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Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation

https://doi.org/10.1101/240275
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Outgoing claims: the papers this work cites, builds on, or argues with.

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Identification of Genetic Loci Jointly Influencing Schizophrenia Risk and the Cognitive Traits of Verbal-Numerical Reasoning, Reaction Time, and General Cognitive Function
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SIMD compression and the intersection of sorted integers
inferredcites →https://doi.org/10.1007/s10519-017-9842-6openalex-snapshot
GW-SEM: A Statistical Package to Conduct Genome-Wide Structural Equation Modeling
inferredcites →https://doi.org/10.1016/j.ajhg.2010.11.011openalex-snapshot
GCTA: A Tool for Genome-wide Complex Trait Analysis
inferredcites →https://doi.org/10.1016/j.ajhg.2011.10.004openalex-snapshot
Abundant Pleiotropy in Human Complex Diseases and Traits
inferredcites →https://doi.org/10.1016/j.ajhg.2013.01.001openalex-snapshot
Improved Detection of Common Variants Associated with Schizophrenia by Leveraging Pleiotropy with Cardiovascular-Disease Risk Factors
inferredcites →https://doi.org/10.1016/j.ajhg.2017.06.005openalex-snapshot
10 Years of GWAS Discovery: Biology, Function, and Translation
inferredcites →https://doi.org/10.1016/j.ajhg.2017.09.022openalex-snapshot
Local Genetic Correlation Gives Insights into the Shared Genetic Architecture of Complex Traits
inferredcites →https://doi.org/10.1016/j.cell.2018.05.046openalex-snapshot
Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes
inferredcites →https://doi.org/10.1016/j.conb.2015.10.008openalex-snapshot
New statistical approaches exploit the polygenic architecture of schizophrenia — implications for the underlying neurobiology
inferredcites →https://doi.org/10.1016/j.schres.2011.01.011openalex-snapshot
Schizophrenia, “Just the Facts” 6. Moving ahead with the schizophrenia concept: From the elephant to the mouse
inferredcites →https://doi.org/10.1023/b:stco.0000035304.20635.31openalex-snapshot
Numerical computation of rectangular bivariate and trivariate normal and t probabilities
inferredcites →https://doi.org/10.1038/nature09298openalex-snapshot
Integrating common and rare genetic variation in diverse human populations
inferredcites →https://doi.org/10.1038/nature13595openalex-snapshot
Biological insights from 108 schizophrenia-associated genetic loci
inferredcites →https://doi.org/10.1038/nature15393openalex-snapshot
A global reference for human genetic variation
inferredcites →https://doi.org/10.1038/nature17671openalex-snapshot
Genome-wide association study identifies 74 loci associated with educational attainment
inferredcites →https://doi.org/10.1038/ng.3211openalex-snapshot
LD Score regression distinguishes confounding from polygenicity in genome-wide association studies
inferredcites →https://doi.org/10.1038/ng.3404openalex-snapshot
Partitioning heritability by functional annotation using genome-wide association summary statistics
inferredcites →https://doi.org/10.1038/ng.3406openalex-snapshot
An atlas of genetic correlations across human diseases and traits
inferredcites →https://doi.org/10.1038/ng.3570openalex-snapshot
Detection and interpretation of shared genetic influences on 42 human traits
inferredcites →https://doi.org/10.1038/ng.3865openalex-snapshot
Reevaluation of SNP heritability in complex human traits
inferredcites →https://doi.org/10.1038/ng.610openalex-snapshot
Estimation of effect size distribution from genome-wide association studies and implications for future discoveries
inferredcites →https://doi.org/10.1038/nrg.2016.142openalex-snapshot
Dissecting the genetics of complex traits using summary association statistics
inferredcites →https://doi.org/10.1038/nrg3118openalex-snapshot
Rare and common variants: twenty arguments
inferredcites →https://doi.org/10.1038/nrg3461openalex-snapshot
Pleiotropy in complex traits: challenges and strategies
inferredcites →https://doi.org/10.1038/s41467-018-05510-zopenalex-snapshot
Genome-wide association study results for educational attainment aid in identifying genetic heterogeneity of schizophrenia
inferredcites →https://doi.org/10.1038/s41588-017-0009-4openalex-snapshot
Multi-trait analysis of genome-wide association summary statistics using MTAG
inferredcites →https://doi.org/10.1038/s41588-018-0090-3openalex-snapshot
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
inferredcites →https://doi.org/10.1038/s41588-018-0101-4openalex-snapshot
Signatures of negative selection in the genetic architecture of human complex traits
inferredcites →https://doi.org/10.1038/s41588-018-0147-3openalex-snapshot
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals
inferredcites →https://doi.org/10.1038/s41588-018-0193-xopenalex-snapshot
Estimation of complex effect-size distributions using summary-level statistics from genome-wide association studies across 32 complex traits
inferredcites →https://doi.org/10.1038/srep17453openalex-snapshot
High level of inbreeding in final phase of 1000 Genomes Project
inferredcites →https://doi.org/10.1086/519795openalex-snapshot
PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage Analyses
inferredcites →https://doi.org/10.1093/bioinformatics/btr341openalex-snapshot
HAPGEN2: simulation of multiple disease SNPs
inferredcites →https://doi.org/10.1093/hmg/ddu328openalex-snapshot
Mendelian randomization: genetic anchors for causal inference in epidemiological studies
inferredcites →https://doi.org/10.1093/hmg/ddy082openalex-snapshot
Beyond heritability: improving discoverability in imaging genetics
inferredcites →https://doi.org/10.1093/hmg/ddy271openalex-snapshot
Meta-analysis of genome-wide association studies for height and body mass index in ∼700000 individuals of European ancestry
inferredcites →https://doi.org/10.1093/schbul/sbw085openalex-snapshot
Identification of Gene Loci That Overlap Between Schizophrenia and Educational Attainment
inferredcites →https://doi.org/10.1101/164939openalex-snapshot
Estimating inflation in GWAS summary statistics due to variance distortion from cryptic relatedness
inferredcites →https://doi.org/10.1137/s1052623496303470openalex-snapshot
Convergence Properties of the Nelder--Mead Simplex Method in Low Dimensions
inferredcites →https://doi.org/10.1198/000313002173openalex-snapshot
Beyond Traditional Statistical Methods
inferredcites →https://doi.org/10.1214/17-aoas1046openalex-snapshot
Bayesian large-scale multiple regression with summary statistics from genome-wide association studies
inferredcites →https://doi.org/10.1214/aoms/1177732951openalex-snapshot
A New Formula for Predicting the Shrinkage of the Coefficient of Multiple Correlation
inferredcites →https://doi.org/10.1371/journal.pgen.1003348openalex-snapshot
Power and Predictive Accuracy of Polygenic Risk Scores
inferredcites →https://doi.org/10.1371/journal.pgen.1003449openalex-snapshot
All SNPs Are Not Created Equal: Genome-Wide Association Studies Reveal a Consistent Pattern of Enrichment among Functionally Annotated SNPs
inferredcites →https://doi.org/10.1371/journal.pgen.1003455openalex-snapshot
Improved Detection of Common Variants Associated with Schizophrenia and Bipolar Disorder Using Pleiotropy-Informed Conditional False Discovery Rate
inferredcites →https://doi.org/10.1371/journal.pgen.1004969openalex-snapshot
Simultaneous Discovery, Estimation and Prediction Analysis of Complex Traits Using a Bayesian Mixture Model
inferredcites →https://doi.org/10.1371/journal.pgen.1005717openalex-snapshot
An Empirical Bayes Mixture Model for Effect Size Distributions in Genome-Wide Association Studies
inferredcites →https://doi.org/10.1371/journal.pgen.1005803openalex-snapshot
Leveraging Genomic Annotations and Pleiotropic Enrichment for Improved Replication Rates in Schizophrenia GWAS
inferredcites →https://doi.org/10.3389/fgene.2016.00015openalex-snapshot
Estimating Effect Sizes and Expected Replication Probabilities from GWAS Summary Statistics

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.3389/fnins.2019.00220openalex-snapshot
Genetic Overlap Between Alzheimer’s Disease and Bipolar Disorder Implicates the MARK2 and VAC14 Genes
inferred← citeshttps://doi.org/10.3389/fpsyt.2019.00534openalex-snapshot
Biophysical Psychiatry—How Computational Neuroscience Can Help to Understand the Complex Mechanisms of Mental Disorders
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