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Differences between the de novo proteome and its non-functional precursor can result from neutral constraints on its birth process, not necessarily from natural selection alone
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/jez.b.22551openalex-snapshot
The role of domain shuffling in the evolution of signaling networks
inferredcites →https://doi.org/10.1016/j.cell.2013.06.009openalex-snapshot
Ribosome Profiling Provides Evidence that Large Noncoding RNAs Do Not Encode Proteins
inferredcites →https://doi.org/10.1016/j.celrep.2014.07.045openalex-snapshot
Ribosome Profiling Reveals Pervasive Translation Outside of Annotated Protein-Coding Genes
inferredcites →https://doi.org/10.1016/j.cub.2009.07.049openalex-snapshot
Emergence of a New Gene from an Intergenic Region
inferredcites →https://doi.org/10.1016/j.febslet.2012.06.007openalex-snapshot
Estimating intrinsic structural preferences of de novo emerging random‐sequence proteins: Is aggregation the main bottleneck?
inferredcites →https://doi.org/10.1016/j.molcel.2013.10.032openalex-snapshot
Dealing with Pervasive Transcription
inferredcites →https://doi.org/10.1016/j.sbi.2015.02.017openalex-snapshot
Found in translation: functions and evolution of a recently discovered alternative proteome
inferredcites →https://doi.org/10.1016/j.tig.2015.02.007openalex-snapshot
Genes from scratch – the evolutionary fate of de novo genes
inferredcites →https://doi.org/10.1017/s0003356100037752openalex-snapshot
A mathematical model of the culling process in dairy cattle
inferredcites →https://doi.org/10.1038/nature11184openalex-snapshot
Proto-genes and de novo gene birth
inferredcites →https://doi.org/10.1038/nrg.2016.78openalex-snapshot
Open questions in the study of de novo genes: what, how and why
inferredcites →https://doi.org/10.1038/nrg2689openalex-snapshot
The evolution of gene duplications: classifying and distinguishing between models
inferredcites →https://doi.org/10.1038/nrg3962openalex-snapshot
Horizontal gene transfer: building the web of life
inferredcites →https://doi.org/10.1038/s41467-018-04026-wopenalex-snapshot
Random sequences rapidly evolve into de novo promoters
inferredcites →https://doi.org/10.1038/s41559-017-0127openalex-snapshot
Random sequences are an abundant source of bioactive RNAs or peptides
inferredcites →https://doi.org/10.1038/s41559-017-0146openalex-snapshot
Young genes are highly disordered as predicted by the preadaptation hypothesis of de novo gene birth
inferredcites →https://doi.org/10.1038/s41559-018-0506-6openalex-snapshot
Translation of neutrally evolving peptides provides a basis for de novo gene evolution
inferredcites →https://doi.org/10.1073/pnas.1318948111openalex-snapshot
Defining functional DNA elements in the human genome
inferredcites →https://doi.org/10.1080/01621459.1969.10501069openalex-snapshot
On the Exact Covariance of Products of Random Variables
inferredcites →https://doi.org/10.1093/bioinformatics/bti541openalex-snapshot
IUPred: web server for the prediction of intrinsically unstructured regions of proteins based on estimated energy content
inferredcites →https://doi.org/10.1093/gbe/evr099openalex-snapshot
Putatively Noncoding Transcripts Show Extensive Association with Ribosomes
inferredcites →https://doi.org/10.1093/gbe/evu098openalex-snapshot
Distinguishing between "Function" and "Effect" in Genome Biology
inferredcites →https://doi.org/10.1093/molbev/msq345openalex-snapshot
Novel Protein Genes in Animal mtDNA: A New Sex Determination System in Freshwater Mussels (Bivalvia: Unionoida)?
inferredcites →https://doi.org/10.1093/molbev/msx210openalex-snapshot
A Comprehensive Analysis of Transcript-Supported De Novo Genes in Saccharomyces sensu stricto Yeasts
inferredcites →https://doi.org/10.1093/molbev/msx315openalex-snapshot
A Molecular Portrait of De Novo Genes in Yeasts
inferredcites →https://doi.org/10.1093/nar/gkv1218openalex-snapshot
Death of a dogma: eukaryotic mRNAs can code for more than one protein
inferredcites →https://doi.org/10.1098/rstb.2014.0332openalex-snapshot
New genes from non-coding sequence: the role of de novo protein-coding genes in eukaryotic evolutionary innovation
inferredcites →https://doi.org/10.1101/224907openalex-snapshot
Deciphering eukaryotic cis -regulatory logic with 100 million random promoters
inferredcites →https://doi.org/10.1126/science.1196380openalex-snapshot
New Genes in Drosophila Quickly Become Essential
inferredcites →https://doi.org/10.1146/annurev.ecolsys.23.1.263openalex-snapshot
The Nearly Neutral Theory of Molecular Evolution
inferredcites →https://doi.org/10.1186/1471-2164-14-117openalex-snapshot
Phylogenetic patterns of emergence of new genes support a model of frequent de novo evolution
inferredcites →https://doi.org/10.1186/1471-2164-14-13openalex-snapshot
Genetic architecture of gene expression in the chicken
inferredcites →https://doi.org/10.1186/s12864-016-2456-1openalex-snapshot
Translatomics combined with transcriptomics and proteomics reveals novel functional, recently evolved orphan genes in Escherichia coli O157:H7 (EHEC)
inferredcites →https://doi.org/10.1371/journal.pcbi.1003325openalex-snapshot
Exploring Fold Space Preferences of New-born and Ancient Protein Superfamilies
inferredcites →https://doi.org/10.1371/journal.pcbi.1003925openalex-snapshot
A Comparative Study and a Phylogenetic Exploration of the Compositional Architectures of Mammalian Nuclear Genomes
inferredcites →https://doi.org/10.1371/journal.pcbi.1005375openalex-snapshot
High GC content causes orphan proteins to be intrinsically disordered
inferredcites →https://doi.org/10.1371/journal.pgen.1003860openalex-snapshot
De Novo ORFs in Drosophila Are Important to Organismal Fitness and Evolved Rapidly from Previously Non-coding Sequences
inferredcites →https://doi.org/10.1371/journal.pone.0070698openalex-snapshot
Direct Detection of Alternative Open Reading Frames Translation Products in Human Significantly Expands the Proteome
inferredcites →https://doi.org/10.1534/g3.113.008995openalex-snapshot
The Reference Genome Sequence ofSaccharomyces cerevisiae: Then and Now
inferredcites →https://doi.org/10.1534/genetics.113.152256openalex-snapshot
Integration of New Genes into Cellular Networks, and Their Structural Maturation
inferredcites →https://doi.org/10.7554/elife.03523openalex-snapshot
Long non-coding RNAs as a source of new peptides
inferredcites →https://doi.org/10.7554/elife.09977openalex-snapshot
Fast turnover of genome transcription across evolutionary time exposes entire non-coding DNA to de novo gene emergence
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1101/329730openalex-snapshot
The high turnover of ribosome-associated transcripts from de novo ORFs produces gene-like characteristics available for de novo gene emergence in wild yeast populations
inferred← citeshttps://doi.org/10.1101/gr.239822.118openalex-snapshot
Turnover of ribosome-associated transcripts from de novo ORFs produces gene-like characteristics available for de novo gene emergence in wild yeast populations
inferred← citeshttps://doi.org/10.1534/genetics.118.301249openalex-snapshot
Gene Birth Contributes to Structural Disorder Encoded by Overlapping Genes
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