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Experimental and Computational Evidence for Self-Assembly of Mitochondrial UCP2 in Lipid Bilayers

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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THE weighted histogram analysis method for free‐energy calculations on biomolecules. I. The method
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Statistical analysis of amino acid patterns in transmembrane helices: the GxxxG motif occurs frequently and in association with β-branched residues at neighboring positions
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The GxxxG motif: A framework for transmembrane helix-helix association
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UCP2, a mitochondrial protein regulated at multiple levels
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Mechanics of water pore formation in lipid membrane under electric field
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A simplification of the protein assay method of Lowry et al. which is more generally applicable
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Reconstitution of membrane proteins into liposomes: application to energy-transducing membrane proteins
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The uncoupling protein from brown adipose tissue mitochondria is a dimer. A hydrodynamic study
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Nonphysical sampling distributions in Monte Carlo free-energy estimation: Umbrella sampling
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Synthesis and in situ insertion of a site-specific fluorescently labeled membrane protein into cell-sized liposomes
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Transmembrane helix dimerization: Beyond the search for sequence motifs
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Gating Charge Calculations by Computational Electrophysiology Simulations
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Conformational Coupling across the Plasma Membrane in Activation of the EGF Receptor
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Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins
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Side-chain Contributions to Membrane Protein Structure and Stability
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Protein production by auto-induction in high-density shaking cultures
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Upregulation of UCP2 in beta-cells confers partial protection against both oxidative stress and glucotoxicity
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GROMACS: High performance molecular simulations through multi-level parallelism from laptops to supercomputers
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The role of lipids in defining membrane protein interactions: insights from mass spectrometry
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The power of two: protein dimerization in biology
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Lipids Can Make Them Stick Together
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Aquaporin water channels: molecular mechanisms for human diseases1
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Selectivity and conductance among the glycerol and water conducting aquaporin family of channels
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Perturbations of Native Membrane Protein Structure in Alkyl Phosphocholine Detergents: A Critical Assessment of NMR and Biophysical Studies
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CHARMM-GUI Input Generator for NAMD, GROMACS, AMBER, OpenMM, and CHARMM/OpenMM Simulations Using the CHARMM36 Additive Force Field
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Lipid-Dependent Alternating Access Mechanism of a Bacterial Multidrug ABC Exporter
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pH-Dependent Tetramerization and Amantadine Binding of the Transmembrane Helix of M2 from the Influenza A Virus
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Membrane protein folding and oligomerization: the two-stage model
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Characteristics of the isolated purine nucleotide binding protein from brown fat mitochondria
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Computed circular dichroism spectra for the evaluation of protein conformation
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Toward Understanding the Mechanism of Ion Transport Activity of Neuronal Uncoupling Proteins UCP2, UCP4, and UCP5
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H+ Transport by Uncoupling Protein (UCP-1) Is Dependent on a Histidine Pair, Absent in UCP-2 and UCP-3
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From Coarse Grained to Atomistic: A Serial Multiscale Approach to Membrane Protein Simulations
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Assessment of Common Simulation Protocols for Simulations of Nanopores, Membrane Proteins, and Channels
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193 nm Ultraviolet Photodissociation Mass Spectrometry of Tetrameric Protein Complexes Provides Insight into Quaternary and Secondary Protein Topology
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Molecular Dynamics Simulations of the Bacterial ABC Transporter SAV1866 in the Closed Form
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CHARMM36 United Atom Chain Model for Lipids and Surfactants
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inferredcites →https://doi.org/10.1038/415096aopenalex-snapshot
Superoxide activates mitochondrial uncoupling proteins
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Structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside
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Mitochondrial uncoupling protein 2 structure determined by NMR molecular fragment searching
inferredcites →https://doi.org/10.1038/nature20820openalex-snapshot
The role of interfacial lipids in stabilizing membrane protein oligomers
inferredcites →https://doi.org/10.1038/ncb1556openalex-snapshot
Uncoupling proteins 2 and 3 are fundamental for mitochondrial Ca2+ uniport
inferredcites →https://doi.org/10.1038/nmeth.4067openalex-snapshot
CHARMM36m: an improved force field for folded and intrinsically disordered proteins
inferredcites →https://doi.org/10.1038/nrm1592openalex-snapshot
The mitochondrial uncoupling-protein homologues
inferredcites →https://doi.org/10.1038/nrm4080openalex-snapshot
The systematic analysis of protein–lipid interactions comes of age
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inferredcites →https://doi.org/10.1042/bsr20150130openalex-snapshot
A biophysical study on molecular physiology of the uncoupling proteins of the central nervous system
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inferredcites →https://doi.org/10.1073/pnas.1317400111openalex-snapshot
UCP2 transports C4 metabolites out of mitochondria, regulating glucose and glutamine oxidation
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Uncoupling protein 1 binds one nucleotide per monomer and is stabilized by tightly bound cardiolipin
inferredcites →https://doi.org/10.1074/jbc.274.37.26003openalex-snapshot
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Lipid, Detergent, and Coomassie Blue G-250 Affect the Migration of Small Membrane Proteins in Blue Native Gels
inferredcites →https://doi.org/10.1074/jbc.m113.509935openalex-snapshot
Expression, Folding, and Proton Transport Activity of Human Uncoupling Protein-1 (UCP1) in Lipid Membranes
inferredcites →https://doi.org/10.1074/jbc.m212850200openalex-snapshot
Activating ω-6 Polyunsaturated Fatty Acids and Inhibitory Purine Nucleotides Are High Affinity Ligands for Novel Mitochondrial Uncoupling Proteins UCP2 and UCP3
inferredcites →https://doi.org/10.1074/jbc.m414489200openalex-snapshot
Crystal Structure of Mycobacterium tuberculosis D-3-Phosphoglycerate Dehydrogenase
inferredcites →https://doi.org/10.1083/jcb.200311074openalex-snapshot
atToc159 is a selective transit peptide receptor for the import of nucleus-encoded chloroplast proteins
inferredcites →https://doi.org/10.1088/1478-3975/3/4/001openalex-snapshot
Nanopore-facilitated, voltage-driven phosphatidylserine translocation in lipid bilayers—in cells andin silico
inferredcites →https://doi.org/10.1089/ars.2017.7225openalex-snapshot
Mitochondrial Uncoupling Proteins: Subtle Regulators of Cellular Redox SignalingReviewing Editors: Jerzy Beltowski, Joseph Burgoyne, Gabor Csanyi, Sergey Dikalov, Frank Krause, Anibal Vercesi, and Jeremy Ward
inferredcites →https://doi.org/10.1093/emboj/cdg412openalex-snapshot
A signalling role for 4‐hydroxy‐2‐nonenal in regulation of mitochondrial uncoupling
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Canonical dynamics: Equilibrium phase-space distributions
inferredcites →https://doi.org/10.1111/j.1432-1033.1989.tb14622.xopenalex-snapshot
The uncoupling protein dimer can form a disulfide cross‐link between the mobile C‐terminal SH groups
inferredcites →https://doi.org/10.1111/j.1471-4159.2008.05383.xopenalex-snapshot
Lipidomic analysis and electron transport chain activities in C57BL/6J mouse brain mitochondria
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Direct integration of cell‐free‐synthesized connexin‐43 into liposomes and hemichannel formation
inferredcites →https://doi.org/10.1214/aos/1176344552openalex-snapshot
Bootstrap Methods: Another Look at the Jackknife
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Cellular Model of Warburg Effect Identifies Tumor Promoting Function of UCP2 in Breast Cancer and Its Suppression by Genipin
inferredcites →https://doi.org/10.1371/journal.pone.0030714openalex-snapshot
UCP2 Inhibits ROS-Mediated Apoptosis in A549 under Hypoxic Conditions
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Mitochondrial uncoupling protein 2 is up-regulated in human head and neck, skin, pancreatic, and prostate tumors
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Mitochondrial uncoupling protein 2 expression in colon cancer and its clinical significance

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Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1021/acschemneuro.0c00694openalex-snapshot
Polyunsaturated Fatty Acid Modulates Membrane-Bound Monomeric α-Synuclein by Modulating Membrane Microenvironment through Preferential Interactions
inferred← citeshttps://doi.org/10.1126/science.aax3102openalex-snapshot
Response to Comment on “Protein assemblies ejected directly from native membranes yield complexes for mass spectrometry”
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