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Exosome Release Promotes Inflammatory Resolution in Activated and Aged Microglia

https://doi.org/10.1101/423558
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/0471143030.cb0322s30openalex-snapshot
Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids
inferredcites →https://doi.org/10.1002/ana.24304openalex-snapshot
Targeting mi R ‐155 restores abnormal microglia and attenuates disease in SOD 1 mice
inferredcites →https://doi.org/10.1002/glia.20468openalex-snapshot
Microglia derived from aging mice exhibit an altered inflammatory profile
inferredcites →https://doi.org/10.1002/glia.22363openalex-snapshot
MicroRNAs are universal regulators of differentiation, activation, and polarization of microglia and macrophages in normal and diseased CNS
inferredcites →https://doi.org/10.1007/s00247-002-0752-1openalex-snapshot
Neuroimaging abnormalities in Griscelli's disease
inferredcites →https://doi.org/10.1016/j.bcp.2014.01.008openalex-snapshot
Microglial dysfunction in brain aging and Alzheimer's disease
inferredcites →https://doi.org/10.1016/j.celrep.2014.07.035openalex-snapshot
Endogenous RNAs Modulate MicroRNA Sorting to Exosomes and Transfer to Acceptor Cells
inferredcites →https://doi.org/10.1016/j.neuron.2013.06.046openalex-snapshot
Microglial Beclin 1 Regulates Retromer Trafficking and Phagocytosis and Is Impaired in Alzheimer’s Disease
inferredcites →https://doi.org/10.1016/s0165-5728(98)00217-3openalex-snapshot
Increased interleukin-6 expression by microglia from brain of aged mice
inferredcites →https://doi.org/10.1038/76024openalex-snapshot
Mutations in RAB27A cause Griscelli syndrome associated with haemophagocytic syndrome
inferredcites →https://doi.org/10.1038/nature10357openalex-snapshot
The ageing systemic milieu negatively regulates neurogenesis and cognitive function
inferredcites →https://doi.org/10.1038/ncb1929openalex-snapshot
Multivesicular bodies associate with components of miRNA effector complexes and modulate miRNA activity
inferredcites →https://doi.org/10.1038/ncb1930openalex-snapshot
Silencing by small RNAs is linked to endosomal trafficking
inferredcites →https://doi.org/10.1038/ncb2000openalex-snapshot
Rab27a and Rab27b control different steps of the exosome secretion pathway
inferredcites →https://doi.org/10.1038/nn.2923openalex-snapshot
Heterogeneity of CNS myeloid cells and their roles in neurodegeneration
inferredcites →https://doi.org/10.1038/nn.3554openalex-snapshot
The microglial sensome revealed by direct RNA sequencing
inferredcites →https://doi.org/10.1038/nn.4222openalex-snapshot
Microglial brain region−dependent diversity and selective regional sensitivities to aging
inferredcites →https://doi.org/10.1038/nri3622openalex-snapshot
Regulation of immune responses by extracellular vesicles
inferredcites →https://doi.org/10.1038/s41593-018-0145-xopenalex-snapshot
Microglial immune checkpoint mechanisms
inferredcites →https://doi.org/10.1073/pnas.1521230113openalex-snapshot
Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes
inferredcites →https://doi.org/10.1074/jbc.m111.293696openalex-snapshot
NADPH Oxidase Is Internalized by Clathrin-coated Pits and Localizes to a Rab27A/B GTPase-regulated Secretory Compartment in Activated Macrophages
inferredcites →https://doi.org/10.1074/jbc.m112.404467openalex-snapshot
The Exosome Secretory Pathway Transports Amyloid Precursor Protein Carboxyl-terminal Fragments from the Cell into the Brain Extracellular Space
inferredcites →https://doi.org/10.1101/cshperspect.a016857openalex-snapshot
The Complex Ultrastructure of the Endolysosomal System
inferredcites →https://doi.org/10.1111/cen3.12307openalex-snapshot
Microglia communication: Parallels between aging and Alzheimer's disease
inferredcites →https://doi.org/10.1126/science.1110647openalex-snapshot
Resting Microglial Cells Are Highly Dynamic Surveillants of Brain Parenchyma in Vivo
inferredcites →https://doi.org/10.1126/science.1153124openalex-snapshot
Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes
inferredcites →https://doi.org/10.1126/science.1252945openalex-snapshot
Aging-induced type I interferon response at the choroid plexus negatively affects brain function
inferredcites →https://doi.org/10.1126/science.aad8670openalex-snapshot
Microglia development follows a stepwise program to regulate brain homeostasis
inferredcites →https://doi.org/10.1146/annurev-immunol-041015-055700openalex-snapshot
Antigen Presentation by Extracellular Vesicles from Professional Antigen-Presenting Cells
inferredcites →https://doi.org/10.1152/physrev.00011.2010openalex-snapshot
Physiology of Microglia
inferredcites →https://doi.org/10.1242/jcs.074088openalex-snapshot
Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis
inferredcites →https://doi.org/10.1371/journal.pbio.1001604openalex-snapshot
Neurotransmitter-Triggered Transfer of Exosomes Mediates Oligodendrocyte–Neuron Communication
inferredcites →https://doi.org/10.1371/journal.pone.0159724openalex-snapshot
Control of the Inflammatory Macrophage Transcriptional Signature by miR-155
inferredcites →https://doi.org/10.3389/fncel.2013.00022openalex-snapshot
Microglial aging in the healthy CNS: phenotypes, drivers, and rejuvenation
inferredcites →https://doi.org/10.4049/jimmunol.1000491openalex-snapshot
Inducible microRNA-155 Feedback Promotes Type I IFN Signaling in Antiviral Innate Immunity by Targeting Suppressor of Cytokine Signaling 1
inferredcites →https://doi.org/10.4049/jimmunol.175.4.2237openalex-snapshot
Proteomic Analysis of Microglia-Derived Exosomes: Metabolic Role of the Aminopeptidase CD13 in Neuropeptide Catabolism

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1007/s00441-023-03853-8openalex-snapshot
Current methods for the microglia isolation: Overview and comparative analysis of approaches
inferred← citeshttps://doi.org/10.1007/s12264-026-01612-7openalex-snapshot
Life Cycle and Circadian Rhythms in Central Resident Immunity and Neuropsychiatric Pathology
inferred← citeshttps://doi.org/10.1016/j.nbd.2021.105431openalex-snapshot
Neonatal stroke enhances interaction of microglia-derived extracellular vesicles with microglial cells
inferred← citeshttps://doi.org/10.1038/s41386-019-0579-1openalex-snapshot
Exosomal secretion of a psychosis-altered miRNA that regulates glutamate receptor expression is affected by antipsychotics
inferred← citeshttps://doi.org/10.1186/s13024-021-00440-9openalex-snapshot
Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model
inferred← citeshttps://doi.org/10.3390/biom12070957openalex-snapshot
Exosomes in Alpha-Synucleinopathies: Propagators of Pathology or Potential Candidates for Nanotherapeutics?
inferred← citeshttps://doi.org/10.3390/cells10051138openalex-snapshot
Microglia in Aging and Alzheimer’s Disease: A Comparative Species Review
inferred← citeshttps://doi.org/10.3390/jcm9061941openalex-snapshot
Glia-Derived Extracellular Vesicles in Parkinson’s Disease
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