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Minimal phenotyping yields GWAS hits of reduced specificity for major depression

https://doi.org/10.1101/440735
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1 of the 81 references listed on this page is in the Retraction Watch database as retracted (export 2026-11-04): 10.1192/bjo.2018.12 (notice 2019-06-17).

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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National Trends in the Treatment for Depression From 1998 to 2007
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Long-term Reliability of Diagnosing Lifetime Major Depression in a Community Sample
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Stability of Psychiatric Diagnoses
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A Longitudinal Twin Study of Personality and Major Depression in Women
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The Lifetime History of Major Depression in Women
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Lifetime Prevalence and Age-of-Onset Distributions of DSM-IV Disorders in the National Comorbidity Survey Replication
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Personality and Major Depression
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Understanding Mental Health Treatment in Persons Without Mental Diagnoses
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The Epidemiology of Major Depressive Disorder
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Quantifying between‐cohort and between‐sex genetic heterogeneity in major depressive disorder
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The World Mental Health (WMH) Survey Initiative version of the World Health Organization (WHO) Composite International Diagnostic Interview (CIDI)
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Genetics of Depression: Progress at Last
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Depressive symptoms, major depression, and generalized anxiety: A comparison of self-reports on CES-D and results from diagnostic interviews
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Long-Range LD Can Confound Genome Scans in Admixed Populations
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Contrasting the Genetic Architecture of 30 Complex Traits from Summary Association Data
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Local Genetic Correlation Gives Insights into the Shared Genetic Architecture of Complex Traits
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Estimating SNP-Based Heritability and Genetic Correlation in Case-Control Studies Directly and with Summary Statistics
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An Analysis of Two Genome-wide Association Meta-analyses Identifies a New Locus for Broad Depression Phenotype
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The Genetics of Major Depression
inferredcites →https://doi.org/10.1016/j.neuron.2019.03.022openalex-snapshot
Uncovering the Genetic Architecture of Major Depression
inferredcites →https://doi.org/10.1016/s0140-6736(09)60879-5openalex-snapshot
Clinical diagnosis of depression in primary care: a meta-analysis
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Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis
inferredcites →https://doi.org/10.1017/s0033291701003907openalex-snapshot
Genetic risk factors for major depression in men and women: similar or different heritabilities and same or partly distinct genes?
inferredcites →https://doi.org/10.1017/s0033291701004755openalex-snapshot
Genetic and environmental risk factors for depression assessed by subject-rated Symptom Check List versus Structured Clinical Interview
inferredcites →https://doi.org/10.1017/s003329171800377xopenalex-snapshot
Shared and specific genetic risk factors for lifetime major depression, depressive symptoms and neuroticism in three population-based twin samples
inferredcites →https://doi.org/10.1017/s0033291719002678openalex-snapshot
Evidence for causal effects of lifetime smoking on risk for depression and schizophrenia: a Mendelian randomisation study
inferredcites →https://doi.org/10.1017/s0033291797004716openalex-snapshot
Stressful life events and genetic liability to major depression: genetic control of exposure to the environment?
inferredcites →https://doi.org/10.1017/s0264180100000813openalex-snapshot
A model of stability and change in minor psychiatric symptoms: results from three longitudinal studies
inferredcites →https://doi.org/10.1038/mp.2012.21openalex-snapshot
A mega-analysis of genome-wide association studies for major depressive disorder
inferredcites →https://doi.org/10.1038/nature11632openalex-snapshot
An integrated map of genetic variation from 1,092 human genomes
inferredcites →https://doi.org/10.1038/nature13595openalex-snapshot
Biological insights from 108 schizophrenia-associated genetic loci
inferredcites →https://doi.org/10.1038/nature14659openalex-snapshot
Sparse whole-genome sequencing identifies two loci for major depressive disorder
inferredcites →https://doi.org/10.1038/nature15393openalex-snapshot
A global reference for human genetic variation
inferredcites →https://doi.org/10.1038/ng.2653openalex-snapshot
The Genotype-Tissue Expression (GTEx) project
inferredcites →https://doi.org/10.1038/ng.2742openalex-snapshot
Genome-wide association analysis identifies 13 new risk loci for schizophrenia
inferredcites →https://doi.org/10.1038/ng.3211openalex-snapshot
LD Score regression distinguishes confounding from polygenicity in genome-wide association studies
inferredcites →https://doi.org/10.1038/ng.3404openalex-snapshot
Partitioning heritability by functional annotation using genome-wide association summary statistics
inferredcites →https://doi.org/10.1038/ng.3406openalex-snapshot
An atlas of genetic correlations across human diseases and traits
inferredcites →https://doi.org/10.1038/ng.3431openalex-snapshot
Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance-components analysis
inferredcites →https://doi.org/10.1038/ng.3552openalex-snapshot
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
inferredcites →https://doi.org/10.1038/ng.3623openalex-snapshot
Identification of 15 genetic loci associated with risk of major depression in individuals of European descent
inferredcites →https://doi.org/10.1038/ng.3643openalex-snapshot
A reference panel of 64,976 haplotypes for genotype imputation
inferredcites →https://doi.org/10.1038/ng.943openalex-snapshot
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4
inferredcites →https://doi.org/10.1038/s41467-018-03819-3openalex-snapshot
Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways
inferredcites →https://doi.org/10.1038/s41576-018-0078-yopenalex-snapshot
Integrating behavioural health tracking in human genetics research
inferredcites →https://doi.org/10.1038/s41588-017-0009-4openalex-snapshot
Multi-trait analysis of genome-wide association summary statistics using MTAG
inferredcites →https://doi.org/10.1038/s41588-018-0081-4openalex-snapshot
Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types
inferredcites →https://doi.org/10.1038/s41588-018-0090-3openalex-snapshot
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
inferredcites →https://doi.org/10.1038/tp.2017.99openalex-snapshot
A continuum of genetic liability for minor and major depression
inferredcites →https://doi.org/10.1073/pnas.1419064111openalex-snapshot
Measuring missing heritability: Inferring the contribution of common variants
inferredcites →https://doi.org/10.1093/aje/kwf182openalex-snapshot
Socioeconomic Inequalities in Depression: A Meta-Analysis
inferredcites →https://doi.org/10.1093/aje/kwx246openalex-snapshot
Comparison of Sociodemographic and Health-Related Characteristics of UK Biobank Participants With Those of the General Population
inferredcites →https://doi.org/10.1093/bioinformatics/btq340openalex-snapshot
METAL: fast and efficient meta-analysis of genomewide association scans
inferredcites →https://doi.org/10.1093/bioinformatics/btv546openalex-snapshot
Approximately independent linkage disequilibrium blocks in human populations
inferredcites →https://doi.org/10.1093/bioinformatics/btz633openalex-snapshot
RICOPILI: Rapid Imputation for COnsortias PIpeLIne
inferredcites →https://doi.org/10.1093/genetics/35.2.212openalex-snapshot
HERITABILITY OF THRESHOLD CHARACTERS
inferredcites →https://doi.org/10.1093/ije/dyz134openalex-snapshot
Factors associated with sharing e-mail information and mental health survey participation in large population cohorts
inferredcites →https://doi.org/10.1093/ntr/ntw140openalex-snapshot
The Association of Cigarette Smoking With Depression and Anxiety: A Systematic Review
inferredcites →https://doi.org/10.1097/00005053-198603000-00004openalex-snapshot
Evaluation of Symptoms of Major Depressive Disorder
inferredcites →https://doi.org/10.1101/166298openalex-snapshot
Genome-wide genetic data on ~500,000 UK Biobank participants
inferredcites →https://doi.org/10.1111/j.1468-2850.1998.tb00151.xopenalex-snapshot
Life stressors as risk factors in depression.
inferredcites →https://doi.org/10.1111/j.1600-0447.1978.tb06888.xopenalex-snapshot
Rates and risks of depressive symptoms in a United States urban community
inferredcites →https://doi.org/10.1126/science.aap8757openalex-snapshot
Analysis of shared heritability in common disorders of the brain
inferredcites →https://doi.org/10.1146/annurev.psych.48.1.191openalex-snapshot
THE EFFECTS OF STRESSFUL LIFE EVENTS ON DEPRESSION
inferredcites →https://doi.org/10.1159/000085146openalex-snapshot
Increased Recognition of Depression in Primary Care
inferredcites →https://doi.org/10.1159/000345968openalex-snapshot
Clinician-Identified Depression in Community Settings: Concordance with Structured-Interview Diagnoses
inferredcites →https://doi.org/10.1176/ajp.136.6.815openalex-snapshot
DSM-III field trials: I. Initial interrater diagnostic reliability
inferredcites →https://doi.org/10.1176/ajp.152.6.843openalex-snapshot
Results of the DSM-IV mood disorders field trial
inferredcites →https://doi.org/10.1176/ajp.152.7.1026openalex-snapshot
Social consequences of psychiatric disorders, I: Educational attainment
inferredcites →https://doi.org/10.1176/appi.ajp.163.1.109openalex-snapshot
A Swedish National Twin Study of Lifetime Major Depression
inferredcites →https://doi.org/10.1176/appi.ajp.2012.12070998openalex-snapshot
DSM-5 Field Trials in the United States and Canada, Part I: Study Design, Sampling Strategy, Implementation, and Analytic Approaches
inferredcites →https://doi.org/10.1176/appi.ajp.2017.17030283openalex-snapshot
Psychiatric Genomics: An Update and an Agenda
inferredcites →https://doi.org/10.1176/appi.ajp.2017.17060621openalex-snapshot
Molecular Genetic Analysis Subdivided by Adversity Exposure Suggests Etiologic Heterogeneity in Major Depression
inferredcites →https://doi.org/10.1186/1471-2458-9-376openalex-snapshot
Low validity of self-report in identifying recent mental health diagnosis among U.S. service members completing Pre-Deployment Health Assessment (PreDHA) and deployed to Afghanistan, 2007: a retrospective cohort study
inferredcites →https://doi.org/10.1186/s13742-015-0047-8openalex-snapshot
Second-generation PLINK: rising to the challenge of larger and richer datasets
inferredcites →https://doi.org/10.1192/bjo.2018.12openalex-snapshot
RETRACTED – Mental health in UK Biobank: development, implementation and results from an online questionnaire completed by 157 366 participants
inferredcites →https://doi.org/10.1371/journal.pmed.1001779openalex-snapshot
UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age
inferredcites →https://doi.org/10.1371/journal.pone.0075362openalex-snapshot
Prevalence and Characteristics of Probable Major Depression and Bipolar Disorder within UK Biobank: Cross-Sectional Study of 172,751 Participants
inferredcites →https://doi.org/10.1371/journal.pone.0093766openalex-snapshot
Fast Principal Component Analysis of Large-Scale Genome-Wide Data
inferredcites →https://doi.org/10.4088/jcp.12m08338openalex-snapshot
The Computerized Adaptive Diagnostic Test for Major Depressive Disorder (CAD-MDD)

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Polygenic Scores and Networks of Psychopathology Symptoms
inferred← citeshttps://doi.org/10.1007/s00401-019-02110-zopenalex-snapshot
Overlapping genetic architecture between Parkinson disease and melanoma
inferred← citeshttps://doi.org/10.1007/s11033-019-05119-5openalex-snapshot
Psychiatric disorders and SLC6A4 gene variants: possible effects on alcohol dependence and alzheimer’s disease
inferred← citeshttps://doi.org/10.1016/j.neulet.2020.134754openalex-snapshot
Genetic variants associated with psychotic symptoms across psychiatric disorders
inferred← citeshttps://doi.org/10.1016/j.neuron.2019.03.022openalex-snapshot
Uncovering the Genetic Architecture of Major Depression
inferred← citeshttps://doi.org/10.1016/j.pnpbp.2020.110170openalex-snapshot
Higher polygenic risk scores for schizophrenia may be suggestive of treatment non-response in major depressive disorder
inferred← citeshttps://doi.org/10.1016/j.socscimed.2019.112638openalex-snapshot
Understanding the population structure of the GHQ-12: Methodological considerations in dimensionally complex measurement outcomes
inferred← citeshttps://doi.org/10.1016/j.xgen.2022.100140openalex-snapshot
Multivariate GWAS of psychiatric disorders and their cardinal symptoms reveal two dimensions of cross-cutting genetic liabilities
inferred← citeshttps://doi.org/10.1017/s0033291719002502openalex-snapshot
Unraveling the genetic architecture of major depressive disorder: merits and pitfalls of the approaches used in genome-wide association studies
inferred← citeshttps://doi.org/10.1017/s0033291719002629openalex-snapshot
Genetic stratification of depression by neuroticism: revisiting a diagnostic tradition
inferred← citeshttps://doi.org/10.1017/s0033291719002678openalex-snapshot
Evidence for causal effects of lifetime smoking on risk for depression and schizophrenia: a Mendelian randomisation study
inferred← citeshttps://doi.org/10.1017/s0033291720005486openalex-snapshot
Genetic contributions to anxiety disorders: where we are and where we are heading
inferred← citeshttps://doi.org/10.1038/s41398-019-0450-5openalex-snapshot
The genetics of depression: successful genome-wide association studies introduce new challenges
inferred← citeshttps://doi.org/10.1038/s41398-021-01545-xopenalex-snapshot
Analysis of genetic differences between psychiatric disorders: exploring pathways and cell types/tissues involved and ability to differentiate the disorders by polygenic scores
inferred← citeshttps://doi.org/10.1038/s41398-022-01877-2openalex-snapshot
Characterizing mood disorders in the AFFECT study: a large, longitudinal, and phenotypically rich genetic cohort in the US
inferred← citeshttps://doi.org/10.1038/s41398-022-01926-wopenalex-snapshot
Structural neuroimaging measures and lifetime depression across levels of phenotyping in UK biobank
inferred← citeshttps://doi.org/10.1038/s41467-021-21280-7openalex-snapshot
GWAS of peptic ulcer disease implicates Helicobacter pylori infection, other gastrointestinal disorders and depression
inferred← citeshttps://doi.org/10.1038/s41467-021-21286-1openalex-snapshot
Population-specific causal disease effect sizes in functionally important regions impacted by selection
inferred← citeshttps://doi.org/10.1038/s41583-019-0221-6openalex-snapshot
The future of rodent models in depression research
inferred← citeshttps://doi.org/10.1038/s41593-020-0609-7openalex-snapshot
Emerging phenotyping strategies will advance our understanding of psychiatric genetics
inferred← citeshttps://doi.org/10.1038/s41598-021-85881-4openalex-snapshot
Genome-wide association study of psychiatric and substance use comorbidity in Mexican individuals
inferred← citeshttps://doi.org/10.1101/603134openalex-snapshot
Multivariate GWAS of psychiatric disorders and their cardinal symptoms reveal two dimensions of cross-cutting genetic liabilities
inferred← citeshttps://doi.org/10.1111/dme.14399openalex-snapshot
Understanding the relationship between type 2 diabetes and depression: lessons from genetically informative study designs
inferred← citeshttps://doi.org/10.1159/000527224openalex-snapshot
Inferring the Genetic Influences on Psychological Traits Using MRI Connectivity Predictive Models: Demonstration with Cognition
inferred← citeshttps://doi.org/10.7488/era/1179openalex-snapshot
Quantifying psychotropic treatment and illness outcome in cohort studies using record-linkage to administrative health data
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