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An atypical CRISPR-Cas locus in Symbiobacterium thermophilum flanked by a transposase, a reverse transcriptase, the endonuclease MutS2 and a putative Cas9-like protein

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/prot.20921openalex-snapshot
MUSTANG: A multiple structural alignment algorithm
inferredcites →https://doi.org/10.1007/978-3-642-65578-4_1openalex-snapshot
Reverse Transcription and the Central Dogma
inferredcites →https://doi.org/10.1007/s00239-004-0046-3openalex-snapshot
Intervening Sequences of Regularly Spaced Prokaryotic Repeats Derive from Foreign Genetic Elements
inferredcites →https://doi.org/10.1007/s13238-015-0153-5openalex-snapshot
CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes
inferredcites →https://doi.org/10.1016/0092-8674(79)90228-9openalex-snapshot
DNA sequence analysis of the transposon Tn3: Three genes and three sites involved in transposition of Tn3
inferredcites →https://doi.org/10.1016/j.cell.2014.02.001openalex-snapshot
Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA
inferredcites →https://doi.org/10.1016/j.dnarep.2017.07.004openalex-snapshot
Molecular basis for the functions of a bacterial MutS2 in DNA repair and recombination
inferredcites →https://doi.org/10.1016/j.gendis.2016.07.003openalex-snapshot
CRISPR-mediated genome editing and human diseases
inferredcites →https://doi.org/10.1021/bi700507dopenalex-snapshot
Stability for Function Trade-Offs in the Enolase Superfamily “Catalytic Module” ,
inferredcites →https://doi.org/10.1038/519410aopenalex-snapshot
Don’t edit the human germ line
inferredcites →https://doi.org/10.1038/mtna.2015.37openalex-snapshot
Off-target Effects in CRISPR/Cas9-mediated Genome Engineering
inferredcites →https://doi.org/10.1038/nature09886openalex-snapshot
CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III
inferredcites →https://doi.org/10.1038/nature13579openalex-snapshot
Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease
inferredcites →https://doi.org/10.1038/nature15386openalex-snapshot
CRISPR-Cas immunity in prokaryotes
inferredcites →https://doi.org/10.1038/nature23305openalex-snapshot
Correction of a pathogenic gene mutation in human embryos
inferredcites →https://doi.org/10.1038/nature24268openalex-snapshot
Enhanced proofreading governs CRISPR–Cas9 targeting accuracy
inferredcites →https://doi.org/10.1038/nbt.2623openalex-snapshot
High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells
inferredcites →https://doi.org/10.1038/nbt.2842openalex-snapshot
CRISPR-Cas systems for editing, regulating and targeting genomes
inferredcites →https://doi.org/10.1038/nmeth.4262openalex-snapshot
Digenome-seq web tool for profiling CRISPR specificity
inferredcites →https://doi.org/10.1038/nmeth.4278openalex-snapshot
CIRCLE-seq: a highly sensitive in vitro screen for genome-wide CRISPR–Cas9 nuclease off-targets
inferredcites →https://doi.org/10.1038/nrmicro.2016.184openalex-snapshot
Diversity and evolution of class 2 CRISPR–Cas systems
inferredcites →https://doi.org/10.1038/nrmicro3569openalex-snapshot
An updated evolutionary classification of CRISPR–Cas systems
inferredcites →https://doi.org/10.1038/nsmb.2043openalex-snapshot
An RNA-induced conformational change required for CRISPR RNA cleavage by the endoribonuclease Cse3
inferredcites →https://doi.org/10.1038/s41591-018-0326-xopenalex-snapshot
Identification of preexisting adaptive immunity to Cas9 proteins in humans
inferredcites →https://doi.org/10.1038/s41598-017-07828-yopenalex-snapshot
The Reverse Transcriptases Associated with CRISPR-Cas Systems
inferredcites →https://doi.org/10.1038/srep32942openalex-snapshot
CRISPRdigger: detecting CRISPRs with better direct repeat annotations
inferredcites →https://doi.org/10.1073/pnas.0401799101openalex-snapshot
Incorporating chemical modification constraints into a dynamic programming algorithm for prediction of RNA secondary structure
inferredcites →https://doi.org/10.1074/jbc.m806755200openalex-snapshot
Crystal Structure of MutS2 Endonuclease Domain and the Mechanism of Homologous Recombination Suppression
inferredcites →https://doi.org/10.1080/15265161.2015.1104160openalex-snapshot
Human Germline CRISPR-Cas Modification: Toward a Regulatory Framework
inferredcites →https://doi.org/10.1093/bioinformatics/bti770openalex-snapshot
The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling
inferredcites →https://doi.org/10.1093/nar/25.17.3389openalex-snapshot
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
inferredcites →https://doi.org/10.1093/nar/gkh830openalex-snapshot
Genome sequence of Symbiobacterium thermophilum, an uncultivable bacterium that depends on microbial commensalism
inferredcites →https://doi.org/10.1093/nar/gkm360openalex-snapshot
CRISPRFinder: a web tool to identify clustered regularly interspaced short palindromic repeats
inferredcites →https://doi.org/10.1093/nar/gku316openalex-snapshot
Deciphering key features in protein structures with the new ENDscript server
inferredcites →https://doi.org/10.1099/00207713-50-5-1829openalex-snapshot
Symbiobacterium thermophilum gen. nov., sp. nov., a symbiotic thermophile that depends on co-culture with a Bacillus strain for growth.
inferredcites →https://doi.org/10.1099/mic.0.28048-0openalex-snapshot
Clustered regularly interspaced short palindrome repeats (CRISPRs) have spacers of extrachromosomal origin
inferredcites →https://doi.org/10.1111/tpj.13207openalex-snapshot
The walnut (Juglans regia) genome sequence reveals diversity in genes coding for the biosynthesis of non‐structural polyphenols
inferredcites →https://doi.org/10.1126/science.1138140openalex-snapshot
CRISPR Provides Acquired Resistance Against Viruses in Prokaryotes
inferredcites →https://doi.org/10.1126/science.1179555openalex-snapshot
CRISPR/Cas, the Immune System of Bacteria and Archaea
inferredcites →https://doi.org/10.1126/science.1225829openalex-snapshot
A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
inferredcites →https://doi.org/10.1126/science.1232033openalex-snapshot
RNA-Guided Human Genome Engineering via Cas9
inferredcites →https://doi.org/10.1126/science.2466332openalex-snapshot
Reverse Transcriptase in a Clinical Strain of Escherichia coli : Production of Branched RNA-Linked msDNA
inferredcites →https://doi.org/10.1126/science.aad4234openalex-snapshot
Direct CRISPR spacer acquisition from RNA by a natural reverse transcriptase–Cas1 fusion protein
inferredcites →https://doi.org/10.1128/jb.00682-16openalex-snapshot
MutS2 Promotes Homologous Recombination in Bacillus subtilis
inferredcites →https://doi.org/10.1128/jb.169.12.5429-5433.1987openalex-snapshot
Nucleotide sequence of the iap gene, responsible for alkaline phosphatase isozyme conversion in Escherichia coli, and identification of the gene product
inferredcites →https://doi.org/10.1128/mbio.00897-17openalex-snapshot
On the Origin of Reverse Transcriptase-Using CRISPR-Cas Systems and Their Hyperdiverse, Enigmatic Spacer Repertoires
inferredcites →https://doi.org/10.1186/1471-2105-8-18openalex-snapshot
PILER-CR: Fast and accurate identification of CRISPR repeats
inferredcites →https://doi.org/10.1186/1471-2105-8-209openalex-snapshot
CRISPR Recognition Tool (CRT): a tool for automatic detection of clustered regularly interspaced palindromic repeats
inferredcites →https://doi.org/10.1186/1759-8753-5-23openalex-snapshot
CRISPR-Cas immunity and mobile DNA: a new superfamily of DNA transposons encoding a Cas1 endonuclease
inferredcites →https://doi.org/10.1186/s13568-015-0171-yopenalex-snapshot
Accessing inoculation methods of maize and wheat with Azospirillum brasilense
inferredcites →https://doi.org/10.1186/s13568-016-0182-3openalex-snapshot
Deep RNA-Seq profile reveals biodiversity, plant–microbe interactions and a large family of NBS-LRR resistance genes in walnut (Juglans regia) tissues
inferredcites →https://doi.org/10.12688/f1000research.6617.1openalex-snapshot
YeATS - a tool suite for analyzing RNA-seq derived transcriptome identifies a highly transcribed putative extensin in heartwood/sapwood transition zone in black walnut
inferredcites →https://doi.org/10.1371/journal.pone.0028470openalex-snapshot
Active Site Detection by Spatial Conformity and Electrostatic Analysis—Unravelling a Proteolytic Function in Shrimp Alkaline Phosphatase
inferredcites →https://doi.org/10.1371/journal.pone.0032011openalex-snapshot
A Measure of the Promiscuity of Proteins and Characteristics of Residues in the Vicinity of the Catalytic Site That Regulate Promiscuity
inferredcites →https://doi.org/10.4161/rna.24203openalex-snapshot
crRNA and tracrRNA guide Cas9-mediated DNA interference in Streptococcus thermophilus
inferredcites →https://doi.org/10.7554/elife.06744openalex-snapshot
MutS/MutL crystal structure reveals that the MutS sliding clamp loads MutL onto DNA

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1101/263558openalex-snapshot
Reverse transcriptase fused CRISPR-Cas1 locus with RNA-seq expression necessitates revisiting hypothesis on acquisition of antibiotic resistance genes in multidrug-resistant Enterococcus faecalis V583
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