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Structure-aware M. tuberculosis functional annotation uncloaks resistance, metabolic, and virulence genes
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Fuzziness enables context dependence of protein interactions
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Scoring function for automated assessment of protein structure template quality
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Evaluating protein structures determined by structural genomics consortia
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Critical assessment of methods of protein structure prediction—Round VII
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Protein structure prediction center in CASP8
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Critical assessment of methods of protein structure prediction (CASP)—round IX
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Interplay of I‐TASSER and QUARK for template‐based and ab initio protein structure prediction in CASP10
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Critical assessment of methods of protein structure prediction (CASP) — round x
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Assessment of template‐based protein structure predictions in CASP10
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Critical assessment of methods of protein structure prediction: Progress and new directions in round XI
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Bacterial serine proteases secreted by the autotransporter pathway: classification, specificity, and role in virulence
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Spatial Patterns of Gene Expression in Bacterial Genomes
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Complex lipid trafficking in Niemann‐Pick disease type C
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Characterization of phthiocerol dimycocerosates from Mycobacterium tuberculosis
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Autophagy regulation revealed by SapM-induced block of autophagosome-lysosome fusion via binding RAB7
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Host Evasion and Exploitation Schemes of Mycobacterium tuberculosis
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Genome-wide Mapping of Transcriptional Start Sites Defines an Extensive Leaderless Transcriptome in Mycobacterium tuberculosis
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Systematic Survey of Serine Hydrolase Activity in Mycobacterium tuberculosis Defines Changes Associated with Persistence
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Mutation in the Transcriptional Regulator PhoP Contributes to Avirulence of Mycobacterium tuberculosis H37Ra Strain
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Pathogens Use Structural Mimicry of Native Host Ligands as a Mechanism for Host Receptor Engagement
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The Oxidative Stress Network of Mycobacterium tuberculosis Reveals Coordination between Radical Detoxification Systems
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A Collaborative Approach for “ReSeq-ing” Mycobacterium tuberculosis Drug Resistance: Convergence for Drug and Diagnostic Developers
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Bxz1, a new generalized transducing phage for mycobacteria
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Mycobacterium tuberculosis PE25/PPE41 protein complex induces necrosis in macrophages: Role in virulence and disease reactivation?
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De Novo Proteins with Life-Sustaining Functions Are Structurally Dynamic
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Using the underlying biological organization of the Mycobacterium tuberculosis functional network for protein function prediction
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Bioinformatics tools and databases for whole genome sequence analysis of Mycobacterium tuberculosis
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Expression of Mycobacterium tuberculosis NLPC/p60 family protein Rv0024 induce biofilm formation and resistance against cell wall acting anti-tuberculosis drugs in Mycobacterium smegmatis
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Expression of Mycobacterium tuberculosis pe_pgrs33 is repressed during stationary phase and stress conditions, and its transcription is mediated by sigma factor A
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Rapid identification of veterinary-relevant Mycobacterium tuberculosis complex species using 16S rDNA, IS6110 and Regions of Difference-targeted dual-labelled hydrolysis probes
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The dimycocerosate ester polyketide virulence factors of mycobacteria
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Apoptosome Structure, Assembly, and Procaspase Activation
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Subversion of Retrograde Trafficking by Translocated Pathogen Effectors
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Functional assignment of Mycobacterium tuberculosis proteome revealed by genome-scale fold-recognition
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Enriching the annotation of Mycobacterium tuberculosis H37Rv proteome using remote homology detection approaches: Insights into structure and function
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The TIM‐barrel fold: a versatile framework for efficient enzymes
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One Fold with Many Functions: The Evolutionary Relationships between TIM Barrel Families Based on their Sequences, Structures and Functions
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The SIS domain: a phosphosugar-binding domain
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Involvement of the C terminus in intramolecular nitrogen channeling in glucosamine 6-phosphate synthase: evidence from a 1.6 å crystal structure of the isomerase domain
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Crystal structure of an aminoglycoside 6′-N-acetyltransferase: defining the GCN5-related N-acetyltransferase superfamily fold
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Pyrazinamide Resistance Is Caused by Two Distinct Mechanisms: Prevention of Coenzyme A Depletion and Loss of Virulence Factor Synthesis
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Structural Basis for Phosphomannose Isomerase Activity in Phosphoglucose Isomerase from Pyrobaculum aerophilum: A Subtle Difference between Distantly Related Enzymes
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The DinB Superfamily Includes Novel Mycothiol, Bacillithiol, and GlutathioneS-Transferases
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Exploring Free-Energy Landscapes of Intrinsically Disordered Proteins at Atomic Resolution Using NMR Spectroscopy
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Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
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Gene Ontology: tool for the unification of biology
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Pyrazinamide inhibits the eukaryotic-like fatty acid synthetase I (FASI) of Mycobacterium tuberculosis
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Substrate-bound structure of the E. coli multidrug resistance transporter MdfA
inferredcites →https://doi.org/10.1038/nature12337openalex-snapshot
The Mycobacterium tuberculosis regulatory network and hypoxia
inferredcites →https://doi.org/10.1038/ncomms6829openalex-snapshot
The DNA-binding network of Mycobacterium tuberculosi s
inferredcites →https://doi.org/10.1038/nm0696-662openalex-snapshot
Mutations in pncA, a gene encoding pyrazinamidase/nicotinamidase, cause resistance to the antituberculous drug pyrazinamide in tubercle bacillus
inferredcites →https://doi.org/10.1038/nm1683openalex-snapshot
In vivo gene silencing identifies the Mycobacterium tuberculosis proteasome as essential for the bacteria to persist in mice
inferredcites →https://doi.org/10.1038/nmeth.3213openalex-snapshot
The I-TASSER Suite: protein structure and function prediction
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Targeting of host organelles by pathogenic bacteria: a sophisticated subversion strategy
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Within-host evolution of bacterial pathogens
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Metabolic crosstalk between host and pathogen: sensing, adapting and competing
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ESX secretion systems: mycobacterial evolution to counter host immunity
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Pathogenesis of HIV-1 and Mycobacterium tuberculosis co-infection
inferredcites →https://doi.org/10.1038/nsmb0110-2openalex-snapshot
Membrane transport proteins: surprises in structural sameness
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Gene inversion potentiates bacterial evolvability and virulence
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PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase
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Anti-tubercular Activity of Pyrazinamide is Independent of trans-Translation and RpsA
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Mycobacterium tuberculosis Inhibits RAB7 Recruitment to Selectively Modulate Autophagy Flux in Macrophages
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Role of Cathepsins in Mycobacterium tuberculosis Survival in Human Macrophages
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Exosomes function in antigen presentation during an in vivo Mycobacterium tuberculosis infection
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Isotuberculosinol: the unusual case of an immunomodulatory diterpenoid from Mycobacterium tuberculosis
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Direct-coupling analysis of residue coevolution captures native contacts across many protein families
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Molecular profiling of Mycobacterium tuberculosis identifies tuberculosinyl nucleoside products of the virulence-associated enzyme Rv3378c
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Structural basis for nuclear import of splicing factors by human Transportin 3
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In vivo transposition of mariner -based elements in enteric bacteria and mycobacteria
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Characterization and Inhibition of a Class II Diterpene Cyclase from Mycobacterium tuberculosis
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Crystal Structure and Computational Analyses Provide Insights into the Catalytic Mechanism of 2,4-Diacetylphloroglucinol Hydrolase PhlG from Pseudomonas fluorescens
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Characterization of a Carbon-Carbon Hydrolase from Mycobacterium tuberculosis Involved in Cholesterol Metabolism
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Proteolytic Activation of Human Cathepsin A
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Glutamine Binding Opens the Ammonia Channel and Activates Glucosamine-6P Synthase
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Crystal Structures and Site-directed Mutagenesis of a Mycothiol-dependent Enzyme Reveal a Novel Folding and Molecular Basis for Mycothiol-mediated Maleylpyruvate Isomerization
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Efflux pump inhibitors as a promising adjunct therapy against drug resistant tuberculosis: a new strategy to revisit mycobacterial targets and repurpose old drugs
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BIOLOGICAL STUDIES OF THE TUBERCLE BACILLUS
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A Bayesian Sampler for Optimization of Protein Domain Hierarchies
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A comprehensive review and comparison of different computational methods for protein remote homology detection
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The BioCyc collection of microbial genomes and metabolic pathways
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Microbial genome analysis: the COG approach
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How significant is a protein structure similarity with TM-score = 0.5?
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Simple topological properties predict functional misannotations in a metabolic network
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Relation between sequence and structure in membrane proteins
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On expert curation and scalability: UniProtKB/Swiss-Prot as a case study
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GO annotation in InterPro: why stability does not indicate accuracy in a sea of changing annotations
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TheRickettsiatype IV secretion system: unrealized complexity mired by gene family expansion
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Cholesterol and fatty acids grease the wheels of Mycobacterium tuberculosis pathogenesis
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Mode of action of pyrazinamide: disruption of Mycobacterium tuberculosis membrane transport and energetics by pyrazinoic acid
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‘Happy the man, who, studying nature's laws, Thro' known effects can trace the secret cause.’† Do we have enough pieces to solve the pyrazinamide puzzle?
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Non-Random Inversion Landscapes in Prokaryotic Genomes Are Shaped by Heterogeneous Selection Pressures
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UniProt: the Universal Protein knowledgebase
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Toxin-antitoxin loci are highly abundant in free-living but lost from host-associated prokaryotes
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The HHpred interactive server for protein homology detection and structure prediction
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TM-align: a protein structure alignment algorithm based on the TM-score
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TB database: an integrated platform for tuberculosis research
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COFACTOR: an accurate comparative algorithm for structure-based protein function annotation
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BioLiP: a semi-manually curated database for biologically relevant ligand–protein interactions
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RefSeq microbial genomes database: new representation and annotation strategy
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Precision methylome characterization ofMycobacterium tuberculosiscomplex (MTBC) using PacBio single-molecule real-time (SMRT) technology
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KEGG: new perspectives on genomes, pathways, diseases and drugs
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CATH: an expanded resource to predict protein function through structure and sequence
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UniProt: the universal protein knowledgebase
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Expansion of the Gene Ontology knowledgebase and resources
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COFACTOR: improved protein function prediction by combining structure, sequence and protein–protein interaction information
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Type V secretion: mechanism(s) of autotransport through the bacterial outer membrane
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Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv
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PROCHECK: validation of protein-structure coordinates
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PROCHECK: a program to check the stereochemical quality of protein structures
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Multiple deletions in the polyketide synthase gene repertoire ofMycobacterium tuberculosisreveal functional overlap of cell envelope lipids in host-pathogen interactions
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Verapamil treatment induces cytoprotective autophagy by modulating cellular metabolism
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Discovery and structural analysis of a phloretin hydrolase from the opportunistic human pathogen Mycobacterium abscessus
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aprABC : a Mycobacterium tuberculosis complex‐specific locus that modulates pH‐driven adaptation to the macrophage phagosome
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Efflux as a mechanism for drug resistance inMycobacterium tuberculosis: Table 1
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Phylogeny to function: PE / PPE protein evolution and impact on M ycobacterium tuberculosis pathogenicity
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The changes in mycolic acid structures caused by hadC mutation have a dramatic effect on the virulence of Mycobacterium tuberculosis
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A Fluoroquinolone Resistance Protein from Mycobacterium tuberculosis That Mimics DNA
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Pyrazinamide Inhibits Trans-Translation in Mycobacterium tuberculosis
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Evolutionarily Conserved Pathways of Energetic Connectivity in Protein Families
inferredcites →https://doi.org/10.1128/aac.00430-18openalex-snapshot
Identification of Novel Mutations in LprG ( rv1411c ), rv0521 , rv3630 , rv0010c , ppsC , and cyp128 Associated with Pyrazinoic Acid/Pyrazinamide Resistance in Mycobacterium tuberculosis
inferredcites →https://doi.org/10.1128/aac.00529-10openalex-snapshot
Mutually Exclusive Genotypes for Pyrazinamide and 5-Chloropyrazinamide Resistance Reveal a Potential Resistance-Proofing Strategy
inferredcites →https://doi.org/10.1128/aac.00967-15openalex-snapshot
Uncoupling Environmental pH and Intrabacterial Acidification from Pyrazinamide Susceptibility in Mycobacterium tuberculosis
inferredcites →https://doi.org/10.1128/aac.02293-13openalex-snapshot
Energy Metabolism and Drug Efflux in Mycobacterium tuberculosis
inferredcites →https://doi.org/10.1128/aac.04028-14openalex-snapshot
Pantothenate and Pantetheine Antagonize the Antitubercular Activity of Pyrazinamide
inferredcites →https://doi.org/10.1128/iai.00072-16openalex-snapshot
Transcriptional Profiling of Mycobacterium tuberculosis Exposed toIn VitroLysosomal Stress
inferredcites →https://doi.org/10.1128/iai.00207-11openalex-snapshot
PATRIC: the Comprehensive Bacterial Bioinformatics Resource with a Focus on Human Pathogenic Species
inferredcites →https://doi.org/10.1128/iai.00269-20openalex-snapshot
Identification of Autophagy-Inhibiting Factors of Mycobacterium tuberculosis by High-Throughput Loss-of-Function Screening
inferredcites →https://doi.org/10.1128/jb.00050-12openalex-snapshot
Novel l -Cysteine-Dependent Maleylpyruvate Isomerase in the Gentisate Pathway of Paenibacillus sp. Strain NyZ101
inferredcites →https://doi.org/10.1128/jb.00166-10openalex-snapshot
Variation among Genome Sequences of H37Rv Strains of Mycobacterium tuberculosis from Multiple Laboratories
inferredcites →https://doi.org/10.1128/jb.00257-07openalex-snapshot
A Genomic View of Sugar Transport inMycobacterium smegmatisandMycobacterium tuberculosis
inferredcites →https://doi.org/10.1128/jb.00488-09openalex-snapshot
Mycobacterium tuberculosis Is Able To Accumulate and Utilize Cholesterol
inferredcites →https://doi.org/10.1128/jb.00935-15openalex-snapshot
Mycobacterium tuberculosis Transcription Machinery: Ready To Respond to Host Attacks
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The Stringent Response of Mycobacterium tuberculosis Is Required for Long-Term Survival
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Effects of Pyrazinamide on Fatty Acid Synthesis by Whole Mycobacterial Cells and Purified Fatty Acid Synthase I
inferredcites →https://doi.org/10.1128/mbio.01092-17openalex-snapshot
The Capacity of Mycobacterium tuberculosis To Survive Iron Starvation Might Enable It To Persist in Iron-Deprived Microenvironments of Human Granulomas
inferredcites →https://doi.org/10.1128/mbio.02205-20openalex-snapshot
Intracellular Density of Wolbachia Is Mediated by Host Autophagy and the Bacterial Cytoplasmic Incompatibility Gene cifB in a Cell Type-Dependent Manner in Drosophila melanogaster
inferredcites →https://doi.org/10.1128/msystems.00396-20openalex-snapshot
Distinct Bacterial Pathways Influence the Efficacy of Antibiotics against Mycobacterium tuberculosis
inferredcites →https://doi.org/10.1139/cjm-2015-0166openalex-snapshot
Creating a customized intracellular niche: subversion of host cell signaling by Legionella type IV secretion system effectors
inferredcites →https://doi.org/10.1155/2021/8899674openalex-snapshot
Identification of CTL Epitopes on Efflux Pumps of the ATP-Binding Cassette and the Major Facilitator Superfamily of Mycobacterium tuberculosis
inferredcites →https://doi.org/10.1159/000454680openalex-snapshot
Natural Terpenes Influence the Activity of Antibiotics against Isolated Mycobacterium tuberculosis
inferredcites →https://doi.org/10.1186/1471-2164-14-710openalex-snapshot
Genome-level analyses of Mycobacterium bovis lineages reveal the role of SNPs and antisense transcription in differential gene expression
inferredcites →https://doi.org/10.1186/gb-2000-1-6-research0011openalex-snapshot
Evidence for symmetric chromosomal inversions around the replication origin in bacteria
inferredcites →https://doi.org/10.1186/s12864-015-2311-9openalex-snapshot
MycoBASE: expanding the functional annotation coverage of mycobacterial genomes
inferredcites →https://doi.org/10.1186/s12864-017-3687-5openalex-snapshot
SMRT genome assembly corrects reference errors, resolving the genetic basis of virulence in Mycobacterium tuberculosis
inferredcites →https://doi.org/10.12688/wellcomeopenres.10036.2openalex-snapshot
Pathogenic mycobacteria achieve cellular persistence by inhibiting the Niemann-Pick Type C disease cellular pathway
inferredcites →https://doi.org/10.1371/journal.pcbi.1000605openalex-snapshot
Annotation Error in Public Databases: Misannotation of Molecular Function in Enzyme Superfamilies
inferredcites →https://doi.org/10.1371/journal.pcbi.1002505openalex-snapshot
Insights into the Fold Organization of TIM Barrel from Interaction Energy Based Structure Networks
inferredcites →https://doi.org/10.1371/journal.pcbi.1004543openalex-snapshot
Integrated Modeling of Gene Regulatory and Metabolic Networks in Mycobacterium tuberculosis
inferredcites →https://doi.org/10.1371/journal.pgen.1005641openalex-snapshot
Leaderless Transcripts and Small Proteins Are Common Features of the Mycobacterial Translational Landscape
inferredcites →https://doi.org/10.1371/journal.pone.0015667openalex-snapshot
Simultaneous Analysis of Multiple Mycobacterium tuberculosis Knockdown Mutants In Vitro and In Vivo
inferredcites →https://doi.org/10.1371/journal.pone.0030593openalex-snapshot
Comparative Analysis of Mycobacterium tuberculosis pe and ppe Genes Reveals High Sequence Variation and an Apparent Absence of Selective Constraints
inferredcites →https://doi.org/10.1371/journal.pone.0034302openalex-snapshot
Annotation of the M. tuberculosis Hypothetical Orfeome: Adding Functional Information to More than Half of the Uncharacterized Proteins
inferredcites →https://doi.org/10.1371/journal.pone.0045741openalex-snapshot
Rhomboids of Mycobacteria: Characterization Using an aarA Mutant of Providencia stuartii and Gene Deletion in Mycobacterium smegmatis
inferredcites →https://doi.org/10.1371/journal.pone.0055320openalex-snapshot
The PE16 (Rv1430) of Mycobacterium tuberculosis Is an Esterase Belonging to Serine Hydrolase Superfamily of Proteins
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Mycobacterium tuberculosis WhiB3 Maintains Redox Homeostasis by Regulating Virulence Lipid Anabolism to Modulate Macrophage Response
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What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Creating an ignorance-base: Exploring known unknowns in the scientific literature
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Lectins ofMycobacterium tuberculosis– rarely studied proteins
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Drivers and sites of diversity in the DNA adenine methylomes of 93 Mycobacterium tuberculosis complex clinical isolates
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