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System-wide identification and prioritization of enzyme substrates by thermal analysis (SIESTA)
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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A Microarray Strategy for Mapping the Substrate Specificity of Protein Tyrosine Phosphatase
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OPLS discriminant analysis: combining the strengths of PLS‐DA and SIMCA classification
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Variable influence on projection (VIP) for orthogonal projections to latent structures (OPLS)
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New use for CETSA: monitoring innate immune receptor stability via post-translational modification by OGT
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Current technologies to identify protein kinase substrates in high throughput
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Focus on mammalian thioredoxin reductases — Important selenoproteins with versatile functions
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A Systematic Screen for CDK4/6 Substrates Links FOXM1 Phosphorylation to Senescence Suppression in Cancer Cells
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Pervasive Protein Thermal Stability Variation during the Cell Cycle
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Modulation of Protein-Interaction States through the Cell Cycle
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Identifying Family-Member-Specific Targets of Mono-ARTDs by Using a Chemical Genetics Approach
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Characterization of human thioredoxin‐like‐1: Potential involvement in the cellular response against glucose deprivation
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Substrate-Induced Conformational Changes Occur in All Cleaved Forms of Caspase-6
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Substrate-Assisted Catalysis by PARP10 Limits Its Activity to Mono-ADP-Ribosylation
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Bcl3 Phosphorylation by Akt, Erk2, and IKK Is Required for Its Transcriptional Activity
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Monitoring structural modulation of redox-sensitive proteins in cells with MS-CETSA
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The thioredoxin and glutaredoxin systems are efficient electron donors to human plasma glutathione peroxidase.
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Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors
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Glycosylation May Reduce Protein Thermodynamic Stability by Inducing a Conformational Distortion
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Proteome Integral Solubility Alteration: A High-Throughput Proteomics Assay for Target Deconvolution
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Deamidation, but Not Truncation, Decreases the Urea Stability of a Lens Structural Protein, βB1-Crystallin
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Deamidation Alters the Structure and Decreases the Stability of Human Lens βΑ3-Crystallin
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Context-Dependent Effects of Asparagine Glycosylation on Pin WW Folding Kinetics and Thermodynamics
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Engineering the Substrate Specificity of ADP-Ribosyltransferases for Identifying Direct Protein Targets
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Targets of the cyclin-dependent kinase Cdk1
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MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification
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ProteomeXchange provides globally coordinated proteomics data submission and dissemination
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Proteomic analysis of post-translational modifications
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The intrinsic and extrinsic effects of N-linked glycans on glycoproteostasis
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Proteome-wide identification of the endogenous ADP-ribosylome of mammalian cells and tissue
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Activation of diverse signalling pathways by oncogenic PIK3CA mutations
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Thermal proteome profiling monitors ligand interactions with cellular membrane proteins
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Thermal proteome profiling for unbiased identification of direct and indirect drug targets using multiplexed quantitative mass spectrometry
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Proteome-wide solubility and thermal stability profiling reveals distinct regulatory roles for ATP
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ProTargetMiner as a proteome signature library of anticancer molecules for functional discovery
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The functional landscape of the human phosphoproteome
inferredcites →https://doi.org/10.1038/s41592-019-0499-3openalex-snapshot
High throughput discovery of functional protein modifications by Hotspot Thermal Profiling
inferredcites →https://doi.org/10.1038/srep11176openalex-snapshot
Functional Identification of Target by Expression Proteomics (FITExP) reveals protein targets and highlights mechanisms of action of small molecule drugs
inferredcites →https://doi.org/10.1038/srep37610openalex-snapshot
Transition steps in peroxide reduction and a molecular switch for peroxide robustness of prokaryotic peroxiredoxins
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Physiological functions of thioredoxin and thioredoxin reductase
inferredcites →https://doi.org/10.1073/pnas.0801340105openalex-snapshot
Effect of glycosylation on protein folding: A close look at thermodynamic stabilization
inferredcites →https://doi.org/10.1073/pnas.1317320111openalex-snapshot
Thioredoxin-related protein of 14 kDa is an efficient L-cystine reductase and S-denitrosylase
inferredcites →https://doi.org/10.1073/pnas.1408472111openalex-snapshot
Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates
inferredcites →https://doi.org/10.1073/pnas.94.5.1680openalex-snapshot
Development of “substrate-trapping” mutants to identify physiological substrates of protein tyrosine phosphatases
inferredcites →https://doi.org/10.1074/jbc.275.13.9542openalex-snapshot
Identification and Characterization of a Dimerization Domain in CED-6, an Adapter Protein Involved in Engulfment of Apoptotic Cells
inferredcites →https://doi.org/10.1074/jbc.h118.001591openalex-snapshot
Chaperone substrate provides missing link for cancer drug discovery
inferredcites →https://doi.org/10.1074/jbc.m117.776310openalex-snapshot
Selenocysteine Insertion at a Predefined UAG Codon in a Release Factor 1 (RF1)-depleted Escherichia coli Host Strain Bypasses Species Barriers in Recombinant Selenoprotein Translation
inferredcites →https://doi.org/10.1074/jbc.m207342200openalex-snapshot
Post-translational Modification of Bone Morphogenetic Protein-1 Is Required for Secretion and Stability of the Protein
inferredcites →https://doi.org/10.1074/mcp.m500007-mcp200openalex-snapshot
High Throughput Identification of Potential Arabidopsis Mitogen-activated Protein Kinases Substrates
inferredcites →https://doi.org/10.1083/jcb.201412008openalex-snapshot
Kinase-interacting substrate screening is a novel method to identify kinase substrates
inferredcites →https://doi.org/10.1093/nar/gkr1122openalex-snapshot
PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse
inferredcites →https://doi.org/10.1093/nar/gkw937openalex-snapshot
The STRING database in 2017: quality-controlled protein–protein association networks, made broadly accessible
inferredcites →https://doi.org/10.1093/nar/gkw952openalex-snapshot
BRENDA in 2017: new perspectives and new tools in BRENDA
inferredcites →https://doi.org/10.1111/febs.12124openalex-snapshot
Caspase‐dependent cleavage of the mono‐ ADP ‐ribosyltransferase ARTD 10 interferes with its pro‐apoptotic function
inferredcites →https://doi.org/10.1126/science.1140321openalex-snapshot
ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage
inferredcites →https://doi.org/10.1126/science.1160462openalex-snapshot
Identification of SCF Ubiquitin Ligase Substrates by Global Protein Stability Profiling
inferredcites →https://doi.org/10.1126/science.1198461openalex-snapshot
Protein Native-State Stabilization by Placing Aromatic Side Chains in N-Glycosylated Reverse Turns
inferredcites →https://doi.org/10.1126/science.1233606openalex-snapshot
Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay
inferredcites →https://doi.org/10.1126/science.1255784openalex-snapshot
Tracking cancer drugs in living cells by thermal profiling of the proteome
inferredcites →https://doi.org/10.1126/scisignal.2005882openalex-snapshot
A systems-wide screen identifies substrates of the SCF βTrCP ubiquitin ligase
inferredcites →https://doi.org/10.1155/2017/8475125openalex-snapshot
Cell Signaling with Extracellular Thioredoxin and Thioredoxin‐Like Proteins: Insight into Their Mechanisms of Action
inferredcites →https://doi.org/10.1186/gb-2004-6-1-r2openalex-snapshot
Computational prediction of human metabolic pathways from the complete human genome
inferredcites →https://doi.org/10.1371/journal.pone.0079795openalex-snapshot
Lysosomal Interaction of Akt with Phafin2: A Critical Step in the Induction of Autophagy
inferredcites →https://doi.org/10.21203/rs.2.10602/v1openalex-snapshot
Discovery and Interrogation of Functional Protein Modifications by Hotspot Thermal Profiling
inferredcites →https://doi.org/10.3390/challe9010022openalex-snapshot
ARTD10/PARP10 Induces ADP-Ribosylation of GAPDH and Recruits GAPDH into Cytosolic Membrane-Free Cell Bodies When Overexpressed in Mammalian Cells
inferredcites →https://doi.org/10.7554/elife.12813openalex-snapshot
Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1016/j.bmc.2019.115174openalex-snapshot
Mass spectrometry-based Cellular Thermal Shift Assay (CETSA®) for target deconvolution in phenotypic drug discovery
inferred← citeshttps://doi.org/10.1021/acs.jproteome.0c00425openalex-snapshot
COVID-19: Nanomedicine Uncovers Blood-Clot Mystery
inferred← citeshttps://doi.org/10.1038/s42003-021-02306-8openalex-snapshot
A Bayesian semi-parametric model for thermal proteome profiling
inferred← citeshttps://doi.org/10.1074/jbc.ra120.014576openalex-snapshot
Mutant thermal proteome profiling for characterization of missense protein variants and their associated phenotypes within the proteome
inferred← citeshttps://doi.org/10.15252/msb.20199232openalex-snapshot
Thermal proteome profiling for interrogating protein interactions
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