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Exposing flaws in S-LDSC; reply to Gazal et al .

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1016/j.ajhg.2010.11.011openalex-snapshot

GCTA: A Tool for Genome-wide Complex Trait Analysis

inferredcites →https://doi.org/10.1016/j.ajhg.2012.10.010openalex-snapshot

Improved Heritability Estimation from Genome-wide SNPs

inferredcites →https://doi.org/10.1016/j.ajhg.2014.10.004openalex-snapshot

Partitioning Heritability of Regulatory and Cell-Type-Specific Variants across 11 Common Diseases

inferredcites →https://doi.org/10.1038/ejhg.2011.39openalex-snapshot

Genomic inflation factors under polygenic inheritance

inferredcites →https://doi.org/10.1038/nature05911openalex-snapshot

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

inferredcites →https://doi.org/10.1038/ng.3097openalex-snapshot

Defining the role of common variation in the genomic and biological architecture of adult human height

inferredcites →https://doi.org/10.1038/ng.3211openalex-snapshot

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

inferredcites →https://doi.org/10.1038/ng.3390openalex-snapshot

Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index

inferredcites →https://doi.org/10.1038/ng.3404openalex-snapshot

Partitioning heritability by functional annotation using genome-wide association summary statistics

inferredcites →https://doi.org/10.1038/ng.3865openalex-snapshot

Reevaluation of SNP heritability in complex human traits

inferredcites →https://doi.org/10.1038/ng.3954openalex-snapshot

Linkage disequilibrium–dependent architecture of human complex traits shows action of negative selection

inferredcites →https://doi.org/10.1038/ng.823openalex-snapshot

Genome partitioning of genetic variation for complex traits using common SNPs

inferredcites →https://doi.org/10.1093/brain/awu206openalex-snapshot

Describing the genetic architecture of epilepsy through heritability analysis

inferredcites →https://doi.org/10.3389/fgene.2014.00370openalex-snapshot

Imputation and quality control steps for combining multiple genome-wide datasets

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1016/j.animal.2021.100341openalex-snapshot

Genome-wide association study reveals a quantitative trait locus and two candidate genes on Sus scrofa chromosome 5 affecting intramuscular fat content in Suhuai pigs

inferred← citeshttps://doi.org/10.1038/s41588-018-0231-8openalex-snapshot

Functional architecture of low-frequency variants highlights strength of negative selection across coding and non-coding annotations

inferred← citeshttps://doi.org/10.1101/2020.10.09.333542openalex-snapshot

Exploring the variance in complex traits captured by DNA methylation assays

inferred← citeshttps://doi.org/10.1101/256412openalex-snapshot

Reconciling S-LDSC and LDAK models and functional enrichment estimates

inferred← citeshttps://doi.org/10.1111/age.13430openalex-snapshot

Genome‐wide association study identified five quantitative trait loci and two candidate genes for digestive traits in Suhuai pigs

inferred← citeshttps://doi.org/10.1534/genetics.119.301909openalex-snapshot

Modeling Heterogeneity in the Genetic Architecture of Ethnically Diverse Groups Using Random Effect Interaction Models

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