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The RZZ complex integrates spindle checkpoint maintenance with dynamic expansion of unattached kinetochores

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/cm.970260305openalex-snapshot
CENP‐F is a ca 400 kDa kinetochore protein that exhibits a cell‐cycle dependent localization
inferredcites →https://doi.org/10.1007/978-1-60327-993-2_2openalex-snapshot
Functional Dissection of Mitotic Regulators Through Gene Targeting in Human Somatic Cells
inferredcites →https://doi.org/10.1007/s004120050266openalex-snapshot
Localization of CENP-E in the fibrous corona and outer plate of mammalian kinetochores from prometaphase through anaphase
inferredcites →https://doi.org/10.1016/j.ccr.2007.04.011openalex-snapshot
Regulators of Mitotic Arrest and Ceramide Metabolism Are Determinants of Sensitivity to Paclitaxel and Other Chemotherapeutic Drugs
inferredcites →https://doi.org/10.1016/j.ccr.2008.07.002openalex-snapshot
Cancer Cells Display Profound Intra- and Interline Variation following Prolonged Exposure to Antimitotic Drugs
inferredcites →https://doi.org/10.1016/j.cell.2014.01.010openalex-snapshot
Nuclear Pores Protect Genome Integrity by Assembling a Premitotic and Mad1-Dependent Anaphase Inhibitor
inferredcites →https://doi.org/10.1016/j.celrep.2016.01.060openalex-snapshot
The Spindle Assembly Checkpoint Is Not Essential for Viability of Human Cells with Genetically Lowered APC/C Activity
inferredcites →https://doi.org/10.1016/j.celrep.2018.01.034openalex-snapshot
BUB1 Is Essential for the Viability of Human Cells in which the Spindle Assembly Checkpoint Is Compromised
inferredcites →https://doi.org/10.1016/j.cub.2015.08.051openalex-snapshot
The Molecular Biology of Spindle Assembly Checkpoint Signaling Dynamics
inferredcites →https://doi.org/10.1016/j.cub.2018.08.056openalex-snapshot
Self-Assembly of the RZZ Complex into Filaments Drives Kinetochore Expansion in the Absence of Microtubule Attachment
inferredcites →https://doi.org/10.1016/j.devcel.2007.08.008openalex-snapshot
Bub1 Maintains Centromeric Cohesion by Activation of the Spindle Checkpoint
inferredcites →https://doi.org/10.1016/j.devcel.2012.06.013openalex-snapshot
Evolution and Function of the Mitotic Checkpoint
inferredcites →https://doi.org/10.1016/j.devcel.2015.11.012openalex-snapshot
KNL1-Bubs and RZZ Provide Two Separable Pathways for Checkpoint Activation at Human Kinetochores
inferredcites →https://doi.org/10.1016/j.devcel.2017.01.012openalex-snapshot
Large-Scale Analysis of CRISPR/Cas9 Cell-Cycle Knockouts Reveals the Diversity of p53-Dependent Responses to Cell-Cycle Defects
inferredcites →https://doi.org/10.1016/j.devcel.2017.03.025openalex-snapshot
Mps1 Regulates Kinetochore-Microtubule Attachment Stability via the Ska Complex to Ensure Error-Free Chromosome Segregation
inferredcites →https://doi.org/10.1016/j.febslet.2014.07.011openalex-snapshot
Dynein‐dependent transport of spindle assembly checkpoint proteins off kinetochores toward spindle poles
inferredcites →https://doi.org/10.1016/j.molcel.2014.12.036openalex-snapshot
Sequential Multisite Phospho-Regulation of KNL1-BUB3 Interfaces at Mitotic Kinetochores
inferredcites →https://doi.org/10.1016/j.str.2010.02.014openalex-snapshot
Structural Analysis of the RZZ Complex Reveals Common Ancestry with Multisubunit Vesicle Tethering Machinery
inferredcites →https://doi.org/10.1016/j.tcb.2010.02.001openalex-snapshot
Dsl1p/Zw10: common mechanisms behind tethering vesicles and microtubules
inferredcites →https://doi.org/10.1016/s0092-8674(00)80875-2openalex-snapshot
Chromosome Missegregation and Apoptosis in Mice Lacking the Mitotic Checkpoint Protein Mad2
inferredcites →https://doi.org/10.1038/emboj.2011.70openalex-snapshot
Evidence that Aurora B is implicated in spindle checkpoint signalling independently of error correction
inferredcites →https://doi.org/10.1038/ncb2223openalex-snapshot
Constitutive Mad1 targeting to kinetochores uncouples checkpoint signalling from chromosome biorientation
inferredcites →https://doi.org/10.1038/ncb3223openalex-snapshot
Adaptive changes in the kinetochore architecture facilitate proper spindle assembly
inferredcites →https://doi.org/10.1038/ncomms1319openalex-snapshot
Aurora B potentiates Mps1 activation to ensure rapid checkpoint establishment at the onset of mitosis
inferredcites →https://doi.org/10.1038/ncomms8162openalex-snapshot
Distinct domains in Bub1 localize RZZ and BubR1 to kinetochores to regulate the checkpoint
inferredcites →https://doi.org/10.1038/ng1382openalex-snapshot
BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice
inferredcites →https://doi.org/10.1038/nrm3888openalex-snapshot
Signalling dynamics in the spindle checkpoint response
inferredcites →https://doi.org/10.1038/s41556-018-0130-3openalex-snapshot
Dynamic kinetochore size regulation promotes microtubule capture and chromosome biorientation in mitosis
inferredcites →https://doi.org/10.1073/pnas.0505053102openalex-snapshot
Generating chromosome instability through the simultaneous deletion of Mad2 and p53
inferredcites →https://doi.org/10.1083/jcb.120.2.301openalex-snapshot
Structure of the colcemid-treated PtK1 kinetochore outer plate as determined by high voltage electron microscopic tomography.
inferredcites →https://doi.org/10.1083/jcb.150.5.975openalex-snapshot
Probing Spindle Assembly Mechanisms with Monastrol, a Small Molecule Inhibitor of the Mitotic Kinesin, Eg5
inferredcites →https://doi.org/10.1083/jcb.200105093openalex-snapshot
Cytoplasmic dynein/dynactin drives kinetochore protein transport to the spindle poles and has a role in mitotic spindle checkpoint inactivation
inferredcites →https://doi.org/10.1083/jcb.200208092openalex-snapshot
The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore–microtubule attachment and in maintaining the spindle assembly checkpoint
inferredcites →https://doi.org/10.1083/jcb.200902128openalex-snapshot
Bub1 regulates chromosome segregation in a kinetochore-independent manner
inferredcites →https://doi.org/10.1083/jcb.201001050openalex-snapshot
Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling
inferredcites →https://doi.org/10.1083/jcb.201301006openalex-snapshot
CDK-dependent phosphorylation and nuclear exclusion coordinately control kinetochore assembly state
inferredcites →https://doi.org/10.1083/jcb.201311015openalex-snapshot
A Bub1–Mad1 interaction targets the Mad1–Mad2 complex to unattached kinetochores to initiate the spindle checkpoint
inferredcites →https://doi.org/10.1083/jcb.201311113openalex-snapshot
Recruitment of Mad1 to metaphase kinetochores is sufficient to reactivate the mitotic checkpoint
inferredcites →https://doi.org/10.1083/jcb.201412139openalex-snapshot
Unattached kinetochores rather than intrakinetochore tension arrest mitosis in taxol-treated cells
inferredcites →https://doi.org/10.1083/jcb.201506020openalex-snapshot
Kinetochore function is controlled by a phospho-dependent coexpansion of inner and outer components
inferredcites →https://doi.org/10.1083/jcb.201610108openalex-snapshot
Molecular mechanism of dynein recruitment to kinetochores by the Rod–Zw10–Zwilch complex and Spindly
inferredcites →https://doi.org/10.1083/jcb.201611060openalex-snapshot
Structure of the RZZ complex and molecular basis of its interaction with Spindly
inferredcites →https://doi.org/10.1091/mbc.12.7.1995openalex-snapshot
Microtubule-dependent Changes in Assembly of Microtubule Motor Proteins and Mitotic Spindle Checkpoint Proteins at PtK1 Kinetochores
inferredcites →https://doi.org/10.1091/mbc.e11-09-0781openalex-snapshot
Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction
inferredcites →https://doi.org/10.1091/mbc.e14-11-1560openalex-snapshot
Preventing farnesylation of the dynein adaptor Spindly contributes to the mitotic defects caused by farnesyltransferase inhibitors
inferredcites →https://doi.org/10.1098/rsob.150160openalex-snapshot
The RZZ complex requires the N-terminus of KNL1 to mediate optimal Mad1 kinetochore localization in human cells
inferredcites →https://doi.org/10.1101/278820openalex-snapshot
Bub1 is not required for the checkpoint response to unattached kinetochores in diploid human cells
inferredcites →https://doi.org/10.1101/gad.186965.112openalex-snapshot
Complexity in the signaling network: insights from the use of targeted inhibitors in cancer therapy
inferredcites →https://doi.org/10.1101/gad.1886810openalex-snapshot
Removal of Spindly from microtubule-attached kinetochores controls spindle checkpoint silencing in human cells
inferredcites →https://doi.org/10.1101/gad.233700.113openalex-snapshot
Mad1 kinetochore recruitment by Mps1-mediated phosphorylation of Bub1 signals the spindle checkpoint
inferredcites →https://doi.org/10.1158/0008-5472.can-06-3326openalex-snapshot
Heterozygous Deletion of Mitotic Arrest–Deficient Protein 1 (MAD1) Increases the Incidence of Tumors in Mice
inferredcites →https://doi.org/10.1242/jcs.169821openalex-snapshot
Dissecting the roles of human BUB1 in the spindle assembly checkpoint
inferredcites →https://doi.org/10.1371/journal.pgen.1006780openalex-snapshot
Genetic compensation: A phenomenon in search of mechanisms
inferredcites →https://doi.org/10.15252/embr.201744102openalex-snapshot
Evolutionary dynamics of the kinetochore network in eukaryotes as revealed by comparative genomics

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1002/cpmb.100openalex-snapshot
Generating Single Cell–Derived Knockout Clones in Mammalian Cells with CRISPR/Cas9
inferred← citeshttps://doi.org/10.2139/ssrn.3193407openalex-snapshot
The RZZ Complex Facilitates Mad1 Binding to Bub1 Ensuring Efficient Checkpoint Signaling
inferred← citeshttps://doi.org/10.3389/fcell.2018.00062openalex-snapshot
Kinase and Phosphatase Cross-Talk at the Kinetochore
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