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NKX2.1 is critical for melanocortin neuron identity, hypothalamic Pomc expression and body weight

https://doi.org/10.1101/460501
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Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/1873-3468.12776openalex-snapshot
Molecular and functional genetics of the proopiomelanocortin gene, food intake regulation and obesity
inferredcites →https://doi.org/10.1002/9780470515075.ch19openalex-snapshot
Mixed‐Effects Models
inferredcites →https://doi.org/10.1002/cne.22132openalex-snapshot
Arcuate nucleus expression of NKX2.1 and DLX and lineages expressing these transcription factors in neuropeptide Y+, proopiomelanocortin+, and tyrosine hydroxylase+ neurons in neonatal and adult mice
inferredcites →https://doi.org/10.1006/dbio.2002.0597openalex-snapshot
Efficient Recombination in Diverse Tissues by a Tamoxifen-Inducible Form of Cre: A Tool for Temporally Regulated Gene Activation/Inactivation in the Mouse
inferredcites →https://doi.org/10.1006/mcne.2000.0933openalex-snapshot
TTF-1, a Homeodomain Gene Required for Diencephalic Morphogenesis, Is Postnatally Expressed in the Neuroendocrine Brain in a Developmentally Regulated and Cell-Specific Fashion
inferredcites →https://doi.org/10.1007/s001250051568openalex-snapshot
Linkage and association studies between the proopiomelanocortin (POMC) gene and obesity in caucasian families
inferredcites →https://doi.org/10.1007/s12311-014-0570-7openalex-snapshot
A Novel De Novo Mutation of the TITF1/NKX2-1 Gene Causing Ataxia, Benign Hereditary Chorea, Hypothyroidism and a Pituitary Mass in a UK Family and Review of the Literature
inferredcites →https://doi.org/10.1016/j.cell.2015.01.033openalex-snapshot
Sensory Detection of Food Rapidly Modulates Arcuate Feeding Circuits
inferredcites →https://doi.org/10.1016/j.ejphar.2010.10.114openalex-snapshot
The estrogen receptor α colocalizes with proopiomelanocortin in hypothalamic neurons and binds to a conserved motif present in the neuron-specific enhancer nPE2
inferredcites →https://doi.org/10.1016/j.molmet.2016.07.012openalex-snapshot
Reprogramming the body weight set point by a reciprocal interaction of hypothalamic leptin sensitivity and Pomc gene expression reverts extreme obesity
inferredcites →https://doi.org/10.1016/j.molmet.2017.01.001openalex-snapshot
Cholinergic neurons in the dorsomedial hypothalamus regulate food intake
inferredcites →https://doi.org/10.1016/j.ydbio.2016.05.021openalex-snapshot
Essential function of the transcription factor Rax in the early patterning of the mammalian hypothalamus
inferredcites →https://doi.org/10.1016/s0092-8674(00)81865-6openalex-snapshot
Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice
inferredcites →https://doi.org/10.1038/12506openalex-snapshot
Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin
inferredcites →https://doi.org/10.1038/35078085openalex-snapshot
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
inferredcites →https://doi.org/10.1038/509openalex-snapshot
Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans
inferredcites →https://doi.org/10.1038/nature13138openalex-snapshot
Obesity-associated variants within FTO form long-range functional connections with IRX3
inferredcites →https://doi.org/10.1038/ng.2607openalex-snapshot
Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity
inferredcites →https://doi.org/10.1038/ng.274openalex-snapshot
Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
inferredcites →https://doi.org/10.1038/ng.3437openalex-snapshot
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci
inferredcites →https://doi.org/10.1038/ng0397-273openalex-snapshot
A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2
inferredcites →https://doi.org/10.1038/nn.2739openalex-snapshot
AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training
inferredcites →https://doi.org/10.1038/nn.3467openalex-snapshot
Synergistic binding of transcription factors to cell-specific enhancers programs motor neuron identity
inferredcites →https://doi.org/10.1073/pnas.1104997108openalex-snapshot
Convergent evolution of two mammalian neuronal enhancers by sequential exaptation of unrelated retroposons
inferredcites →https://doi.org/10.1073/pnas.1308275110openalex-snapshot
The LIM homeobox gene Isl1 is required for the correct development of the striatonigral pathway in the mouse
inferredcites →https://doi.org/10.1073/pnas.1500672112openalex-snapshot
Islet 1 specifies the identity of hypothalamic melanocortin neurons and is critical for normal food intake and adiposity in adulthood
inferredcites →https://doi.org/10.1101/gad.10.1.60openalex-snapshot
The T/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary.
inferredcites →https://doi.org/10.1111/j.1467-789x.2008.00481.xopenalex-snapshot
FTO: the first gene contributing to common forms of human obesity
inferredcites →https://doi.org/10.1126/science.1072327openalex-snapshot
Activation of Central Melanocortin Pathways by Fenfluramine
inferredcites →https://doi.org/10.1128/mcb.25.8.3076-3086.2005openalex-snapshot
Identification of Neuronal Enhancers of the Proopiomelanocortin Gene by Transgenic Mouse Analysis and Phylogenetic Footprinting
inferredcites →https://doi.org/10.1172/jci200524301openalex-snapshot
PI3K integrates the action of insulin and leptin on hypothalamic neurons
inferredcites →https://doi.org/10.1172/jci62543openalex-snapshot
Obesity-programmed mice are rescued by early genetic intervention
inferredcites →https://doi.org/10.1172/jci79220openalex-snapshot
Differentiation of hypothalamic-like neurons from human pluripotent stem cells
inferredcites →https://doi.org/10.1172/jci9397openalex-snapshot
Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency
inferredcites →https://doi.org/10.1177/42.8.8027530openalex-snapshot
In situ hybridization analysis of anterior pituitary hormone gene expression during fetal mouse development.
inferredcites →https://doi.org/10.1210/en.2002-221033openalex-snapshot
Hypothalamic Proopiomelanocortin Neurons Are Glucose Responsive and Express KATPChannels
inferredcites →https://doi.org/10.1210/jc.84.9.3187openalex-snapshot
Normal Variation in Leptin Levels Is Associated with Polymorphisms in the Proopiomelanocortin Gene, POMC
inferredcites →https://doi.org/10.1210/jcem.84.9.5951openalex-snapshot
Normal Variation in Leptin Levels Is Associated with Polymorphisms in the Proopiomelanocortin Gene,POMC1
inferredcites →https://doi.org/10.1210/me.16.4.837openalex-snapshot
The Synergistic Activity of Thyroid Transcription Factor 1 and Pax 8 Relies on the Promoter/Enhancer Interplay
inferredcites →https://doi.org/10.1210/me.2005-0327openalex-snapshot
Thyroid-Specific Enhancer-Binding Protein/NKX2.1 Is Required for the Maintenance of Ordered Architecture and Function of the Differentiated Thyroid
inferredcites →https://doi.org/10.1242/dev.02322openalex-snapshot
Isl1Cre reveals a common Bmp pathway in heart and limb development
inferredcites →https://doi.org/10.1242/dev.117978openalex-snapshot
Generation of neuropeptidergic hypothalamic neurons from human pluripotent stem cells
inferredcites →https://doi.org/10.1242/dev.126.15.3359openalex-snapshot
Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatum
inferredcites →https://doi.org/10.1242/dev.129.3.761openalex-snapshot
Patterning of the basal telencephalon and hypothalamus is essential for guidance of cortical projections
inferredcites →https://doi.org/10.1242/dev.133967openalex-snapshot
The LIM-homeobox transcription factor Isl1 plays crucial roles in the development of multiple arcuate nucleus neurons
inferredcites →https://doi.org/10.1371/journal.pbio.2004399openalex-snapshot
Activation of temperature-sensitive TRPV1-like receptors in ARC POMC neurons reduces food intake
inferredcites →https://doi.org/10.1371/journal.pgen.0030115openalex-snapshot
Genome-Wide Association Scan Shows Genetic Variants in the FTO Gene Are Associated with Obesity-Related Traits
inferredcites →https://doi.org/10.1371/journal.pgen.0030166openalex-snapshot
Ancient Exaptation of a CORE-SINE Retroposon into a Highly Conserved Mammalian Neuronal Enhancer of the Proopiomelanocortin Gene
inferredcites →https://doi.org/10.1371/journal.pgen.1004280openalex-snapshot
Isl1 Directly Controls a Cholinergic Neuronal Identity in the Developing Forebrain and Spinal Cord by Forming Cell Type-Specific Complexes
inferredcites →https://doi.org/10.1371/journal.pgen.1004935openalex-snapshot
Partially Redundant Enhancers Cooperatively Maintain Mammalian Pomc Expression Above a Critical Functional Threshold
inferredcites →https://doi.org/10.1523/jneurosci.0647-17.2017openalex-snapshot
The Relevance of AgRP Neuron-Derived GABA Inputs to POMC Neurons Differs for Spontaneous and Evoked Release
inferredcites →https://doi.org/10.1523/jneurosci.18-17-06631.1998openalex-snapshot
Authentic Cell-Specific and Developmentally Regulated Expression of Pro-Opiomelanocortin Genomic Fragments in Hypothalamic and Hindbrain Neurons of Transgenic Mice
inferredcites →https://doi.org/10.1523/jneurosci.22-20-09048.2002openalex-snapshot
The Catabolic Action of Insulin in the Brain Is Mediated by Melanocortins
inferredcites →https://doi.org/10.2337/diabetes.48.3.643openalex-snapshot
The quantitative trait locus on chromosome 2 for serum leptin levels is confirmed in African-Americans.
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