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Balancing dynamic tradeoffs drives cellular reprogramming

https://doi.org/10.1101/393934
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Three modes of repetitive firing and the role of threshold time course between spikes
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Ion Channels of Excitable Cells
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Target-Induced Transcriptional Control of Dendritic Patterning and Connectivity in Motor Neurons by the ETS Gene Pea3
inferredcites →https://doi.org/10.1016/j.cell.2012.09.045openalex-snapshot
Facilitators and Impediments of the Pluripotency Reprogramming Factors' Initial Engagement with the Genome
inferredcites →https://doi.org/10.1016/j.cell.2013.02.043openalex-snapshot
Epigenetics of Reprogramming to Induced Pluripotency
inferredcites →https://doi.org/10.1016/j.cell.2014.01.020openalex-snapshot
Nonstochastic Reprogramming from a Privileged Somatic Cell State
inferredcites →https://doi.org/10.1016/j.cell.2014.07.020openalex-snapshot
CellNet: Network Biology Applied to Stem Cell Engineering
inferredcites →https://doi.org/10.1016/j.cell.2014.07.021openalex-snapshot
Dissecting Engineered Cell Types and Enhancing Cell Fate Conversion via CellNet
inferredcites →https://doi.org/10.1016/j.celrep.2014.03.019openalex-snapshot
Intrinsic Membrane Hyperexcitability of Amyotrophic Lateral Sclerosis Patient-Derived Motor Neurons
inferredcites →https://doi.org/10.1016/j.celrep.2017.05.036openalex-snapshot
Global Hypertranscription in the Mouse Embryonic Germline
inferredcites →https://doi.org/10.1016/j.celrep.2018.04.105openalex-snapshot
Mitochondrial Aging Defects Emerge in Directly Reprogrammed Human Neurons due to Their Metabolic Profile
inferredcites →https://doi.org/10.1016/j.cub.2005.08.023openalex-snapshot
The Development of Neuronal Morphology in Insects
inferredcites →https://doi.org/10.1016/j.devcel.2016.11.010openalex-snapshot
Hypertranscription in Development, Stem Cells, and Regeneration
inferredcites →https://doi.org/10.1016/j.molcel.2012.09.008openalex-snapshot
Molecular Roadblocks for Cellular Reprogramming
inferredcites →https://doi.org/10.1016/j.stem.2009.09.012openalex-snapshot
A Small-Molecule Inhibitor of Tgf-β Signaling Replaces Sox2 in Reprogramming by Inducing Nanog
inferredcites →https://doi.org/10.1016/j.stem.2011.07.014openalex-snapshot
Conversion of Mouse and Human Fibroblasts into Functional Spinal Motor Neurons
inferredcites →https://doi.org/10.1016/j.stem.2015.09.001openalex-snapshot
Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects
inferredcites →https://doi.org/10.1038/nature08235openalex-snapshot
Suppression of induced pluripotent stem cell generation by the p53–p21 pathway
inferredcites →https://doi.org/10.1038/nature08287openalex-snapshot
A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity
inferredcites →https://doi.org/10.1038/nature08311openalex-snapshot
Linking the p53 tumour suppressor pathway to somatic cell reprogramming
inferredcites →https://doi.org/10.1038/nature08797openalex-snapshot
Direct conversion of fibroblasts to functional neurons by defined factors
inferredcites →https://doi.org/10.1038/nature12587openalex-snapshot
Deterministic direct reprogramming of somatic cells to pluripotency
inferredcites →https://doi.org/10.1038/nature18323openalex-snapshot
Dissecting direct reprogramming from fibroblast to neuron using single-cell RNA-seq
inferredcites →https://doi.org/10.1038/nbt.1502openalex-snapshot
Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2
inferredcites →https://doi.org/10.1038/nbt1418openalex-snapshot
Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds
inferredcites →https://doi.org/10.1038/ncomms13087openalex-snapshot
Increased global transcription activity as a mechanism of replication stress in cancer
inferredcites →https://doi.org/10.1038/ncomms3174openalex-snapshot
The p53–PUMA axis suppresses iPSC generation
inferredcites →https://doi.org/10.1038/nm.4490openalex-snapshot
Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons
inferredcites →https://doi.org/10.1038/nrm.2016.111openalex-snapshot
Roles of eukaryotic topoisomerases in transcription, replication and genomic stability
inferredcites →https://doi.org/10.1038/nrm831openalex-snapshot
Cellular roles of DNA topoisomerases: a molecular perspective
inferredcites →https://doi.org/10.1073/pnas.1105135108openalex-snapshot
Direct conversion of human fibroblasts to dopaminergic neurons
inferredcites →https://doi.org/10.1073/pnas.1310291110openalex-snapshot
Maturation, not initiation, is the major roadblock during reprogramming toward pluripotency from human fibroblasts
inferredcites →https://doi.org/10.1073/pnas.1702059115openalex-snapshot
Establishment of human pluripotent stem cell-derived pancreatic β-like cells in the mouse pancreas
inferredcites →https://doi.org/10.1074/jbc.275.9.6135openalex-snapshot
Regulation of Cloned Cardiac L-type Calcium Channels by cGMP-dependent Protein Kinase
inferredcites →https://doi.org/10.1093/hmg/ddq159openalex-snapshot
Pluripotent stem cells in neurodegenerative and neurodevelopmental diseases
inferredcites →https://doi.org/10.1101/gad.10.7.826openalex-snapshot
Tissue-specific inactivation of p53 tumor suppression in the mouse.
inferredcites →https://doi.org/10.1103/physreve.89.022710openalex-snapshot
Stability of bacterial toggle switches is enhanced by cell-cycle lengthening by several orders of magnitude
inferredcites →https://doi.org/10.1111/j.1469-7793.1999.0203r.xopenalex-snapshot
Specific distribution of sodium channels in axons of rat embryo spinal motoneurones
inferredcites →https://doi.org/10.1113/jphysiol.1980.sp013323openalex-snapshot
Voltage‐sensitive outward currents in cat motoneurones.
inferredcites →https://doi.org/10.1126/science.1240831openalex-snapshot
Positive Feedback Between PU.1 and the Cell Cycle Controls Myeloid Differentiation
inferredcites →https://doi.org/10.1161/circresaha.111.249235openalex-snapshot
Progress in the Reprogramming of Somatic Cells
inferredcites →https://doi.org/10.1242/dev.119149openalex-snapshot
Generation of sensory hair cells by genetic programming with a combination of transcription factors
inferredcites →https://doi.org/10.1371/journal.pone.0026406openalex-snapshot
Efficient Generation of iPS Cells from Skeletal Muscle Stem Cells
inferredcites →https://doi.org/10.1371/journal.pone.0040154openalex-snapshot
Maturation of Spinal Motor Neurons Derived from Human Embryonic Stem Cells
inferredcites →https://doi.org/10.1517/17460441.2.4.571openalex-snapshot
Gateway®recombinational cloning: a biological operating system
inferredcites →https://doi.org/10.1517/17460441.2015.1037737openalex-snapshot
Human pluripotent stem cells as tools for neurodegenerative and neurodevelopmental disease modeling and drug discovery
inferredcites →https://doi.org/10.15252/embr.201540717openalex-snapshot
Myc coordinates transcription and translation to enhance transformation and suppress invasiveness
inferredcites →https://doi.org/10.3389/fnmol.2017.00359openalex-snapshot
Direct Reprogramming Rather than iPSC-Based Reprogramming Maintains Aging Hallmarks in Human Motor Neurons

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Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1038/s41586-018-0744-4openalex-snapshot
Single-cell mapping of lineage and identity in direct reprogramming
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