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Discovering patterns of pleiotropy in genome-wide association studies

https://doi.org/10.1101/273540
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/gepi.20257openalex-snapshot
Pleiotropy and principal components of heritability combine to increase power for association analysis
inferredcites →https://doi.org/10.1007/s00439-015-1595-9openalex-snapshot
Heritabilities, proportions of heritabilities explained by GWAS findings, and implications of cross-phenotype effects on PR interval
inferredcites →https://doi.org/10.1016/j.ajhg.2010.06.009openalex-snapshot
A Versatile Gene-Based Test for Genome-wide Association Studies
inferredcites →https://doi.org/10.1016/j.ajhg.2011.05.029openalex-snapshot
Rare-Variant Association Testing for Sequencing Data with the Sequence Kernel Association Test
inferredcites →https://doi.org/10.1016/j.ajhg.2014.11.011openalex-snapshot
Meta-analysis of Correlated Traits via Summary Statistics from GWASs with an Application in Hypertension
inferredcites →https://doi.org/10.1016/j.jbi.2015.06.028openalex-snapshot
Biclustering on expression data: A review
inferredcites →https://doi.org/10.1038/nature09534openalex-snapshot
A map of human genome variation from population-scale sequencing
inferredcites →https://doi.org/10.1038/ng.3014openalex-snapshot
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization
inferredcites →https://doi.org/10.1038/ng.362openalex-snapshot
Common variants at ten loci modulate the QT interval duration in the QTSCD Study
inferredcites →https://doi.org/10.1038/ng.517openalex-snapshot
Genome-wide association study of PR interval
inferredcites →https://doi.org/10.1038/ng.716openalex-snapshot
Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction
inferredcites →https://doi.org/10.1093/bioinformatics/btp041openalex-snapshot
Genome-wide association analysis by lasso penalized logistic regression
inferredcites →https://doi.org/10.1093/bioinformatics/btr260openalex-snapshot
Molecular signatures database (MSigDB) 3.0
inferredcites →https://doi.org/10.1093/nar/gkt1229openalex-snapshot
The NHGRI GWAS Catalog, a curated resource of SNP-trait associations
inferredcites →https://doi.org/10.1093/oxfordjournals.aje.a115184openalex-snapshot
THE ATHEROSCLEROSIS RISK IN COMMUNIT (ARIC) STUDY: DESIGN AND OBJECTIVES
inferredcites →https://doi.org/10.1172/jci84840openalex-snapshot
Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function
inferredcites →https://doi.org/10.1214/aos/1176344136openalex-snapshot
Estimating the Dimension of a Model
inferredcites →https://doi.org/10.1371/journal.pgen.1000529openalex-snapshot
A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies
inferredcites →https://doi.org/10.1371/journal.pgen.1000587openalex-snapshot
Statistical Estimation of Correlated Genome Associations to a Quantitative Trait Network
inferredcites →https://doi.org/10.1371/journal.pgen.1002158openalex-snapshot
Identification of a Sudden Cardiac Death Susceptibility Locus at 2q24.2 through Genome-Wide Association in European Ancestry Individuals
inferredcites →https://doi.org/10.1371/journal.pgen.1002177openalex-snapshot
Gene-Based Tests of Association
inferredcites →https://doi.org/10.1371/journal.pone.0034861openalex-snapshot
MultiPhen: Joint Model of Multiple Phenotypes Can Increase Discovery in GWAS
inferredcites →https://doi.org/10.1371/journal.pone.0068585openalex-snapshot
Fast Association Tests for Genes with FAST
inferredcites →https://doi.org/10.1534/g3.111.001198openalex-snapshot
Genotype Imputation with Thousands of Genomes
inferredcites →https://doi.org/10.5555/944919.944937openalex-snapshot
Latent dirichlet allocation

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1098/rstb.2018.0248openalex-snapshot
Integrating natural history collections and comparative genomics to study the genetic architecture of convergent evolution
inferred← citeshttps://doi.org/10.1101/574756openalex-snapshot
Integrating natural history-derived phenomics with comparative genomics to study the genetic architecture of convergent evolution
inferred← citeshttps://doi.org/10.1101/737676openalex-snapshot
Priors, population sizes, and power in genome-wide hypothesis tests
inferred← citeshttps://doi.org/10.1186/s13059-019-1844-7openalex-snapshot
HOPS: a quantitative score reveals pervasive horizontal pleiotropy in human genetic variation is driven by extreme polygenicity of human traits and diseases
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