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Stable networks of water-mediated interactions are conserved in activation of diverse GPCRs

https://doi.org/10.1101/351502
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Outgoing claims: the papers this work cites, builds on, or argues with.

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The Mechanism of Ligand‐Induced Activation or Inhibition of μ‐ and κ‐Opioid Receptors
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The Mechanism of Ligand‐Induced Activation or Inhibition of μ‐ and κ‐Opioid Receptors
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The Role of Internal Water Molecules in the Structure and Function of the Rhodopsin Family of G Protein‐Coupled Receptors
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CHARMM general force field: A force field for drug‐like molecules compatible with the CHARMM all‐atom additive biological force fields
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An overview of the Amber biomolecular simulation package
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VMD: Visual molecular dynamics
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Crystal Structures of Human Orexin 2 Receptor Bound to the Subtype-Selective Antagonist EMPA
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[19] Integrated methods for the construction of three-dimensional models and computational probing of structure-function relations in G protein-coupled receptors
inferredcites →https://doi.org/10.1021/acs.chemrev.5b00664openalex-snapshot
Water Determines the Structure and Dynamics of Proteins
inferredcites →https://doi.org/10.1021/acs.chemrev.6b00177openalex-snapshot
GPCR Dynamics: Structures in Motion
inferredcites →https://doi.org/10.1021/acs.jmedchem.6b00653openalex-snapshot
Controlling the Dissociation of Ligands from the Adenosine A 2A Receptor through Modulation of Salt Bridge Strength
inferredcites →https://doi.org/10.1021/ci4001458openalex-snapshot
Water Network Perturbation in Ligand Binding: Adenosine A2AAntagonists as a Case Study
inferredcites →https://doi.org/10.1021/ct5010406openalex-snapshot
Long-Time-Step Molecular Dynamics through Hydrogen Mass Repartitioning
inferredcites →https://doi.org/10.1021/ja4075776openalex-snapshot
Water Networks Contribute to Enthalpy/Entropy Compensation in Protein–Ligand Binding
inferredcites →https://doi.org/10.1038/nature06325openalex-snapshot
Crystal structure of the human β2 adrenergic G-protein-coupled receptor
inferredcites →https://doi.org/10.1038/nature10361openalex-snapshot
Crystal structure of the β2 adrenergic receptor–Gs protein complex
inferredcites →https://doi.org/10.1038/nature10753openalex-snapshot
Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist
inferredcites →https://doi.org/10.1038/nature10954openalex-snapshot
Crystal structure of the µ-opioid receptor bound to a morphinan antagonist
inferredcites →https://doi.org/10.1038/nature12735openalex-snapshot
Activation and allosteric modulation of a muscarinic acetylcholine receptor
inferredcites →https://doi.org/10.1038/nature12944openalex-snapshot
Molecular control of δ-opioid receptor signalling
inferredcites →https://doi.org/10.1038/nature14886openalex-snapshot
Structural insights into µ-opioid receptor activation
inferredcites →https://doi.org/10.1038/nature18966openalex-snapshot
Structure of the adenosine A2A receptor bound to an engineered G protein
inferredcites →https://doi.org/10.1038/nature19107openalex-snapshot
Diverse activation pathways in class A GPCRs converge near the G-protein-coupling region
inferredcites →https://doi.org/10.1038/nature19112openalex-snapshot
Structure-based discovery of opioid analgesics with reduced side effects
inferredcites →https://doi.org/10.1038/nature22394openalex-snapshot
Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein
inferredcites →https://doi.org/10.1038/ncomms5733openalex-snapshot
Activation of G-protein-coupled receptors correlates with the formation of a continuous internal water pathway
inferredcites →https://doi.org/10.1038/nrd.2016.230openalex-snapshot
A comprehensive map of molecular drug targets
inferredcites →https://doi.org/10.1038/nsmb0709-681openalex-snapshot
Energetics of protein hydrogen bonds
inferredcites →https://doi.org/10.1073/pnas.0901074106openalex-snapshot
Structural waters define a functional channel mediating activation of the GPCR, rhodopsin
inferredcites →https://doi.org/10.1073/pnas.0903545106openalex-snapshot
Conserved waters mediate structural and functional activation of family A (rhodopsin-like) G protein-coupled receptors
inferredcites →https://doi.org/10.1073/pnas.1104614108openalex-snapshot
Pathway and mechanism of drug binding to G-protein-coupled receptors
inferredcites →https://doi.org/10.1073/pnas.1114107108openalex-snapshot
Mechanism of the hydrophobic effect in the biomolecular recognition of arylsulfonamides by carbonic anhydrase
inferredcites →https://doi.org/10.1073/pnas.1417888112openalex-snapshot
Buried ionizable networks are an ancient hallmark of G protein-coupled receptor activation
inferredcites →https://doi.org/10.1074/jbc.r115.668251openalex-snapshot
From G Protein-coupled Receptor Structure Resolution to Rational Drug Design
inferredcites →https://doi.org/10.1093/bioinformatics/btk023openalex-snapshot
OPM: Orientations of Proteins in Membranes database
inferredcites →https://doi.org/10.1093/nar/gkv1178openalex-snapshot
GPCRdb: an information system for G protein-coupled receptors
inferredcites →https://doi.org/10.1124/mol.115.102657openalex-snapshot
Molecular Basis of Ligand Dissociation from the Adenosine A2A Receptor
inferredcites →https://doi.org/10.1124/mol.63.6.1256openalex-snapshot
The G-Protein-Coupled Receptors in the Human Genome Form Five Main Families. Phylogenetic Analysis, Paralogon Groups, and Fingerprints
inferredcites →https://doi.org/10.1126/science.1066115openalex-snapshot
Water Permeation Across Biological Membranes: Mechanism and Dynamics of Aquaporin-1 and GlpF
inferredcites →https://doi.org/10.1126/science.1067778openalex-snapshot
Control of the Selectivity of the Aquaporin Water Channel Family by Global Orientational Tuning
inferredcites →https://doi.org/10.1126/science.aan5468openalex-snapshot
D4dopamine receptor high-resolution structures enable the discovery of selective agonists
inferredcites →https://doi.org/10.1146/annurev.biophys.35.040405.102134openalex-snapshot
WATER MEDIATION IN PROTEIN FOLDING AND MOLECULAR RECOGNITION
inferredcites →https://doi.org/10.1371/journal.pone.0092727openalex-snapshot
The 2.1 Å Resolution Structure of Cyanopindolol-Bound β1-Adrenoceptor Identifies an Intramembrane Na+ Ion that Stabilises the Ligand-Free Receptor

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inferred← citeshttps://doi.org/10.4155/fmc-2018-0393openalex-snapshot
Peeking at G-protein-coupled Receptors Through the Molecular Dynamics Keyhole
inferred← citeshttps://doi.org/10.7554/elife.54895openalex-snapshot
Structural and functional characterization of G protein–coupled receptors with deep mutational scanning
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