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Rho-mediated gene transcription promotes BRAF inhibitor resistance in de-differentiated melanoma cells

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1 of the 65 references listed on this page is in the Retraction Watch database as retracted (export 2026-11-04): 10.18632/oncotarget.22628 (notice 2025-12-31).

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1016/0014-5793(96)00811-3openalex-snapshot

ROCK‐I and ROCK‐II, two isoforms of Rho‐associated coiled‐coil forming protein serine/threonine kinase in mice

inferredcites →https://doi.org/10.1016/j.bmcl.2013.04.080openalex-snapshot

Optimization of novel nipecotic bis(amide) inhibitors of the Rho/MKL1/SRF transcriptional pathway as potential anti-metastasis agents

inferredcites →https://doi.org/10.1016/j.bmcl.2017.02.070openalex-snapshot

Pharmacokinetic optimitzation of CCG-203971: Novel inhibitors of the Rho/MRTF/SRF transcriptional pathway as potential antifibrotic therapeutics for systemic scleroderma

inferredcites →https://doi.org/10.1016/j.ccell.2014.11.018openalex-snapshot

Tunable-Combinatorial Mechanisms of Acquired Resistance Limit the Efficacy of BRAF/MEK Cotargeting but Result in Melanoma Drug Addiction

inferredcites →https://doi.org/10.1016/j.ccell.2018.03.017openalex-snapshot

Multi-stage Differentiation Defines Melanoma Subtypes with Differential Vulnerability to Drug-Induced Iron-Dependent Oxidative Stress

inferredcites →https://doi.org/10.1016/j.cell.2012.06.024openalex-snapshot

A Landscape of Driver Mutations in Melanoma

inferredcites →https://doi.org/10.1016/j.cell.2012.11.026openalex-snapshot

β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis

inferredcites →https://doi.org/10.1016/j.cell.2015.07.061openalex-snapshot

Non-genomic and Immune Evolution of Melanoma Acquiring MAPKi Resistance

inferredcites →https://doi.org/10.1016/j.cell.2018.05.061openalex-snapshot

Recovering Gene Interactions from Single-Cell Data Using Data Diffusion

inferredcites →https://doi.org/10.1016/j.ejca.2015.08.022openalex-snapshot

Acquired BRAF inhibitor resistance: A multicenter meta-analysis of the spectrum and frequencies, clinical behaviour, and phenotypic associations of resistance mechanisms

inferredcites →https://doi.org/10.1016/j.molcel.2008.11.002openalex-snapshot

Inhibition of PAX3 by TGF-β Modulates Melanocyte Viability

inferredcites →https://doi.org/10.1016/j.stem.2009.12.010openalex-snapshot

Key Roles for Transforming Growth Factor β in Melanocyte Stem Cell Maintenance

inferredcites →https://doi.org/10.1016/j.tcb.2006.09.008openalex-snapshot

Actin’ together: serum response factor, its cofactors and the link to signal transduction

inferredcites →https://doi.org/10.1021/acsptsci.8b00048openalex-snapshot

Identification of Pirin as a Molecular Target of the CCG-1423/CCG-203971 Series of Antifibrotic and Antimetastatic Compounds

inferredcites →https://doi.org/10.1038/35020106openalex-snapshot

Genomic analysis of metastasis reveals an essential role for RhoC

inferredcites →https://doi.org/10.1038/emboj.2008.235openalex-snapshot

Molecular basis for G‐actin binding to RPEL motifs from the serum response factor coactivator MAL

inferredcites →https://doi.org/10.1038/nature09626openalex-snapshot

Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation

inferredcites →https://doi.org/10.1038/nature10662openalex-snapshot

RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)

inferredcites →https://doi.org/10.1038/nature11814openalex-snapshot

Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance

inferredcites →https://doi.org/10.1038/nature13121openalex-snapshot

Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma

inferredcites →https://doi.org/10.1038/nature22794openalex-snapshot

Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance

inferredcites →https://doi.org/10.1038/ncb1833openalex-snapshot

Myocardin-related transcription factors and SRF are required for cytoskeletal dynamics and experimental metastasis

inferredcites →https://doi.org/10.1038/ncb3410openalex-snapshot

Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation

inferredcites →https://doi.org/10.1038/ncomms1727openalex-snapshot

Melanoma whole-exome sequencing identifies V600EB-RAF amplification-mediated acquired B-RAF inhibitor resistance

inferredcites →https://doi.org/10.1038/ng.3218openalex-snapshot

The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies

inferredcites →https://doi.org/10.1038/nrm.2016.67openalex-snapshot

Regulating Rho GTPases and their regulators

inferredcites →https://doi.org/10.1038/s41388-018-0301-5openalex-snapshot

YAP and MRTF-A, transcriptional co-activators of RhoA-mediated gene expression, are critical for glioblastoma tumorigenicity

inferredcites →https://doi.org/10.1038/sj.jid.5700211openalex-snapshot

RhoC Promotes Human Melanoma Invasion in a PI3K/Akt-Dependent Pathway

inferredcites →https://doi.org/10.1056/nejmoa1103782openalex-snapshot

Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation

inferredcites →https://doi.org/10.1056/nejmoa1408868openalex-snapshot

Combined Vemurafenib and Cobimetinib in BRAF -Mutated Melanoma

inferredcites →https://doi.org/10.1056/nejmoa1412690openalex-snapshot

Improved Overall Survival in Melanoma with Combined Dabrafenib and Trametinib

inferredcites →https://doi.org/10.1073/pnas.2536483100openalex-snapshot

TGF-β-induced RhoA and p160 ROCK activation is involved in the inhibition of Cdc25A with resultant cell-cycle arrest

inferredcites →https://doi.org/10.1074/jbc.271.38.23022openalex-snapshot

Identification of the Rho-binding Domain of p160 , a Rho-associated Coiled-coil Containing Protein Kinase

inferredcites →https://doi.org/10.1074/jbc.m003816200openalex-snapshot

Direct Regulation of the Microphthalmia Promoter by Sox10 Links Waardenburg-Shah Syndrome (WS4)-associated Hypopigmentation and Deafness to WS2

inferredcites →https://doi.org/10.1074/jbc.m113.518019openalex-snapshot

Phosphorylation of Angiomotin by Lats1/2 Kinases Inhibits F-actin Binding, Cell Migration, and Angiogenesis

inferredcites →https://doi.org/10.1074/jbc.ra118.004364openalex-snapshot

SRC tyrosine kinase activates the YAP/TAZ axis and thereby drives tumor growth and metastasis

inferredcites →https://doi.org/10.1083/jcb.144.6.1235openalex-snapshot

Rho GTPases Control Polarity, Protrusion, and Adhesion during Cell Movement

inferredcites →https://doi.org/10.1083/jcb.201011038openalex-snapshot

RhoA and RhoC have distinct roles in migration and invasion by acting through different targets

inferredcites →https://doi.org/10.1091/mbc.e13-11-0701openalex-snapshot

Angiomotins link F-actin architecture to Hippo pathway signaling

inferredcites →https://doi.org/10.1097/pai.0b013e318279bc0aopenalex-snapshot

SOX10 Expression in Malignant Melanoma, Carcinoma, and Normal Tissues

inferredcites →https://doi.org/10.1101/gad.239327.114openalex-snapshot

Rho-actin signaling to the MRTF coactivators dominates the immediate transcriptional response to serum in fibroblasts

inferredcites →https://doi.org/10.1101/gad.304501.117openalex-snapshot

Mutual dependence of the MRTF–SRF and YAP–TEAD pathways in cancer-associated fibroblasts is indirect and mediated by cytoskeletal dynamics

inferredcites →https://doi.org/10.1111/j.1755-148x.2010.00711.xopenalex-snapshot

Sox proteins in melanocyte development and melanoma

inferredcites →https://doi.org/10.1126/science.aad0501openalex-snapshot

Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

inferredcites →https://doi.org/10.1126/scisignal.2001750openalex-snapshot

Structure of a Pentavalent G-Actin•MRTF-A Complex Reveals How G-Actin Controls Nucleocytoplasmic Shuttling of a Transcriptional Coactivator

inferredcites →https://doi.org/10.1158/0008-5472.can-07-5424openalex-snapshot

TGFBR1*6A Enhances the Migration and Invasion of MCF-7 Breast Cancer Cells through RhoA Activation

inferredcites →https://doi.org/10.1158/0008-5472.can-17-0391openalex-snapshot

Src Inhibits the Hippo Tumor Suppressor Pathway through Tyrosine Phosphorylation of Lats1

inferredcites →https://doi.org/10.1158/1535-7163.mct-06-0689openalex-snapshot

Fasudil inhibits vascular endothelial growth factor–induced angiogenesisin vitroandin vivo

inferredcites →https://doi.org/10.1158/1535-7163.mct-16-0482openalex-snapshot

Pharmacological Inhibition of Myocardin-related Transcription Factor Pathway Blocks Lung Metastases of RhoC-Overexpressing Melanoma

inferredcites →https://doi.org/10.1158/2159-8290.cd-13-0424openalex-snapshot

A Melanoma Cell State Distinction Influences Sensitivity to MAPK Pathway Inhibitors

inferredcites →https://doi.org/10.1158/2159-8290.cd-13-0617openalex-snapshot

The Genetic Landscape of Clinical Resistance to RAF Inhibition in Metastatic Melanoma

inferredcites →https://doi.org/10.1158/2159-8290.cd-13-0642openalex-snapshot

Acquired Resistance and Clonal Evolution in Melanoma during BRAF Inhibitor Therapy

inferredcites →https://doi.org/10.1158/2159-8290.cd-17-0401openalex-snapshot

Recurrent Tumor Cell–Intrinsic and –Extrinsic Alterations during MAPKi-Induced Melanoma Regression and Early Adaptation

inferredcites →https://doi.org/10.1158/2159-8290.cd-17-0682openalex-snapshot

Exploiting Drug Addiction Mechanisms to Select against MAPKi-Resistant Melanoma

inferredcites →https://doi.org/10.1186/1476-4598-10-114openalex-snapshot

A switch in RND3-RHOA signaling is critical for melanoma cell invasion following mutant-BRAF inhibition

inferredcites →https://doi.org/10.1242/jcs.064964openalex-snapshot

Rho GTPases and their role in organizing the actin cytoskeleton

inferredcites →https://doi.org/10.1371/journal.pgen.1004877openalex-snapshot

Antagonistic Cross-Regulation between Sox9 and Sox10 Controls an Anti-tumorigenic Program in Melanoma

inferredcites →https://doi.org/10.15252/embj.201592081openalex-snapshot

Actin remodeling confers BRAF inhibitor resistance to melanoma cells through YAP/TAZ activation

inferredcites →https://doi.org/10.15252/msb.20166796openalex-snapshot

Adaptive resistance of melanoma cells to RAF inhibition via reversible induction of a slowly dividing de‐differentiated state

inferredcites →https://doi.org/10.18632/oncotarget.22628openalex-snapshot

Inhibition of YAP function overcomes BRAF inhibitor resistance in melanoma cancer stem cells

inferredcites →https://doi.org/10.18632/oncotarget.3888openalex-snapshot

The c-Jun/RHOB/AKT pathway confers resistance ofBRAF-mutant melanoma cells to MAPK inhibitors

inferredcites →https://doi.org/10.3892/or_00000708openalex-snapshot

Pharmacological inhibition of Rho-kinase signaling with Y-27632 blocks melanoma tumor growth

inferredcites →https://doi.org/10.4161/cam.5.2.14403openalex-snapshot

Dynamics of the Rho-family small GTPases in actin regulation and motility

inferredcites →https://doi.org/10.5114/aoms.2016.60655openalex-snapshot

SOX10-MITF pathway activity in melanoma cells

inferredcites →https://doi.org/10.5483/bmbrep.2018.51.3.012openalex-snapshot

Regulation of Hippo signaling by actin remodeling

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1016/j.omtn.2019.07.003openalex-snapshot

Genetic Interaction-Based Biomarkers Identification for Drug Resistance and Sensitivity in Cancer Cells

inferred← citeshttps://doi.org/10.3390/cancers13092012openalex-snapshot

Inhibition of the Myocardin-Related Transcription Factor Pathway Increases Efficacy of Trametinib in NRAS-Mutant Melanoma Cell Lines

inferred← citeshttps://doi.org/10.3390/ijms21010113openalex-snapshot

Characterization of Melanoma Cell Lines Resistant to Vemurafenib and Evaluation of Their Responsiveness to EGFR- and MET-Inhibitor Treatment

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