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TMEM135 is an LXR-inducible regulator of peroxisomal metabolism

https://doi.org/10.1101/334979
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1007/s00018-002-8416-8openalex-snapshot
Sterol carrier protein-2: structure reveals function
inferredcites →https://doi.org/10.1016/j.bbalip.2013.11.003openalex-snapshot
LXR antagonists induce ABCD2 expression
inferredcites →https://doi.org/10.1016/j.bbamcr.2015.09.035openalex-snapshot
Hepatic dysfunction in peroxisomal disorders
inferredcites →https://doi.org/10.1016/j.bbamcr.2015.11.015openalex-snapshot
Human disorders of peroxisome metabolism and biogenesis
inferredcites →https://doi.org/10.1016/j.biochi.2016.12.019openalex-snapshot
The role and regulation of the peroxisome proliferator activated receptor alpha in human liver
inferredcites →https://doi.org/10.1016/j.cbi.2013.11.006openalex-snapshot
A map of the PPARα transcription regulatory network for primary human hepatocytes
inferredcites →https://doi.org/10.1016/j.cmet.2013.10.002openalex-snapshot
LXRs Regulate ER Stress and Inflammation through Dynamic Modulation of Membrane Phospholipid Composition
inferredcites →https://doi.org/10.1016/j.jhep.2013.05.030openalex-snapshot
The metabolomic window into hepatobiliary disease
inferredcites →https://doi.org/10.1016/j.lfs.2018.04.049openalex-snapshot
Omega-3 and omega-6 polyunsaturated fatty acids: Dietary sources, metabolism, and significance — A review
inferredcites →https://doi.org/10.1016/j.mce.2018.01.011openalex-snapshot
The liver X receptors and sterol regulatory element binding proteins alter progesterone secretion and are regulated by human chorionic gonadotropin in human luteinized granulosa cells
inferredcites →https://doi.org/10.1016/j.tem.2016.12.003openalex-snapshot
Peroxisomal Dysfunction in Age-Related Diseases
inferredcites →https://doi.org/10.1016/s0959-437x(98)80013-0openalex-snapshot
The LXRs: a new class of oxysterol receptors
inferredcites →https://doi.org/10.1021/cr0001030openalex-snapshot
Cyclin-Dependent Kinases
inferredcites →https://doi.org/10.1038/nrd4280openalex-snapshot
Liver X receptors in lipid metabolism: opportunities for drug discovery
inferredcites →https://doi.org/10.1073/pnas.92.6.2096openalex-snapshot
OR-1, a member of the nuclear receptor superfamily that interacts with the 9-cis-retinoic acid receptor.
inferredcites →https://doi.org/10.1074/jbc.m003337200openalex-snapshot
Sterol-dependent Transactivation of theABC1 Promoter by the Liver X Receptor/Retinoid X Receptor
inferredcites →https://doi.org/10.1074/jbc.m105863200openalex-snapshot
Characterization of the Human ABCG1 Gene
inferredcites →https://doi.org/10.1074/jbc.m106155200openalex-snapshot
Liver X Receptor (LXR) Regulation of the LXRα Gene in Human Macrophages
inferredcites →https://doi.org/10.1074/jbc.m610910200openalex-snapshot
Rat Liver Peroxisomes after Fibrate Treatment
inferredcites →https://doi.org/10.1074/jbc.m709135200openalex-snapshot
Structural Basis for Substrate Fatty Acyl Chain Specificity
inferredcites →https://doi.org/10.1074/mcp.m700169-mcp200openalex-snapshot
Proteomics Characterization of Mouse Kidney Peroxisomes by Tandem Mass Spectrometry and Protein Correlation Profiling
inferredcites →https://doi.org/10.1093/bioinformatics/bti473openalex-snapshot
MatInspector and beyond: promoter analysis based on transcription factor binding sites
inferredcites →https://doi.org/10.1093/molehr/gax061openalex-snapshot
Increased 27-hydroxycholesterol production during luteolysis may mediate the progressive decline in progesterone secretion
inferredcites →https://doi.org/10.1095/biolreprod.111.096347openalex-snapshot
Liver X Receptor Modulation of Gene Expression Leading to Proluteolytic Effects in Primate Luteal Cells1
inferredcites →https://doi.org/10.1095/biolreprod.114.124941openalex-snapshot
Decreased Cholesterol Uptake and Increased Liver X Receptor-Mediated Cholesterol Efflux Pathways During Prostaglandin F2 Alpha-Induced and Spontaneous Luteolysis in Sheep1
inferredcites →https://doi.org/10.1101/gad.844900openalex-snapshot
Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ
inferredcites →https://doi.org/10.1101/gad.9.9.1033openalex-snapshot
LXR, a nuclear receptor that defines a distinct retinoid response pathway.
inferredcites →https://doi.org/10.1124/jpet.103.064535openalex-snapshot
Coadministration of a Liver X Receptor Agonist and a Peroxisome Proliferator Activator Receptor-α Agonist in Mice: Effects of Nuclear Receptor Interplay on High-Density Lipoprotein and Triglyceride Metabolism in Vivo
inferredcites →https://doi.org/10.1126/science.1168974openalex-snapshot
LXR Regulates Cholesterol Uptake Through Idol-Dependent Ubiquitination of the LDL Receptor
inferredcites →https://doi.org/10.1128/mcb.21.22.7558-7568.2001openalex-snapshot
Autoregulation of the Human Liver X Receptor α Promoter
inferredcites →https://doi.org/10.1128/mcb.21.9.2991-3000.2001openalex-snapshot
Identification of Liver X Receptor-Retinoid X Receptor as an Activator of the Sterol Regulatory Element-Binding Protein 1c Gene Promoter
inferredcites →https://doi.org/10.1146/annurev-nutr-071816-064916openalex-snapshot
β-Hydroxybutyrate: A Signaling Metabolite
inferredcites →https://doi.org/10.1152/ajpendo.00399.2006openalex-snapshot
Peroxisomal-mitochondrial oxidation in a rodent model of obesity-associated insulin resistance
inferredcites →https://doi.org/10.1152/ajprenal.00131.2005openalex-snapshot
Liver X receptor agonist TO-901317 upregulates SCD1 expression in renal proximal straight tubule
inferredcites →https://doi.org/10.1158/1541-7786.mcr-13-0350openalex-snapshot
The Molecular Balancing Act of p16INK4a in Cancer and Aging
inferredcites →https://doi.org/10.1186/s12986-016-0122-xopenalex-snapshot
Hepatic adaptations to maintain metabolic homeostasis in response to fasting and refeeding in mice
inferredcites →https://doi.org/10.1186/s13062-016-0157-yopenalex-snapshot
Evolution of the Tim17 protein family
inferredcites →https://doi.org/10.1194/jlr.d500022-jlr200openalex-snapshot
A simplified and efficient method for the analysis of fatty acid methyl esters suitable for large clinical studies
inferredcites →https://doi.org/10.1194/jlr.d700017-jlr200openalex-snapshot
A simple and rapid method to assay triacylglycerol in cells and tissues
inferredcites →https://doi.org/10.1194/jlr.m004978openalex-snapshot
Activation of LXR increases acyl-CoA synthetase activity through direct regulation of ACSL3 in human placental trophoblast cells
inferredcites →https://doi.org/10.1210/en.2005-0591openalex-snapshot
Hepatic Peroxisomal Fatty Acid β-Oxidation Is Regulated by Liver X Receptor α
inferredcites →https://doi.org/10.1210/jc.2016-3456openalex-snapshot
Ovarian Lipid Metabolism Modulates Circulating Lipids in Premenopausal Women
inferredcites →https://doi.org/10.1210/me.2007-0484openalex-snapshot
Systematic Determination of Differential Gene Expression in the Primate Corpus Luteum during the Luteal Phase of the Menstrual Cycle
inferredcites →https://doi.org/10.1371/journal.pgen.1003286openalex-snapshot
Tysnd1 Deficiency in Mice Interferes with the Peroxisomal Localization of PTS2 Enzymes, Causing Lipid Metabolic Abnormalities and Male Infertility
inferredcites →https://doi.org/10.1371/journal.pone.0014228openalex-snapshot
Stressed-Induced TMEM135 Protein Is Part of a Conserved Genetic Network Involved in Fat Storage and Longevity Regulation in Caenorhabditis elegans
inferredcites →https://doi.org/10.1530/rep-09-0005openalex-snapshot
The reverse cholesterol transport system as a potential mediator of luteolysis in the primate corpus luteum
inferredcites →https://doi.org/10.3389/fcell.2015.00056openalex-snapshot
The different facets of organelle interplay—an overview of organelle interactions
inferredcites →https://doi.org/10.7554/elife.19264openalex-snapshot
Mouse Tmem135 mutation reveals a mechanism involving mitochondrial dynamics that leads to age-dependent retinal pathologies

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1007/978-3-030-58532-7_9openalex-snapshot
Lysosomes and Peroxisomes
inferred← citeshttps://doi.org/10.1007/s00418-018-1722-5openalex-snapshot
The peroxisome: an update on mysteries 2.0
inferred← citeshttps://doi.org/10.1016/j.molmet.2024.102080openalex-snapshot
TMEM135 deficiency improves hepatic steatosis by suppressing CD36 in a SIRT1-dependent manner
inferred← citeshttps://doi.org/10.1101/529297openalex-snapshot
Leveraging functional annotation to identify genes associated with complex diseases
inferred← citeshttps://doi.org/10.1371/journal.pcbi.1008315openalex-snapshot
Leveraging functional annotation to identify genes associated with complex diseases
inferred← citeshttps://doi.org/10.3389/fcell.2020.613892openalex-snapshot
Peroxisomal Metabolite and Cofactor Transport in Humans
inferred← citeshttps://doi.org/10.3390/cells10071750openalex-snapshot
TMEM135 is a Novel Regulator of Mitochondrial Dynamics and Physiology with Implications for Human Health Conditions
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