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Repurposing covalent EGFR/HER2 inhibitors for on-target degradation of human Tribbles 2 (TRIB2) pseudokinase

https://doi.org/10.1101/305243
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Tribbles in acute leukemia
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Regulation of Trib2 by an E2F1-C/EBPα feedback loop in AML cell proliferation
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Trib2 expression in granulocyte-monocyte progenitors drives a highly drug resistant acute myeloid leukaemia linked to elevated Bcl2
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TRIB3 suppresses tumorigenesis by controlling mTORC2/AKT/FOXO signaling.
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