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A macrophage-pericyte axis directs tissue restoration via Amphiregulin-induced TGFβ activation

https://doi.org/10.1101/367474
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Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/hep.22437openalex-snapshot
The epidermal growth factor receptor ligand amphiregulin participates in the development of mouse liver fibrosis†
inferredcites →https://doi.org/10.1002/stem.150190openalex-snapshot
TGF‐β Latency: Biological Significance and Mechanisms of Activation
inferredcites →https://doi.org/10.1007/b99966openalex-snapshot
Regenerative Capacity and the Developing Immune System
inferredcites →https://doi.org/10.1007/s10549-007-9748-8openalex-snapshot
Amphiregulin-EGFR signaling regulates PTHrP gene expression in breast cancer cells
inferredcites →https://doi.org/10.1016/0092-8674(95)90401-8openalex-snapshot
Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
inferredcites →https://doi.org/10.1016/j.bbadis.2012.10.005openalex-snapshot
Integrin-mediated regulation of TGFβ in fibrosis
inferredcites →https://doi.org/10.1016/j.cell.2012.02.042openalex-snapshot
The Pan-ErbB Negative Regulator Lrig1 Is an Intestinal Stem Cell Marker that Functions as a Tumor Suppressor
inferredcites →https://doi.org/10.1016/j.cell.2013.10.054openalex-snapshot
A Special Population of Regulatory T Cells Potentiates Muscle Repair
inferredcites →https://doi.org/10.1016/j.cell.2015.08.021openalex-snapshot
A Distinct Function of Regulatory T Cells in Tissue Protection
inferredcites →https://doi.org/10.1016/j.cell.2017.09.017openalex-snapshot
EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics
inferredcites →https://doi.org/10.1016/j.immuni.2012.09.023openalex-snapshot
Amphiregulin Enhances Regulatory T Cell-Suppressive Function via the Epidermal Growth Factor Receptor
inferredcites →https://doi.org/10.1016/j.immuni.2015.01.020openalex-snapshot
Emerging Functions of Amphiregulin in Orchestrating Immunity, Inflammation, and Tissue Repair
inferredcites →https://doi.org/10.1016/j.immuni.2017.09.013openalex-snapshot
Epidermal Growth Factor Receptor Expression Licenses Type-2 Helper T Cells to Function in a T Cell Receptor-Independent Fashion
inferredcites →https://doi.org/10.1016/j.semcdb.2014.01.005openalex-snapshot
Amphiregulin
inferredcites →https://doi.org/10.1016/j.semcdb.2016.08.006openalex-snapshot
Tissue-specific contribution of macrophages to wound healing
inferredcites →https://doi.org/10.1016/j.stem.2014.06.009openalex-snapshot
Immune Modulation of Stem Cells and Regeneration
inferredcites →https://doi.org/10.1016/j.stem.2016.11.001openalex-snapshot
Induced Quiescence of Lgr5+ Stem Cells in Intestinal Organoids Enables Differentiation of Hormone-Producing Enteroendocrine Cells
inferredcites →https://doi.org/10.1016/j.tcb.2005.09.002openalex-snapshot
Inflammatory cells during wound repair: the good, the bad and the ugly
inferredcites →https://doi.org/10.1016/s0092-8674(00)80545-0openalex-snapshot
A Mechanism for Regulating Pulmonary Inflammation and Fibrosis: The Integrin αvβ6 Binds and Activates Latent TGF β1
inferredcites →https://doi.org/10.1031/ni.2131openalex-snapshot
Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus.
inferredcites →https://doi.org/10.1038/35043051openalex-snapshot
How cells read TGF-β signals
inferredcites →https://doi.org/10.1038/nature12034openalex-snapshot
Macrophage biology in development, homeostasis and disease
inferredcites →https://doi.org/10.1038/ncb2464openalex-snapshot
Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling
inferredcites →https://doi.org/10.1038/ni.2131openalex-snapshot
Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus
inferredcites →https://doi.org/10.1038/ni.3005openalex-snapshot
Induction of the nuclear receptor PPAR-γ by the cytokine GM-CSF is critical for the differentiation of fetal monocytes into alveolar macrophages
inferredcites →https://doi.org/10.1038/ni.3023openalex-snapshot
Chitinase-like proteins promote IL-17-mediated neutrophilia in a tradeoff between nematode killing and host damage
inferredcites →https://doi.org/10.1038/nm.2628openalex-snapshot
An essential role for TH2-type responses in limiting acute tissue damage during experimental helminth infection
inferredcites →https://doi.org/10.1038/nm.3282openalex-snapshot
Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs
inferredcites →https://doi.org/10.1038/nrm2871openalex-snapshot
The final steps of integrin activation: the end game
inferredcites →https://doi.org/10.1042/bj20071505openalex-snapshot
EGF and amphiregulin differentially regulate Cbl recruitment to endosomes and EGF receptor fate
inferredcites →https://doi.org/10.1042/bj2880351openalex-snapshot
Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor
inferredcites →https://doi.org/10.1093/emboj/20.1.128openalex-snapshot
Epidermal growth factor signaling via Ras controls the Smad transcriptional co‐repressor TGIF
inferredcites →https://doi.org/10.1101/cshperspect.a021907openalex-snapshot
Regulation of the Bioavailability of TGF-β and TGF-β-Related Proteins
inferredcites →https://doi.org/10.1126/science.1133715openalex-snapshot
Amphiregulin, a T H 2 Cytokine Enhancing Resistance to Nematodes
inferredcites →https://doi.org/10.1126/science.1233632openalex-snapshot
Role of Tissue Protection in Lethal Respiratory Viral-Bacterial Coinfection
inferredcites →https://doi.org/10.1126/science.277.5323.242openalex-snapshot
Pericyte Loss and Microaneurysm Formation in PDGF-B-Deficient Mice
inferredcites →https://doi.org/10.1126/science.aaj2067openalex-snapshot
Local amplifiers of IL-4Rα–mediated macrophage activation promote repair in lung and liver
inferredcites →https://doi.org/10.1146/annurev.immunol.24.021605.090737openalex-snapshot
TRANSFORMING GROWTH FACTOR-β REGULATION OF IMMUNE RESPONSES
inferredcites →https://doi.org/10.1158/1078-0432.ccr-10-3338openalex-snapshot
Expression of Amphiregulin and EGFRvIII Affect Outcome of Patients with Squamous Cell Carcinoma of the Head and Neck Receiving Cetuximab–Docetaxel Treatment
inferredcites →https://doi.org/10.1159/000315380openalex-snapshot
Amphiregulin and Epiregulin Expression in Colorectal Carcinoma and the Correlation with Clinicopathological Characteristics
inferredcites →https://doi.org/10.1200/jco.2006.10.5437openalex-snapshot
Expression of Epiregulin and Amphiregulin and K-ras Mutation Status Predict Disease Control in Metastatic Colorectal Cancer Patients Treated With Cetuximab
inferredcites →https://doi.org/10.4049/jimmunol.1502218openalex-snapshot
Myeloid-Restricted AMPKα1 Promotes Host Immunity and Protects against IL-12/23p40–Dependent Lung Injury during Hookworm Infection
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