snapshot
Genome-wide specificity of DNA binding, gene regulation, and chromatin remodeling by TALE- and CRISPR/Cas9-based transcriptional activators
inferredcites →https://doi.org/10.1126/science.1149042openalex-snapshot
Demethylation of H3K27 Regulates Polycomb Recruitment and H2A Ubiquitination
inferredcites →https://doi.org/10.1126/science.1225829openalex-snapshot
A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
inferredcites →https://doi.org/10.1128/mcb.00266-15openalex-snapshot
Pluripotency and Epigenetic Factors in Mouse Embryonic Stem Cell Fate Regulation
inferredcites →https://doi.org/10.1158/0008-5472.can-06-2029openalex-snapshot
DNA Methylation and Complete Transcriptional Silencing of Cancer Genes Persist after Depletion of EZH2
inferredcites →https://doi.org/10.1186/1471-2164-10-549openalex-snapshot
Novel motifs distinguish multiple homologues of Polycomb in vertebrates: expansion and diversification of the epigenetic toolkit
inferredcites →https://doi.org/10.1371/journal.pone.0152683openalex-snapshot
Cas9 Functionally Opens Chromatin
inferredcites →https://doi.org/10.1371/journal.pone.0182528openalex-snapshot
Using local chromatin structure to improve CRISPR/Cas9 efficiency in zebrafish
inferredcites →https://doi.org/10.7554/elife.12677openalex-snapshot
Nucleosomes impede Cas9 access to DNA in vivo and in vitro
inferredcites →https://doi.org/10.7554/elife.13450openalex-snapshot
Nucleosome breathing and remodeling constrain CRISPR-Cas9 function

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1007/s00018-019-03021-8openalex-snapshot
Orthologous CRISPR/Cas9 systems for specific and efficient degradation of covalently closed circular DNA of hepatitis B virus
inferred← citeshttps://doi.org/10.1007/s00438-019-01564-wopenalex-snapshot
Efficient genome editing of Brassica campestris based on the CRISPR/Cas9 system
inferred← citeshttps://doi.org/10.1101/368480openalex-snapshot
Uncovering the interplay between epigenome editing efficiency and sequence context using a novel inducible targeting system
inferred← citeshttps://doi.org/10.1111/nph.18212openalex-snapshot
DNA methylation can alter CRISPR/Cas9 editing frequency and DNA repair outcome in a target‐specific manner
inferred← citeshttps://doi.org/10.3390/epigenomes5030017openalex-snapshot
Deciphering Plant Chromatin Regulation via CRISPR/dCas9-Based Epigenome Engineering
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