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Structural basis for σ 1 receptor ligand recognition

https://doi.org/10.1101/333765
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Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/jat.3576openalex-snapshot
Involvement of the delayed rectifier outward potassium channel Kv2.1 in methamphetamine‐induced neuronal apoptosis via the p38 mitogen‐activated protein kinase signaling pathway
inferredcites →https://doi.org/10.1007/s10048-015-0453-1openalex-snapshot
In silico analysis of SIGMAR1 variant (rs4879809) segregating in a consanguineous Pakistani family showing amyotrophic lateral sclerosis without frontotemporal lobar dementia
inferredcites →https://doi.org/10.1007/s12640-017-9838-2openalex-snapshot
Sigma-1 Receptor Agonists Induce Oxidative Stress in Mitochondria and Enhance Complex I Activity in Physiological Condition but Protect Against Pathological Oxidative Stress
inferredcites →https://doi.org/10.1007/s13311-012-0140-yopenalex-snapshot
Sigma-1R Agonist Improves Motor Function and Motoneuron Survival in ALS Mice
inferredcites →https://doi.org/10.1007/s13311-017-0572-5openalex-snapshot
Efficacy of a Novel Sigma-1 Receptor Antagonist for Oxaliplatin-Induced Neuropathy: A Randomized, Double-Blind, Placebo-Controlled Phase IIa Clinical Trial
inferredcites →https://doi.org/10.1016/0014-2999(95)00383-vopenalex-snapshot
Discrepancies in characterization of σ sites in the mouse central nervous system
inferredcites →https://doi.org/10.1016/bs.apha.2015.11.003openalex-snapshot
Antinociception by Sigma-1 Receptor Antagonists
inferredcites →https://doi.org/10.1016/j.bbrc.2012.08.052openalex-snapshot
Inhibition of tumor cell growth by Sigma1 ligand mediated translational repression
inferredcites →https://doi.org/10.1016/j.bmcl.2017.04.088openalex-snapshot
Reevaluation of fenpropimorph as a σ receptor ligand: Structure-affinity relationship studies at human σ1 receptors
inferredcites →https://doi.org/10.1016/j.cell.2007.08.036openalex-snapshot
Sigma-1 Receptor Chaperones at the ER- Mitochondrion Interface Regulate Ca2+ Signaling and Cell Survival
inferredcites →https://doi.org/10.1016/j.cell.2012.12.004openalex-snapshot
Dynamic Interaction between Sigma-1 Receptor and Kv1.2 Shapes Neuronal and Behavioral Responses to Cocaine
inferredcites →https://doi.org/10.1016/j.neuropharm.2018.01.042openalex-snapshot
Pharmacological profiling of sigma 1 receptor ligands by novel receptor homomer assays
inferredcites →https://doi.org/10.1016/j.pharmthera.2009.07.001openalex-snapshot
The pharmacology of sigma-1 receptors
inferredcites →https://doi.org/10.1016/j.tins.2012.09.007openalex-snapshot
The sigma-1 receptor: roles in neuronal plasticity and disease
inferredcites →https://doi.org/10.1016/s0022-3565(25)30536-7openalex-snapshot
The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog.
inferredcites →https://doi.org/10.1016/s0031-6997(25)00047-xopenalex-snapshot
Sigma receptors: biology and function.
inferredcites →https://doi.org/10.1016/s0896-6273(02)00677-3openalex-snapshot
The Sigma Receptor as a Ligand-Regulated Auxiliary Potassium Channel Subunit
inferredcites →https://doi.org/10.1021/ct300284copenalex-snapshot
Routine Access to Millisecond Time Scale Events with Accelerated Molecular Dynamics
inferredcites →https://doi.org/10.1021/jm00034a020openalex-snapshot
Structural Features Important for .sigma.1 Receptor Binding
inferredcites →https://doi.org/10.1038/cddis.2015.194openalex-snapshot
Sigma-1 receptor deficiency reduces MPTP-induced parkinsonism and death of dopaminergic neurons
inferredcites →https://doi.org/10.1038/nature09665openalex-snapshot
Structure and function of an irreversible agonist-β2 adrenoceptor complex
inferredcites →https://doi.org/10.1038/nature17391openalex-snapshot
Crystal structure of the human σ1 receptor
inferredcites →https://doi.org/10.1038/nprot.2009.31openalex-snapshot
Crystallizing membrane proteins using lipidic mesophases
inferredcites →https://doi.org/10.1038/s41598-018-22217-9openalex-snapshot
Critical role of sigma-1 receptors in central neuropathic pain-related behaviours after mild spinal cord injury in mice
inferredcites →https://doi.org/10.1042/bj20141321openalex-snapshot
The sigma-1 receptors are present in monomeric and oligomeric forms in living cells in the presence and absence of ligands
inferredcites →https://doi.org/10.1073/pnas.1008911107openalex-snapshot
Direct involvement of σ-1 receptors in the dopamine D 1 receptor-mediated effects of cocaine
inferredcites →https://doi.org/10.1073/pnas.1715972115openalex-snapshot
TRPV1 channels and the progesterone receptor Sig-1R interact to regulate pain
inferredcites →https://doi.org/10.1073/pnas.93.15.8072openalex-snapshot
Purification, molecular cloning, and expression of the mammalian sigma1-binding site.
inferredcites →https://doi.org/10.1074/jbc.m113.537993openalex-snapshot
The Oligomeric States of the Purified Sigma-1 Receptor Are Stabilized by Ligands
inferredcites →https://doi.org/10.1074/jbc.m116.774075openalex-snapshot
The sigma-1 receptor modulates dopamine transporter conformation and cocaine binding and may thereby potentiate cocaine self-administration in rats
inferredcites →https://doi.org/10.1093/hmg/ddw220openalex-snapshot
Loss-of-function mutations in theSIGMAR1gene cause distal hereditary motor neuropathy by impairing ER-mitochondria tethering and Ca2+signalling
inferredcites →https://doi.org/10.1097/fbp.0000000000000209openalex-snapshot
A role for sigma receptors in stimulant self-administration and addiction
inferredcites →https://doi.org/10.1107/s0907444904019158openalex-snapshot
Coot : model-building tools for molecular graphics
inferredcites →https://doi.org/10.1107/s0907444909042073openalex-snapshot
MolProbity : all-atom structure validation for macromolecular crystallography
inferredcites →https://doi.org/10.1107/s0907444909047337openalex-snapshot
XDS
inferredcites →https://doi.org/10.1107/s0907444912001308openalex-snapshot
Towards automated crystallographic structure refinement with phenix.refine
inferredcites →https://doi.org/10.1107/s0907444913000061openalex-snapshot
How good are my data and what is the resolution?
inferredcites →https://doi.org/10.1111/cns.12768openalex-snapshot
Sigma‐1 receptor agonist increases axon outgrowth of hippocampal neurons via voltage‐gated calcium ions channels
inferredcites →https://doi.org/10.1124/mol.109.057083openalex-snapshot
σ1 Receptor Modulation of G-Protein-Coupled Receptor Signaling: Potentiation of Opioid Transduction Independent from Receptor Binding
inferredcites →https://doi.org/10.1124/mol.115.101170openalex-snapshot
Biochemical Pharmacology of the Sigma-1 Receptor
inferredcites →https://doi.org/10.1124/mol.116.104018openalex-snapshot
Aberrant Subcellular Dynamics of Sigma-1 Receptor Mutants Underlying Neuromuscular Diseases
inferredcites →https://doi.org/10.1158/1541-7786.mcr-17-0166openalex-snapshot
Small-Molecule Sigma1 Modulator Induces Autophagic Degradation of PD-L1
inferredcites →https://doi.org/10.1161/strokeaha.114.005835openalex-snapshot
Phase II Trial of the Sigma-1 Receptor Agonist Cutamesine (SA4503) for Recovery Enhancement After Acute Ischemic Stroke
inferredcites →https://doi.org/10.7554/elife.01456openalex-snapshot
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