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∆ 9 -tetrahydrocannabinol negatively regulates neurite outgrowth and Akt signaling in hiPSC-derived cortical neurons

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/embj.201386035openalex-snapshot
Miswiring the brain: Δ9‐tetrahydrocannabinol disrupts cortical development by inducing an SCG10/stathmin‐2 degradation pathway
inferredcites →https://doi.org/10.1007/3-540-26573-2_2openalex-snapshot
Cannabinoid Receptor Signaling
inferredcites →https://doi.org/10.1007/s00213-013-3196-4openalex-snapshot
The utility of patient specific induced pluripotent stem cells for the modelling of Autistic Spectrum Disorders
inferredcites →https://doi.org/10.1016/j.bbamcr.2011.01.027openalex-snapshot
Essential role of ERK activation in neurite outgrowth induced by α-lipoic acid
inferredcites →https://doi.org/10.1016/j.biopsych.2015.07.028openalex-snapshot
An Introduction to the Endogenous Cannabinoid System
inferredcites →https://doi.org/10.1016/j.biopsych.2015.08.001openalex-snapshot
Association Between Cannabis and Psychosis: Epidemiologic Evidence
inferredcites →https://doi.org/10.1016/j.biopsych.2016.08.038openalex-snapshot
Psychosis Risk Candidate ZNF804A Localizes to Synapses and Regulates Neurite Formation and Dendritic Spine Structure
inferredcites →https://doi.org/10.1016/j.cell.2006.07.024openalex-snapshot
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
inferredcites →https://doi.org/10.1016/j.cell.2007.11.019openalex-snapshot
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
inferredcites →https://doi.org/10.1016/j.ejca.2008.10.010openalex-snapshot
A high cannabinoid CB1 receptor immunoreactivity is associated with disease severity and outcome in prostate cancer
inferredcites →https://doi.org/10.1016/j.exer.2015.05.007openalex-snapshot
Synthetic and endogenous cannabinoids protect retinal neurons from AMPA excitotoxicity in vivo, via activation of CB1 receptors: Involvement of PI3K/Akt and MEK/ERK signaling pathways
inferredcites →https://doi.org/10.1016/j.mcn.2008.02.001openalex-snapshot
The endocannabinoid receptor, CB1, is required for normal axonal growth and fasciculation
inferredcites →https://doi.org/10.1016/j.phymed.2012.04.002openalex-snapshot
Effects of cannabinoids Δ(9)-tetrahydrocannabinol, Δ(9)-tetrahydrocannabinolic acid and cannabidiol in MPP+ affected murine mesencephalic cultures
inferredcites →https://doi.org/10.1016/j.yhbeh.2015.06.014openalex-snapshot
Utilizing induced pluripotent stem cells (iPSCs) to understand the actions of estrogens in human neurons
inferredcites →https://doi.org/10.1016/s0896-6273(01)00246-xopenalex-snapshot
Retrograde Inhibition of Presynaptic Calcium Influx by Endogenous Cannabinoids at Excitatory Synapses onto Purkinje Cells
inferredcites →https://doi.org/10.1016/s0896-6273(01)00247-1openalex-snapshot
Endogenous Cannabinoids Mediate Retrograde Signals from Depolarized Postsynaptic Neurons to Presynaptic Terminals
inferredcites →https://doi.org/10.1016/s0896-6273(03)00235-6openalex-snapshot
Heterosynaptic LTD of Hippocampal GABAergic Synapses
inferredcites →https://doi.org/10.1016/s0898-6568(03)00036-6openalex-snapshot
Activation of phosphoinositide 3-kinase/PKB pathway by CB1 and CB2 cannabinoid receptors expressed in prostate PC-3 cells. Involvement in Raf-1 stimulation and NGF induction
inferredcites →https://doi.org/10.1017/s0033291715001786openalex-snapshot
Abnormalities in neuroendocrine stress response in psychosis: the role of endocannabinoids
inferredcites →https://doi.org/10.1038/346561a0openalex-snapshot
Structure of a cannabinoid receptor and functional expression of the cloned cDNA
inferredcites →https://doi.org/10.1038/mp.2016.252openalex-snapshot
Cannabis use and risk of schizophrenia: a Mendelian randomization study
inferredcites →https://doi.org/10.1038/mp.2017.185openalex-snapshot
Stem cell-derived neurons from autistic individuals with SHANK3 mutation show morphogenetic abnormalities during early development
inferredcites →https://doi.org/10.1038/mp.2017.66openalex-snapshot
An update on stem cell biology and engineering for brain development
inferredcites →https://doi.org/10.1038/s41398-018-0137-3openalex-snapshot
THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders
inferredcites →https://doi.org/10.1038/s41593-018-0206-1openalex-snapshot
GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal effect of schizophrenia liability
inferredcites →https://doi.org/10.1042/bj3120637openalex-snapshot
Activation of mitogen-activated protein kinases by stimulation of the central cannabinoid receptor CB1
inferredcites →https://doi.org/10.1074/jbc.m109.049841openalex-snapshot
Cannabinoid 1 Receptor and Interleukin-6 Receptor Together Induce Integration of Protein Kinase and Transcription Factor Signaling to Trigger Neurite Outgrowth
inferredcites →https://doi.org/10.1074/jbc.m709930200openalex-snapshot
Clathrin-dependent Endocytosis Is Required for TrkB-dependent Akt-mediated Neuronal Protection and Dendritic Growth
inferredcites →https://doi.org/10.1111/adb.12394openalex-snapshot
Functional effects of cannabinoids during dopaminergic specification of human neural precursors derived from induced pluripotent stem cells
inferredcites →https://doi.org/10.1111/j.1460-9568.2008.06484.xopenalex-snapshot
The type 1 cannabinoid receptor is highly expressed in embryonic cortical projection neurons and negatively regulates neurite growth in vitro
inferredcites →https://doi.org/10.1111/j.1460-9568.2010.07337.xopenalex-snapshot
Requirement of cannabinoid CB1 receptors in cortical pyramidal neurons for appropriate development of corticothalamic and thalamocortical projections
inferredcites →https://doi.org/10.1111/j.1471-4159.2007.04642.xopenalex-snapshot
Regulation of PI3K/Akt/GSK‐3 pathway by cannabinoids in the brain
inferredcites →https://doi.org/10.1124/pr.110.003004openalex-snapshot
International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2
inferredcites →https://doi.org/10.1124/pr.110.003491openalex-snapshot
The Highs and Lows of Cannabinoid Receptor Expression in Disease: Mechanisms and Their Therapeutic Implications
inferredcites →https://doi.org/10.1159/000339075openalex-snapshot
Type-1 Cannabinoid Receptor Signaling in Neuronal Development
inferredcites →https://doi.org/10.1159/000477762openalex-snapshot
THC Treatment Alters Glutamate Receptor Gene Expression in Human Stem Cell-Derived Neurons
inferredcites →https://doi.org/10.1371/journal.pbio.1002286openalex-snapshot
The Cannabinoid Receptor CB1 Interacts with the WAVE1 Complex and Plays a Role in Actin Dynamics and Structural Plasticity in Neurons
inferredcites →https://doi.org/10.1371/journal.pone.0024731openalex-snapshot
Increased Expression of Cannabinoid CB1 Receptors in Achilles Tendinosis
inferredcites →https://doi.org/10.1523/jneurosci.20-23-08932.2000openalex-snapshot
Cannabinoids Reveal the Necessity of Hippocampal Neural Encoding for Short-Term Memory in Rats
inferredcites →https://doi.org/10.1523/jneurosci.23-06-02371.2003openalex-snapshot
Regulation of Extracellular Signal-Regulated Kinase by Cannabinoids in Hippocampus
inferredcites →https://doi.org/10.1523/jneurosci.4134-09.2011openalex-snapshot
Concerted Action of CB1 Cannabinoid Receptor and Deleted in Colorectal Cancer in Axon Guidance
inferredcites →https://doi.org/10.1523/jneurosci.4884-11.2012openalex-snapshot
Dock3 Stimulates Axonal Outgrowth via GSK-3β-Mediated Microtubule Assembly
inferredcites →https://doi.org/10.7554/elife.03159openalex-snapshot
Cannabinoid-induced actomyosin contractility shapes neuronal morphology and growth

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1101/789321openalex-snapshot
Antiviral signalling in human IPSC-derived neurons recapitulates neurodevelopmental disorder phenotypes
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